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The map label for this gene is parC [H]

Identifier: 158423631

GI number: 158423631

Start: 2313468

End: 2315705

Strand: Direct

Name: parC [H]

Synonym: AZC_2007

Alternate gene names: 158423631

Gene position: 2313468-2315705 (Clockwise)

Preceding gene: 158423630

Following gene: 158423632

Centisome position: 43.08

GC content: 67.25

Gene sequence:

>2238_bases
ATGGCCACAAAAACCTTGCCCCCCGGCGGCGGCTCCGTCGAGCCGGTCGATCTGAAAGCAGCGCTCGAGGAGCGCTATCT
GGCCTATGCCCTCTCGACCATCATGCACCGGGCGCTGCCCGATGCGCGGGACGGGCTGAAGCCGGTGCACCGCCGCATCC
TCCACGCCATGCGGCAGCTCAAGCTCGATCCGGGGTCCGGCTTCAAGAAATGCGCCCGCGTGGTGGGCGACGTCATCGGT
AAGTTCCATCCGCACGGCGATCAGGCGGTCTATGACGCCTTGGTGCGTCTCGCGCAGGATTTCGCGCAGCGCTACCCGCT
GGTGGACGGGCAGGGCAATTTCGGCAATGTGGACGGCGATAACGCCGCCGCCATGCGATACACGGAAGCCCGCCTCACCG
AGACGGCGCGCCTGCTGCTGGACGGCATCGACGATGATGCGGTGGACTTCCGGCCGACCTATGACGGCTCCGAGGAGGAG
CCGGTGGTGCTGCCCGCCGCCTTCCCGAACCTGCTGGCCAACGGCTCGCAGGGCATCGCGGTGGGCATGGCGACGTCCAT
CCCGCCGCACAACGCCGCCGAACTGCTGGACGCCTCGCTCCATTTGCTGGAGCACCCGAACGCGCCGGCTTCTGATCTGC
TCCAGTTCGTGCCCGGCCCCGATTTCCCCACCGGCGGCATTCTGGTGGAAGACCCGGTCGGCACGGCGGAAGCCTATGCC
ACGGGACGCGGCGCCTTCCGCGTGCGCGCCCGCTGGCACAAGGAAGAGACCGGGCGCGGCACCTATGTGGTTGTGGTGAC
GGAGATCCCCTATGGCGTGCCGAAGTCGCGCCTCGTGGAGAAGATCGCCGAGCTCCTCACCGACAAGAAGCTGCCGCTGC
TGGCGGACGTGCGCGACGAGAGCGCAGAGGACATCCGCCTCGTTCTGGAGCCCCGCGCCCGCACGGTGGATGCCGAAGTG
CTCATGGAGAGCCTGTTCAAGCTCACCGAGCTTGAGTCCCGCGTCTCCCTGAACATGAACGTGCTGGTGCGCGGTCAGGT
GCCCAAGGTGCTCTCGCTGGCCGATGCGCTGCGCGAGTGGCTGGACCACCGCCGCGAGGTGCTGCTGCGCCGTTCGCGCA
ACCGGCTCAGCCAGATCGCTCACCGGCTGGAAGTGCTGGGTGGCTATCTGATCGCCTATCTCAACCTTGACGAGGTGATC
CGCATCATCCGCGAGGAGGACGAGCCGAAGGTCGAGCTGATGCGGACCTTCGAGTTGACCGACCTTCAGGCCGAATCCAT
CCTCAACATGCGCTTGCGGTCCTTGCGGCGCCTCGAGGAGATGGAGCTGCGCAAGGAGCATGCGGCCCTCACCAAGGAGC
AGGAACAGCTGAACAAGCTGGTCGCTTCCGAGGCCGCCCAGTGGAAGGCCATCGGCAAGGAGATCCGCGAGACCCGCAAG
ACCTATGGGCCGGACACCGAGATCGGCCGTCGCCGCACCGATTTCGCCGTTCCGCCGGACGTGCACGAGAGCGCCTTCAC
CGAGGCGCTGGTGGAGCGCGAGCCCATCACCATCGTCATGTCCGCCAAGGGCTGGATCCGCGCGCTGAAAGGCCATGTGG
CCGACGTGACGGGCGTGCCTTTCAAGGGCGATGACACGCTCGCCCACGCCTTCTATGCGGAGACCACCTCCAAGATCATG
GTGCTCTCCTCCAACGGGCGATTCTTCACGCTGGATGCGGCCAAGCTCCCCGGCGGGCGCGGCCATGGCGAGCCCGTGCG
CCTGATGATCGAGCTGGAGCAGGAAGCGGAGATTGTATCCGTCTTCGCGCACCGGCCGGGCGGCAAGCTCATTGTCGCCT
CCAGGGAGGGACGGGGCTTCGTGGTGGCGGAGGACGATTGCCTCGCCAACACCCGCAAGGGCAAGCAGGTGCTGGGCGTG
GACGCGCCCGATGCAGCCGTTCTGGCAGTGCCGGCAGATGGCGATACGGTTGCCGTGATCGGCGACAACCGCAAGCTGCT
CCTCTTCCCCATCGCGCAGGTGCCGGAAATGACCCGCGGCCGCGGCGTCCGCCTCCAGCGCTACAAGGAAGGCGGCCTCT
CGGACCTCAAGGTGTTCAACCGCGCCGACGGCCTCACCTGGGAGGATTCCTCCGGCCGCACCTGGACGGTGACGGAACTG
CTGGACTGGCAGGGCGAGCGGGCCTCCTCCGGCCGCCTGCCGCCCAAGGGGTTCCCGCGCAACAACAAGTTCGCCTGA

Upstream 100 bases:

>100_bases
GCCGTTCATTCTTGGGACGGGCCGGAGGCAGCGTCACGACAAAGCTGTGCGGATATGTGTCCGGCTTGTTTCGCGCGGGC
GGGCGCGCTAGTCGGAAGCC

Downstream 100 bases:

>100_bases
CCCCATGAGCGCGGGCGTCGAGGCGACGGGGACCGAGGCCGCCTCGACGCGCGGCTTCGCCCAGCGCCTGCGGACGCTGG
CGCGTGGGCGCGAGACCTCG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 745; Mature: 744

Protein sequence:

>745_residues
MATKTLPPGGGSVEPVDLKAALEERYLAYALSTIMHRALPDARDGLKPVHRRILHAMRQLKLDPGSGFKKCARVVGDVIG
KFHPHGDQAVYDALVRLAQDFAQRYPLVDGQGNFGNVDGDNAAAMRYTEARLTETARLLLDGIDDDAVDFRPTYDGSEEE
PVVLPAAFPNLLANGSQGIAVGMATSIPPHNAAELLDASLHLLEHPNAPASDLLQFVPGPDFPTGGILVEDPVGTAEAYA
TGRGAFRVRARWHKEETGRGTYVVVVTEIPYGVPKSRLVEKIAELLTDKKLPLLADVRDESAEDIRLVLEPRARTVDAEV
LMESLFKLTELESRVSLNMNVLVRGQVPKVLSLADALREWLDHRREVLLRRSRNRLSQIAHRLEVLGGYLIAYLNLDEVI
RIIREEDEPKVELMRTFELTDLQAESILNMRLRSLRRLEEMELRKEHAALTKEQEQLNKLVASEAAQWKAIGKEIRETRK
TYGPDTEIGRRRTDFAVPPDVHESAFTEALVEREPITIVMSAKGWIRALKGHVADVTGVPFKGDDTLAHAFYAETTSKIM
VLSSNGRFFTLDAAKLPGGRGHGEPVRLMIELEQEAEIVSVFAHRPGGKLIVASREGRGFVVAEDDCLANTRKGKQVLGV
DAPDAAVLAVPADGDTVAVIGDNRKLLLFPIAQVPEMTRGRGVRLQRYKEGGLSDLKVFNRADGLTWEDSSGRTWTVTEL
LDWQGERASSGRLPPKGFPRNNKFA

Sequences:

>Translated_745_residues
MATKTLPPGGGSVEPVDLKAALEERYLAYALSTIMHRALPDARDGLKPVHRRILHAMRQLKLDPGSGFKKCARVVGDVIG
KFHPHGDQAVYDALVRLAQDFAQRYPLVDGQGNFGNVDGDNAAAMRYTEARLTETARLLLDGIDDDAVDFRPTYDGSEEE
PVVLPAAFPNLLANGSQGIAVGMATSIPPHNAAELLDASLHLLEHPNAPASDLLQFVPGPDFPTGGILVEDPVGTAEAYA
TGRGAFRVRARWHKEETGRGTYVVVVTEIPYGVPKSRLVEKIAELLTDKKLPLLADVRDESAEDIRLVLEPRARTVDAEV
LMESLFKLTELESRVSLNMNVLVRGQVPKVLSLADALREWLDHRREVLLRRSRNRLSQIAHRLEVLGGYLIAYLNLDEVI
RIIREEDEPKVELMRTFELTDLQAESILNMRLRSLRRLEEMELRKEHAALTKEQEQLNKLVASEAAQWKAIGKEIRETRK
TYGPDTEIGRRRTDFAVPPDVHESAFTEALVEREPITIVMSAKGWIRALKGHVADVTGVPFKGDDTLAHAFYAETTSKIM
VLSSNGRFFTLDAAKLPGGRGHGEPVRLMIELEQEAEIVSVFAHRPGGKLIVASREGRGFVVAEDDCLANTRKGKQVLGV
DAPDAAVLAVPADGDTVAVIGDNRKLLLFPIAQVPEMTRGRGVRLQRYKEGGLSDLKVFNRADGLTWEDSSGRTWTVTEL
LDWQGERASSGRLPPKGFPRNNKFA
>Mature_744_residues
ATKTLPPGGGSVEPVDLKAALEERYLAYALSTIMHRALPDARDGLKPVHRRILHAMRQLKLDPGSGFKKCARVVGDVIGK
FHPHGDQAVYDALVRLAQDFAQRYPLVDGQGNFGNVDGDNAAAMRYTEARLTETARLLLDGIDDDAVDFRPTYDGSEEEP
VVLPAAFPNLLANGSQGIAVGMATSIPPHNAAELLDASLHLLEHPNAPASDLLQFVPGPDFPTGGILVEDPVGTAEAYAT
GRGAFRVRARWHKEETGRGTYVVVVTEIPYGVPKSRLVEKIAELLTDKKLPLLADVRDESAEDIRLVLEPRARTVDAEVL
MESLFKLTELESRVSLNMNVLVRGQVPKVLSLADALREWLDHRREVLLRRSRNRLSQIAHRLEVLGGYLIAYLNLDEVIR
IIREEDEPKVELMRTFELTDLQAESILNMRLRSLRRLEEMELRKEHAALTKEQEQLNKLVASEAAQWKAIGKEIRETRKT
YGPDTEIGRRRTDFAVPPDVHESAFTEALVEREPITIVMSAKGWIRALKGHVADVTGVPFKGDDTLAHAFYAETTSKIMV
LSSNGRFFTLDAAKLPGGRGHGEPVRLMIELEQEAEIVSVFAHRPGGKLIVASREGRGFVVAEDDCLANTRKGKQVLGVD
APDAAVLAVPADGDTVAVIGDNRKLLLFPIAQVPEMTRGRGVRLQRYKEGGLSDLKVFNRADGLTWEDSSGRTWTVTELL
DWQGERASSGRLPPKGFPRNNKFA

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=397, Percent_Identity=27.2040302267003, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI19913406, Length=414, Percent_Identity=24.1545893719807, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1789396, Length=670, Percent_Identity=40.5970149253731, Blast_Score=506, Evalue=1e-144,
Organism=Escherichia coli, GI1788562, Length=795, Percent_Identity=35.4716981132075, Blast_Score=413, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI212645845, Length=474, Percent_Identity=23.4177215189873, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17535065, Length=453, Percent_Identity=24.2825607064018, Blast_Score=75, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=351, Percent_Identity=27.0655270655271, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136538, Length=355, Percent_Identity=24.2253521126761, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 82317; Mature: 82186

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATKTLPPGGGSVEPVDLKAALEERYLAYALSTIMHRALPDARDGLKPVHRRILHAMRQL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHC
KLDPGSGFKKCARVVGDVIGKFHPHGDQAVYDALVRLAQDFAQRYPLVDGQGNFGNVDGD
CCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NAAAMRYTEARLTETARLLLDGIDDDAVDFRPTYDGSEEEPVVLPAAFPNLLANGSQGIA
CCHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCCCCEE
VGMATSIPPHNAAELLDASLHLLEHPNAPASDLLQFVPGPDFPTGGILVEDPVGTAEAYA
EEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCHHHHH
TGRGAFRVRARWHKEETGRGTYVVVVTEIPYGVPKSRLVEKIAELLTDKKLPLLADVRDE
CCCCEEEEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCC
SAEDIRLVLEPRARTVDAEVLMESLFKLTELESRVSLNMNVLVRGQVPKVLSLADALREW
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHH
LDHRREVLLRRSRNRLSQIAHRLEVLGGYLIAYLNLDEVIRIIREEDEPKVELMRTFELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCCHHHHHHHHHHH
DLQAESILNMRLRSLRRLEEMELRKEHAALTKEQEQLNKLVASEAAQWKAIGKEIRETRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYGPDTEIGRRRTDFAVPPDVHESAFTEALVEREPITIVMSAKGWIRALKGHVADVTGVP
HCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCCCC
FKGDDTLAHAFYAETTSKIMVLSSNGRFFTLDAAKLPGGRGHGEPVRLMIELEQEAEIVS
CCCCCHHHHHHHHCCCCEEEEEECCCCEEEEEHHHCCCCCCCCCCEEEEEEECCHHHHHH
VFAHRPGGKLIVASREGRGFVVAEDDCLANTRKGKQVLGVDAPDAAVLAVPADGDTVAVI
HHHCCCCCEEEEEECCCCEEEEECCHHHCCCCCCCEEEECCCCCCEEEEEECCCCEEEEE
GDNRKLLLFPIAQVPEMTRGRGVRLQRYKEGGLSDLKVFNRADGLTWEDSSGRTWTVTEL
ECCCEEEEEECHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCEECCCCCEEEEHHH
LDWQGERASSGRLPPKGFPRNNKFA
HCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATKTLPPGGGSVEPVDLKAALEERYLAYALSTIMHRALPDARDGLKPVHRRILHAMRQL
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHC
KLDPGSGFKKCARVVGDVIGKFHPHGDQAVYDALVRLAQDFAQRYPLVDGQGNFGNVDGD
CCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
NAAAMRYTEARLTETARLLLDGIDDDAVDFRPTYDGSEEEPVVLPAAFPNLLANGSQGIA
CCHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCHHHHCCCCCCEE
VGMATSIPPHNAAELLDASLHLLEHPNAPASDLLQFVPGPDFPTGGILVEDPVGTAEAYA
EEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCHHHHH
TGRGAFRVRARWHKEETGRGTYVVVVTEIPYGVPKSRLVEKIAELLTDKKLPLLADVRDE
CCCCEEEEEEEECCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCC
SAEDIRLVLEPRARTVDAEVLMESLFKLTELESRVSLNMNVLVRGQVPKVLSLADALREW
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHH
LDHRREVLLRRSRNRLSQIAHRLEVLGGYLIAYLNLDEVIRIIREEDEPKVELMRTFELT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCCHHHHHHHHHHH
DLQAESILNMRLRSLRRLEEMELRKEHAALTKEQEQLNKLVASEAAQWKAIGKEIRETRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TYGPDTEIGRRRTDFAVPPDVHESAFTEALVEREPITIVMSAKGWIRALKGHVADVTGVP
HCCCCCHHCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHCCCCCCCCCC
FKGDDTLAHAFYAETTSKIMVLSSNGRFFTLDAAKLPGGRGHGEPVRLMIELEQEAEIVS
CCCCCHHHHHHHHCCCCEEEEEECCCCEEEEEHHHCCCCCCCCCCEEEEEEECCHHHHHH
VFAHRPGGKLIVASREGRGFVVAEDDCLANTRKGKQVLGVDAPDAAVLAVPADGDTVAVI
HHHCCCCCEEEEEECCCCEEEEECCHHHCCCCCCCEEEECCCCCCEEEEEECCCCEEEEE
GDNRKLLLFPIAQVPEMTRGRGVRLQRYKEGGLSDLKVFNRADGLTWEDSSGRTWTVTEL
ECCCEEEEEECHHCCCCCCCCCCEEEECCCCCCHHHHHHHHCCCCCEECCCCCEEEEHHH
LDWQGERASSGRLPPKGFPRNNKFA
HCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]