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The map label for this gene is clpX

Identifier: 15888589

GI number: 15888589

Start: 1247190

End: 1248467

Strand: Direct

Name: clpX

Synonym: Atu1259

Alternate gene names: 15888589

Gene position: 1247190-1248467 (Clockwise)

Preceding gene: 15888588

Following gene: 15888590

Centisome position: 43.89

GC content: 58.29

Gene sequence:

>1278_bases
ATGAGCAAAGTCAGCGGCAGCAACGGCGGCGACTCTAAGAATACACTCTATTGTTCATTCTGCGGCAAGAGCCAGCACGA
AGTCCGGAAACTCATTGCCGGACCGACGGTATTCATCTGCGATGAATGCGTCGAATTGTGCATGGACATCATCCGCGAGG
AGAACAAGACGTCGATGGTGAAGTCGCGCGAGGGTGTTCCCACCCCGCAGGACATCATCAAGATCCTCGACGAATATGTC
ATCGGTCAGAAGCAGGCGAAGAAAATCCTGTCGGTGGCCGTTCACAACCATTACAAGCGCCTCGCGCACGCCTCCAAGAA
CGGCGATGTCGAGCTTGCGAAGTCGAACATCATGCTCGTCGGTCCGACGGGTTGCGGCAAGACTTATCTTGCCCAGACGC
TCGCCCGCATCATCGACGTTCCCTTCACCATGGCGGACGCAACGACGCTGACCGAAGCCGGTTATGTCGGCGAGGACGTG
GAAAACATCATCCTGAAGCTGCTGCAGGCTGCGGATTACAATGTCGAACGCGCCCAGCGCGGTATCGTCTATATCGACGA
AGTCGACAAGATTTCCCGCAAGTCGGACAACCCGTCCATCACGCGCGACGTGTCGGGCGAGGGCGTTCAGCAGGCGCTTC
TGAAGATCATGGAAGGCACGGTCGCTTCCGTTCCGCCGCAGGGTGGCCGTAAGCATCCGCAGCAGGAATTCCTGCAGGTG
GATACGACCAACATCCTGTTCATCTGCGGCGGCGCTTTTGCCGGCCTCGACAAGATCATCTCGGCCCGTGGTGAAAAGAC
CTCGATCGGCTTCGGTGCGACCGTCAAGGCGGAAGACGATCGTCGTGTGGGCGAGGTGCTGCGTGAACTGGAGCCGGAAG
ATCTGGTGAAGTTCGGTCTTATTCCGGAATTCATCGGCCGTCTGCCCGTTCTCGCGACGCTGGAAGACCTTGATGAAGAT
GCGCTGATCCAGATTCTGTCTGAGCCGAAGAATGCGCTGGTCAAGCAGTATCAGCGCCTGTTCGAGATGGAAGATGTGGA
GCTGACATTCCACGAGGACGCGCTGCGCGAGATTGCCCGCCGGGCGATCACCCGCAAGACGGGTGCCCGCGGTCTGCGCT
CGATCATGGAAAAGATCCTTCTGGATACCATGTTCGAACTGCCGACGCTGGAAGGCGTACGCGAAGTGGTGATCTCCAAC
GATGTCGTCAGCGGCGTCGCTCGTCCGCTCTACATCTATGCGGACCGCCAGGAAGAAAAGGCCAACGTTTCGGCCTGA

Upstream 100 bases:

>100_bases
GGCGGATACGGCGATGCACCCCAAGGCGAGCCGTATCGGCGGGCGGTAAGTTGACCGCGATCCGTTTGGCGGACCTGCGG
CGTGCTGGAAGGAAAGTGAT

Downstream 100 bases:

>100_bases
TCGGCTGATCCGCCGCGTTGACGAATTTCGAAGGCCCGCATCCGTGCGGGCCTTTTTTATTATGTCCGGTTGCGAAACTT
GCGCCTAACTTGGCGTTATC

Product: ATP-dependent protease ATP-binding subunit ClpX

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MSKVSGSNGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKTSMVKSREGVPTPQDIIKILDEYV
IGQKQAKKILSVAVHNHYKRLAHASKNGDVELAKSNIMLVGPTGCGKTYLAQTLARIIDVPFTMADATTLTEAGYVGEDV
ENIILKLLQAADYNVERAQRGIVYIDEVDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQV
DTTNILFICGGAFAGLDKIISARGEKTSIGFGATVKAEDDRRVGEVLRELEPEDLVKFGLIPEFIGRLPVLATLEDLDED
ALIQILSEPKNALVKQYQRLFEMEDVELTFHEDALREIARRAITRKTGARGLRSIMEKILLDTMFELPTLEGVREVVISN
DVVSGVARPLYIYADRQEEKANVSA

Sequences:

>Translated_425_residues
MSKVSGSNGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKTSMVKSREGVPTPQDIIKILDEYV
IGQKQAKKILSVAVHNHYKRLAHASKNGDVELAKSNIMLVGPTGCGKTYLAQTLARIIDVPFTMADATTLTEAGYVGEDV
ENIILKLLQAADYNVERAQRGIVYIDEVDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQV
DTTNILFICGGAFAGLDKIISARGEKTSIGFGATVKAEDDRRVGEVLRELEPEDLVKFGLIPEFIGRLPVLATLEDLDED
ALIQILSEPKNALVKQYQRLFEMEDVELTFHEDALREIARRAITRKTGARGLRSIMEKILLDTMFELPTLEGVREVVISN
DVVSGVARPLYIYADRQEEKANVSA
>Mature_424_residues
SKVSGSNGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKTSMVKSREGVPTPQDIIKILDEYVI
GQKQAKKILSVAVHNHYKRLAHASKNGDVELAKSNIMLVGPTGCGKTYLAQTLARIIDVPFTMADATTLTEAGYVGEDVE
NIILKLLQAADYNVERAQRGIVYIDEVDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQVD
TTNILFICGGAFAGLDKIISARGEKTSIGFGATVKAEDDRRVGEVLRELEPEDLVKFGLIPEFIGRLPVLATLEDLDEDA
LIQILSEPKNALVKQYQRLFEMEDVELTFHEDALREIARRAITRKTGARGLRSIMEKILLDTMFELPTLEGVREVVISND
VVSGVARPLYIYADRQEEKANVSA

Specific function: ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP

COG id: COG1219

COG function: function code O; ATP-dependent protease Clp, ATPase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ClpX chaperone family

Homologues:

Organism=Homo sapiens, GI7242140, Length=338, Percent_Identity=53.5502958579882, Blast_Score=330, Evalue=1e-90,
Organism=Escherichia coli, GI1786642, Length=414, Percent_Identity=70.5314009661836, Blast_Score=596, Evalue=1e-172,
Organism=Escherichia coli, GI1790366, Length=104, Percent_Identity=40.3846153846154, Blast_Score=92, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI71982908, Length=313, Percent_Identity=46.6453674121406, Blast_Score=284, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI71982905, Length=313, Percent_Identity=46.6453674121406, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI71988663, Length=390, Percent_Identity=38.2051282051282, Blast_Score=251, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI71988660, Length=258, Percent_Identity=39.1472868217054, Blast_Score=168, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6319704, Length=417, Percent_Identity=38.6091127098321, Blast_Score=268, Evalue=1e-72,
Organism=Drosophila melanogaster, GI24648291, Length=320, Percent_Identity=50.625, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24648289, Length=320, Percent_Identity=50.625, Blast_Score=312, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPX_AGRT5 (Q8UFY5)

Other databases:

- EMBL:   AE007869
- PIR:   AF2731
- PIR:   F97512
- RefSeq:   NP_354270.1
- ProteinModelPortal:   Q8UFY5
- STRING:   Q8UFY5
- GeneID:   1133297
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1259
- eggNOG:   COG1219
- HOGENOM:   HBG745965
- OMA:   CGKSQEQ
- PhylomeDB:   Q8UFY5
- ProtClustDB:   PRK05342
- BioCyc:   ATUM176299-1:ATU1259-MONOMER
- HAMAP:   MF_00175
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR019489
- InterPro:   IPR004487
- InterPro:   IPR010603
- PANTHER:   PTHR11262:SF4
- SMART:   SM00382
- TIGRFAMs:   TIGR00382

Pfam domain/function: PF07724 AAA_2; PF10431 ClpB_D2-small; PF06689 zf-C4_ClpX

EC number: NA

Molecular weight: Translated: 46896; Mature: 46765

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVSGSNGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKTSMV
CCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHH
KSREGVPTPQDIIKILDEYVIGQKQAKKILSVAVHNHYKRLAHASKNGDVELAKSNIMLV
HHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEE
GPTGCGKTYLAQTLARIIDVPFTMADATTLTEAGYVGEDVENIILKLLQAADYNVERAQR
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHC
GIVYIDEVDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQV
CCEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHH
DTTNILFICGGAFAGLDKIISARGEKTSIGFGATVKAEDDRRVGEVLRELEPEDLVKFGL
CCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHCC
IPEFIGRLPVLATLEDLDEDALIQILSEPKNALVKQYQRLFEMEDVELTFHEDALREIAR
HHHHHCCCCHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHH
RAITRKTGARGLRSIMEKILLDTMFELPTLEGVREVVISNDVVSGVARPLYIYADRQEEK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
ANVSA
CCCCC
>Mature Secondary Structure 
SKVSGSNGGDSKNTLYCSFCGKSQHEVRKLIAGPTVFICDECVELCMDIIREENKTSMV
CCCCCCCCCCCCCEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHH
KSREGVPTPQDIIKILDEYVIGQKQAKKILSVAVHNHYKRLAHASKNGDVELAKSNIMLV
HHCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCEEEE
GPTGCGKTYLAQTLARIIDVPFTMADATTLTEAGYVGEDVENIILKLLQAADYNVERAQR
CCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHC
GIVYIDEVDKISRKSDNPSITRDVSGEGVQQALLKIMEGTVASVPPQGGRKHPQQEFLQV
CCEEEECHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHCCCCCCCCCCCHHHHHHH
DTTNILFICGGAFAGLDKIISARGEKTSIGFGATVKAEDDRRVGEVLRELEPEDLVKFGL
CCCCEEEEECCHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHCC
IPEFIGRLPVLATLEDLDEDALIQILSEPKNALVKQYQRLFEMEDVELTFHEDALREIAR
HHHHHCCCCHHHHHHHCCHHHHHHHHHCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHH
RAITRKTGARGLRSIMEKILLDTMFELPTLEGVREVVISNDVVSGVARPLYIYADRQEEK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCC
ANVSA
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194