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The map label for this gene is hbd [H]

Identifier: 158423961

GI number: 158423961

Start: 2663901

End: 2664899

Strand: Reverse

Name: hbd [H]

Synonym: AZC_2337

Alternate gene names: 158423961

Gene position: 2664899-2663901 (Counterclockwise)

Preceding gene: 158423969

Following gene: 158423960

Centisome position: 49.63

GC content: 69.87

Gene sequence:

>999_bases
ATGGACACAGGACGAAATGGCCCGGTGGCTGTCGTGGGCGGCGGCAGCATGGGGGTGGGGTGGGCAATCGTGTTCGCTCG
CTCCGGCCGGGAGGTGCGCGTCCATGACGCCGCGCCAGCCGTGCGTAGCGCGGTGCTCGGAGCTGTGGCGGAACGCCTGG
CCGCGCTCGCCGCCCATGACCTGCTGTCGGAGGCACCTGGCGTTGTGATGGCACGGATCACAGTGGCAGAAACGGTCGGC
GCCGCCATCGCCGGCGCCGTTCATGTCCAGGAGAACGTGCCGGAGCGGCTCGACCTCAAGACGCAGGTCTTCCGTGCCAT
GGATGCGGTGGCGGCGCCGGAGGCGGTGCTCGCCAGTTCCACATCGTCGCTGCCGGCATCCGAGTTCGCGGCGGCCCTTC
CGGGGCGCGCACGCTGCCTCGTGGCCCATCCGGCCAACCCGCCCCATCTCCTGCCCATCGTCGAGATCGTGCCGGCCCCC
TTCACCGATCCGGAGGCCGTCGAGCGCACCCGCGCCCTCATGGCCCAGGCCGGGCAGGTTCCGGTGGTGCTGCAACGCGA
GGTCAACGGCTTCATCTACAACCGGCTGCAAGGGGCTGTGCTGAGAGAAGCCTATTGGATGCTGGAGCAGGGCATTGCAG
ATGTGGCGTCGATCGATCGGGTCATGACCTCCGGCCTCGGCCTGCGCTGGTCGATCATCGGCCCGTTCGAGACGGCCGAT
CTCAACTATCAGGGCGGCCTTGAGGAGCACGCCCGCCGCATGGGCGAGCGTTATCGGCAGATGGGCGCCGAGCGGGGCCA
GCCGGACGGATGGGACGAGACCCTCGTCGCCCGTGCTGCGGCTGAAAGACGGGCGCTGCTGCCCCTGGAAGACTGGGGCG
CACGGGTTGCCTGGCGGGACGAGCGGCTGATGAAGGCCCGTGCTGCCGAACGGGAAAGTCCCCCCTATACTGCGTCCGGG
GAGAACACCGCCGCCGGCGGTCTGCGGGAGGGGGCATGA

Upstream 100 bases:

>100_bases
TCGACCCAAATCGGTCGAGCACTCGCTTGAAAAGCTTTCGGGTCCCGCTTTGTGTTCGCATAACGAACATTTTCCCTCAA
TTCGCACATCGGTGATCACC

Downstream 100 bases:

>100_bases
CGAGCGAGGTGCTGGAGGGGCGGGCCGAGGGGGCGGCCGACGAGAAGGATTACGTCCAGTCCCTCGCGCGTGGCCTGCAG
GTGCTGCGGGCCTTCAGTCA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MDTGRNGPVAVVGGGSMGVGWAIVFARSGREVRVHDAAPAVRSAVLGAVAERLAALAAHDLLSEAPGVVMARITVAETVG
AAIAGAVHVQENVPERLDLKTQVFRAMDAVAAPEAVLASSTSSLPASEFAAALPGRARCLVAHPANPPHLLPIVEIVPAP
FTDPEAVERTRALMAQAGQVPVVLQREVNGFIYNRLQGAVLREAYWMLEQGIADVASIDRVMTSGLGLRWSIIGPFETAD
LNYQGGLEEHARRMGERYRQMGAERGQPDGWDETLVARAAAERRALLPLEDWGARVAWRDERLMKARAAERESPPYTASG
ENTAAGGLREGA

Sequences:

>Translated_332_residues
MDTGRNGPVAVVGGGSMGVGWAIVFARSGREVRVHDAAPAVRSAVLGAVAERLAALAAHDLLSEAPGVVMARITVAETVG
AAIAGAVHVQENVPERLDLKTQVFRAMDAVAAPEAVLASSTSSLPASEFAAALPGRARCLVAHPANPPHLLPIVEIVPAP
FTDPEAVERTRALMAQAGQVPVVLQREVNGFIYNRLQGAVLREAYWMLEQGIADVASIDRVMTSGLGLRWSIIGPFETAD
LNYQGGLEEHARRMGERYRQMGAERGQPDGWDETLVARAAAERRALLPLEDWGARVAWRDERLMKARAAERESPPYTASG
ENTAAGGLREGA
>Mature_332_residues
MDTGRNGPVAVVGGGSMGVGWAIVFARSGREVRVHDAAPAVRSAVLGAVAERLAALAAHDLLSEAPGVVMARITVAETVG
AAIAGAVHVQENVPERLDLKTQVFRAMDAVAAPEAVLASSTSSLPASEFAAALPGRARCLVAHPANPPHLLPIVEIVPAP
FTDPEAVERTRALMAQAGQVPVVLQREVNGFIYNRLQGAVLREAYWMLEQGIADVASIDRVMTSGLGLRWSIIGPFETAD
LNYQGGLEEHARRMGERYRQMGAERGQPDGWDETLVARAAAERRALLPLEDWGARVAWRDERLMKARAAERESPPYTASG
ENTAAGGLREGA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=319, Percent_Identity=35.1097178683386, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI296179429, Length=241, Percent_Identity=31.9502074688797, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI261878539, Length=239, Percent_Identity=28.8702928870293, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI68989263, Length=239, Percent_Identity=28.8702928870293, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI296179427, Length=258, Percent_Identity=29.8449612403101, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787661, Length=234, Percent_Identity=31.6239316239316, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788682, Length=123, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790281, Length=139, Percent_Identity=31.6546762589928, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI193203623, Length=245, Percent_Identity=34.2857142857143, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI115533614, Length=244, Percent_Identity=33.1967213114754, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17553560, Length=245, Percent_Identity=29.3877551020408, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71985923, Length=250, Percent_Identity=26, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17549919, Length=238, Percent_Identity=27.7310924369748, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17563036, Length=255, Percent_Identity=26.2745098039216, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25144276, Length=216, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508951, Length=216, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508953, Length=216, Percent_Identity=27.7777777777778, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17558304, Length=250, Percent_Identity=28, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45549573, Length=312, Percent_Identity=37.5, Blast_Score=220, Evalue=1e-57,
Organism=Drosophila melanogaster, GI20129993, Length=305, Percent_Identity=39.0163934426229, Blast_Score=201, Evalue=5e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 35298; Mature: 35298

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTGRNGPVAVVGGGSMGVGWAIVFARSGREVRVHDAAPAVRSAVLGAVAERLAALAAHD
CCCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LLSEAPGVVMARITVAETVGAAIAGAVHVQENVPERLDLKTQVFRAMDAVAAPEAVLASS
HHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCC
TSSLPASEFAAALPGRARCLVAHPANPPHLLPIVEIVPAPFTDPEAVERTRALMAQAGQV
CCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
PVVLQREVNGFIYNRLQGAVLREAYWMLEQGIADVASIDRVMTSGLGLRWSIIGPFETAD
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
LNYQGGLEEHARRMGERYRQMGAERGQPDGWDETLVARAAAERRALLPLEDWGARVAWRD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCEEEHH
ERLMKARAAERESPPYTASGENTAAGGLREGA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDTGRNGPVAVVGGGSMGVGWAIVFARSGREVRVHDAAPAVRSAVLGAVAERLAALAAHD
CCCCCCCCEEEEECCCCCCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
LLSEAPGVVMARITVAETVGAAIAGAVHVQENVPERLDLKTQVFRAMDAVAAPEAVLASS
HHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCC
TSSLPASEFAAALPGRARCLVAHPANPPHLLPIVEIVPAPFTDPEAVERTRALMAQAGQV
CCCCCHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCC
PVVLQREVNGFIYNRLQGAVLREAYWMLEQGIADVASIDRVMTSGLGLRWSIIGPFETAD
CEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
LNYQGGLEEHARRMGERYRQMGAERGQPDGWDETLVARAAAERRALLPLEDWGARVAWRD
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCEEEHH
ERLMKARAAERESPPYTASGENTAAGGLREGA
HHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]