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The map label for this gene is nuoH

Identifier: 15888606

GI number: 15888606

Start: 1264347

End: 1265393

Strand: Direct

Name: nuoH

Synonym: Atu1277

Alternate gene names: 15888606

Gene position: 1264347-1265393 (Clockwise)

Preceding gene: 159184690

Following gene: 15888607

Centisome position: 44.49

GC content: 59.31

Gene sequence:

>1047_bases
ATGGAACAGTTTTTCTGGAGCTACGTCTGGCCCGCGCTGATCATGGTCGGCCAGTCCCTGCTGCTTCTCGTTTGCCTTCT
GGTGGCCATCGCCTTCCTGCTGCTTGCCGACCGTAAGGTCTGGGCAGCCGTGCAGCTGCGCCGTGGTCCGAACGTCGTTG
GTCCCTTCGGTCTCTTCCAGTCCTTCGCCGACCTCTTGAAGTTCATCCTGAAGGAGCCCGTCATTCCGGCCGGCGCCAAC
AAGGCGGTCTTCCTTCTGGCGCCGCTGGTTGCCGTGACGCTGGCGCTCGCTACCTATGCCGTTATTCCGTTTGCGGATGG
CTGGGTCGTCGCCAATATCAATGTCGGCATTCTCTACATCTTCGCGATTTCCTCGCTTGAAGTGTACGGCATCATCATGG
GCGGCTGGGCTTCGAACTCGAAGTATCCGTTCCTTGGCGCGCTGCGTTCGGCCGCGCAGATGGTGTCCTACGAAGTGTCG
ATCGGTCTCGTCATCGTTACCGTTCTGCTCTGCGTCGGCTCGCTGAACCTGACGGACATCGTTCTTGCCCAGCGCACCGG
GCTCGGCACCATGATGGGTCTGCCGGCCTCGTTCCTCGACTGGCACTGGCTGTCGCTGTTCCCGATGTTCATCGTGTTCT
TCATTTCCGGCCTTGCCGAAACCAACCGTCCGCCCTTCGATCTTCCGGAAGCGGAATCGGAACTGGTCGCCGGTCACATG
GTCGAATATGGCTCGACGCCTTACATGATGTTCATGCTCGGCGAATATGCTGCGATCGTCCTGATCTGCTGCCTGACGAC
GATCCTGTTCCTCGGCGGCTGGCTGCCGATCGTGGATGTGTGGTTCCTGAACTGGGTTCCGGGCATTGTCTGGTTCGCGT
TGAAGGGCTGCATGGTCTTCTTCATGATCGCGCTCACCAAGGCTTTCGTTCCGCGTTACCGTTATGACCAGCTCATGCGC
CTTGGCTGGAAGGTCTTCCTGCCGCTGTCGCTCGCCATGGTCGTTATTGTTGCATTCGTATTGAAGCTGACGGGGTGGGC
CGGTTGA

Upstream 100 bases:

>100_bases
TTGACGAACCCGATTGCGCGCGCCTCAGCTGTGATGGCCGAGTGCTCCGCATTGGCCCGCAACAATTTCCAGGCTGCGGC
AGAGTAAGGGTAGGGGATTT

Downstream 100 bases:

>100_bases
TGTCTGTATTCCCCGCGCAGAAATCTGGAGACTGAGATGGCAAGCCTCTCCCAAGCCGTCAACTCGCTGTTCCTGAAGGA
ATTCGTAGGCGCGATCTTCC

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 348; Mature: 348

Protein sequence:

>348_residues
MEQFFWSYVWPALIMVGQSLLLLVCLLVAIAFLLLADRKVWAAVQLRRGPNVVGPFGLFQSFADLLKFILKEPVIPAGAN
KAVFLLAPLVAVTLALATYAVIPFADGWVVANINVGILYIFAISSLEVYGIIMGGWASNSKYPFLGALRSAAQMVSYEVS
IGLVIVTVLLCVGSLNLTDIVLAQRTGLGTMMGLPASFLDWHWLSLFPMFIVFFISGLAETNRPPFDLPEAESELVAGHM
VEYGSTPYMMFMLGEYAAIVLICCLTTILFLGGWLPIVDVWFLNWVPGIVWFALKGCMVFFMIALTKAFVPRYRYDQLMR
LGWKVFLPLSLAMVVIVAFVLKLTGWAG

Sequences:

>Translated_348_residues
MEQFFWSYVWPALIMVGQSLLLLVCLLVAIAFLLLADRKVWAAVQLRRGPNVVGPFGLFQSFADLLKFILKEPVIPAGAN
KAVFLLAPLVAVTLALATYAVIPFADGWVVANINVGILYIFAISSLEVYGIIMGGWASNSKYPFLGALRSAAQMVSYEVS
IGLVIVTVLLCVGSLNLTDIVLAQRTGLGTMMGLPASFLDWHWLSLFPMFIVFFISGLAETNRPPFDLPEAESELVAGHM
VEYGSTPYMMFMLGEYAAIVLICCLTTILFLGGWLPIVDVWFLNWVPGIVWFALKGCMVFFMIALTKAFVPRYRYDQLMR
LGWKVFLPLSLAMVVIVAFVLKLTGWAG
>Mature_348_residues
MEQFFWSYVWPALIMVGQSLLLLVCLLVAIAFLLLADRKVWAAVQLRRGPNVVGPFGLFQSFADLLKFILKEPVIPAGAN
KAVFLLAPLVAVTLALATYAVIPFADGWVVANINVGILYIFAISSLEVYGIIMGGWASNSKYPFLGALRSAAQMVSYEVS
IGLVIVTVLLCVGSLNLTDIVLAQRTGLGTMMGLPASFLDWHWLSLFPMFIVFFISGLAETNRPPFDLPEAESELVAGHM
VEYGSTPYMMFMLGEYAAIVLICCLTTILFLGGWLPIVDVWFLNWVPGIVWFALKGCMVFFMIALTKAFVPRYRYDQLMR
LGWKVFLPLSLAMVVIVAFVLKLTGWAG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=307, Percent_Identity=41.042345276873, Blast_Score=228, Evalue=5e-60,
Organism=Escherichia coli, GI1788618, Length=340, Percent_Identity=39.4117647058824, Blast_Score=236, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_AGRT5 (Q8UFX0)

Other databases:

- EMBL:   AE007869
- PIR:   AE2733
- PIR:   G97514
- RefSeq:   NP_354287.1
- STRING:   Q8UFX0
- GeneID:   1133315
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1277
- eggNOG:   COG1005
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- PhylomeDB:   Q8UFX0
- ProtClustDB:   PRK06076
- BioCyc:   ATUM176299-1:ATU1277-MONOMER
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 38449; Mature: 38449

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe429e00)-; HASH(0xe9dd6b8)-; HASH(0xe7c3310)-; HASH(0xe6a6228)-; HASH(0xb4fa0f4)-; HASH(0xe9dd604)-; HASH(0xe8beb8c)-; HASH(0xe010bc8)-; HASH(0xd50d8f4)-;

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQFFWSYVWPALIMVGQSLLLLVCLLVAIAFLLLADRKVWAAVQLRRGPNVVGPFGLFQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHH
SFADLLKFILKEPVIPAGANKAVFLLAPLVAVTLALATYAVIPFADGWVVANINVGILYI
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHH
FAISSLEVYGIIMGGWASNSKYPFLGALRSAAQMVSYEVSIGLVIVTVLLCVGSLNLTDI
HHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VLAQRTGLGTMMGLPASFLDWHWLSLFPMFIVFFISGLAETNRPPFDLPEAESELVAGHM
HHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
VEYGSTPYMMFMLGEYAAIVLICCLTTILFLGGWLPIVDVWFLNWVPGIVWFALKGCMVF
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMIALTKAFVPRYRYDQLMRLGWKVFLPLSLAMVVIVAFVLKLTGWAG
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
>Mature Secondary Structure
MEQFFWSYVWPALIMVGQSLLLLVCLLVAIAFLLLADRKVWAAVQLRRGPNVVGPFGLFQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHH
SFADLLKFILKEPVIPAGANKAVFLLAPLVAVTLALATYAVIPFADGWVVANINVGILYI
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHH
FAISSLEVYGIIMGGWASNSKYPFLGALRSAAQMVSYEVSIGLVIVTVLLCVGSLNLTDI
HHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
VLAQRTGLGTMMGLPASFLDWHWLSLFPMFIVFFISGLAETNRPPFDLPEAESELVAGHM
HHHHHCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
VEYGSTPYMMFMLGEYAAIVLICCLTTILFLGGWLPIVDVWFLNWVPGIVWFALKGCMVF
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMIALTKAFVPRYRYDQLMRLGWKVFLPLSLAMVVIVAFVLKLTGWAG
HHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194