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The map label for this gene is maeA [H]

Identifier: 157963003

GI number: 157963003

Start: 3905579

End: 3907267

Strand: Direct

Name: maeA [H]

Synonym: Spea_3186

Alternate gene names: 157963003

Gene position: 3905579-3907267 (Clockwise)

Preceding gene: 157963002

Following gene: 157963009

Centisome position: 75.48

GC content: 49.26

Gene sequence:

>1689_bases
ATGGACGATAACAAACGCCCGCTCTATCTTCCTTTTGCCGGTCCAGCCATTCTTGAAGCACCTTTGATCAACAAAGGTAG
CGCTTTCACCGACGAAGAACGGATATTTTTTAATCTCGAAGGCCTACTGCCCCACGTCATCGAGACCATCGAAGAGCAAG
CCTCTCGCGCTTATGATCAATACAAGAACTTCAGCAACGATCTCGACAAACATATCTACCTAAGAAACATTCAAGACACC
AACGAGACTCTCTATTATCGCCTGGTGCAAAACCACATTACCGAGATGATGCCTATCATCTACACCCCTACAGTGGGGAT
GGCCTGTGAGCGTTTCTCTAAAGATTACCGTCGTAACCGTGGCCTGTTTATCTCTTACGCCAATAAAGACCGTATCGACG
ATATTCTTAATAACTCAACCCGCCAAAAAGTAAAAATCATCGTAGTGACCGACGGTGAGCGCATCTTAGGTCTAGGTGAT
CAAGGCATTGGTGGTATGGGGATCCCGATTGGTAAGTTATCTCTATACACCAGCTGTGGCGGTATTAGCCCGGCTTACAC
CTTGCCGATTACACTCGATGTAGGAACCGATAACCCACACCTACTCGAAGACCCTATGTACATGGGGATGCGTAGCCCAC
GTATTGGCGGCGAAGAATACACAGAATTTGTAGAAGCCTTTATGCAAGCGGTTCACCGCCGCTGGCCCGACGCACTGATC
CAGTTCGAAGACTTTGCTCAGAAGAACGCCATGCCACTGCTTGAGCGTTATAAAGATCAATACTGCTGCTTTAATGATGA
CATTCAAGGCACTGCCGCAGTAACTGTTGGCTCACTGTTAGCAGCCTGTAAGGCGGCAAAAACACAGCTTAGCGAACAGC
GCATCACCTTCTTAGGTGCAGGCTCAGCCGGTTGTGGTATTGCCGAGGCTATCGTGGCGCAGATGGTGTCTGAAGGGATT
AGTGAAGCACAGGCACGCAAGCAAGTGTTTATGGTTGATCGCTGGGGCATGTTGCAATCAAATATGCCTAACTTGCTACC
GTTCCAGCAAAAGTTAGCGCAAAATTGTGATGACATTACCAGCTGGGATAATTTCAGCGACAACATCTCACTGCTGGATG
TGGTAAACAATGCCAAGCCAACGGTATTGATTGGCGTTTCAGGCGCGCCGGGTCTGTTCACCGAAGAGATCATCAAGGCG
ATGCACAGCCATTGTAAGCGCCCAATCGTGTTCCCGTTGTCGAACCCAACTAGCCGCGTTGAAGCCACGCCGAAAGATAT
CCTACACTGGACCCAAGGCCAGGCGCTTGTAGCAACAGGTAGCCCGTTTGAGCCAGTAGTGGTTGACGATGTGACCTATG
AAATTGCCCAGTGTAATAACAGTTATATCTTCCCAGGTATTGGCCTTGGCGTATTAGCCTCTGGGGCAAAACGTGTCAGC
GACGCCATGTTGATGGCATCGAGCCGCGCGTTAGCCGAGTGTTCACCACTGGCGATTGACGGTGAAGGCTCACTGCTGCC
AAAGCTTGAAGATATTCATAAGGTGAGTAAGCATATTGCGTTTGCCGTTGCCAGAACTGCAATTGAAGAAGGCCATGCGT
TGCCAACAACCAATGAGTTGCTGACCTATGCGATTGAGGATAACTTCTGGACCGCAGAGTATCGTAGTTATAAACGAACT
GCGTTCTAG

Upstream 100 bases:

>100_bases
TATTCACCTTGAAACAGTTTGCCAAAAACCGCTCTGAGCAGATAAAGTTCTTATACTGATTGGTATTACTCTACTAACAA
AAACAAAGAAAAGGTTTCCA

Downstream 100 bases:

>100_bases
TTCTGAACGTTAGTATTCGCAACGTTCATTAGCGAAGTTGAAACAAAAAGCAGTCATATTTGGCTGCTTTTTTGTTTTTT
GGCTTTTGTGTTATCCGGTA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 562; Mature: 562

Protein sequence:

>562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFTDEERIFFNLEGLLPHVIETIEEQASRAYDQYKNFSNDLDKHIYLRNIQDT
NETLYYRLVQNHITEMMPIIYTPTVGMACERFSKDYRRNRGLFISYANKDRIDDILNNSTRQKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPHLLEDPMYMGMRSPRIGGEEYTEFVEAFMQAVHRRWPDALI
QFEDFAQKNAMPLLERYKDQYCCFNDDIQGTAAVTVGSLLAACKAAKTQLSEQRITFLGAGSAGCGIAEAIVAQMVSEGI
SEAQARKQVFMVDRWGMLQSNMPNLLPFQQKLAQNCDDITSWDNFSDNISLLDVVNNAKPTVLIGVSGAPGLFTEEIIKA
MHSHCKRPIVFPLSNPTSRVEATPKDILHWTQGQALVATGSPFEPVVVDDVTYEIAQCNNSYIFPGIGLGVLASGAKRVS
DAMLMASSRALAECSPLAIDGEGSLLPKLEDIHKVSKHIAFAVARTAIEEGHALPTTNELLTYAIEDNFWTAEYRSYKRT
AF

Sequences:

>Translated_562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFTDEERIFFNLEGLLPHVIETIEEQASRAYDQYKNFSNDLDKHIYLRNIQDT
NETLYYRLVQNHITEMMPIIYTPTVGMACERFSKDYRRNRGLFISYANKDRIDDILNNSTRQKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPHLLEDPMYMGMRSPRIGGEEYTEFVEAFMQAVHRRWPDALI
QFEDFAQKNAMPLLERYKDQYCCFNDDIQGTAAVTVGSLLAACKAAKTQLSEQRITFLGAGSAGCGIAEAIVAQMVSEGI
SEAQARKQVFMVDRWGMLQSNMPNLLPFQQKLAQNCDDITSWDNFSDNISLLDVVNNAKPTVLIGVSGAPGLFTEEIIKA
MHSHCKRPIVFPLSNPTSRVEATPKDILHWTQGQALVATGSPFEPVVVDDVTYEIAQCNNSYIFPGIGLGVLASGAKRVS
DAMLMASSRALAECSPLAIDGEGSLLPKLEDIHKVSKHIAFAVARTAIEEGHALPTTNELLTYAIEDNFWTAEYRSYKRT
AF
>Mature_562_residues
MDDNKRPLYLPFAGPAILEAPLINKGSAFTDEERIFFNLEGLLPHVIETIEEQASRAYDQYKNFSNDLDKHIYLRNIQDT
NETLYYRLVQNHITEMMPIIYTPTVGMACERFSKDYRRNRGLFISYANKDRIDDILNNSTRQKVKIIVVTDGERILGLGD
QGIGGMGIPIGKLSLYTSCGGISPAYTLPITLDVGTDNPHLLEDPMYMGMRSPRIGGEEYTEFVEAFMQAVHRRWPDALI
QFEDFAQKNAMPLLERYKDQYCCFNDDIQGTAAVTVGSLLAACKAAKTQLSEQRITFLGAGSAGCGIAEAIVAQMVSEGI
SEAQARKQVFMVDRWGMLQSNMPNLLPFQQKLAQNCDDITSWDNFSDNISLLDVVNNAKPTVLIGVSGAPGLFTEEIIKA
MHSHCKRPIVFPLSNPTSRVEATPKDILHWTQGQALVATGSPFEPVVVDDVTYEIAQCNNSYIFPGIGLGVLASGAKRVS
DAMLMASSRALAECSPLAIDGEGSLLPKLEDIHKVSKHIAFAVARTAIEEGHALPTTNELLTYAIEDNFWTAEYRSYKRT
AF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=515, Percent_Identity=43.495145631068, Blast_Score=443, Evalue=1e-124,
Organism=Homo sapiens, GI62420882, Length=520, Percent_Identity=42.5, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI62420880, Length=520, Percent_Identity=42.5, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI239049447, Length=520, Percent_Identity=42.5, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI4505145, Length=556, Percent_Identity=42.0863309352518, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI270265879, Length=464, Percent_Identity=45.4741379310345, Blast_Score=400, Evalue=1e-111,
Organism=Escherichia coli, GI87081919, Length=558, Percent_Identity=68.2795698924731, Blast_Score=793, Evalue=0.0,
Organism=Escherichia coli, GI1788806, Length=406, Percent_Identity=24.6305418719212, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17537199, Length=550, Percent_Identity=43.6363636363636, Blast_Score=426, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6322823, Length=526, Percent_Identity=46.3878326996198, Blast_Score=450, Evalue=1e-127,
Organism=Drosophila melanogaster, GI281362672, Length=516, Percent_Identity=43.2170542635659, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281362674, Length=516, Percent_Identity=43.2170542635659, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI21356279, Length=516, Percent_Identity=43.2170542635659, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24646386, Length=513, Percent_Identity=43.2748538011696, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24646388, Length=513, Percent_Identity=43.2748538011696, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI78707242, Length=515, Percent_Identity=39.8058252427184, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707238, Length=515, Percent_Identity=39.8058252427184, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707232, Length=509, Percent_Identity=38.3104125736739, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707240, Length=516, Percent_Identity=39.7286821705426, Blast_Score=376, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363505, Length=536, Percent_Identity=36.7537313432836, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI78707236, Length=536, Percent_Identity=36.7537313432836, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI281363503, Length=537, Percent_Identity=36.4990689013035, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI19922384, Length=544, Percent_Identity=28.8602941176471, Blast_Score=247, Evalue=2e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 62324; Mature: 62324

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDNKRPLYLPFAGPAILEAPLINKGSAFTDEERIFFNLEGLLPHVIETIEEQASRAYDQ
CCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
YKNFSNDLDKHIYLRNIQDTNETLYYRLVQNHITEMMPIIYTPTVGMACERFSKDYRRNR
HHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHCC
GLFISYANKDRIDDILNNSTRQKVKIIVVTDGERILGLGDQGIGGMGIPIGKLSLYTSCG
CEEEEECCCHHHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCEEEEECCC
GISPAYTLPITLDVGTDNPHLLEDPMYMGMRSPRIGGEEYTEFVEAFMQAVHRRWPDALI
CCCCCEEEEEEEEECCCCCCEECCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHH
QFEDFAQKNAMPLLERYKDQYCCFNDDIQGTAAVTVGSLLAACKAAKTQLSEQRITFLGA
HHHHHHHCCCCHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
GSAGCGIAEAIVAQMVSEGISEAQARKQVFMVDRWGMLQSNMPNLLPFQQKLAQNCDDIT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHCCCCCCCHHHHHHHCCCCCCC
SWDNFSDNISLLDVVNNAKPTVLIGVSGAPGLFTEEIIKAMHSHCKRPIVFPLSNPTSRV
CCCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHC
EATPKDILHWTQGQALVATGSPFEPVVVDDVTYEIAQCNNSYIFPGIGLGVLASGAKRVS
CCCHHHHHHHCCCCEEEECCCCCCCEEECCCHHHHHHCCCCEECCCCCHHHHHHHHHHHH
DAMLMASSRALAECSPLAIDGEGSLLPKLEDIHKVSKHIAFAVARTAIEEGHALPTTNEL
HHHHHHCCCHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LTYAIEDNFWTAEYRSYKRTAF
EEEEEECCEEEHHHHHHHHCCC
>Mature Secondary Structure
MDDNKRPLYLPFAGPAILEAPLINKGSAFTDEERIFFNLEGLLPHVIETIEEQASRAYDQ
CCCCCCEEEEECCCCHHHCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHH
YKNFSNDLDKHIYLRNIQDTNETLYYRLVQNHITEMMPIIYTPTVGMACERFSKDYRRNR
HHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHCEEECCCHHHHHHHHHHHHHHCC
GLFISYANKDRIDDILNNSTRQKVKIIVVTDGERILGLGDQGIGGMGIPIGKLSLYTSCG
CEEEEECCCHHHHHHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCCCCCCCEEEEECCC
GISPAYTLPITLDVGTDNPHLLEDPMYMGMRSPRIGGEEYTEFVEAFMQAVHRRWPDALI
CCCCCEEEEEEEEECCCCCCEECCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCHHHH
QFEDFAQKNAMPLLERYKDQYCCFNDDIQGTAAVTVGSLLAACKAAKTQLSEQRITFLGA
HHHHHHHCCCCHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEC
GSAGCGIAEAIVAQMVSEGISEAQARKQVFMVDRWGMLQSNMPNLLPFQQKLAQNCDDIT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHCCCCCCCHHHHHHHCCCCCCC
SWDNFSDNISLLDVVNNAKPTVLIGVSGAPGLFTEEIIKAMHSHCKRPIVFPLSNPTSRV
CCCCCCCCEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCHHC
EATPKDILHWTQGQALVATGSPFEPVVVDDVTYEIAQCNNSYIFPGIGLGVLASGAKRVS
CCCHHHHHHHCCCCEEEECCCCCCCEEECCCHHHHHHCCCCEECCCCCHHHHHHHHHHHH
DAMLMASSRALAECSPLAIDGEGSLLPKLEDIHKVSKHIAFAVARTAIEEGHALPTTNEL
HHHHHHCCCHHHCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
LTYAIEDNFWTAEYRSYKRTAF
EEEEEECCEEEHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA