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The map label for this gene is hisC [H]

Identifier: 157962279

GI number: 157962279

Start: 3001700

End: 3002755

Strand: Direct

Name: hisC [H]

Synonym: Spea_2458

Alternate gene names: 157962279

Gene position: 3001700-3002755 (Clockwise)

Preceding gene: 157962278

Following gene: 157962280

Centisome position: 58.01

GC content: 46.78

Gene sequence:

>1056_bases
ATGAACACTGCAACTAACGGCTTGAACTTAGCTCAACGCCTAGCCAGACCTGAATTGCTCGATCTACAGATCTATCAATC
GGCAAGGCGTATTGGCGGTCAAGGTGATATCTGGATCAATGCAAACGAGTCGCCATTTAATAATAGTGAACTTGAAGGGC
TGAACCGCTACCCGGAATGTCAGCCTCCAGAACTTGTTAATGCCTATAGCAACTACAGCAAGGTCGCAACTGACAGCATC
ATTACGAGTCGCGGCGCCGATGAGGCGATTGAGTTACTGATCCGTGCTTTTTGTATACCAGCCAAAGACTGTATCGCCAC
TTTTGGCCCAACTTATGGCATGTACGCCATCAGCGCGAAAACCTTTAATGTTGGGGTGAAAGCGTTATCACTAACCGAAG
ATTTTCAGCTACCCAGTGATTACCTTTCTCAAGTAAGCGGCGCCAAGTTGGTATTTATCTGCAACCCTAATAATCCAACG
GGTAGCGTTATAGCGCGGGATAAGGTGATTGAAGTTATCAACAACTGTCAAGATGCTATTGTGGTTGTGGATGAGGCTTA
TATCGAATTTAGCCCCGAATTCAGCGTCGCCGATTTAGTCGCGACTTTCCCCAACCTTGTGGTTCTGCGCACTCTGTCGA
AAGCTTTTGCATTGGCGGGAGCGCGGTGCGGTTTTTTACTGGCTAACCCTAATATTGTTGATATCTGCATGCGAGTTATC
GCTCCCTACCCTGTGCCTCTTCCTGTCAGTCTTGTGGCTGAAAAGGCGCTTAGCACATCAGGACTTGAAACCATGAGCCG
ACAAGTCAATGACATGAAGCAGCAGGGATTAAGGTTAGCGAATGCATTACAGCGCTATGGTGCCAAGGTCGTAAAGGCAC
ACGGTAACTATGTACTTGCCGAGTTTGCAGATAAACAACAGGTTCAGCAAAAGCTATCGCAAGCGGGAGTTATCGCCAGA
AGTTATAGCGACCCGCGCCTTAGCCAAGCAATTCGATTTAGCTTTACTAATCAAGCACAAACAGACTATCTCATTCAACT
GTTTCAACAAAAATAA

Upstream 100 bases:

>100_bases
CAGCAGCCGAGCTACTCGATGCCCACAAGAATGCCATAGCCATTCGACTCGCAAGCCTTAGTGCAGATGATGACACTAAT
AGCGGTAATGAGGAGGAGTT

Downstream 100 bases:

>100_bases
AATAGCTAGAAAGCTAATAATTAAAAAATAACGATAGCTTGACTGGTATTGATTTAGTTAAGCGCAAATTTGAAAGGTAT
ACCCGCTATGAAGCAGAAAA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MNTATNGLNLAQRLARPELLDLQIYQSARRIGGQGDIWINANESPFNNSELEGLNRYPECQPPELVNAYSNYSKVATDSI
ITSRGADEAIELLIRAFCIPAKDCIATFGPTYGMYAISAKTFNVGVKALSLTEDFQLPSDYLSQVSGAKLVFICNPNNPT
GSVIARDKVIEVINNCQDAIVVVDEAYIEFSPEFSVADLVATFPNLVVLRTLSKAFALAGARCGFLLANPNIVDICMRVI
APYPVPLPVSLVAEKALSTSGLETMSRQVNDMKQQGLRLANALQRYGAKVVKAHGNYVLAEFADKQQVQQKLSQAGVIAR
SYSDPRLSQAIRFSFTNQAQTDYLIQLFQQK

Sequences:

>Translated_351_residues
MNTATNGLNLAQRLARPELLDLQIYQSARRIGGQGDIWINANESPFNNSELEGLNRYPECQPPELVNAYSNYSKVATDSI
ITSRGADEAIELLIRAFCIPAKDCIATFGPTYGMYAISAKTFNVGVKALSLTEDFQLPSDYLSQVSGAKLVFICNPNNPT
GSVIARDKVIEVINNCQDAIVVVDEAYIEFSPEFSVADLVATFPNLVVLRTLSKAFALAGARCGFLLANPNIVDICMRVI
APYPVPLPVSLVAEKALSTSGLETMSRQVNDMKQQGLRLANALQRYGAKVVKAHGNYVLAEFADKQQVQQKLSQAGVIAR
SYSDPRLSQAIRFSFTNQAQTDYLIQLFQQK
>Mature_351_residues
MNTATNGLNLAQRLARPELLDLQIYQSARRIGGQGDIWINANESPFNNSELEGLNRYPECQPPELVNAYSNYSKVATDSI
ITSRGADEAIELLIRAFCIPAKDCIATFGPTYGMYAISAKTFNVGVKALSLTEDFQLPSDYLSQVSGAKLVFICNPNNPT
GSVIARDKVIEVINNCQDAIVVVDEAYIEFSPEFSVADLVATFPNLVVLRTLSKAFALAGARCGFLLANPNIVDICMRVI
APYPVPLPVSLVAEKALSTSGLETMSRQVNDMKQQGLRLANALQRYGAKVVKAHGNYVLAEFADKQQVQQKLSQAGVIAR
SYSDPRLSQAIRFSFTNQAQTDYLIQLFQQK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=341, Percent_Identity=43.108504398827, Blast_Score=271, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6322075, Length=374, Percent_Identity=30.7486631016043, Blast_Score=153, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38457; Mature: 38457

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTATNGLNLAQRLARPELLDLQIYQSARRIGGQGDIWINANESPFNNSELEGLNRYPEC
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHCCCCCCC
QPPELVNAYSNYSKVATDSIITSRGADEAIELLIRAFCIPAKDCIATFGPTYGMYAISAK
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEEE
TFNVGVKALSLTEDFQLPSDYLSQVSGAKLVFICNPNNPTGSVIARDKVIEVINNCQDAI
EEECCEEEEEECCCCCCCHHHHHHCCCCEEEEEECCCCCCCCEEHHHHHHHHHHCCCCEE
VVVDEAYIEFSPEFSVADLVATFPNLVVLRTLSKAFALAGARCGFLLANPNIVDICMRVI
EEEEHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHH
APYPVPLPVSLVAEKALSTSGLETMSRQVNDMKQQGLRLANALQRYGAKVVKAHGNYVLA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCEEEE
EFADKQQVQQKLSQAGVIARSYSDPRLSQAIRFSFTNQAQTDYLIQLFQQK
HHHHHHHHHHHHHHHCEEHCCCCCHHHHHHHHHEECCCCHHHHHHHHHHCC
>Mature Secondary Structure
MNTATNGLNLAQRLARPELLDLQIYQSARRIGGQGDIWINANESPFNNSELEGLNRYPEC
CCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHCCCCCCC
QPPELVNAYSNYSKVATDSIITSRGADEAIELLIRAFCIPAKDCIATFGPTYGMYAISAK
CCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEEEEEE
TFNVGVKALSLTEDFQLPSDYLSQVSGAKLVFICNPNNPTGSVIARDKVIEVINNCQDAI
EEECCEEEEEECCCCCCCHHHHHHCCCCEEEEEECCCCCCCCEEHHHHHHHHHHCCCCEE
VVVDEAYIEFSPEFSVADLVATFPNLVVLRTLSKAFALAGARCGFLLANPNIVDICMRVI
EEEEHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHH
APYPVPLPVSLVAEKALSTSGLETMSRQVNDMKQQGLRLANALQRYGAKVVKAHGNYVLA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCEEEE
EFADKQQVQQKLSQAGVIARSYSDPRLSQAIRFSFTNQAQTDYLIQLFQQK
HHHHHHHHHHHHHHHCEEHCCCCCHHHHHHHHHEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]