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The map label for this gene is ppiB [H]

Identifier: 15888986

GI number: 15888986

Start: 1667571

End: 1668140

Strand: Reverse

Name: ppiB [H]

Synonym: Atu1680

Alternate gene names: 15888986

Gene position: 1668140-1667571 (Counterclockwise)

Preceding gene: 15888987

Following gene: 15888985

Centisome position: 58.7

GC content: 60.53

Gene sequence:

>570_bases
ATGAAACTCGTTCGATTTGCCTTTGCCGGCGCCCTGTTTGCCGGCGCGCTTGCCGCCAGCACTTTTGCTTCGGCTGCTGA
ACTTCTGACCGTCCAGCTGAAGGACGGCCCTGTTGTCATCGAACTGATGCCTCAGGTTGCGCCCAAGCATGTGGCGCAGA
TCGAGGCGCTGGCGAAAAAGGGCGCTTATGACAACGTTGCCTTCCACCGCGTCATCGACGGGTTCATGGCGCAGACCGGT
GACGTTCAGTATGGCAACATGGAGAAGGGCTTCAATGCCCAGCGCGCCGGCACCGGCGGCTCCGACATGGCCGATATTCC
GGCTGAATTCTCCAAGACACCGTTCACCCGCGGCGTGGTCGGCATGGCTCGCTCCAGCGATCCGAATTCCGCCAATTCGC
AGTTCTTCATCATGTTTGCCGACGGTCCGTTCCTGAACGGTCAGTACACCGTGGTCGGCAAGGTCGTGTCCGGCATGGAA
GCCGTGGACAAGATCAAGCGCGGCGCCGGCGGCAACGGCGAAGTTTCCAACCCCGACCGGATGATCAAGGTCACCGTCGG
CAAGAAGTAA

Upstream 100 bases:

>100_bases
TGGGCGGCAATGTCGATGCCTTCGTGCCGAAAGCCGTGCTTGAAGCCCTCAACGCCAAGCTGAAGCGCTGACTTCAGCCT
TACATTCTGGAGCCAATCCG

Downstream 100 bases:

>100_bases
GGTAGGGCAATAGAGCCCGAAAAGAGGAGAATAACCATGACCGAGATCAAGGATCCGGAAAACACCATCATCATGGAAAC
GACGACCGGTAAGGTCGTGA

Product: peptidyl prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MKLVRFAFAGALFAGALAASTFASAAELLTVQLKDGPVVIELMPQVAPKHVAQIEALAKKGAYDNVAFHRVIDGFMAQTG
DVQYGNMEKGFNAQRAGTGGSDMADIPAEFSKTPFTRGVVGMARSSDPNSANSQFFIMFADGPFLNGQYTVVGKVVSGME
AVDKIKRGAGGNGEVSNPDRMIKVTVGKK

Sequences:

>Translated_189_residues
MKLVRFAFAGALFAGALAASTFASAAELLTVQLKDGPVVIELMPQVAPKHVAQIEALAKKGAYDNVAFHRVIDGFMAQTG
DVQYGNMEKGFNAQRAGTGGSDMADIPAEFSKTPFTRGVVGMARSSDPNSANSQFFIMFADGPFLNGQYTVVGKVVSGME
AVDKIKRGAGGNGEVSNPDRMIKVTVGKK
>Mature_189_residues
MKLVRFAFAGALFAGALAASTFASAAELLTVQLKDGPVVIELMPQVAPKHVAQIEALAKKGAYDNVAFHRVIDGFMAQTG
DVQYGNMEKGFNAQRAGTGGSDMADIPAEFSKTPFTRGVVGMARSSDPNSANSQFFIMFADGPFLNGQYTVVGKVVSGME
AVDKIKRGAGGNGEVSNPDRMIKVTVGKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=146, Percent_Identity=34.9315068493151, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI5031987, Length=147, Percent_Identity=36.734693877551, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI24308049, Length=137, Percent_Identity=33.5766423357664, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI4505991, Length=173, Percent_Identity=34.6820809248555, Blast_Score=68, Evalue=4e-12,
Organism=Homo sapiens, GI10863927, Length=149, Percent_Identity=34.8993288590604, Blast_Score=67, Evalue=7e-12,
Organism=Homo sapiens, GI7706339, Length=151, Percent_Identity=31.1258278145695, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=152, Percent_Identity=34.8684210526316, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1789763, Length=166, Percent_Identity=37.3493975903614, Blast_Score=78, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71980590, Length=142, Percent_Identity=33.0985915492958, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71980594, Length=142, Percent_Identity=33.0985915492958, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=139, Percent_Identity=33.0935251798561, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=153, Percent_Identity=32.6797385620915, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17566266, Length=154, Percent_Identity=33.7662337662338, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539496, Length=138, Percent_Identity=31.1594202898551, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=136, Percent_Identity=36.7647058823529, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=137, Percent_Identity=37.2262773722628, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6322492, Length=162, Percent_Identity=30.2469135802469, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17986117, Length=168, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19922376, Length=152, Percent_Identity=33.5526315789474, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19922912, Length=149, Percent_Identity=34.2281879194631, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24664125, Length=149, Percent_Identity=35.5704697986577, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21357783, Length=149, Percent_Identity=35.5704697986577, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19882; Mature: 19882

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVRFAFAGALFAGALAASTFASAAELLTVQLKDGPVVIELMPQVAPKHVAQIEALAKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHC
GAYDNVAFHRVIDGFMAQTGDVQYGNMEKGFNAQRAGTGGSDMADIPAEFSKTPFTRGVV
CCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHH
GMARSSDPNSANSQFFIMFADGPFLNGQYTVVGKVVSGMEAVDKIKRGAGGNGEVSNPDR
HCCCCCCCCCCCCEEEEEEECCCEECCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
MIKVTVGKK
EEEEEECCC
>Mature Secondary Structure
MKLVRFAFAGALFAGALAASTFASAAELLTVQLKDGPVVIELMPQVAPKHVAQIEALAKK
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHC
GAYDNVAFHRVIDGFMAQTGDVQYGNMEKGFNAQRAGTGGSDMADIPAEFSKTPFTRGVV
CCCCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHH
GMARSSDPNSANSQFFIMFADGPFLNGQYTVVGKVVSGMEAVDKIKRGAGGNGEVSNPDR
HCCCCCCCCCCCCEEEEEEECCCEECCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCE
MIKVTVGKK
EEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA