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The map label for this gene is degS [H]

Identifier: 157963413

GI number: 157963413

Start: 4391967

End: 4393049

Strand: Direct

Name: degS [H]

Synonym: Spea_3599

Alternate gene names: 157963413

Gene position: 4391967-4393049 (Clockwise)

Preceding gene: 157963412

Following gene: 157963424

Centisome position: 84.88

GC content: 45.61

Gene sequence:

>1083_bases
ATGATCATTAAAGACACTCTTATATATGTCGGTAAAGCCATTCTGTTTGGCCTTATCATGGCTGCAGTTATTATTTTTGT
TTTGCCATTTATTACAGGGCAGAGCTTAACCAATGGCATCACTAGCCGTGTTTCGACAAGTAGCAACGAGCTATCTTTCT
CGAAAGCTGTGCGCAGAGCTGCCCCTGCCGTAGTAAATATCTACAGCCTAAGTATCGATCAATCTAAACCGTTAAACCCT
GGGTCTCTTCAAGGTCTAGGTTCTGGCGTGATAATGAGTAAAGAGGGCTACATACTCACCAACTACCACGTTATCAAGAA
AGCTGATGAAATTGTCGTTGCTTTGCAAGATGGCCGTAAGTTCACCTCTGAAGTGGTTGGCTCCGACCCTGAAACCGATT
TAGCCGTACTCAAAGTTGAAGGTGATAATCTCCCTGTTGTACCAGTCAATTTAGAGATCCCCGCACGTGTCGGTGATGTC
GTTCTAGCTATTGGTAATCCATATAACCTTGGGCAAACGATTACCCAAGGCATTATCAGCGCGACAGGACGCAACGGTTT
AAGCTCTGGTTATCTAGATTTCTTGCAAACAGACGCGGCAATTAATGCCGGTAACTCAGGCGGCGCACTAATAGATACCA
CTGGCCAGCTTATTGGTATTAATACCGCAGCCTTTCAGGTTGGCGGCGAAGGTGGTGGTCACGGTATTAACTTCGCGATT
CCAATTAAGCTAGCCCACAGCATTATGGGTAAACTAATAAAGAATGGTCGAGTGATCCGTGGCGCCCTTGGTATTGGCGG
TGAGCCCGTAGGTCCTGTTATGGCACAAATTTTAAACCTACCAGATCTAACTGGTGTTGTAATTACTAGCATTGACCGTA
ACGGCCCGGCCGCACAGGCTAAGCTACAACCTCGAGATGTGATCACTAAGTATGAAGGTGAGTCAATTCCAGGTGTTGAG
ATGCTGATGGATAGAATTGCCGAAACTACGCCAGGAAAGAAGGTGATGATGACAGTTATTCGAGATGGTAAATCTTACGA
AGTGCCGGTAGTGATAGCCGAGAAGCCTGTTCATTATAATTAG

Upstream 100 bases:

>100_bases
CTCGGCTCTCTTTTTGGATTTAAAGCGCTTTATCATGATTGCGTACAAGCTAGTACAATCATGTTAATATAATTCATCTT
TTCAGTATTTATTCTCAGAC

Downstream 100 bases:

>100_bases
GTTCTAGGTTCTAGGTTCTAGGTTCTAGGTTCTAGGTTCTAGGTTCTAGGTTCTAGGTTTGAGCATCAAACAAAACGCGA
AAAGGCAAAACAGGTTCAGC

Product: periplasmic serine protease DegS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MIIKDTLIYVGKAILFGLIMAAVIIFVLPFITGQSLTNGITSRVSTSSNELSFSKAVRRAAPAVVNIYSLSIDQSKPLNP
GSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGSDPETDLAVLKVEGDNLPVVPVNLEIPARVGDV
VLAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTTGQLIGINTAAFQVGGEGGGHGINFAI
PIKLAHSIMGKLIKNGRVIRGALGIGGEPVGPVMAQILNLPDLTGVVITSIDRNGPAAQAKLQPRDVITKYEGESIPGVE
MLMDRIAETTPGKKVMMTVIRDGKSYEVPVVIAEKPVHYN

Sequences:

>Translated_360_residues
MIIKDTLIYVGKAILFGLIMAAVIIFVLPFITGQSLTNGITSRVSTSSNELSFSKAVRRAAPAVVNIYSLSIDQSKPLNP
GSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGSDPETDLAVLKVEGDNLPVVPVNLEIPARVGDV
VLAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTTGQLIGINTAAFQVGGEGGGHGINFAI
PIKLAHSIMGKLIKNGRVIRGALGIGGEPVGPVMAQILNLPDLTGVVITSIDRNGPAAQAKLQPRDVITKYEGESIPGVE
MLMDRIAETTPGKKVMMTVIRDGKSYEVPVVIAEKPVHYN
>Mature_360_residues
MIIKDTLIYVGKAILFGLIMAAVIIFVLPFITGQSLTNGITSRVSTSSNELSFSKAVRRAAPAVVNIYSLSIDQSKPLNP
GSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRKFTSEVVGSDPETDLAVLKVEGDNLPVVPVNLEIPARVGDV
VLAIGNPYNLGQTITQGIISATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTTGQLIGINTAAFQVGGEGGGHGINFAI
PIKLAHSIMGKLIKNGRVIRGALGIGGEPVGPVMAQILNLPDLTGVVITSIDRNGPAAQAKLQPRDVITKYEGESIPGVE
MLMDRIAETTPGKKVMMTVIRDGKSYEVPVVIAEKPVHYN

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=315, Percent_Identity=29.8412698412698, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI4506141, Length=316, Percent_Identity=30.379746835443, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI24308541, Length=246, Percent_Identity=32.520325203252, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI7019477, Length=273, Percent_Identity=32.6007326007326, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1789630, Length=351, Percent_Identity=48.7179487179487, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1789629, Length=280, Percent_Identity=42.5, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1786356, Length=266, Percent_Identity=41.3533834586466, Blast_Score=194, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24646839, Length=286, Percent_Identity=32.1678321678322, Blast_Score=121, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 37750; Mature: 37750

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIKDTLIYVGKAILFGLIMAAVIIFVLPFITGQSLTNGITSRVSTSSNELSFSKAVRRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
APAVVNIYSLSIDQSKPLNPGSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRK
CCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEHEEECCCEEEEEEECCCH
FTSEVVGSDPETDLAVLKVEGDNLPVVPVNLEIPARVGDVVLAIGNPYNLGQTITQGIIS
HHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHH
ATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTTGQLIGINTAAFQVGGEGGGHGINFAI
HCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCCCEEEEEEEEEEECCCCCCCCEEEEE
PIKLAHSIMGKLIKNGRVIRGALGIGGEPVGPVMAQILNLPDLTGVVITSIDRNGPAAQA
HHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
KLQPRDVITKYEGESIPGVEMLMDRIAETTPGKKVMMTVIRDGKSYEVPVVIAEKPVHYN
CCCHHHHHEECCCCCCCCHHHHHHHHHHCCCCHHEEEEEEECCCCEEEEEEEECCCCCCC
>Mature Secondary Structure
MIIKDTLIYVGKAILFGLIMAAVIIFVLPFITGQSLTNGITSRVSTSSNELSFSKAVRRA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHH
APAVVNIYSLSIDQSKPLNPGSLQGLGSGVIMSKEGYILTNYHVIKKADEIVVALQDGRK
CCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCCEEEEEEHEEECCCEEEEEEECCCH
FTSEVVGSDPETDLAVLKVEGDNLPVVPVNLEIPARVGDVVLAIGNPYNLGQTITQGIIS
HHHHHCCCCCCCCEEEEEECCCCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHH
ATGRNGLSSGYLDFLQTDAAINAGNSGGALIDTTGQLIGINTAAFQVGGEGGGHGINFAI
HCCCCCCCHHHHHHHHCCCEEECCCCCCEEEECCCCEEEEEEEEEEECCCCCCCCEEEEE
PIKLAHSIMGKLIKNGRVIRGALGIGGEPVGPVMAQILNLPDLTGVVITSIDRNGPAAQA
HHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEEEECCCCCCCCC
KLQPRDVITKYEGESIPGVEMLMDRIAETTPGKKVMMTVIRDGKSYEVPVVIAEKPVHYN
CCCHHHHHEECCCCCCCCHHHHHHHHHHCCCCHHEEEEEEECCCCEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]