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The map label for this gene is clpP

Identifier: 15888588

GI number: 15888588

Start: 1246266

End: 1246898

Strand: Direct

Name: clpP

Synonym: Atu1258

Alternate gene names: 15888588

Gene position: 1246266-1246898 (Clockwise)

Preceding gene: 159184685

Following gene: 15888589

Centisome position: 43.86

GC content: 58.14

Gene sequence:

>633_bases
ATGAAAAATCCAGTTGATACCGCCATGGCTCTGGTGCCGATGGTCGTTGAGCAGACCAATCGCGGCGAACGCTCCTACGA
CATATTTTCCCGTCTTCTCAAGGAACGCATCATTTTCCTCACCGGACCGGTGGAAGACCAGATGGCCTCGCTCGTCTGCG
CGCAGCTGCTTTTCCTCGAGGCTGAAAACCCGAAGAAGGAAATCGCGCTTTACATCAATTCGCCGGGTGGCGTCGTGACC
GCCGGCATGGCGATCTATGATACGATGCAGTTCATCCGCCCCGCGGTTTCGACGCTGTGCGTCGGTCAGGCCGCATCGAT
GGGTTCGCTGCTTCTGGCCGCCGGTGAAAAGGGCATGCGTTTCGCCACCCCGAACGCCCGCATCATGGTGCACCAGCCTT
CCGGCGGTTTCCAGGGGCAGGCTTCGGATATCGAACGTCACGCTCGTGACATCATCAAGATGAAGCGTCGCCTCAATGAA
GTCTACGTGAAGCACACCGGCCGCACGCTCGAAGAGGTTGAAAAAACCCTTGATCGCGACCATTTCATGGATGCAGACGA
GGCGAAGGACTGGGGCGTGATCGACAAGATCCTGACCTCGCGCCAGGAAATGGAAGGCGCCGTCGCGAATTGA

Upstream 100 bases:

>100_bases
CTTGAAGTGCGGGGCAGGGACACTCTATGTAGGGAGAATGAAGGTTAGAAGTGATTCCGGAGCGGTTATCCGCGAAGGGC
AGAGTTGACAAAGGACGGAC

Downstream 100 bases:

>100_bases
GGCGCGCCGCTCTCTGACGTTTGTTTGACTCCGCAAAAGTAATTTCGGGGCTTTCAACCGCAACAGAAAGCGATATTAGT
ATATATAAAGGCTATGTTGA

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 2

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKNPVDTAMALVPMVVEQTNRGERSYDIFSRLLKERIIFLTGPVEDQMASLVCAQLLFLEAENPKKEIALYINSPGGVVT
AGMAIYDTMQFIRPAVSTLCVGQAASMGSLLLAAGEKGMRFATPNARIMVHQPSGGFQGQASDIERHARDIIKMKRRLNE
VYVKHTGRTLEEVEKTLDRDHFMDADEAKDWGVIDKILTSRQEMEGAVAN

Sequences:

>Translated_210_residues
MKNPVDTAMALVPMVVEQTNRGERSYDIFSRLLKERIIFLTGPVEDQMASLVCAQLLFLEAENPKKEIALYINSPGGVVT
AGMAIYDTMQFIRPAVSTLCVGQAASMGSLLLAAGEKGMRFATPNARIMVHQPSGGFQGQASDIERHARDIIKMKRRLNE
VYVKHTGRTLEEVEKTLDRDHFMDADEAKDWGVIDKILTSRQEMEGAVAN
>Mature_210_residues
MKNPVDTAMALVPMVVEQTNRGERSYDIFSRLLKERIIFLTGPVEDQMASLVCAQLLFLEAENPKKEIALYINSPGGVVT
AGMAIYDTMQFIRPAVSTLCVGQAASMGSLLLAAGEKGMRFATPNARIMVHQPSGGFQGQASDIERHARDIIKMKRRLNE
VYVKHTGRTLEEVEKTLDRDHFMDADEAKDWGVIDKILTSRQEMEGAVAN

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=191, Percent_Identity=60.2094240837696, Blast_Score=255, Evalue=2e-68,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=67.8756476683938, Blast_Score=293, Evalue=6e-81,
Organism=Caenorhabditis elegans, GI17538017, Length=193, Percent_Identity=60.6217616580311, Blast_Score=246, Evalue=5e-66,
Organism=Drosophila melanogaster, GI20129427, Length=188, Percent_Identity=66.4893617021277, Blast_Score=269, Evalue=7e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP2_AGRT5 (Q8UFY6)

Other databases:

- EMBL:   AE007869
- PIR:   AE2731
- PIR:   E97512
- RefSeq:   NP_354269.1
- ProteinModelPortal:   Q8UFY6
- SMR:   Q8UFY6
- STRING:   Q8UFY6
- MEROPS:   S14.001
- GeneID:   1133296
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1258
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   KFGLVDN
- PhylomeDB:   Q8UFY6
- ProtClustDB:   PRK00277
- BioCyc:   ATUM176299-1:ATU1258-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 23301; Mature: 23301

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 106-106 ACT_SITE 131-131

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNPVDTAMALVPMVVEQTNRGERSYDIFSRLLKERIIFLTGPVEDQMASLVCAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHC
AENPKKEIALYINSPGGVVTAGMAIYDTMQFIRPAVSTLCVGQAASMGSLLLAAGEKGMR
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FATPNARIMVHQPSGGFQGQASDIERHARDIIKMKRRLNEVYVKHTGRTLEEVEKTLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
HFMDADEAKDWGVIDKILTSRQEMEGAVAN
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MKNPVDTAMALVPMVVEQTNRGERSYDIFSRLLKERIIFLTGPVEDQMASLVCAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHC
AENPKKEIALYINSPGGVVTAGMAIYDTMQFIRPAVSTLCVGQAASMGSLLLAAGEKGMR
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FATPNARIMVHQPSGGFQGQASDIERHARDIIKMKRRLNEVYVKHTGRTLEEVEKTLDRD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
HFMDADEAKDWGVIDKILTSRQEMEGAVAN
HCCCCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194