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The map label for this gene is lysR [H]

Identifier: 158423621

GI number: 158423621

Start: 2302584

End: 2303558

Strand: Direct

Name: lysR [H]

Synonym: AZC_1997

Alternate gene names: 158423621

Gene position: 2302584-2303558 (Clockwise)

Preceding gene: 158423620

Following gene: 158423623

Centisome position: 42.88

GC content: 68.1

Gene sequence:

>975_bases
ATGGATCAGCTTGCCGCGATGCGGTGCTTCATCGGCGTGGTGGAGGCCGGCACCTTCAGCCGCGCGTCCACCGTGCTTCG
GGTGCCGAAGGCGACCCTCACCAAGAACGTGCAGGCGCTCGAAGCCCATCTGCGCACCAAGCTCCTGCACCGCACCACCC
GCCGCGTGACCGTAACGCCGGATGGCGAGGCCTATTACGAGCGCGCGGTGCGTCTGCTGGCGGACCTAGAAGACCTGGAC
AGCACGATGGCGGTGTCGCAGGCCAATCCGCAGGGGCGCCTGCGCGTCGATATCTCCGCTGCCCTTGCCACCATGCTGCT
GATCCCGGCGCTGCCGGACTTCCACGCCCGCTATCCCGACATCCAGATCGATCTCGGCGTGACCGACGACGTGGTGGACC
TGCTGGGCGAGAATGTGGACTGCGTGATCCGCGCCGGTCAGCTGGCCGACCAGTCTCTGGTGGCCCGCCGCATCGGCGAG
ATGCACTCGGTCCTGGTTGCCGCGCCCGGCTATCTCGAGGCCCATGGCACGCCTGCCCATCCGCTGGACCTTGAGACCTC
CCACCGGGCGGTCGGCTATTTCAAGCCGCGCATGGGACGATCCCTCTCGCTCACCCTGAGCAAGGATGCCGACGAGGCCG
TCGAGGTGAACGGGCGCTATATGCTCGCGGTGAGCGACAGCAACGCCTACATCACGGCCGCCATGGCGGGGATCGGGATT
GCCATGATGCCGGTGTTCATGGCCCGGCCGCACATCGAGAGCGGGGCGCTGGTGCCGGTTCTCACCGAGTGGCGGGCGCC
GGCAAAGCCCATCTATGCGGTCTTCCCGCCCTCCCGGCACCTCAGCAACCGGCTCCGCGTGTTCGTGGACTGGGTCGCGG
CGCTCGTGGCGCGCACCGATTTCGGCATGCGGGATGCTCCCGCCAAGCCGCGCGAGGCGGCGGTGACGTCGCCCCGCATC
TCGGTCGTGAAATAA

Upstream 100 bases:

>100_bases
CCGGGAGGATTGTTTATAAAGAGGATCAAGTCTGGCGTGAGTGGCGGTAATAATTTCCCGTCAGAAACAATCCGCCGGAC
GCCCTCCTCGGAGCCTCTGC

Downstream 100 bases:

>100_bases
GGGACGCTCAGGCCGCGCGGTTGCCGAGGCCGAGGCGCATCACCGTGCGCCGCAGCGGCCCCACGCGGTCGAGCAGATAA
AGGCCGAAGCCGCGCACGCT

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MDQLAAMRCFIGVVEAGTFSRASTVLRVPKATLTKNVQALEAHLRTKLLHRTTRRVTVTPDGEAYYERAVRLLADLEDLD
STMAVSQANPQGRLRVDISAALATMLLIPALPDFHARYPDIQIDLGVTDDVVDLLGENVDCVIRAGQLADQSLVARRIGE
MHSVLVAAPGYLEAHGTPAHPLDLETSHRAVGYFKPRMGRSLSLTLSKDADEAVEVNGRYMLAVSDSNAYITAAMAGIGI
AMMPVFMARPHIESGALVPVLTEWRAPAKPIYAVFPPSRHLSNRLRVFVDWVAALVARTDFGMRDAPAKPREAAVTSPRI
SVVK

Sequences:

>Translated_324_residues
MDQLAAMRCFIGVVEAGTFSRASTVLRVPKATLTKNVQALEAHLRTKLLHRTTRRVTVTPDGEAYYERAVRLLADLEDLD
STMAVSQANPQGRLRVDISAALATMLLIPALPDFHARYPDIQIDLGVTDDVVDLLGENVDCVIRAGQLADQSLVARRIGE
MHSVLVAAPGYLEAHGTPAHPLDLETSHRAVGYFKPRMGRSLSLTLSKDADEAVEVNGRYMLAVSDSNAYITAAMAGIGI
AMMPVFMARPHIESGALVPVLTEWRAPAKPIYAVFPPSRHLSNRLRVFVDWVAALVARTDFGMRDAPAKPREAAVTSPRI
SVVK
>Mature_324_residues
MDQLAAMRCFIGVVEAGTFSRASTVLRVPKATLTKNVQALEAHLRTKLLHRTTRRVTVTPDGEAYYERAVRLLADLEDLD
STMAVSQANPQGRLRVDISAALATMLLIPALPDFHARYPDIQIDLGVTDDVVDLLGENVDCVIRAGQLADQSLVARRIGE
MHSVLVAAPGYLEAHGTPAHPLDLETSHRAVGYFKPRMGRSLSLTLSKDADEAVEVNGRYMLAVSDSNAYITAAMAGIGI
AMMPVFMARPHIESGALVPVLTEWRAPAKPIYAVFPPSRHLSNRLRVFVDWVAALVARTDFGMRDAPAKPREAAVTSPRI
SVVK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693193, Length=302, Percent_Identity=38.4105960264901, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1786401, Length=285, Percent_Identity=29.8245614035088, Blast_Score=147, Evalue=7e-37,
Organism=Escherichia coli, GI1789639, Length=290, Percent_Identity=29.6551724137931, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787128, Length=285, Percent_Identity=27.3684210526316, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI87081978, Length=303, Percent_Identity=31.023102310231, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1789440, Length=292, Percent_Identity=27.7397260273973, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1787589, Length=292, Percent_Identity=27.7397260273973, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789173, Length=294, Percent_Identity=24.4897959183673, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787601, Length=146, Percent_Identity=24.6575342465753, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI157672245, Length=116, Percent_Identity=30.1724137931034, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1787879, Length=281, Percent_Identity=23.4875444839858, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35282; Mature: 35282

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQLAAMRCFIGVVEAGTFSRASTVLRVPKATLTKNVQALEAHLRTKLLHRTTRRVTVTP
CCHHHHHHHHHHHHCCCCCHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
DGEAYYERAVRLLADLEDLDSTMAVSQANPQGRLRVDISAALATMLLIPALPDFHARYPD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCHHCCCCC
IQIDLGVTDDVVDLLGENVDCVIRAGQLADQSLVARRIGEMHSVLVAAPGYLEAHGTPAH
EEEECCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHEEEECCCEEECCCCCCC
PLDLETSHRAVGYFKPRMGRSLSLTLSKDADEAVEVNGRYMLAVSDSNAYITAAMAGIGI
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCEEECCEEEEEEECCCCEEEEHHHHHHH
AMMPVFMARPHIESGALVPVLTEWRAPAKPIYAVFPPSRHLSNRLRVFVDWVAALVARTD
HHHHHHHHCCCCCCCCEEEEHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
FGMRDAPAKPREAAVTSPRISVVK
CCCCCCCCCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MDQLAAMRCFIGVVEAGTFSRASTVLRVPKATLTKNVQALEAHLRTKLLHRTTRRVTVTP
CCHHHHHHHHHHHHCCCCCHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHHHCCEEEECC
DGEAYYERAVRLLADLEDLDSTMAVSQANPQGRLRVDISAALATMLLIPALPDFHARYPD
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHCCCCHHCCCCC
IQIDLGVTDDVVDLLGENVDCVIRAGQLADQSLVARRIGEMHSVLVAAPGYLEAHGTPAH
EEEECCCCHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHEEEECCCEEECCCCCCC
PLDLETSHRAVGYFKPRMGRSLSLTLSKDADEAVEVNGRYMLAVSDSNAYITAAMAGIGI
CCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCEEECCEEEEEEECCCCEEEEHHHHHHH
AMMPVFMARPHIESGALVPVLTEWRAPAKPIYAVFPPSRHLSNRLRVFVDWVAALVARTD
HHHHHHHHCCCCCCCCEEEEHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCC
FGMRDAPAKPREAAVTSPRISVVK
CCCCCCCCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503 [H]