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The map label for this gene is mmgC [H]

Identifier: 157962618

GI number: 157962618

Start: 3415858

End: 3417027

Strand: Direct

Name: mmgC [H]

Synonym: Spea_2797

Alternate gene names: 157962618

Gene position: 3415858-3417027 (Clockwise)

Preceding gene: 157962617

Following gene: 157962619

Centisome position: 66.01

GC content: 49.49

Gene sequence:

>1170_bases
ATGACTCAACTCTACACATCTCTAAACTTCGGACTCGGTGAAGATGTCGATATGTTACGCGATGCCGTGCAAAACTTTGC
CGCCAATGAAATTGCGCCTATCGCCGCAAAAACAGATCTAGATAACGCCTTCCCTAATGAGCTTTGGCCTGTGCTGGGTG
ATATGGGATTACTCGGTGTCACCGTCTCTGAGGAGTATGGTGGGGCTGGCATGGGCTATCTCGCCCACGTTGTTGCTATG
GAAGAGATCTCCCGCGCCTCTGCATCGATTGGCCTAAGTTACGGTGCGCACTCCAACCTCTGCGTTAACCAAATCAACCG
TAACGGTAATAGTGAGCAAAAAGCCAAATACTTGCCAAAACTCATCACGGGTGAGCACATTGGAGCCCTCGCTATGAGCG
AGCCCAATGCAGGTTCTGATGTGGTATCGATGAAACTCCACGCCCGTAAAGAGGGTGACAGATACATACTCAACGGCAAC
AAGATGTGGATCACCAATGGCCCAGACGCGCACACCTATGTGATCTATGCCAAGACAGATCTCGATAAGGGTGCCCACGG
CATTACCGCATTTATCGTTGAGCGCGGCTATAAGGGTTTCAGTACCGCTCAGAAGCTAGACAAACTCGGTATGCGCGGCT
CAAACACCTGTGAGTTGGTATTTGAAGATTGCGAAGTACCAGAAGAGAACATTCTTGGCGGGCTTAACAACGGCGTAAAA
GTGTTGATGAGTGGTCTTGATTACGAGCGCGTAGTCTTGTCAGGTGGTCCACTTGGGATCATGACCGCCTGCATGGATAT
TGTGGTGCCATATATCCATGAGCGTGAACAGTTTGGTAAATCAATCGGCGAATTCCAGCTTGTACAAGGCAAACTTGCTG
ATATGTACACAGGCATGAACGCGGCTAAATCTTATATCTACAACGTGGCAAAATCTTGTGACCGTGGCGAGACTACTCGT
AAAGATGCCGCTGGCGCGATTCTCTATTCTGCTGAACTGGCAACCAAGATGGCGCTCGATGCGATTCAGTTACTTGGCGG
TAATGGCTACGTCAATGAATACGCAACGGGTCGCTTACTTCGTGATGCCAAGCTTTATGAAATCGGCGCTGGCACCTCAG
AAATTCGCCGCATGCTGATTGGTCGCGAGTTATTTACCGAATCTAAGTAA

Upstream 100 bases:

>100_bases
AAAGCATAATTTAACAATCTAATAAATAGATGGATTTATCAAGTATCACGGCAAAGATCGGTGAACTTGTATTCAAATAA
AATTGACAGGACACAAGCAA

Downstream 100 bases:

>100_bases
AGATCTAGCACTTAGCACCTAAGGTGGACAATTGGGCGCTCGCATAGCGACGCCCTTATATCTCAGCTTCAAAAGGATTG
AAATTGTGACGCAACTTAGC

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 3-methylbut-2-enoyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MTQLYTSLNFGLGEDVDMLRDAVQNFAANEIAPIAAKTDLDNAFPNELWPVLGDMGLLGVTVSEEYGGAGMGYLAHVVAM
EEISRASASIGLSYGAHSNLCVNQINRNGNSEQKAKYLPKLITGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGN
KMWITNGPDAHTYVIYAKTDLDKGAHGITAFIVERGYKGFSTAQKLDKLGMRGSNTCELVFEDCEVPEENILGGLNNGVK
VLMSGLDYERVVLSGGPLGIMTACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMNAAKSYIYNVAKSCDRGETTR
KDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFTESK

Sequences:

>Translated_389_residues
MTQLYTSLNFGLGEDVDMLRDAVQNFAANEIAPIAAKTDLDNAFPNELWPVLGDMGLLGVTVSEEYGGAGMGYLAHVVAM
EEISRASASIGLSYGAHSNLCVNQINRNGNSEQKAKYLPKLITGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGN
KMWITNGPDAHTYVIYAKTDLDKGAHGITAFIVERGYKGFSTAQKLDKLGMRGSNTCELVFEDCEVPEENILGGLNNGVK
VLMSGLDYERVVLSGGPLGIMTACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMNAAKSYIYNVAKSCDRGETTR
KDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFTESK
>Mature_388_residues
TQLYTSLNFGLGEDVDMLRDAVQNFAANEIAPIAAKTDLDNAFPNELWPVLGDMGLLGVTVSEEYGGAGMGYLAHVVAME
EISRASASIGLSYGAHSNLCVNQINRNGNSEQKAKYLPKLITGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGNK
MWITNGPDAHTYVIYAKTDLDKGAHGITAFIVERGYKGFSTAQKLDKLGMRGSNTCELVFEDCEVPEENILGGLNNGVKV
LMSGLDYERVVLSGGPLGIMTACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMNAAKSYIYNVAKSCDRGETTRK
DAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLLRDAKLYEIGAGTSEIRRMLIGRELFTESK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=376, Percent_Identity=65.1595744680851, Blast_Score=516, Evalue=1e-146,
Organism=Homo sapiens, GI226958414, Length=370, Percent_Identity=64.054054054054, Blast_Score=497, Evalue=1e-141,
Organism=Homo sapiens, GI4557233, Length=382, Percent_Identity=40.5759162303665, Blast_Score=282, Evalue=4e-76,
Organism=Homo sapiens, GI4501859, Length=370, Percent_Identity=36.7567567567568, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI21361497, Length=375, Percent_Identity=37.3333333333333, Blast_Score=232, Evalue=3e-61,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=35.6200527704486, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=35.6200527704486, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI4501857, Length=373, Percent_Identity=33.7801608579088, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI4557235, Length=353, Percent_Identity=34.5609065155807, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI76496475, Length=353, Percent_Identity=34.5609065155807, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=32.1148825065274, Blast_Score=208, Evalue=6e-54,
Organism=Homo sapiens, GI4503943, Length=385, Percent_Identity=29.8701298701299, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI7669494, Length=371, Percent_Identity=30.188679245283, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI211971008, Length=284, Percent_Identity=24.2957746478873, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI48976061, Length=284, Percent_Identity=24.2957746478873, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1786223, Length=383, Percent_Identity=28.1984334203655, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI87081958, Length=384, Percent_Identity=29.9479166666667, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI87082384, Length=261, Percent_Identity=26.4367816091954, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87081702, Length=333, Percent_Identity=25.2252252252252, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538396, Length=380, Percent_Identity=63.9473684210526, Blast_Score=511, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17506239, Length=378, Percent_Identity=33.3333333333333, Blast_Score=242, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17508101, Length=371, Percent_Identity=33.6927223719677, Blast_Score=240, Evalue=7e-64,
Organism=Caenorhabditis elegans, GI17569725, Length=381, Percent_Identity=36.2204724409449, Blast_Score=236, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI17534899, Length=381, Percent_Identity=34.6456692913386, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI17570075, Length=385, Percent_Identity=33.5064935064935, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI71990804, Length=276, Percent_Identity=39.4927536231884, Blast_Score=218, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=31.9261213720317, Blast_Score=210, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=34.5609065155807, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=36.7965367965368, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17505929, Length=356, Percent_Identity=32.5842696629214, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=34.3065693430657, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=30.4812834224599, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI17534353, Length=375, Percent_Identity=29.6, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI71985192, Length=313, Percent_Identity=33.5463258785943, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=246, Percent_Identity=30.0813008130081, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21355753, Length=386, Percent_Identity=61.9170984455959, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=40.8488063660477, Blast_Score=295, Evalue=3e-80,
Organism=Drosophila melanogaster, GI24646207, Length=376, Percent_Identity=37.5, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24666513, Length=381, Percent_Identity=35.1706036745407, Blast_Score=258, Evalue=4e-69,
Organism=Drosophila melanogaster, GI24660351, Length=387, Percent_Identity=35.6589147286822, Blast_Score=244, Evalue=7e-65,
Organism=Drosophila melanogaster, GI281363737, Length=383, Percent_Identity=32.6370757180157, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19920834, Length=389, Percent_Identity=29.305912596401, Blast_Score=158, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.10

Molecular weight: Translated: 42130; Mature: 41998

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLYTSLNFGLGEDVDMLRDAVQNFAANEIAPIAAKTDLDNAFPNELWPVLGDMGLLGV
CCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCEEEE
TVSEEYGGAGMGYLAHVVAMEEISRASASIGLSYGAHSNLCVNQINRNGNSEQKAKYLPK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCHHHHHHHHHH
LITGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGNKMWITNGPDAHTYVIYAKTD
HHCCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCEEEEEEEECC
LDKGAHGITAFIVERGYKGFSTAQKLDKLGMRGSNTCELVFEDCEVPEENILGGLNNGVK
CCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCHH
VLMSGLDYERVVLSGGPLGIMTACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMN
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHH
AAKSYIYNVAKSCDRGETTRKDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLL
HHHHHHHHHHHHCCCCCCCHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHH
RDAKLYEIGAGTSEIRRMLIGRELFTESK
HCCEEEEECCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQLYTSLNFGLGEDVDMLRDAVQNFAANEIAPIAAKTDLDNAFPNELWPVLGDMGLLGV
CCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCEEEE
TVSEEYGGAGMGYLAHVVAMEEISRASASIGLSYGAHSNLCVNQINRNGNSEQKAKYLPK
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCHHHHHHHHHH
LITGEHIGALAMSEPNAGSDVVSMKLHARKEGDRYILNGNKMWITNGPDAHTYVIYAKTD
HHCCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCEEEEEEEECC
LDKGAHGITAFIVERGYKGFSTAQKLDKLGMRGSNTCELVFEDCEVPEENILGGLNNGVK
CCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHCCCCCCCHH
VLMSGLDYERVVLSGGPLGIMTACMDIVVPYIHEREQFGKSIGEFQLVQGKLADMYTGMN
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCHH
AAKSYIYNVAKSCDRGETTRKDAAGAILYSAELATKMALDAIQLLGGNGYVNEYATGRLL
HHHHHHHHHHHHCCCCCCCHHHHCCEEEEHHHHHHHHHHHHHHHHCCCCCCCHHHHCHHH
RDAKLYEIGAGTSEIRRMLIGRELFTESK
HCCEEEEECCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-methylbutanoyl-CoA; acceptor

Specific reaction: 3-methylbutanoyl-CoA + acceptor = 3-methylbut-2-enoyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]