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The map label for this gene is uppS

Identifier: 15888704

GI number: 15888704

Start: 1371567

End: 1372310

Strand: Direct

Name: uppS

Synonym: Atu1378

Alternate gene names: 15888704

Gene position: 1371567-1372310 (Clockwise)

Preceding gene: 15888703

Following gene: 15888705

Centisome position: 48.27

GC content: 61.42

Gene sequence:

>744_bases
ATGCCGACGACGACACGTTCCTCCATACCCGAGCACGTCGCCATCATCATGGATGGCAATGGCCGCTGGGCAAAGCAGCG
CGGACTTCCGCGCGTGATGGGGCATCGCCGTGGGGTTGAGGCCGTGCGCGAGACTGTGCGTGCGGCAGGCGACTGCGGTA
TCAGCTATCTCACGCTGTTCGCTTTCTCCTCGGAAAACTGGCGCAGACCCGAATCCGAGGTGAGCGATCTGATGGGCCTT
CTGAAGGCCTTCATCCGTCGCGACCTTGCGGAACTTCATCGCGAAAATGTCCGCGTGCGGATCATCGGCGACCGGCAGGG
GCTGAAGACCGATATACGCTCTCTCCTCGAAGAGGCGGAGCAGATGACGGCTGGCAATACCAAGCTGACGCTGGTGATCG
CCTTTAATTACGGCAGCCGTGACGAGATTACCCGCGCGACAGCGTCAATCGCCCGTGATGTCGCCGAAGGCCGGCTCAGT
GCTGACGCCATTACGCCTGAGATGATTTCGTCGAGGCTCGATACATCGGGAATGCCGGATCCGGATCTCATCATCCGCAC
CAGCGGCGAGGAGCGCCTGTCGAACTTCCTGCTCTGGCAGGCAGCCTATTCCGAGTTCCTGTTCGTGCCGGAATATTGGC
CCGACTTCGACCGCCAGCGGTTCTTCTCCGCAATTGAGCAATATGCAACGCGTGACCGCCGCTTCGGTGCTCTGGCCGAG
CAGGTTGCCGTGGCAGGCGCCTGA

Upstream 100 bases:

>100_bases
CTTGCCGAGAAGGAAAAGGAAATCATGCAGGTCTGATATCGCTCGCGATAGACCTGTATTTTATTCGTTTTAATTCCGCG
CTGCCTGTTACTGGATCGAT

Downstream 100 bases:

>100_bases
TGAGCCGTGAACTCAAACTGCGGATCGTGTCCGCAATCGTCATGGCCGCGGTCATTCTGGCCGCGACCTGGTATGGTGGC
ATTCTGTTCCGCATCGTTGC

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MPTTTRSSIPEHVAIIMDGNGRWAKQRGLPRVMGHRRGVEAVRETVRAAGDCGISYLTLFAFSSENWRRPESEVSDLMGL
LKAFIRRDLAELHRENVRVRIIGDRQGLKTDIRSLLEEAEQMTAGNTKLTLVIAFNYGSRDEITRATASIARDVAEGRLS
ADAITPEMISSRLDTSGMPDPDLIIRTSGEERLSNFLLWQAAYSEFLFVPEYWPDFDRQRFFSAIEQYATRDRRFGALAE
QVAVAGA

Sequences:

>Translated_247_residues
MPTTTRSSIPEHVAIIMDGNGRWAKQRGLPRVMGHRRGVEAVRETVRAAGDCGISYLTLFAFSSENWRRPESEVSDLMGL
LKAFIRRDLAELHRENVRVRIIGDRQGLKTDIRSLLEEAEQMTAGNTKLTLVIAFNYGSRDEITRATASIARDVAEGRLS
ADAITPEMISSRLDTSGMPDPDLIIRTSGEERLSNFLLWQAAYSEFLFVPEYWPDFDRQRFFSAIEQYATRDRRFGALAE
QVAVAGA
>Mature_246_residues
PTTTRSSIPEHVAIIMDGNGRWAKQRGLPRVMGHRRGVEAVRETVRAAGDCGISYLTLFAFSSENWRRPESEVSDLMGLL
KAFIRRDLAELHRENVRVRIIGDRQGLKTDIRSLLEEAEQMTAGNTKLTLVIAFNYGSRDEITRATASIARDVAEGRLSA
DAITPEMISSRLDTSGMPDPDLIIRTSGEERLSNFLLWQAAYSEFLFVPEYWPDFDRQRFFSAIEQYATRDRRFGALAEQ
VAVAGA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=39.4618834080717, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=39.4618834080717, Blast_Score=166, Evalue=1e-41,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=49.1150442477876, Blast_Score=224, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71993029, Length=225, Percent_Identity=37.3333333333333, Blast_Score=144, Evalue=4e-35,
Organism=Saccharomyces cerevisiae, GI6323748, Length=255, Percent_Identity=30.9803921568627, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=215, Percent_Identity=35.3488372093023, Blast_Score=113, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=39.0350877192982, Blast_Score=155, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_AGRT5 (Q8UFL9)

Other databases:

- EMBL:   AE007869
- PIR:   A97527
- PIR:   AB2746
- RefSeq:   NP_354385.1
- ProteinModelPortal:   Q8UFL9
- SMR:   Q8UFL9
- STRING:   Q8UFL9
- GeneID:   1133416
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1378
- eggNOG:   COG0020
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- PhylomeDB:   Q8UFL9
- BioCyc:   ATUM176299-1:ATU1378-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 27815; Mature: 27684

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 18-18

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTTTRSSIPEHVAIIMDGNGRWAKQRGLPRVMGHRRGVEAVRETVRAAGDCGISYLTLF
CCCCCCCCCCCEEEEEECCCCCCHHHCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHH
AFSSENWRRPESEVSDLMGLLKAFIRRDLAELHRENVRVRIIGDRQGLKTDIRSLLEEAE
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHH
QMTAGNTKLTLVIAFNYGSRDEITRATASIARDVAEGRLSADAITPEMISSRLDTSGMPD
HHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHCCCCCCCC
PDLIIRTSGEERLSNFLLWQAAYSEFLFVPEYWPDFDRQRFFSAIEQYATRDRRFGALAE
CCEEEECCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QVAVAGA
HHHHCCC
>Mature Secondary Structure 
PTTTRSSIPEHVAIIMDGNGRWAKQRGLPRVMGHRRGVEAVRETVRAAGDCGISYLTLF
CCCCCCCCCCEEEEEECCCCCCHHHCCCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHH
AFSSENWRRPESEVSDLMGLLKAFIRRDLAELHRENVRVRIIGDRQGLKTDIRSLLEEAE
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHH
QMTAGNTKLTLVIAFNYGSRDEITRATASIARDVAEGRLSADAITPEMISSRLDTSGMPD
HHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHCCCCCCCC
PDLIIRTSGEERLSNFLLWQAAYSEFLFVPEYWPDFDRQRFFSAIEQYATRDRRFGALAE
CCEEEECCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QVAVAGA
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194