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The map label for this gene is yngE [H]

Identifier: 157962619

GI number: 157962619

Start: 3417059

End: 3418720

Strand: Direct

Name: yngE [H]

Synonym: Spea_2798

Alternate gene names: 157962619

Gene position: 3417059-3418720 (Clockwise)

Preceding gene: 157962618

Following gene: 157962620

Centisome position: 66.04

GC content: 50.12

Gene sequence:

>1662_bases
TTGGGCGCTCGCATAGCGACGCCCTTATATCTCAGCTTCAAAAGGATTGAAATTGTGACGCAACTTAGCAGCCGTATTAA
TGCTCGCAGCGATGAATTCAAAGCTAAATTTGATGACATGACCGCTGTGGTTCAAGACCTAAAACTAAAACTCCATCAAA
TTGAACAGGGCGGCGGAGAAGTCGCTCGAAACCGTCATCTTTCAAGAGGTAAGCTCCTGCCTCGTCAGCGTGTTGAGAAG
CTGCTGGATCCGGGATCGCCCTTCCTAGAGATTTCTCAATTTGCCGCCTACGAGTTGTATGAAGACATAGTGCCAGCAGC
GGGAGTTATCGCCGGTATTGGCCGTGTGAGTGGCGTTGAGTGCATGATTATCGCCAACGATGCTACCGTAAAAGGCGGCA
CTTACTACCCTGTAACTGTTAAAAAACACCTGCGCGCACAAGAGATTGCTAGTCGTTGCCATCTGCCATGCATCTATTTG
GTCGATTCAGGCGGCGCTAACCTACCCCGCCAAGATGAAGTGTTTCCCGATAGAGACCATTTCGGTCGCATCTTCTATAA
CCAAGCACAGATGTCAGCCAAAGGCATTCCGCAAATCGCGGTTGTTATGGGGCTTTGTACCGCCGGCGGCGCCTATGTGC
CTGCGATGGCAGATGAATCGATTATCGTTAAAGAGCAAGGCACCATCTTCTTGGCTGGTCCACCACTCGTAAAAGCTGCG
ACTGGTGAAGAGGTCACAGCAGAAGAGCTTGGCGGCGCAGAGGTACACACTAAGATTTCAGGCGTGGCCGATCATATGGC
GCAAAACGATGAACACGCGCTAGAACTTGCCCGCAAAGCGGTAACACGCCTCAATCATCAAAAACAAATTGCTGCTCAGC
TTAGCCCTGTTAAACCACCAAAATTTGATATCAACGAGCTTTACGGCATCGTAGGGACGGATCTTAAAAAACCCTTCGAT
GTTAAAGAGGTAATTGCTCGCCTAGTCGATGATTCTGATTTCGATGAGTTTAAGGCTAATTACGGTAATACCTTAGTCTG
TGGTTTTGCCCGTATTCATGGCTACCCAGTAGGCATTGTCGCTAACAACGGCATCTTGTTCTCAGAGTCGGCGCAAAAAG
GCGCGCACTTTATCGAGCTATGTTGCCAGCGCAAGATCCCACTGCTGTTCCTGCAAAACATTACCGGCTTTATGGTGGGT
AAGAAATACGAGCACGAAGGCATTGCTAAACACGGCGCCAAAATGGTGACCGCTGTATCTTGCGCCAATGTACCTAAGTT
TACCGTGATTATTGGCGGCAGCTATGGTGCAGGGAACTACGGCATGTGTGGCCGCGCGTTTGAACCAACCATGATGTGGA
TGTGGCCCAACGCCCGCATATCTGTGATGGGTGGCGAGCAAGCCGCTGGCGTATTGGCCACAGTTAAGCGCGACGGCTTA
GCTCGTAAAGGTGTCGAGTGGTCTGATAGTGAAGAACAAGACTTCCGTAAGCCGATTGTTGAGCAATATGATAAAGAGGG
CCACCCCTATCATGCCAGCGCCCGTTTATGGGATGACGGCATTATCGATCCGGCGCAAACCCGTGATGTTGTTGGTTTAG
CGCTATCAGCTGCGCTAAACGCACCGATTGAAGACACTAAGTTTGGTGTGTTCCGTATGTAG

Upstream 100 bases:

>100_bases
ATCGGCGCTGGCACCTCAGAAATTCGCCGCATGCTGATTGGTCGCGAGTTATTTACCGAATCTAAGTAAAGATCTAGCAC
TTAGCACCTAAGGTGGACAA

Downstream 100 bases:

>100_bases
TGGCTTAACGCCATTGCAAATAGAACATCAACTTAGCTAACAGAGTGGATCGACAACAATGAATAATTCAGTCGCAACCC
AGACAGAAATACTGGACCAA

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; 3-methylglutaconyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 553; Mature: 552

Protein sequence:

>553_residues
MGARIATPLYLSFKRIEIVTQLSSRINARSDEFKAKFDDMTAVVQDLKLKLHQIEQGGGEVARNRHLSRGKLLPRQRVEK
LLDPGSPFLEISQFAAYELYEDIVPAAGVIAGIGRVSGVECMIIANDATVKGGTYYPVTVKKHLRAQEIASRCHLPCIYL
VDSGGANLPRQDEVFPDRDHFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKEQGTIFLAGPPLVKAA
TGEEVTAEELGGAEVHTKISGVADHMAQNDEHALELARKAVTRLNHQKQIAAQLSPVKPPKFDINELYGIVGTDLKKPFD
VKEVIARLVDDSDFDEFKANYGNTLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVG
KKYEHEGIAKHGAKMVTAVSCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVKRDGL
ARKGVEWSDSEEQDFRKPIVEQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTKFGVFRM

Sequences:

>Translated_553_residues
MGARIATPLYLSFKRIEIVTQLSSRINARSDEFKAKFDDMTAVVQDLKLKLHQIEQGGGEVARNRHLSRGKLLPRQRVEK
LLDPGSPFLEISQFAAYELYEDIVPAAGVIAGIGRVSGVECMIIANDATVKGGTYYPVTVKKHLRAQEIASRCHLPCIYL
VDSGGANLPRQDEVFPDRDHFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKEQGTIFLAGPPLVKAA
TGEEVTAEELGGAEVHTKISGVADHMAQNDEHALELARKAVTRLNHQKQIAAQLSPVKPPKFDINELYGIVGTDLKKPFD
VKEVIARLVDDSDFDEFKANYGNTLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVG
KKYEHEGIAKHGAKMVTAVSCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVKRDGL
ARKGVEWSDSEEQDFRKPIVEQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTKFGVFRM
>Mature_552_residues
GARIATPLYLSFKRIEIVTQLSSRINARSDEFKAKFDDMTAVVQDLKLKLHQIEQGGGEVARNRHLSRGKLLPRQRVEKL
LDPGSPFLEISQFAAYELYEDIVPAAGVIAGIGRVSGVECMIIANDATVKGGTYYPVTVKKHLRAQEIASRCHLPCIYLV
DSGGANLPRQDEVFPDRDHFGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKEQGTIFLAGPPLVKAAT
GEEVTAEELGGAEVHTKISGVADHMAQNDEHALELARKAVTRLNHQKQIAAQLSPVKPPKFDINELYGIVGTDLKKPFDV
KEVIARLVDDSDFDEFKANYGNTLVCGFARIHGYPVGIVANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGK
KYEHEGIAKHGAKMVTAVSCANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVKRDGLA
RKGVEWSDSEEQDFRKPIVEQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALNAPIEDTKFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=536, Percent_Identity=67.910447761194, Blast_Score=752, Evalue=0.0,
Organism=Homo sapiens, GI119943100, Length=501, Percent_Identity=32.9341317365269, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI295821216, Length=521, Percent_Identity=31.8618042226488, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI310133460, Length=146, Percent_Identity=60.2739726027397, Blast_Score=164, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17552936, Length=533, Percent_Identity=63.2270168855535, Blast_Score=713, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25147359, Length=487, Percent_Identity=33.0595482546201, Blast_Score=241, Evalue=6e-64,
Organism=Caenorhabditis elegans, GI25147362, Length=487, Percent_Identity=33.0595482546201, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI24586065, Length=549, Percent_Identity=65.3916211293261, Blast_Score=745, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.4

Molecular weight: Translated: 60389; Mature: 60258

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGARIATPLYLSFKRIEIVTQLSSRINARSDEFKAKFDDMTAVVQDLKLKLHQIEQGGGE
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VARNRHLSRGKLLPRQRVEKLLDPGSPFLEISQFAAYELYEDIVPAAGVIAGIGRVSGVE
HHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
CMIIANDATVKGGTYYPVTVKKHLRAQEIASRCHLPCIYLVDSGGANLPRQDEVFPDRDH
EEEEECCCEECCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHH
FGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKEQGTIFLAGPPLVKAA
CCCEEEEHHHHCCCCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCEEEEECCCEEEEC
TGEEVTAEELGGAEVHTKISGVADHMAQNDEHALELARKAVTRLNHQKQIAAQLSPVKPP
CCCCCCHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KFDINELYGIVGTDLKKPFDVKEVIARLVDDSDFDEFKANYGNTLVCGFARIHGYPVGIV
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCEEEEEEHHHCCEEEEEE
ANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAVS
ECCCEEEECCHHHHHHHHHHHHHCCCCEEEHHCCHHHHCCCCCCCCCHHHHCHHHEEEEH
CANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVKRDGL
HCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCC
ARKGVEWSDSEEQDFRKPIVEQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALN
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHHC
APIEDTKFGVFRM
CCCCCCCCCEECC
>Mature Secondary Structure 
GARIATPLYLSFKRIEIVTQLSSRINARSDEFKAKFDDMTAVVQDLKLKLHQIEQGGGE
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
VARNRHLSRGKLLPRQRVEKLLDPGSPFLEISQFAAYELYEDIVPAAGVIAGIGRVSGVE
HHHHCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
CMIIANDATVKGGTYYPVTVKKHLRAQEIASRCHLPCIYLVDSGGANLPRQDEVFPDRDH
EEEEECCCEECCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCHHH
FGRIFYNQAQMSAKGIPQIAVVMGLCTAGGAYVPAMADESIIVKEQGTIFLAGPPLVKAA
CCCEEEEHHHHCCCCCCHHHHHHHHHHCCCCEEECCCCCEEEEEECCEEEEECCCEEEEC
TGEEVTAEELGGAEVHTKISGVADHMAQNDEHALELARKAVTRLNHQKQIAAQLSPVKPP
CCCCCCHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
KFDINELYGIVGTDLKKPFDVKEVIARLVDDSDFDEFKANYGNTLVCGFARIHGYPVGIV
CCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCHHHHHHCCCCEEEEEEHHHCCEEEEEE
ANNGILFSESAQKGAHFIELCCQRKIPLLFLQNITGFMVGKKYEHEGIAKHGAKMVTAVS
ECCCEEEECCHHHHHHHHHHHHHCCCCEEEHHCCHHHHCCCCCCCCCHHHHCHHHEEEEH
CANVPKFTVIIGGSYGAGNYGMCGRAFEPTMMWMWPNARISVMGGEQAAGVLATVKRDGL
HCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCEEEEECCCCHHHHHHHHHHCCC
ARKGVEWSDSEEQDFRKPIVEQYDKEGHPYHASARLWDDGIIDPAQTRDVVGLALSAALN
HHCCCCCCCCCHHHHHHHHHHHHCCCCCCEECCCEECCCCCCCCHHHHHHHHHHHHHHHC
APIEDTKFGVFRM
CCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; 3-methylcrotonoyl-CoA; HCO3-

Specific reaction: ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]