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The map label for this gene is glmS [H]

Identifier: 158423343

GI number: 158423343

Start: 1967545

End: 1969368

Strand: Direct

Name: glmS [H]

Synonym: AZC_1719

Alternate gene names: 158423343

Gene position: 1967545-1969368 (Clockwise)

Preceding gene: 158423342

Following gene: 158423345

Centisome position: 36.64

GC content: 66.61

Gene sequence:

>1824_bases
ATGTGCGGCATTGTCGGCATTCTCGGTCAGGGTCCGGTTGCGGAAGACGTCATCGATGCCCTGAAGCGGCTCGAATATCG
CGGCTATGATTCCGCCGGCATCGCCACGCTGGAGCACGGGCATCTCGCCATCTGCCGGGCCGAGGGCAAGCTGCGCAATC
TCGACCAGAAGCTTGCGCGCCATCCGCTCGCCGGCCACAGCGCCATCGGCCACACCCGCTGGGCCACCCACGGCAAGCCC
TCCGAGCGCAATGCCCATCCCCACTCGGGCAAGAAGGTCGCGGTGGTGCACAATGGCATCATCGAGAACTTCCGCGAGCT
GAAGGACGAACTGATCGCCGGCGGCGCACACTTTCTCTCCGAGACCGACACGGAAGTGGTGGCCCTGCTGGTGGACCGCG
AGCTGCGTGCCGGCCGCTCGCCCGTGGAGGCGGTGGGCAAGGTGCTGCCCCGCCTGCGCGGCGCGTTCGCGCTCGCCTTC
CTGTTCGACGGCGAGGACGATCTCCTGATCGCCGCCCGCAAGGGCTCGCCGCTCGCCATCGGCTACGGCAAGGGCACCAT
GTATCTGGGCTCGGACGCCATCGCGCTCGGCTCCTTCACGGACGAGATCGTCTATCTGGAAGAGGGCGACTGGGCGGTCA
TCACCCGCGCCGGGGCGGAGATCCGCGACCTCACCGGCGCGGTGGTGAAGCGGCCGATGGTGAAGGTACCGGCCGGGGCC
ATGCTGGTGGACAAGGGTAACCACCGCCACTTCATGGCCAAGGAGATCTACGAGCAGCCGGAAGTCATCCCCCACACCTT
CGGCCATTATATCGACCCGACCAAAGAGACGGTGGTGCTGCCCGAGCTGCCCCTCGATCTCGGCTCGGTGACCCACATCT
CCATCACCGCCTGCGGCACCGCGCTCTATGCCGGTGCCGTTGCGGAATACTGGTTCGAACGCTTCGCCCGCGTGCCGGTG
AGCATCGATATCGCCTCCGAATTCCGCTACCGCGAAACCCCGCTCCAGCCGGGCGGCATCACCATCGTCATCTCCCAGTC
GGGCGAGACGGCCGATACGCTGGCCTCCCTGCGCTATGCCAAGGAACTGGGCCAGAAGGTGGTCGCGGTGGTGAACGTCC
CCACCTCCACCATCGCCCGCGAGGCCGACGTGGTGCTGCCCACGCTGGCCGGGGTTGAGATCGGCGTCGCCTCCACCAAG
GCCTTCACCTGCCAGCTCGCGACGCTCGCCTGCCTCGCCGTGGCGACGGGCCGGGCCAAGGGCGTGCTCACCTCCGACGA
CGAGCACCGCCTGGTGCGCGCCATGATGGAAGTGCCGCGCCTGATGACCGAGGCGCTGAAGCTGAGCCCGGAGATCGAGT
TGCTCTCGCGCACCCTCGCGAAGGCACAGGATGTGCTCTATCTGGGCCGCGGCACCAATTATCCGCTGGCGCTGGAAGGT
GCGCTGAAGCTGAAGGAGATCAGCTACATCCACGCCGAAGGCTATGCGGCGGGCGAACTGAAGCATGGCCCCATCGCGCT
GATCGACGAGAAGATGCCGGTGGTGGTGATCGCGCCCTATGACCGGGTGTTCGAGAAGACCGTCTCGAACATGGAGGAGG
TGGCGGCGCGCGGCGGGCGCATCATCCTCGTCACCGACCAGAAGGGCGCGGACCTTGCCAACGTCACCGCCATGCAGAAG
CTGATCCTGCCCGAGATGCCGGCGACGATCGCTCCGCTGATTTATTCCATCCCCGTGCAGCTCATCGCCTATCACACGGC
GGTGCTCATGGGCACGGACGTGGACCAGCCGCGCAATCTCGCCAAATCCGTCACCGTGGAGTGA

Upstream 100 bases:

>100_bases
GAAAAGCTGTGTTGTTCGGTCGCGATGCAGGCCGGGCGACCTTCCCATACAGCACGTGCCGGAGCGCGTGCGGCGTGACC
CTTGTGGAGTTCTATCCCTC

Downstream 100 bases:

>100_bases
GGGCAGGCGCCCTCATTTCCCCCCGCCCATTCCCGTTTCGGCGGTGCGCAGCAGGTCGTCCTGCTGCGCCTGCGAGAGGA
CGCGTCGGGGCACCATCCGG

Product: glucosamine-fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 607; Mature: 607

Protein sequence:

>607_residues
MCGIVGILGQGPVAEDVIDALKRLEYRGYDSAGIATLEHGHLAICRAEGKLRNLDQKLARHPLAGHSAIGHTRWATHGKP
SERNAHPHSGKKVAVVHNGIIENFRELKDELIAGGAHFLSETDTEVVALLVDRELRAGRSPVEAVGKVLPRLRGAFALAF
LFDGEDDLLIAARKGSPLAIGYGKGTMYLGSDAIALGSFTDEIVYLEEGDWAVITRAGAEIRDLTGAVVKRPMVKVPAGA
MLVDKGNHRHFMAKEIYEQPEVIPHTFGHYIDPTKETVVLPELPLDLGSVTHISITACGTALYAGAVAEYWFERFARVPV
SIDIASEFRYRETPLQPGGITIVISQSGETADTLASLRYAKELGQKVVAVVNVPTSTIAREADVVLPTLAGVEIGVASTK
AFTCQLATLACLAVATGRAKGVLTSDDEHRLVRAMMEVPRLMTEALKLSPEIELLSRTLAKAQDVLYLGRGTNYPLALEG
ALKLKEISYIHAEGYAAGELKHGPIALIDEKMPVVVIAPYDRVFEKTVSNMEEVAARGGRIILVTDQKGADLANVTAMQK
LILPEMPATIAPLIYSIPVQLIAYHTAVLMGTDVDQPRNLAKSVTVE

Sequences:

>Translated_607_residues
MCGIVGILGQGPVAEDVIDALKRLEYRGYDSAGIATLEHGHLAICRAEGKLRNLDQKLARHPLAGHSAIGHTRWATHGKP
SERNAHPHSGKKVAVVHNGIIENFRELKDELIAGGAHFLSETDTEVVALLVDRELRAGRSPVEAVGKVLPRLRGAFALAF
LFDGEDDLLIAARKGSPLAIGYGKGTMYLGSDAIALGSFTDEIVYLEEGDWAVITRAGAEIRDLTGAVVKRPMVKVPAGA
MLVDKGNHRHFMAKEIYEQPEVIPHTFGHYIDPTKETVVLPELPLDLGSVTHISITACGTALYAGAVAEYWFERFARVPV
SIDIASEFRYRETPLQPGGITIVISQSGETADTLASLRYAKELGQKVVAVVNVPTSTIAREADVVLPTLAGVEIGVASTK
AFTCQLATLACLAVATGRAKGVLTSDDEHRLVRAMMEVPRLMTEALKLSPEIELLSRTLAKAQDVLYLGRGTNYPLALEG
ALKLKEISYIHAEGYAAGELKHGPIALIDEKMPVVVIAPYDRVFEKTVSNMEEVAARGGRIILVTDQKGADLANVTAMQK
LILPEMPATIAPLIYSIPVQLIAYHTAVLMGTDVDQPRNLAKSVTVE
>Mature_607_residues
MCGIVGILGQGPVAEDVIDALKRLEYRGYDSAGIATLEHGHLAICRAEGKLRNLDQKLARHPLAGHSAIGHTRWATHGKP
SERNAHPHSGKKVAVVHNGIIENFRELKDELIAGGAHFLSETDTEVVALLVDRELRAGRSPVEAVGKVLPRLRGAFALAF
LFDGEDDLLIAARKGSPLAIGYGKGTMYLGSDAIALGSFTDEIVYLEEGDWAVITRAGAEIRDLTGAVVKRPMVKVPAGA
MLVDKGNHRHFMAKEIYEQPEVIPHTFGHYIDPTKETVVLPELPLDLGSVTHISITACGTALYAGAVAEYWFERFARVPV
SIDIASEFRYRETPLQPGGITIVISQSGETADTLASLRYAKELGQKVVAVVNVPTSTIAREADVVLPTLAGVEIGVASTK
AFTCQLATLACLAVATGRAKGVLTSDDEHRLVRAMMEVPRLMTEALKLSPEIELLSRTLAKAQDVLYLGRGTNYPLALEG
ALKLKEISYIHAEGYAAGELKHGPIALIDEKMPVVVIAPYDRVFEKTVSNMEEVAARGGRIILVTDQKGADLANVTAMQK
LILPEMPATIAPLIYSIPVQLIAYHTAVLMGTDVDQPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=687, Percent_Identity=35.2256186317322, Blast_Score=383, Evalue=1e-106,
Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=35.3711790393013, Blast_Score=374, Evalue=1e-103,
Organism=Escherichia coli, GI1790167, Length=613, Percent_Identity=50.8972267536705, Blast_Score=579, Evalue=1e-166,
Organism=Escherichia coli, GI1788651, Length=196, Percent_Identity=31.1224489795918, Blast_Score=77, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532899, Length=727, Percent_Identity=33.5625859697386, Blast_Score=339, Evalue=2e-93,
Organism=Caenorhabditis elegans, GI17532897, Length=428, Percent_Identity=35.2803738317757, Blast_Score=268, Evalue=9e-72,
Organism=Caenorhabditis elegans, GI17539970, Length=428, Percent_Identity=35.0467289719626, Blast_Score=263, Evalue=3e-70,
Organism=Saccharomyces cerevisiae, GI6322745, Length=491, Percent_Identity=36.8635437881874, Blast_Score=268, Evalue=3e-72,
Organism=Saccharomyces cerevisiae, GI6323731, Length=435, Percent_Identity=30.5747126436782, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6323730, Length=204, Percent_Identity=36.7647058823529, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21357745, Length=690, Percent_Identity=35.3623188405797, Blast_Score=373, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65401; Mature: 65401

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGILGQGPVAEDVIDALKRLEYRGYDSAGIATLEHGHLAICRAEGKLRNLDQKLAR
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHH
HPLAGHSAIGHTRWATHGKPSERNAHPHSGKKVAVVHNGIIENFRELKDELIAGGAHFLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHHC
ETDTEVVALLVDRELRAGRSPVEAVGKVLPRLRGAFALAFLFDGEDDLLIAARKGSPLAI
CCCHHHEEEEECHHHHCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCCEEEE
GYGKGTMYLGSDAIALGSFTDEIVYLEEGDWAVITRAGAEIRDLTGAVVKRPMVKVPAGA
EECCCEEEECCCEEEECCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCEECCCCE
MLVDKGNHRHFMAKEIYEQPEVIPHTFGHYIDPTKETVVLPELPLDLGSVTHISITACGT
EEEECCCCCCHHHHHHHCCCCCCCHHHCCCCCCCCCEEEECCCCCCCCCEEEEEEEHHHH
ALYAGAVAEYWFERFARVPVSIDIASEFRYRETPLQPGGITIVISQSGETADTLASLRYA
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
KELGQKVVAVVNVPTSTIAREADVVLPTLAGVEIGVASTKAFTCQLATLACLAVATGRAK
HHHCCEEEEEEECCHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCCC
GVLTSDDEHRLVRAMMEVPRLMTEALKLSPEIELLSRTLAKAQDVLYLGRGTNYPLALEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEEECCCCCCEEECC
ALKLKEISYIHAEGYAAGELKHGPIALIDEKMPVVVIAPYDRVFEKTVSNMEEVAARGGR
CEEEEHEEEEEECCEECCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCE
IILVTDQKGADLANVTAMQKLILPEMPATIAPLIYSIPVQLIAYHTAVLMGTDVDQPRNL
EEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHH
AKSVTVE
HHHCCCC
>Mature Secondary Structure
MCGIVGILGQGPVAEDVIDALKRLEYRGYDSAGIATLEHGHLAICRAEGKLRNLDQKLAR
CCCEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCEEEEECCCHHHHHHHHHHH
HPLAGHSAIGHTRWATHGKPSERNAHPHSGKKVAVVHNGIIENFRELKDELIAGGAHFLS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCHHHHC
ETDTEVVALLVDRELRAGRSPVEAVGKVLPRLRGAFALAFLFDGEDDLLIAARKGSPLAI
CCCHHHEEEEECHHHHCCCCHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEEECCCEEEE
GYGKGTMYLGSDAIALGSFTDEIVYLEEGDWAVITRAGAEIRDLTGAVVKRPMVKVPAGA
EECCCEEEECCCEEEECCCCCEEEEEECCCEEEEEECCCHHHHHHHHHHHCCCEECCCCE
MLVDKGNHRHFMAKEIYEQPEVIPHTFGHYIDPTKETVVLPELPLDLGSVTHISITACGT
EEEECCCCCCHHHHHHHCCCCCCCHHHCCCCCCCCCEEEECCCCCCCCCEEEEEEEHHHH
ALYAGAVAEYWFERFARVPVSIDIASEFRYRETPLQPGGITIVISQSGETADTLASLRYA
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
KELGQKVVAVVNVPTSTIAREADVVLPTLAGVEIGVASTKAFTCQLATLACLAVATGRAK
HHHCCEEEEEEECCHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCCC
GVLTSDDEHRLVRAMMEVPRLMTEALKLSPEIELLSRTLAKAQDVLYLGRGTNYPLALEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCEEEEECCCCCCEEECC
ALKLKEISYIHAEGYAAGELKHGPIALIDEKMPVVVIAPYDRVFEKTVSNMEEVAARGGR
CEEEEHEEEEEECCEECCCCCCCCEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHCCCE
IILVTDQKGADLANVTAMQKLILPEMPATIAPLIYSIPVQLIAYHTAVLMGTDVDQPRNL
EEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCHHHH
AKSVTVE
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]