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The map label for this gene is glmU

Identifier: 158423342

GI number: 158423342

Start: 1965985

End: 1967331

Strand: Direct

Name: glmU

Synonym: AZC_1718

Alternate gene names: 158423342

Gene position: 1965985-1967331 (Clockwise)

Preceding gene: 158423341

Following gene: 158423343

Centisome position: 36.61

GC content: 70.23

Gene sequence:

>1347_bases
ATGTCCGAACGCAGCCTTCTGGTGGTGGTCCTCGCGGCGGGCGAGGGCACGCGCATGGCGTCCCGCCTGCCGAAGGTGCT
GCACAGGATCGCCGGCCGTTCGATGCTCCACCATGTGCTGGAAACCACGCGGCAGGCCGGCGCCACCCGTGTCGCGGTGG
TGATCGGACCCGACCGCGAGGATGTTGCCGCCGAAGCGCACCGCGTGCGCCCCGATGCGCAGGTCTTCGTCCAGACCGAG
CGCCTCGGCACCGCCCATGCGGTGCTCGCCGCGCGCGCCGCGCTGGAAGAGCCGGCCGATGACGTGCTGGTGCTCTATGC
GGACACGCCTCTGCTGCGGCCGGAGACGCTGGAGAACCTGCGCGCGCCACTGGCCGATGGCGCGGCCGTCGCCGTCCTCG
GTTTCCGGCCCGCCGATCCCACCGGGTACGGCCGCCTGCTGACACAGGGCGATGCGCTGGTGGCCATCCGCGAGGAAAAG
GACGCCACCCCGGACGAGCGCCGGGTGGATTTCTGCAATGCCGGCGTCATGGCGCTGCGGGCGCGCGAGGCGCTGTCCAT
TCTCACCCGCATCGGCAATGCCAATGCCAAGGGCGAATATTATCTGACCGACGCGGTTGAGATCGCCCGTGCCGACGGCC
TCTCCGCTGTGGCCACCGAGGCCGAGGTGGACGAGGTGGCGGGCGTCAACAGCCGCCTCCAGCTTGCCGAGGCCGAGGCG
ATCCTCCAGGGCCGCCTCCGCCGGGCCGCCATGGCGGGCGGGGCAACGCTGGTGGCGCCGGAGACGGTCTTCCTCTCCGT
CGATACCAGGCTCGGCCGCGACGTTCTCGTGGAGCCTAACGTGGTGTTCGGTCCCGGCGTGACCGTGGAGGACGACGTGG
TCATCCACGCCTTCAGCCATCTGGAAGGCGCCCATCTGGAGCGCGGTGTCTCCATCGGTCCCTATGCCAGGCTGCGGCCG
GGCACCCGCCTCGGGGAAGGCGTGCGCATCGGCAATTTCGTGGAGACCAAGGCGGCGCTCATCGATGCCGGCGCCAAGGT
CAACCATCTCTCCTACGTGGGCGACGCCCATGTGGGGTCCAATGCCAATGTCGGTGCCGGCACCATCACCTGCAATTACG
ACGGCTTCTCCAAACATCGCACCGAGATCGGCGCGGGCGCCTTCATCGGCACCAATTCCTCGCTGGTCGCACCGGTGAGC
GTCGGGGCAGGGGCCTATATCGGCTCGGGCTCGGTCATCACCGATGACGTACCGGCGGACGCCCTCGCGCTGGGGCGCGG
CCGGCAGGCGGTGAAGGAAGGCTGGGCCGCGGCCCTGCGCGCTGCGCGGGGCAAGCCGAAGGTGTGA

Upstream 100 bases:

>100_bases
CCGGCCAGCGGCTTTAGGGCGGTATTCATCCGGCAGGTGCATTCAATTTCCCCCGCTCGCCCTCTATGAGACGGGCATGA
ACGCGCAAGGGGAAAGTCCG

Downstream 100 bases:

>100_bases
CGATTGGAAAGGCGAAGTGATTCCTCACTTTTGCCCGAAGCAGGCTAGAGATTTGAACCTGAAGCTCGGCTTGCGGCGTG
TCTGCCCAACGAACACCTGA

Product: glucosamine-1-phosphate N-acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSERSLLVVVLAAGEGTRMASRLPKVLHRIAGRSMLHHVLETTRQAGATRVAVVIGPDREDVAAEAHRVRPDAQVFVQTE
RLGTAHAVLAARAALEEPADDVLVLYADTPLLRPETLENLRAPLADGAAVAVLGFRPADPTGYGRLLTQGDALVAIREEK
DATPDERRVDFCNAGVMALRAREALSILTRIGNANAKGEYYLTDAVEIARADGLSAVATEAEVDEVAGVNSRLQLAEAEA
ILQGRLRRAAMAGGATLVAPETVFLSVDTRLGRDVLVEPNVVFGPGVTVEDDVVIHAFSHLEGAHLERGVSIGPYARLRP
GTRLGEGVRIGNFVETKAALIDAGAKVNHLSYVGDAHVGSNANVGAGTITCNYDGFSKHRTEIGAGAFIGTNSSLVAPVS
VGAGAYIGSGSVITDDVPADALALGRGRQAVKEGWAAALRAARGKPKV

Sequences:

>Translated_448_residues
MSERSLLVVVLAAGEGTRMASRLPKVLHRIAGRSMLHHVLETTRQAGATRVAVVIGPDREDVAAEAHRVRPDAQVFVQTE
RLGTAHAVLAARAALEEPADDVLVLYADTPLLRPETLENLRAPLADGAAVAVLGFRPADPTGYGRLLTQGDALVAIREEK
DATPDERRVDFCNAGVMALRAREALSILTRIGNANAKGEYYLTDAVEIARADGLSAVATEAEVDEVAGVNSRLQLAEAEA
ILQGRLRRAAMAGGATLVAPETVFLSVDTRLGRDVLVEPNVVFGPGVTVEDDVVIHAFSHLEGAHLERGVSIGPYARLRP
GTRLGEGVRIGNFVETKAALIDAGAKVNHLSYVGDAHVGSNANVGAGTITCNYDGFSKHRTEIGAGAFIGTNSSLVAPVS
VGAGAYIGSGSVITDDVPADALALGRGRQAVKEGWAAALRAARGKPKV
>Mature_447_residues
SERSLLVVVLAAGEGTRMASRLPKVLHRIAGRSMLHHVLETTRQAGATRVAVVIGPDREDVAAEAHRVRPDAQVFVQTER
LGTAHAVLAARAALEEPADDVLVLYADTPLLRPETLENLRAPLADGAAVAVLGFRPADPTGYGRLLTQGDALVAIREEKD
ATPDERRVDFCNAGVMALRAREALSILTRIGNANAKGEYYLTDAVEIARADGLSAVATEAEVDEVAGVNSRLQLAEAEAI
LQGRLRRAAMAGGATLVAPETVFLSVDTRLGRDVLVEPNVVFGPGVTVEDDVVIHAFSHLEGAHLERGVSIGPYARLRPG
TRLGEGVRIGNFVETKAALIDAGAKVNHLSYVGDAHVGSNANVGAGTITCNYDGFSKHRTEIGAGAFIGTNSSLVAPVSV
GAGAYIGSGSVITDDVPADALALGRGRQAVKEGWAAALRAARGKPKV

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=454, Percent_Identity=40.3083700440529, Blast_Score=315, Evalue=3e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_AZOC5 (A8I4D4)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001524634.1
- ProteinModelPortal:   A8I4D4
- SMR:   A8I4D4
- GeneID:   5689815
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_1718
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   CLSK980299
- BioCyc:   ACAU438753:AZC_1718-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR018357
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 46870; Mature: 46739

Theoretical pI: Translated: 6.30; Mature: 6.30

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 349-349 BINDING 78-78 BINDING 144-144 BINDING 158-158 BINDING 173-173 BINDING 373-373 BINDING 426-426

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERSLLVVVLAAGEGTRMASRLPKVLHRIAGRSMLHHVLETTRQAGATRVAVVIGPDRE
CCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHH
DVAAEAHRVRPDAQVFVQTERLGTAHAVLAARAALEEPADDVLVLYADTPLLRPETLENL
HHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHH
RAPLADGAAVAVLGFRPADPTGYGRLLTQGDALVAIREEKDATPDERRVDFCNAGVMALR
HCCCCCCCEEEEEECCCCCCCCCCCEEECCCEEEEEECCCCCCCCHHHHHHHCCCHHHHH
AREALSILTRIGNANAKGEYYLTDAVEIARADGLSAVATEAEVDEVAGVNSRLQLAEAEA
HHHHHHHHHHHCCCCCCCCEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
ILQGRLRRAAMAGGATLVAPETVFLSVDTRLGRDVLVEPNVVFGPGVTVEDDVVIHAFSH
HHHHHHHHHHHCCCEEEEECCEEEEEECCCCCCEEEECCCEEECCCCCCCCCEEEEEHHH
LEGAHLERGVSIGPYARLRPGTRLGEGVRIGNFVETKAALIDAGAKVNHLSYVGDAHVGS
CCCHHHHCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHCCCCEEEEEEECCCCCCC
NANVGAGTITCNYDGFSKHRTEIGAGAFIGTNSSLVAPVSVGAGAYIGSGSVITDDVPAD
CCCCCCEEEEEECCCCHHHHHHCCCCEEECCCCCEEEEEECCCCEEECCCCEEECCCCHH
ALALGRGRQAVKEGWAAALRAARGKPKV
HHHHCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SERSLLVVVLAAGEGTRMASRLPKVLHRIAGRSMLHHVLETTRQAGATRVAVVIGPDRE
CCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHH
DVAAEAHRVRPDAQVFVQTERLGTAHAVLAARAALEEPADDVLVLYADTPLLRPETLENL
HHHHHHHHCCCCCEEEEEEHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHH
RAPLADGAAVAVLGFRPADPTGYGRLLTQGDALVAIREEKDATPDERRVDFCNAGVMALR
HCCCCCCCEEEEEECCCCCCCCCCCEEECCCEEEEEECCCCCCCCHHHHHHHCCCHHHHH
AREALSILTRIGNANAKGEYYLTDAVEIARADGLSAVATEAEVDEVAGVNSRLQLAEAEA
HHHHHHHHHHHCCCCCCCCEEEEHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
ILQGRLRRAAMAGGATLVAPETVFLSVDTRLGRDVLVEPNVVFGPGVTVEDDVVIHAFSH
HHHHHHHHHHHCCCEEEEECCEEEEEECCCCCCEEEECCCEEECCCCCCCCCEEEEEHHH
LEGAHLERGVSIGPYARLRPGTRLGEGVRIGNFVETKAALIDAGAKVNHLSYVGDAHVGS
CCCHHHHCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHCCCCEEEEEEECCCCCCC
NANVGAGTITCNYDGFSKHRTEIGAGAFIGTNSSLVAPVSVGAGAYIGSGSVITDDVPAD
CCCCCCEEEEEECCCCHHHHHHCCCCEEECCCCCEEEEEECCCCEEECCCCEEECCCCHH
ALALGRGRQAVKEGWAAALRAARGKPKV
HHHHCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA