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The map label for this gene is iclR [H]

Identifier: 158423960

GI number: 158423960

Start: 2663107

End: 2663904

Strand: Reverse

Name: iclR [H]

Synonym: AZC_2336

Alternate gene names: 158423960

Gene position: 2663904-2663107 (Counterclockwise)

Preceding gene: 158423961

Following gene: 158423958

Centisome position: 49.61

GC content: 68.17

Gene sequence:

>798_bases
ATGACGAGCGAGGTGCTGGAGGGGCGGGCCGAGGGGGCGGCCGACGAGAAGGATTACGTCCAGTCCCTCGCGCGTGGCCT
GCAGGTGCTGCGGGCCTTCAGTCAGTACAAGCCGCGCATGACGCTCAGCGAAGTGGCCCAGCATACCGGCCTCACCCGCG
CTGCTGCCCGGCGCTTCCTTCTGACCCTCGTGCGCGAGGGCTTTGCGGAGACGGACGGCAAGCGGTTTGCCCTGCGCCCG
AAGGTGCTGGAACTGGGCTTTGCCTATCTGTCCTCCCTGCCCATGTGGGAGGTCGCCCAGCCCGTGATGCGGGATGTGGT
GAATGCCCTGCAGGAATCCTGCTCTCTCTCCGTTCTGGACGGCGAGGACATCGTCTACGTGGCGCGCGAGCCCACGGCGC
GGGTCATGACCATCGGGCTGTCCATCGGCTCGCGCCTGCCGGCCTATTGCAGTTCCATGGGTCGGGTGCTGCTGTCCGGC
CTGCCGCCGGCGGAGCTCGCCGCCTTCTACGACCGGGTGCGGATCGAGAAGCGCACGCCGCGCACCGTACCGACCATGGT
CGCTCTCAAGGATGAGGTGGAAACGGCGCGCCGGCAGGGCTGGGCGCTGGTGGATCAAGAACTCGAACTGGGCCTGCGCT
CCATTGCCGTCCCGATCCGAAATCGCCGCGGCGAGGTGCTGGCTGCGCTCAACGTCTCGACCCATGAGGGGCGCACCCCT
CTTGAGGCCATGCGCAACCGCTTCCTGCCCGTGCTTCTGGACGCCGCCCAGCGCATTTCCGCCGCCCTGCCGCAATAG

Upstream 100 bases:

>100_bases
GGGACGAGCGGCTGATGAAGGCCCGTGCTGCCGAACGGGAAAGTCCCCCCTATACTGCGTCCGGGGAGAACACCGCCGCC
GGCGGTCTGCGGGAGGGGGC

Downstream 100 bases:

>100_bases
GCCTCGCCTCGATCCGCGCCCCGCAGCAGGCTCGCGGGGCAGCTTCTAAGTGAGGGGCTTCGGCACGGCGCAGGTGCGGG
CTTCGCGCGGGCCTTCGGGG

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MTSEVLEGRAEGAADEKDYVQSLARGLQVLRAFSQYKPRMTLSEVAQHTGLTRAAARRFLLTLVREGFAETDGKRFALRP
KVLELGFAYLSSLPMWEVAQPVMRDVVNALQESCSLSVLDGEDIVYVAREPTARVMTIGLSIGSRLPAYCSSMGRVLLSG
LPPAELAAFYDRVRIEKRTPRTVPTMVALKDEVETARRQGWALVDQELELGLRSIAVPIRNRRGEVLAALNVSTHEGRTP
LEAMRNRFLPVLLDAAQRISAALPQ

Sequences:

>Translated_265_residues
MTSEVLEGRAEGAADEKDYVQSLARGLQVLRAFSQYKPRMTLSEVAQHTGLTRAAARRFLLTLVREGFAETDGKRFALRP
KVLELGFAYLSSLPMWEVAQPVMRDVVNALQESCSLSVLDGEDIVYVAREPTARVMTIGLSIGSRLPAYCSSMGRVLLSG
LPPAELAAFYDRVRIEKRTPRTVPTMVALKDEVETARRQGWALVDQELELGLRSIAVPIRNRRGEVLAALNVSTHEGRTP
LEAMRNRFLPVLLDAAQRISAALPQ
>Mature_264_residues
TSEVLEGRAEGAADEKDYVQSLARGLQVLRAFSQYKPRMTLSEVAQHTGLTRAAARRFLLTLVREGFAETDGKRFALRPK
VLELGFAYLSSLPMWEVAQPVMRDVVNALQESCSLSVLDGEDIVYVAREPTARVMTIGLSIGSRLPAYCSSMGRVLLSGL
PPAELAAFYDRVRIEKRTPRTVPTMVALKDEVETARRQGWALVDQELELGLRSIAVPIRNRRGEVLAALNVSTHEGRTPL
EAMRNRFLPVLLDAAQRISAALPQ

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1786468, Length=218, Percent_Identity=29.3577981651376, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082359, Length=218, Percent_Identity=27.5229357798165, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI1788131, Length=248, Percent_Identity=28.6290322580645, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1789999, Length=271, Percent_Identity=28.0442804428044, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786715, Length=261, Percent_Identity=26.4367816091954, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788581, Length=218, Percent_Identity=25.2293577981651, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29332; Mature: 29201

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSEVLEGRAEGAADEKDYVQSLARGLQVLRAFSQYKPRMTLSEVAQHTGLTRAAARRFL
CCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHH
LTLVREGFAETDGKRFALRPKVLELGFAYLSSLPMWEVAQPVMRDVVNALQESCSLSVLD
HHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEC
GEDIVYVAREPTARVMTIGLSIGSRLPAYCSSMGRVLLSGLPPAELAAFYDRVRIEKRTP
CCCEEEEECCCCCEEEEEHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
RTVPTMVALKDEVETARRQGWALVDQELELGLRSIAVPIRNRRGEVLAALNVSTHEGRTP
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCH
LEAMRNRFLPVLLDAAQRISAALPQ
HHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSEVLEGRAEGAADEKDYVQSLARGLQVLRAFSQYKPRMTLSEVAQHTGLTRAAARRFL
CCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHH
LTLVREGFAETDGKRFALRPKVLELGFAYLSSLPMWEVAQPVMRDVVNALQESCSLSVLD
HHHHHHHHHCCCCCEEECCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCEEEEC
GEDIVYVAREPTARVMTIGLSIGSRLPAYCSSMGRVLLSGLPPAELAAFYDRVRIEKRTP
CCCEEEEECCCCCEEEEEHHHHCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCC
RTVPTMVALKDEVETARRQGWALVDQELELGLRSIAVPIRNRRGEVLAALNVSTHEGRTP
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCH
LEAMRNRFLPVLLDAAQRISAALPQ
HHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]