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The map label for this gene is gor [H]

Identifier: 158423958

GI number: 158423958

Start: 2659372

End: 2660730

Strand: Reverse

Name: gor [H]

Synonym: AZC_2334

Alternate gene names: 158423958

Gene position: 2660730-2659372 (Counterclockwise)

Preceding gene: 158423960

Following gene: 158423956

Centisome position: 49.55

GC content: 69.61

Gene sequence:

>1359_bases
ATGTCGCGTAGCGTGGATCTTTTCGTCATCGGCGGCGGCTCGGGCGGCGTGCGGGCCGGACGCATCGCGGCCCAGCACGG
CGCGAAGGTGATGCTGGCGGAGGAATATCGCCTCGGCGGGACCTGCGTGATCCGCGGCTGCGTGCCGAAGAAGCTGTTCG
TCTATGCCGGACGCTATGCCCATGATCTGGAGGACATGGCCGGCTTCGGCTGGACCGTGGAGGGCGCCCGCTTCGACTGG
CCGACGCTGATCGCACGGAAGGACCAGGAGATCGCCCGTCTGGAGGGCATCTACCGCCGCAACCTCGTGGCGCCGGGCGT
CGAGATCGTGGACGGGCGGGCCGAGATCATCGGCCCCAACCGCGTGCGCCTCGTCGCCACGGGCGAGGAGATCGAGGCCG
GCCACATCCTCGTCGCCACCGGCGCGCATCCCGCGCTCGGCCCCGCGATTCCCGGCGCCGAGCGCGCCATCACCTCCAAC
GAGGCCTTCCATCTGCCCCGCCTGCCGCCGCGCATCCTGATCCAGGGCGGCGGCTATATCGCGGTGGAGTTCGCCTGCCT
GTTCCGCGCGCTGGGCAGCGAGGTGCATCTCGTGTTCCGCGCCGACCAGATTCTGCGCGGCTTCGACGAGGACGTGCGCG
CGCTGGTGGCGCAGGAGATGGCCCATTCCGGCATCGTGTTCCACACTGGCCAGACCCTCACAGGAATCACCGCCGAGGGC
GGCACGAAGACGGTCACGCTGTCCGACGGCTCCGCCATCGCGGTGGACGAGGTGATGCTGGCCATCGGCCGTCTGCCCAA
CACCTCGGGCCTGGGGCTGGACGCCGTGGGCGTTGCCACCGACAAGGTGGGCGCGGTGATCGTGGACGCGGACGGGCGCA
CCAATGTGCCGTCCATCTATGCGGTGGGCGATGTCACCAACCGGATCAACCTGACCCCCGTCGCCATTCGCGAGGGCCAT
GCCTTCGCCGACAGCGTGTTCGGCAACAAGCCCTGGCGGGTGGATCACAGCCTCGTCGCGACCGCCGTCTTCACCGAGCC
GGAGGTGGGCACCTGCGGCCTCAGCGAGACCGCCGCGCGCGCCGCCGGGCATGCGGTGGACATCTACAAGTCCCAGTTCC
GGCCCATGCGGGCGACCCTCTCGGGCCGCGAGACGCGCATGCTGGTGAAACTCATCGTCGATCAGCAGAGCGACAAGGTG
CTGGGCTGCCACGTGGTGGGCGAGGGCGCGGGCGAGATCATCCAGATGGCCGCCATCGCCATGGGCATGGGCGCCACCAA
GGCGGATTTCGATCGCACGGTCGCTGTCCATCCCACGGCGGCCGAGGAACTCGTGACGCTGCGCACCAAGAGCGCGTGA

Upstream 100 bases:

>100_bases
CTGCGCCGCCGCCGCTCCGGCCTTTCGGTCGTGGGCCGTCGCACCTATCTCAGCCGCACCGCACAGACGCGGGCTTTGCC
GGCCGCCGGAGGAATCAGTC

Downstream 100 bases:

>100_bases
GCTCGCCAGCGGACCCTCTGGACGAACGCCCGCCGGCTTTGCCATAGAGCCGGCGGGCGTCGATGGATTTCGGGCGGAGC
GACTCGCCTCCGGCCGATCC

Product: glutathione reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MSRSVDLFVIGGGSGGVRAGRIAAQHGAKVMLAEEYRLGGTCVIRGCVPKKLFVYAGRYAHDLEDMAGFGWTVEGARFDW
PTLIARKDQEIARLEGIYRRNLVAPGVEIVDGRAEIIGPNRVRLVATGEEIEAGHILVATGAHPALGPAIPGAERAITSN
EAFHLPRLPPRILIQGGGYIAVEFACLFRALGSEVHLVFRADQILRGFDEDVRALVAQEMAHSGIVFHTGQTLTGITAEG
GTKTVTLSDGSAIAVDEVMLAIGRLPNTSGLGLDAVGVATDKVGAVIVDADGRTNVPSIYAVGDVTNRINLTPVAIREGH
AFADSVFGNKPWRVDHSLVATAVFTEPEVGTCGLSETAARAAGHAVDIYKSQFRPMRATLSGRETRMLVKLIVDQQSDKV
LGCHVVGEGAGEIIQMAAIAMGMGATKADFDRTVAVHPTAAEELVTLRTKSA

Sequences:

>Translated_452_residues
MSRSVDLFVIGGGSGGVRAGRIAAQHGAKVMLAEEYRLGGTCVIRGCVPKKLFVYAGRYAHDLEDMAGFGWTVEGARFDW
PTLIARKDQEIARLEGIYRRNLVAPGVEIVDGRAEIIGPNRVRLVATGEEIEAGHILVATGAHPALGPAIPGAERAITSN
EAFHLPRLPPRILIQGGGYIAVEFACLFRALGSEVHLVFRADQILRGFDEDVRALVAQEMAHSGIVFHTGQTLTGITAEG
GTKTVTLSDGSAIAVDEVMLAIGRLPNTSGLGLDAVGVATDKVGAVIVDADGRTNVPSIYAVGDVTNRINLTPVAIREGH
AFADSVFGNKPWRVDHSLVATAVFTEPEVGTCGLSETAARAAGHAVDIYKSQFRPMRATLSGRETRMLVKLIVDQQSDKV
LGCHVVGEGAGEIIQMAAIAMGMGATKADFDRTVAVHPTAAEELVTLRTKSA
>Mature_451_residues
SRSVDLFVIGGGSGGVRAGRIAAQHGAKVMLAEEYRLGGTCVIRGCVPKKLFVYAGRYAHDLEDMAGFGWTVEGARFDWP
TLIARKDQEIARLEGIYRRNLVAPGVEIVDGRAEIIGPNRVRLVATGEEIEAGHILVATGAHPALGPAIPGAERAITSNE
AFHLPRLPPRILIQGGGYIAVEFACLFRALGSEVHLVFRADQILRGFDEDVRALVAQEMAHSGIVFHTGQTLTGITAEGG
TKTVTLSDGSAIAVDEVMLAIGRLPNTSGLGLDAVGVATDKVGAVIVDADGRTNVPSIYAVGDVTNRINLTPVAIREGHA
FADSVFGNKPWRVDHSLVATAVFTEPEVGTCGLSETAARAAGHAVDIYKSQFRPMRATLSGRETRMLVKLIVDQQSDKVL
GCHVVGEGAGEIIQMAAIAMGMGATKADFDRTVAVHPTAAEELVTLRTKSA

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=464, Percent_Identity=39.8706896551724, Blast_Score=305, Evalue=6e-83,
Organism=Homo sapiens, GI148277071, Length=457, Percent_Identity=35.4485776805252, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI33519430, Length=457, Percent_Identity=35.4485776805252, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI33519428, Length=457, Percent_Identity=35.4485776805252, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI33519426, Length=457, Percent_Identity=35.4485776805252, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI148277065, Length=457, Percent_Identity=35.4485776805252, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI22035672, Length=452, Percent_Identity=33.8495575221239, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI291045266, Length=465, Percent_Identity=33.5483870967742, Blast_Score=213, Evalue=4e-55,
Organism=Homo sapiens, GI291045268, Length=463, Percent_Identity=30.6695464362851, Blast_Score=179, Evalue=6e-45,
Organism=Homo sapiens, GI91199540, Length=455, Percent_Identity=30.1098901098901, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1789915, Length=432, Percent_Identity=39.3518518518519, Blast_Score=287, Evalue=9e-79,
Organism=Escherichia coli, GI1786307, Length=454, Percent_Identity=29.5154185022026, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI87082354, Length=454, Percent_Identity=26.2114537444934, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI87081717, Length=448, Percent_Identity=27.9017857142857, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71983429, Length=434, Percent_Identity=38.9400921658986, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71983419, Length=434, Percent_Identity=38.9400921658986, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI17557007, Length=471, Percent_Identity=33.5456475583864, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI71982272, Length=480, Percent_Identity=32.5, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI32565766, Length=453, Percent_Identity=32.8918322295806, Blast_Score=203, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=37.0689655172414, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=26.8240343347639, Blast_Score=149, Evalue=9e-37,
Organism=Saccharomyces cerevisiae, GI6325240, Length=461, Percent_Identity=26.6811279826464, Blast_Score=138, Evalue=2e-33,
Organism=Drosophila melanogaster, GI17737741, Length=472, Percent_Identity=34.7457627118644, Blast_Score=215, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=32.9087048832272, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=32.9087048832272, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=31.7391304347826, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=32.9087048832272, Blast_Score=208, Evalue=6e-54,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 47769; Mature: 47638

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSVDLFVIGGGSGGVRAGRIAAQHGAKVMLAEEYRLGGTCVIRGCVPKKLFVYAGRYA
CCCCEEEEEEECCCCCCEECEEEHHCCCEEEEEECCCCCCEEEEECCCCCEEEEECCCHH
HDLEDMAGFGWTVEGARFDWPTLIARKDQEIARLEGIYRRNLVAPGVEIVDGRAEIIGPN
HHHHHHCCCCEEECCCCCCCHHHEECCCHHHHHHHHHHHHCCCCCCCEEECCCEEEECCC
RVRLVATGEEIEAGHILVATGAHPALGPAIPGAERAITSNEAFHLPRLPPRILIQGGGYI
EEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCEECCCCCCEEEEECCCEE
AVEFACLFRALGSEVHLVFRADQILRGFDEDVRALVAQEMAHSGIVFHTGQTLTGITAEG
EEHHHHHHHHCCCCEEEEEEHHHHHHCCCHHHHHHHHHHHHHCCEEEECCCEEEEEEECC
GTKTVTLSDGSAIAVDEVMLAIGRLPNTSGLGLDAVGVATDKVGAVIVDADGRTNVPSIY
CEEEEEECCCCEEHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCEEE
AVGDVTNRINLTPVAIREGHAFADSVFGNKPWRVDHSLVATAVFTEPEVGTCGLSETAAR
EECCCCCEEECEEEEEECCCCHHHHHCCCCCCEECHHEEEEEEECCCCCCCCCCCHHHHH
AAGHAVDIYKSQFRPMRATLSGRETRMLVKLIVDQQSDKVLGCHVVGEGAGEIIQMAAIA
HCCCEEEHHHHCCCCEEECCCCCHHHEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHH
MGMGATKADFDRTVAVHPTAAEELVTLRTKSA
HCCCCCCCCCCCEEEECCCCHHHEEEEEECCC
>Mature Secondary Structure 
SRSVDLFVIGGGSGGVRAGRIAAQHGAKVMLAEEYRLGGTCVIRGCVPKKLFVYAGRYA
CCCEEEEEEECCCCCCEECEEEHHCCCEEEEEECCCCCCEEEEECCCCCEEEEECCCHH
HDLEDMAGFGWTVEGARFDWPTLIARKDQEIARLEGIYRRNLVAPGVEIVDGRAEIIGPN
HHHHHHCCCCEEECCCCCCCHHHEECCCHHHHHHHHHHHHCCCCCCCEEECCCEEEECCC
RVRLVATGEEIEAGHILVATGAHPALGPAIPGAERAITSNEAFHLPRLPPRILIQGGGYI
EEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCEECCCCCEECCCCCCEEEEECCCEE
AVEFACLFRALGSEVHLVFRADQILRGFDEDVRALVAQEMAHSGIVFHTGQTLTGITAEG
EEHHHHHHHHCCCCEEEEEEHHHHHHCCCHHHHHHHHHHHHHCCEEEECCCEEEEEEECC
GTKTVTLSDGSAIAVDEVMLAIGRLPNTSGLGLDAVGVATDKVGAVIVDADGRTNVPSIY
CEEEEEECCCCEEHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCEEEEECCCCCCCCEEE
AVGDVTNRINLTPVAIREGHAFADSVFGNKPWRVDHSLVATAVFTEPEVGTCGLSETAAR
EECCCCCEEECEEEEEECCCCHHHHHCCCCCCEECHHEEEEEEECCCCCCCCCCCHHHHH
AAGHAVDIYKSQFRPMRATLSGRETRMLVKLIVDQQSDKVLGCHVVGEGAGEIIQMAAIA
HCCCEEEHHHHCCCCEEECCCCCHHHEEEEEECCCCCCCEEEEEEECCCHHHHHHHHHHH
MGMGATKADFDRTVAVHPTAAEELVTLRTKSA
HCCCCCCCCCCCEEEECCCCHHHEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]