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The map label for this gene is ddc [H]

Identifier: 157962536

GI number: 157962536

Start: 3318677

End: 3320323

Strand: Direct

Name: ddc [H]

Synonym: Spea_2715

Alternate gene names: 157962536

Gene position: 3318677-3320323 (Clockwise)

Preceding gene: 157962535

Following gene: 157962539

Centisome position: 64.13

GC content: 47.3

Gene sequence:

>1647_bases
ATGACAGCAAGAAAAGCCACCGCATCAGAAGAGGCGTTACTGCGAATTTTTACGGTTCCAGAAGCCCCAGACTCTACCCT
CAGTGTGATTGAGCAAAACATCTCGCAAAACCTAATGGGTTTCTTGCAAGAAAGCGTGGTGGCTGTCGAGAAACCGCTTT
CTGAAGTTGAACTGGACTTTCAACAGTACCATATTCCTGCTGCGCCGCAGTTTGTGTCTGATTATGCCGATAATATGATG
CAAACATTAGTAGCCCACTCAGTGCACACCTCTGCGCCCAGTTTTATCGGTCATATGACCTCGGCTCTACCTTACTTTGT
ATTACCTCTGTCTAAGATGATGGTCGGGCTTAATCAAAACTTAGTAAAAATAGAGACCTCTAAAGCCTTTACGCCGTTAG
AGCGCCAAGTGCTGGGGATGATGCATCATCTTATTTATAACCAAGATGAAACCTTTTACCAAAGCTGGATGCACAGCGCC
AATGTCTCTTTGGGCGCATTTTGCTCTGGCGGCACAGTCGCTAATATCACCGCCTTGTGGACGGCTCGTAACCAACTGCT
TAAGGCCGACGGTGACTTTAAAGGTATCGCCAAGCAAGGCCTACTCAAAGGCCTGCGTCACTATGGTTACGATGACTTAG
CTATCTTGGTCTCTGAGCGCGGTCACTATTCGCTTGCTAAAACTGCAGACTTACTAGGTATTGGCCGAGAAAACATCATT
CAGGTACCTACATCGGACGATAACAAGGTCGATGTGGTTAAGATGCGTGAAATAGCTGAGCAACTTGATAAAGACAACAT
TAAAGTCATGGCGATTGTTGGCGTTGCTGGTACCACTGAAACTGGCAATATTGATCCGCTAAATGCGCTTGCCGATCTAG
CCGCTGAGCTAAACTGTCACTTCCATGTCGACGCTGCATGGGGCGGCGCCAGTCTATTATCGAATAAATACCGTCACTTG
TTAGCCGGGATTGAGCGCGCCGATTCGGTCACCATCGATGCCCATAAGCAGATGTATGTCCCCATGGGCGCAGGTATGGT
GATCTTTAAAGACCCAACCTTTGCTAACGCCATTAAACATCATGCCGAGTATATCCTACGTCAAGGCTCGAAAGACTTAG
GCAGTCAGACCTTAGAGGGCTCTCGCCCAGGTATGGCAATGCTAGTACATGCTTGCCTTAAGGTGATAGGCCGCGAAGGT
TATGAAATTTTGATTAATAACAGCCTAGAGAAGGCGCGTTATTTTGCAGACTTGATCACCGCTGAAGCCGACTTTGAGCT
GGTGTCTAAACCTGAACTTTGTCTACTTACCTACCGTTATGTGCCACAATCGGTACAAATTGCCATGGCTAAAGCTCGTG
AAATAGGTGATACAGCAACGCTTGCACAGTTCAATGGTTTGCTCGATGGTCTAACTAAGTTTGTACAAAAAACTCAGCGC
GAGCAAGGCACCTCGTTTGTATCACGAACCCGAATTAATCCTGAAAGCCACCAGCTCATGGATCTCAAAGCCGTGGTATT
TAGGGTGGTATTAGCCAACCCACTCACTAGCCATGACATTTTACAGCAAGTGTTAGCCGAGCAAGCCCAAATAGCCAAGA
GTGAAACTCACTTCCTACCTCAGTTGCTCACTCTGGCGCAGAGCTAA

Upstream 100 bases:

>100_bases
AAGTAAAGTGACCGTCCGTTTTGAGCATCCGTTTTGACCATCTGTTTCGATAGGCAGTTCAGTTAAGAAAACAGCGTGAT
TAGTAGAGAATTTTAGCCCC

Downstream 100 bases:

>100_bases
CAAGTAAAGTCATTTCCGACTCATTAACCTAAGATTGAGTCACTGACGCTTTCTAAAACGAAAAAAGCCCCAAAAGGGGC
TTTAATCCGATAACAAAATA

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MTARKATASEEALLRIFTVPEAPDSTLSVIEQNISQNLMGFLQESVVAVEKPLSEVELDFQQYHIPAAPQFVSDYADNMM
QTLVAHSVHTSAPSFIGHMTSALPYFVLPLSKMMVGLNQNLVKIETSKAFTPLERQVLGMMHHLIYNQDETFYQSWMHSA
NVSLGAFCSGGTVANITALWTARNQLLKADGDFKGIAKQGLLKGLRHYGYDDLAILVSERGHYSLAKTADLLGIGRENII
QVPTSDDNKVDVVKMREIAEQLDKDNIKVMAIVGVAGTTETGNIDPLNALADLAAELNCHFHVDAAWGGASLLSNKYRHL
LAGIERADSVTIDAHKQMYVPMGAGMVIFKDPTFANAIKHHAEYILRQGSKDLGSQTLEGSRPGMAMLVHACLKVIGREG
YEILINNSLEKARYFADLITAEADFELVSKPELCLLTYRYVPQSVQIAMAKAREIGDTATLAQFNGLLDGLTKFVQKTQR
EQGTSFVSRTRINPESHQLMDLKAVVFRVVLANPLTSHDILQQVLAEQAQIAKSETHFLPQLLTLAQS

Sequences:

>Translated_548_residues
MTARKATASEEALLRIFTVPEAPDSTLSVIEQNISQNLMGFLQESVVAVEKPLSEVELDFQQYHIPAAPQFVSDYADNMM
QTLVAHSVHTSAPSFIGHMTSALPYFVLPLSKMMVGLNQNLVKIETSKAFTPLERQVLGMMHHLIYNQDETFYQSWMHSA
NVSLGAFCSGGTVANITALWTARNQLLKADGDFKGIAKQGLLKGLRHYGYDDLAILVSERGHYSLAKTADLLGIGRENII
QVPTSDDNKVDVVKMREIAEQLDKDNIKVMAIVGVAGTTETGNIDPLNALADLAAELNCHFHVDAAWGGASLLSNKYRHL
LAGIERADSVTIDAHKQMYVPMGAGMVIFKDPTFANAIKHHAEYILRQGSKDLGSQTLEGSRPGMAMLVHACLKVIGREG
YEILINNSLEKARYFADLITAEADFELVSKPELCLLTYRYVPQSVQIAMAKAREIGDTATLAQFNGLLDGLTKFVQKTQR
EQGTSFVSRTRINPESHQLMDLKAVVFRVVLANPLTSHDILQQVLAEQAQIAKSETHFLPQLLTLAQS
>Mature_547_residues
TARKATASEEALLRIFTVPEAPDSTLSVIEQNISQNLMGFLQESVVAVEKPLSEVELDFQQYHIPAAPQFVSDYADNMMQ
TLVAHSVHTSAPSFIGHMTSALPYFVLPLSKMMVGLNQNLVKIETSKAFTPLERQVLGMMHHLIYNQDETFYQSWMHSAN
VSLGAFCSGGTVANITALWTARNQLLKADGDFKGIAKQGLLKGLRHYGYDDLAILVSERGHYSLAKTADLLGIGRENIIQ
VPTSDDNKVDVVKMREIAEQLDKDNIKVMAIVGVAGTTETGNIDPLNALADLAAELNCHFHVDAAWGGASLLSNKYRHLL
AGIERADSVTIDAHKQMYVPMGAGMVIFKDPTFANAIKHHAEYILRQGSKDLGSQTLEGSRPGMAMLVHACLKVIGREGY
EILINNSLEKARYFADLITAEADFELVSKPELCLLTYRYVPQSVQIAMAKAREIGDTATLAQFNGLLDGLTKFVQKTQRE
QGTSFVSRTRINPESHQLMDLKAVVFRVVLANPLTSHDILQQVLAEQAQIAKSETHFLPQLLTLAQS

Specific function: Catalyzes The Production Of Gaba. [C]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=375, Percent_Identity=29.3333333333333, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI197276620, Length=462, Percent_Identity=25.974025974026, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI4503875, Length=462, Percent_Identity=25.974025974026, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI58331246, Length=476, Percent_Identity=25.6302521008403, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI194294551, Length=375, Percent_Identity=28, Blast_Score=139, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17555682, Length=457, Percent_Identity=25.382932166302, Blast_Score=148, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI71993062, Length=457, Percent_Identity=25.382932166302, Blast_Score=148, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71993058, Length=350, Percent_Identity=28, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17543922, Length=247, Percent_Identity=25.9109311740891, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17136594, Length=391, Percent_Identity=27.1099744245524, Blast_Score=146, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24657193, Length=400, Percent_Identity=26.25, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24657185, Length=400, Percent_Identity=26.25, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24657188, Length=400, Percent_Identity=26.25, Blast_Score=136, Evalue=5e-32,
Organism=Drosophila melanogaster, GI21356415, Length=382, Percent_Identity=23.8219895287958, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24585139, Length=255, Percent_Identity=27.0588235294118, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221476190, Length=255, Percent_Identity=27.0588235294118, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585143, Length=255, Percent_Identity=27.0588235294118, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24652373, Length=244, Percent_Identity=28.6885245901639, Blast_Score=84, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 60337; Mature: 60206

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARKATASEEALLRIFTVPEAPDSTLSVIEQNISQNLMGFLQESVVAVEKPLSEVELDF
CCCCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QQYHIPAAPQFVSDYADNMMQTLVAHSVHTSAPSFIGHMTSALPYFVLPLSKMMVGLNQN
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LVKIETSKAFTPLERQVLGMMHHLIYNQDETFYQSWMHSANVSLGAFCSGGTVANITALW
EEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCEEHHHHHH
TARNQLLKADGDFKGIAKQGLLKGLRHYGYDDLAILVSERGHYSLAKTADLLGIGRENII
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCEE
QVPTSDDNKVDVVKMREIAEQLDKDNIKVMAIVGVAGTTETGNIDPLNALADLAAELNCH
ECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCE
FHVDAAWGGASLLSNKYRHLLAGIERADSVTIDAHKQMYVPMGAGMVIFKDPTFANAIKH
EEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCEEEECCCCHHHHHHH
HAEYILRQGSKDLGSQTLEGSRPGMAMLVHACLKVIGREGYEILINNSLEKARYFADLIT
HHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
AEADFELVSKPELCLLTYRYVPQSVQIAMAKAREIGDTATLAQFNGLLDGLTKFVQKTQR
CCCCCHHCCCCCEEEEEEHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
EQGTSFVSRTRINPESHQLMDLKAVVFRVVLANPLTSHDILQQVLAEQAQIAKSETHFLP
HHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLLTLAQS
HHHHHHCC
>Mature Secondary Structure 
TARKATASEEALLRIFTVPEAPDSTLSVIEQNISQNLMGFLQESVVAVEKPLSEVELDF
CCCCCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
QQYHIPAAPQFVSDYADNMMQTLVAHSVHTSAPSFIGHMTSALPYFVLPLSKMMVGLNQN
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LVKIETSKAFTPLERQVLGMMHHLIYNQDETFYQSWMHSANVSLGAFCSGGTVANITALW
EEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCEEHHHHHH
TARNQLLKADGDFKGIAKQGLLKGLRHYGYDDLAILVSERGHYSLAKTADLLGIGRENII
HHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCCCEE
QVPTSDDNKVDVVKMREIAEQLDKDNIKVMAIVGVAGTTETGNIDPLNALADLAAELNCH
ECCCCCCCCCHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCE
FHVDAAWGGASLLSNKYRHLLAGIERADSVTIDAHKQMYVPMGAGMVIFKDPTFANAIKH
EEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCEEEEECCCCEEEECCCCHHHHHHH
HAEYILRQGSKDLGSQTLEGSRPGMAMLVHACLKVIGREGYEILINNSLEKARYFADLIT
HHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
AEADFELVSKPELCLLTYRYVPQSVQIAMAKAREIGDTATLAQFNGLLDGLTKFVQKTQR
CCCCCHHCCCCCEEEEEEHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
EQGTSFVSRTRINPESHQLMDLKAVVFRVVLANPLTSHDILQQVLAEQAQIAKSETHFLP
HHCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
QLLTLAQS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]