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The map label for this gene is clcB [H]

Identifier: 158423632

GI number: 158423632

Start: 2315710

End: 2317479

Strand: Direct

Name: clcB [H]

Synonym: AZC_2008

Alternate gene names: 158423632

Gene position: 2315710-2317479 (Clockwise)

Preceding gene: 158423631

Following gene: 158423634

Centisome position: 43.12

GC content: 69.38

Gene sequence:

>1770_bases
ATGAGCGCGGGCGTCGAGGCGACGGGGACCGAGGCCGCCTCGACGCGCGGCTTCGCCCAGCGCCTGCGGACGCTGGCGCG
TGGGCGCGAGACCTCGCTGGTGGTGCTCGCCGCCCTGATCGGCGTTCTCGCCGGCCTGTCCGTCACCCTCATCAGCCGGG
GGGCGGAACTGCTGCACAGCGTGCTGTTCGGCGCCGCCCGCATCAGCTCCATTCCCCGGCTGCCCCTCCATGTGCTGCTC
TGGCCGGCGATCGGCGGCCTCATCATGGGCGGCGTCATCCTAGCTCTGAAGCGCTGGCGGCCCCATTCCATCGTTGATCC
CATCGAGGCCAATGCGCTGCATGGCGGACGCATGTCGCTGCCCGACAGCATCATCCTGTCCCTCCAGACCATGCTGGCGA
ACGGCTTCGGCGCGTCGGTGGGCATGGAGGCGGGCTATACGCAGTCGGGGTCGGGCCTTGCGTCCGTGATCGGCCAGTGG
CTGCGCCTGCGTCGCATGGACCTGCGCATTCTGGTCGGCTGCGGCGCTGCTGGCGGCATTGCGGCGGCCTTCCAGGCGCC
GCTGACGGGGGCTTTCTACGGCTTCGAGCTCATCATCGGCGTCTATGCCATTCCCGCCGCCGCGCCGGTGATGACCTCGG
CCCTCATCGCCTATCTCACCGCCCGGCAGCTCGGGGCGGCCTCGACGCCCATCTATGTGCCCGAGATCGGCCCGCTCGAA
CCTTCCGCCTATCTGCCATTCCTGCTGCTTGGGCTGATCGCCGGGGGCGTCGCCATCGGCATCATGCGGCTGGTGACGCT
GGTGGAGCGTGGCTTTGCGCGCAGCGGCCTGCCGCTCTGGTTGCGGCCCGCGGTCGGCGGCCTCGGCGTTGGCGCTCTCG
CCTATGTCTCGCCGCAGGTACTCTCCAGCGGCGAGGGGGCATTGCGCATCCAGGTGGGGACGGGGATCACCAGCGCCGTG
GCGCTGATCCTTCTGCTGAAGGTCTGCGCCTCATCGCTGTCGCTGGGCTCCGGTTTTCGCGGGGGACTGTTCTTCTCCTC
GCTCTTCATGGGCTCGCTGCTCGGCAAGCTGTTCGCGGGCCTTGCCGGGAGCGTGGTGCCGTGGCTCGCGCTCGATCCGG
TCATCGCCGCCGTGGTGGGCATGAGCGCGCTGGCGGTGGGCGTGGTCGGCGGCCCCTTCACCATGACGTTCCTGACGCTG
GAGATCACAGGTGATCTCCACATCGCGGGTCTCGTGCTCACCGCTTCCATCGGCTGCTCGCTGCTGGTGCGCGAGACCTT
CGGCTACTCCTTCTCCACCTGGCGTCTGCATCTGCGGGGGGAAACCATCCGCAGCGCGCTGGATGTGGGCTGGCTCAGGG
CGCTCACTGTGGAGCGGATGATGCGCACCGACGTCTCCGTGTTCGGTGCCGGCGCGGATCTTGCCGCCTTCCGTGCCGCC
TTCCCTCTGGGCTCGGTGAAGACCGTGGCGCTGCAGGACGGGGAGGGGCGCTATGTGGGCCTCGTGCCTGTGGCGGTCGC
CCATTCGGACGCCCATCCCCCGACGGAGCGGATCGAGGTGCTGGCCTGCAACGGCGACGACATCCTGCTGGCGGACATGA
ATGTGAAGCAGGCCGCCGCCGTGTTCGACCGTGCCCAGATCGACGAACTGGTGGTCGTGGATCATGCCGAGGGCCGGCGT
ATCATCGGCCTGCTCAGCGAGGCCTTCCTGCTGCGTCGCTATGCGGACGAACTGGACAAGGCGCGCCGGGGGGTGGCCGG
CGACGCCTGA

Upstream 100 bases:

>100_bases
TGGACGGTGACGGAACTGCTGGACTGGCAGGGCGAGCGGGCCTCCTCCGGCCGCCTGCCGCCCAAGGGGTTCCCGCGCAA
CAACAAGTTCGCCTGACCCC

Downstream 100 bases:

>100_bases
CGACCAGTTCGATCGCCCCTCAGGTGCGGTAGGCGGGCTCTTCGCGGTCGAGGATGCGCTTCATGCTTTCGAGGTGCAGG
CGGGCGGATTCCGCATCTCC

Product: voltage gated chloride channel family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 589; Mature: 588

Protein sequence:

>589_residues
MSAGVEATGTEAASTRGFAQRLRTLARGRETSLVVLAALIGVLAGLSVTLISRGAELLHSVLFGAARISSIPRLPLHVLL
WPAIGGLIMGGVILALKRWRPHSIVDPIEANALHGGRMSLPDSIILSLQTMLANGFGASVGMEAGYTQSGSGLASVIGQW
LRLRRMDLRILVGCGAAGGIAAAFQAPLTGAFYGFELIIGVYAIPAAAPVMTSALIAYLTARQLGAASTPIYVPEIGPLE
PSAYLPFLLLGLIAGGVAIGIMRLVTLVERGFARSGLPLWLRPAVGGLGVGALAYVSPQVLSSGEGALRIQVGTGITSAV
ALILLLKVCASSLSLGSGFRGGLFFSSLFMGSLLGKLFAGLAGSVVPWLALDPVIAAVVGMSALAVGVVGGPFTMTFLTL
EITGDLHIAGLVLTASIGCSLLVRETFGYSFSTWRLHLRGETIRSALDVGWLRALTVERMMRTDVSVFGAGADLAAFRAA
FPLGSVKTVALQDGEGRYVGLVPVAVAHSDAHPPTERIEVLACNGDDILLADMNVKQAAAVFDRAQIDELVVVDHAEGRR
IIGLLSEAFLLRRYADELDKARRGVAGDA

Sequences:

>Translated_589_residues
MSAGVEATGTEAASTRGFAQRLRTLARGRETSLVVLAALIGVLAGLSVTLISRGAELLHSVLFGAARISSIPRLPLHVLL
WPAIGGLIMGGVILALKRWRPHSIVDPIEANALHGGRMSLPDSIILSLQTMLANGFGASVGMEAGYTQSGSGLASVIGQW
LRLRRMDLRILVGCGAAGGIAAAFQAPLTGAFYGFELIIGVYAIPAAAPVMTSALIAYLTARQLGAASTPIYVPEIGPLE
PSAYLPFLLLGLIAGGVAIGIMRLVTLVERGFARSGLPLWLRPAVGGLGVGALAYVSPQVLSSGEGALRIQVGTGITSAV
ALILLLKVCASSLSLGSGFRGGLFFSSLFMGSLLGKLFAGLAGSVVPWLALDPVIAAVVGMSALAVGVVGGPFTMTFLTL
EITGDLHIAGLVLTASIGCSLLVRETFGYSFSTWRLHLRGETIRSALDVGWLRALTVERMMRTDVSVFGAGADLAAFRAA
FPLGSVKTVALQDGEGRYVGLVPVAVAHSDAHPPTERIEVLACNGDDILLADMNVKQAAAVFDRAQIDELVVVDHAEGRR
IIGLLSEAFLLRRYADELDKARRGVAGDA
>Mature_588_residues
SAGVEATGTEAASTRGFAQRLRTLARGRETSLVVLAALIGVLAGLSVTLISRGAELLHSVLFGAARISSIPRLPLHVLLW
PAIGGLIMGGVILALKRWRPHSIVDPIEANALHGGRMSLPDSIILSLQTMLANGFGASVGMEAGYTQSGSGLASVIGQWL
RLRRMDLRILVGCGAAGGIAAAFQAPLTGAFYGFELIIGVYAIPAAAPVMTSALIAYLTARQLGAASTPIYVPEIGPLEP
SAYLPFLLLGLIAGGVAIGIMRLVTLVERGFARSGLPLWLRPAVGGLGVGALAYVSPQVLSSGEGALRIQVGTGITSAVA
LILLLKVCASSLSLGSGFRGGLFFSSLFMGSLLGKLFAGLAGSVVPWLALDPVIAAVVGMSALAVGVVGGPFTMTFLTLE
ITGDLHIAGLVLTASIGCSLLVRETFGYSFSTWRLHLRGETIRSALDVGWLRALTVERMMRTDVSVFGAGADLAAFRAAF
PLGSVKTVALQDGEGRYVGLVPVAVAHSDAHPPTERIEVLACNGDDILLADMNVKQAAAVFDRAQIDELVVVDHAEGRRI
IGLLSEAFLLRRYADELDKARRGVAGDA

Specific function: Probably acts as an electrical shunt for an outwardly- directed proton pump that is linked to amino acid decarboxylation, as part of the extreme acid resistance (XAR) response [H]

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcB subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081943, Length=415, Percent_Identity=27.9518072289157, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 61185; Mature: 61054

Theoretical pI: Translated: 8.86; Mature: 8.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAGVEATGTEAASTRGFAQRLRTLARGRETSLVVLAALIGVLAGLSVTLISRGAELLHS
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLFGAARISSIPRLPLHVLLWPAIGGLIMGGVILALKRWRPHSIVDPIEANALHGGRMSL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PDSIILSLQTMLANGFGASVGMEAGYTQSGSGLASVIGQWLRLRRMDLRILVGCGAAGGI
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCH
AAAFQAPLTGAFYGFELIIGVYAIPAAAPVMTSALIAYLTARQLGAASTPIYVPEIGPLE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCC
PSAYLPFLLLGLIAGGVAIGIMRLVTLVERGFARSGLPLWLRPAVGGLGVGALAYVSPQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHCCHHH
LSSGEGALRIQVGTGITSAVALILLLKVCASSLSLGSGFRGGLFFSSLFMGSLLGKLFAG
HCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LAGSVVPWLALDPVIAAVVGMSALAVGVVGGPFTMTFLTLEITGDLHIAGLVLTASIGCS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCEEHHHHHHHHHHCHH
LLVRETFGYSFSTWRLHLRGETIRSALDVGWLRALTVERMMRTDVSVFGAGADLAAFRAA
HEEHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHH
FPLGSVKTVALQDGEGRYVGLVPVAVAHSDAHPPTERIEVLACNGDDILLADMNVKQAAA
CCCCCEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCEEEEEECCCEEEEECCCHHHHHH
VFDRAQIDELVVVDHAEGRRIIGLLSEAFLLRRYADELDKARRGVAGDA
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAGVEATGTEAASTRGFAQRLRTLARGRETSLVVLAALIGVLAGLSVTLISRGAELLHS
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLFGAARISSIPRLPLHVLLWPAIGGLIMGGVILALKRWRPHSIVDPIEANALHGGRMSL
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PDSIILSLQTMLANGFGASVGMEAGYTQSGSGLASVIGQWLRLRRMDLRILVGCGAAGGI
CHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCH
AAAFQAPLTGAFYGFELIIGVYAIPAAAPVMTSALIAYLTARQLGAASTPIYVPEIGPLE
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCC
PSAYLPFLLLGLIAGGVAIGIMRLVTLVERGFARSGLPLWLRPAVGGLGVGALAYVSPQV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHCCHHH
LSSGEGALRIQVGTGITSAVALILLLKVCASSLSLGSGFRGGLFFSSLFMGSLLGKLFAG
HCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
LAGSVVPWLALDPVIAAVVGMSALAVGVVGGPFTMTFLTLEITGDLHIAGLVLTASIGCS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEECCEEHHHHHHHHHHCHH
LLVRETFGYSFSTWRLHLRGETIRSALDVGWLRALTVERMMRTDVSVFGAGADLAAFRAA
HEEHHHCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCHHHHHHHH
FPLGSVKTVALQDGEGRYVGLVPVAVAHSDAHPPTERIEVLACNGDDILLADMNVKQAAA
CCCCCEEEEEEECCCCCEEEEEEEEEECCCCCCCCCCEEEEEECCCEEEEECCCHHHHHH
VFDRAQIDELVVVDHAEGRRIIGLLSEAFLLRRYADELDKARRGVAGDA
HHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA