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The map label for this gene is mvaB [H]

Identifier: 158423620

GI number: 158423620

Start: 2301560

End: 2302456

Strand: Direct

Name: mvaB [H]

Synonym: AZC_1996

Alternate gene names: 158423620

Gene position: 2301560-2302456 (Clockwise)

Preceding gene: 158423617

Following gene: 158423621

Centisome position: 42.86

GC content: 70.01

Gene sequence:

>897_bases
ATGGCCTTCCCCGCAGATGTGCGCGTTGTCGAGGTCGGCCCGCGCGACGGGCTGCAGAATGAAGCCACGCTGGTTCCCGA
GGCGGTGAAGGTCGACCTCATCGCCCGCCTTGCGGCGGCGGGCCTCAGGACCATCGAGGCCGGCAGCTTCGTGGCGCCCA
AATGGGTGCCGCAGATGGCCGGAAGCGCCGAAGTCCTGAAAGCCGCGCCGCGGCGGCCGGGCGTCTCCTATCCGGTGCTG
GTGCCGAACATGAAGGGATTCGAGGCGGCGCTGGCGGCGGGCGCGCAAGAGGTGGCGGTTTTCGCCGCGGCCTCCGAGGC
CTTCTCGCAGAAGAACATCAACTGCTCCATTGCCGAGAGCCTGGCGCGCTTTGCGCCGGTGATGGAGGCCGCGCGCGCCG
CCGGGGTGCGGGTGCGGGGCTATGTGTCCTGCGTGCTCGGATGCCCCTATCAGGGGGAGGTGCCGCTGGCCGCGGTGGTG
GACGTGGCGGAGCGCCTCTCTCAGATGGGCTGCTACGAAATCTCGCTTGGCGACACCATCGGCGTCGGCACGCCGCGGAA
GGCCGTCGCGATGCTCGACGCGGTGCTGGGAGCGCTGCCCGTGGAGCAGGTGGCCCTGCATTTCCACGACACCTACGGGC
AGGCGCTCGCCAACATCTATGCCTGCCTCGATCGTGGGGTGGCCGTGCTCGATGCCTCCGTGGGCGGGCTCGGCGGGTGC
CCCTATGCGGCGGGAGCGAGCGGCAATGTGGCCACGGAGGATCTCGTCTACATGCTGGAAGGCATGGGCATCCGTACCGG
GGTCGATCTCGAGGCGCTGGTGGAAGCCGCCGCCTTCATCTCGGCGGCCATCGGCCGCGCGCCCGCCTCCCATCTCGCCA
AGGCTCGCGGCTATTAG

Upstream 100 bases:

>100_bases
CGCGACGCAAGGGAGACGATGATGAGGATCTGCCCGCCTGCGGCCCGCCCGCATGTTGAACGCAAGGCCCGTCCGGATCT
GGCGCAGGGAGCGGTCTGAC

Downstream 100 bases:

>100_bases
CCGGCTGGGGCCTGACGTTGCTGTGCACCGGGAGGATTGTTTATAAAGAGGATCAAGTCTGGCGTGAGTGGCGGTAATAA
TTTCCCGTCAGAAACAATCC

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MAFPADVRVVEVGPRDGLQNEATLVPEAVKVDLIARLAAAGLRTIEAGSFVAPKWVPQMAGSAEVLKAAPRRPGVSYPVL
VPNMKGFEAALAAGAQEVAVFAAASEAFSQKNINCSIAESLARFAPVMEAARAAGVRVRGYVSCVLGCPYQGEVPLAAVV
DVAERLSQMGCYEISLGDTIGVGTPRKAVAMLDAVLGALPVEQVALHFHDTYGQALANIYACLDRGVAVLDASVGGLGGC
PYAAGASGNVATEDLVYMLEGMGIRTGVDLEALVEAAAFISAAIGRAPASHLAKARGY

Sequences:

>Translated_298_residues
MAFPADVRVVEVGPRDGLQNEATLVPEAVKVDLIARLAAAGLRTIEAGSFVAPKWVPQMAGSAEVLKAAPRRPGVSYPVL
VPNMKGFEAALAAGAQEVAVFAAASEAFSQKNINCSIAESLARFAPVMEAARAAGVRVRGYVSCVLGCPYQGEVPLAAVV
DVAERLSQMGCYEISLGDTIGVGTPRKAVAMLDAVLGALPVEQVALHFHDTYGQALANIYACLDRGVAVLDASVGGLGGC
PYAAGASGNVATEDLVYMLEGMGIRTGVDLEALVEAAAFISAAIGRAPASHLAKARGY
>Mature_297_residues
AFPADVRVVEVGPRDGLQNEATLVPEAVKVDLIARLAAAGLRTIEAGSFVAPKWVPQMAGSAEVLKAAPRRPGVSYPVLV
PNMKGFEAALAAGAQEVAVFAAASEAFSQKNINCSIAESLARFAPVMEAARAAGVRVRGYVSCVLGCPYQGEVPLAAVVD
VAERLSQMGCYEISLGDTIGVGTPRKAVAMLDAVLGALPVEQVALHFHDTYGQALANIYACLDRGVAVLDASVGGLGGCP
YAAGASGNVATEDLVYMLEGMGIRTGVDLEALVEAAAFISAAIGRAPASHLAKARGY

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=294, Percent_Identity=59.8639455782313, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI109150427, Length=293, Percent_Identity=56.3139931740614, Blast_Score=355, Evalue=2e-98,
Organism=Homo sapiens, GI109150422, Length=293, Percent_Identity=56.3139931740614, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI260654708, Length=294, Percent_Identity=41.4965986394558, Blast_Score=204, Evalue=6e-53,
Organism=Caenorhabditis elegans, GI17510563, Length=289, Percent_Identity=54.3252595155709, Blast_Score=325, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24582381, Length=290, Percent_Identity=61.7241379310345, Blast_Score=373, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 30584; Mature: 30452

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFPADVRVVEVGPRDGLQNEATLVPEAVKVDLIARLAAAGLRTIEAGSFVAPKWVPQMA
CCCCCCEEEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHC
GSAEVLKAAPRRPGVSYPVLVPNMKGFEAALAAGAQEVAVFAAASEAFSQKNINCSIAES
CCHHHHHHCCCCCCCCCCEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHH
LARFAPVMEAARAAGVRVRGYVSCVLGCPYQGEVPLAAVVDVAERLSQMGCYEISLGDTI
HHHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEE
GVGTPRKAVAMLDAVLGALPVEQVALHFHDTYGQALANIYACLDRGVAVLDASVGGLGGC
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCC
PYAAGASGNVATEDLVYMLEGMGIRTGVDLEALVEAAAFISAAIGRAPASHLAKARGY
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure 
AFPADVRVVEVGPRDGLQNEATLVPEAVKVDLIARLAAAGLRTIEAGSFVAPKWVPQMA
CCCCCEEEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHEECCCCCCCCHHHHHHC
GSAEVLKAAPRRPGVSYPVLVPNMKGFEAALAAGAQEVAVFAAASEAFSQKNINCSIAES
CCHHHHHHCCCCCCCCCCEECCCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHHHH
LARFAPVMEAARAAGVRVRGYVSCVLGCPYQGEVPLAAVVDVAERLSQMGCYEISLGDTI
HHHHHHHHHHHHHCCCCHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCEE
GVGTPRKAVAMLDAVLGALPVEQVALHFHDTYGQALANIYACLDRGVAVLDASVGGLGGC
CCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCC
PYAAGASGNVATEDLVYMLEGMGIRTGVDLEALVEAAAFISAAIGRAPASHLAKARGY
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]