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The map label for this gene is hisA [H]

Identifier: 15887398

GI number: 15887398

Start: 41891

End: 42634

Strand: Reverse

Name: hisA [H]

Synonym: Atu0040

Alternate gene names: 15887398

Gene position: 42634-41891 (Counterclockwise)

Preceding gene: 159184136

Following gene: 15887397

Centisome position: 1.5

GC content: 59.81

Gene sequence:

>744_bases
ATGATTCTTTTTCCCGCAATCGATCTCAAAGACGGTGAGTGCGTTCGCCTGAAACTCGGCGATATGGAGCAGGCAACCGT
CTATAACGAGGACCCCGGTGCGCAGGCGAAGGCCTTTGAGGACCAGGGGTTTGAATGGCTGCATGTGGTTGATCTCAACG
GTGCCTTTGCTGGTGAGACGGTCAATGGCGCAGCGGTTGATGCCATTTTGAAATCCACGAAAAACCCGGTGCAGCTGGGC
GGTGGTATTCGCACACTCGACCATATCGAAGCTTGGCTCAGCCGTGGGCTGGCCCGTGTCATCCTCGGCACCGTGGCAGT
GCGCGATCCGGTGCTGGTTATCGAAGCCTGCAAACGTTTCCCCGGCCAGGTCGCCGTCGGCATCGACGCCAAGGGCGGCA
AGGTTGCGGTGGAAGGCTGGGCGGAAGCCTCCGAGCTCGGTATCATCGAACTTGCCAAACGTTTCGAAGGTGCCGGCGTT
GCCGCCATCATCTATACCGACATCGATCGCGACGGCATTCTGGCCGGCATCAACTGGGCCTCGACGCTGGAACTGGCGGA
TGCCGTGTCGATCCCTGTCATCGCTTCCGGCGGCCTTGCCTCCATCGACGACATCAAACGAATGTTGCAGCCGGATGCCG
CAAAGCTCGAGGGTGCGATTTCAGGCCGTGCCCTTTATGACGGGCGTATCGACCCCACCGAAGCGCTTGACCTCATCAAG
GCCGCGAAGGAGGTACGTGCATGA

Upstream 100 bases:

>100_bases
GTCGGCCGCGACAACATGGCGGGCGCGCAGTTCCACCCGGAAAAAAGCCAGACGCTCGGCCTTGCCCTGATTTCCAATTT
CCTGCGCTGGAAGCCCTGAC

Downstream 100 bases:

>100_bases
CCCTCAAAGCCCGCATTATTCCCTGCCTCGACGTGAAAGACGGACGTGTCGTCAAGGGTGTGAACTTCGTCGACCTGATC
GATGCTGGCGACCCGGTCGA

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MILFPAIDLKDGECVRLKLGDMEQATVYNEDPGAQAKAFEDQGFEWLHVVDLNGAFAGETVNGAAVDAILKSTKNPVQLG
GGIRTLDHIEAWLSRGLARVILGTVAVRDPVLVIEACKRFPGQVAVGIDAKGGKVAVEGWAEASELGIIELAKRFEGAGV
AAIIYTDIDRDGILAGINWASTLELADAVSIPVIASGGLASIDDIKRMLQPDAAKLEGAISGRALYDGRIDPTEALDLIK
AAKEVRA

Sequences:

>Translated_247_residues
MILFPAIDLKDGECVRLKLGDMEQATVYNEDPGAQAKAFEDQGFEWLHVVDLNGAFAGETVNGAAVDAILKSTKNPVQLG
GGIRTLDHIEAWLSRGLARVILGTVAVRDPVLVIEACKRFPGQVAVGIDAKGGKVAVEGWAEASELGIIELAKRFEGAGV
AAIIYTDIDRDGILAGINWASTLELADAVSIPVIASGGLASIDDIKRMLQPDAAKLEGAISGRALYDGRIDPTEALDLIK
AAKEVRA
>Mature_247_residues
MILFPAIDLKDGECVRLKLGDMEQATVYNEDPGAQAKAFEDQGFEWLHVVDLNGAFAGETVNGAAVDAILKSTKNPVQLG
GGIRTLDHIEAWLSRGLARVILGTVAVRDPVLVIEACKRFPGQVAVGIDAKGGKVAVEGWAEASELGIIELAKRFEGAGV
AAIIYTDIDRDGILAGINWASTLELADAVSIPVIASGGLASIDDIKRMLQPDAAKLEGAISGRALYDGRIDPTEALDLIK
AAKEVRA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=242, Percent_Identity=34.7107438016529, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788336, Length=236, Percent_Identity=22.4576271186441, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 26027; Mature: 26027

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILFPAIDLKDGECVRLKLGDMEQATVYNEDPGAQAKAFEDQGFEWLHVVDLNGAFAGET
CEEECEEECCCCCEEEEEECCCCCEEEECCCCCCCCHHHHCCCCEEEEEEECCCCCCCCC
VNGAAVDAILKSTKNPVQLGGGIRTLDHIEAWLSRGLARVILGTVAVRDPVLVIEACKRF
CCHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
PGQVAVGIDAKGGKVAVEGWAEASELGIIELAKRFEGAGVAAIIYTDIDRDGILAGINWA
CCCEEEEEECCCCEEEEECCCCCHHCHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCHH
STLELADAVSIPVIASGGLASIDDIKRMLQPDAAKLEGAISGRALYDGRIDPTEALDLIK
HHHHHHHHCCCCEEECCCCCCHHHHHHHHCCCHHHHHHCCCCCEEECCCCCHHHHHHHHH
AAKEVRA
HHHHHCC
>Mature Secondary Structure
MILFPAIDLKDGECVRLKLGDMEQATVYNEDPGAQAKAFEDQGFEWLHVVDLNGAFAGET
CEEECEEECCCCCEEEEEECCCCCEEEECCCCCCCCHHHHCCCCEEEEEEECCCCCCCCC
VNGAAVDAILKSTKNPVQLGGGIRTLDHIEAWLSRGLARVILGTVAVRDPVLVIEACKRF
CCHHHHHHHHHCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCC
PGQVAVGIDAKGGKVAVEGWAEASELGIIELAKRFEGAGVAAIIYTDIDRDGILAGINWA
CCCEEEEEECCCCEEEEECCCCCHHCHHHHHHHHCCCCCEEEEEEEECCCCCEEEECCHH
STLELADAVSIPVIASGGLASIDDIKRMLQPDAAKLEGAISGRALYDGRIDPTEALDLIK
HHHHHHHHCCCCEEECCCCCCHHHHHHHHCCCHHHHHHCCCCCEEECCCCCHHHHHHHHH
AAKEVRA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA