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The map label for this gene is hisD [H]

Identifier: 157962278

GI number: 157962278

Start: 3000375

End: 3001703

Strand: Direct

Name: hisD [H]

Synonym: Spea_2457

Alternate gene names: 157962278

Gene position: 3000375-3001703 (Clockwise)

Preceding gene: 157962277

Following gene: 157962279

Centisome position: 57.98

GC content: 49.51

Gene sequence:

>1329_bases
ATGCAGATCCTCAACTGGCAATCACTCTCACCACAAGCGCAATTAGCGGCGCTGAAACGCTCGCCATTAATTGGTGACAA
CAGCCTTGAGCAAAATGTAGCGAGGATCATCGAAGCCGTTGTAGCTAACGGCGATCAGGCGCTAAAGGACTTTAACCGTG
AGTTCGATGGGGTAAACCTAGAAACGCTAAAGCTAACGACTACACAAATTGAGCAGAGCTGTAAACTGGTGCCTGAAAGT
CTAAAACAGGCTATCGCTCAGGCTAAAAACAACATAGAGCGGTTTCACCAGGCGCAGTTACAGCCAAAAGTTGATATCGA
GACTCAGGCAGGCATCCGCTGTGAGCTTCGCTCCGAGCCTATTGAGCGTGTCGGACTCTATATCCCTGGTGGCACGGCGC
CGCTTATATCAACCGTACTCATGTTAGCCCTACCGGCAAAAATTGCTGGCTGTAACAAACGCGTTCTAGTGAGCCCACCA
CCGATTAATGACGCTATCATTTATGCGGCAAATGAGTGTGGCATTGAAGAGATCTATCAGGTCGGTGGCGCGCAAGCTAT
TGCTGCATTAGCCTTCGGCACAGAGTCTCTGCCACAGGTAGATAAAATTTTTGGCCCCGGAAATCGTTTTGTCACCGAAG
CAAAGCGTGCCGTCAGCCAAGATAATCGCTGCACAGTGAGTATCGATATGCCTGCGGGCCCATCAGAAGTACTGATTATT
GCCGATGGCCAAGCCAATGCTGAATTTGTCGCCGCCGATCTGTTATCTCAAGCTGAACACGGTGCTGACTCACAGGTCAT
GCTAGTCACCGACTCAACTGAGCTCGCAGAAGCGGTCAACACAGCCCTTGCTAATCAGCTTAAGCAGTTATCGCGCACTG
AGATAGCGACGACAGCACTTAAGAGTAGTCGTACTTTGATTGTTGATGATATACAGATGGCGGCTCTGGTTTCAAACCAA
TACGGGCCAGAGCACCTCATCATTCAAACTAAGCAACCAAGAGACGTATTACGCAATATTCGCGCCGCGGGCTCTGTGTT
TTTAGGCGCTTATACTCCAGAATCTGTCGGCGATTATGCCAGCGGTACTAATCACGTCTTACCGACCTACGGCTATAGCA
AAACCGTTTCTAGCCTATCTCTGGCAGACTTTAGCCGCAGATTCACGGTACAAGAGCTCAATGCTAAAGGGCTACAAACT
ATTGCAGATAGCGTAATGACACTGGCAGCAGCCGAGCTACTCGATGCCCACAAGAATGCCATAGCCATTCGACTCGCAAG
CCTTAGTGCAGATGATGACACTAATAGCGGTAATGAGGAGGAGTTATGA

Upstream 100 bases:

>100_bases
AGCACCGAAGATCTGTTCTGGGACACCATGGAGCAATTAACTCAGTTAGGTGCCAGCTCTATTCTGGTCATGCCTATCGA
AAAAATGATGGGGTAAGAGC

Downstream 100 bases:

>100_bases
ACACTGCAACTAACGGCTTGAACTTAGCTCAACGCCTAGCCAGACCTGAATTGCTCGATCTACAGATCTATCAATCGGCA
AGGCGTATTGGCGGTCAAGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MQILNWQSLSPQAQLAALKRSPLIGDNSLEQNVARIIEAVVANGDQALKDFNREFDGVNLETLKLTTTQIEQSCKLVPES
LKQAIAQAKNNIERFHQAQLQPKVDIETQAGIRCELRSEPIERVGLYIPGGTAPLISTVLMLALPAKIAGCNKRVLVSPP
PINDAIIYAANECGIEEIYQVGGAQAIAALAFGTESLPQVDKIFGPGNRFVTEAKRAVSQDNRCTVSIDMPAGPSEVLII
ADGQANAEFVAADLLSQAEHGADSQVMLVTDSTELAEAVNTALANQLKQLSRTEIATTALKSSRTLIVDDIQMAALVSNQ
YGPEHLIIQTKQPRDVLRNIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSKTVSSLSLADFSRRFTVQELNAKGLQT
IADSVMTLAAAELLDAHKNAIAIRLASLSADDDTNSGNEEEL

Sequences:

>Translated_442_residues
MQILNWQSLSPQAQLAALKRSPLIGDNSLEQNVARIIEAVVANGDQALKDFNREFDGVNLETLKLTTTQIEQSCKLVPES
LKQAIAQAKNNIERFHQAQLQPKVDIETQAGIRCELRSEPIERVGLYIPGGTAPLISTVLMLALPAKIAGCNKRVLVSPP
PINDAIIYAANECGIEEIYQVGGAQAIAALAFGTESLPQVDKIFGPGNRFVTEAKRAVSQDNRCTVSIDMPAGPSEVLII
ADGQANAEFVAADLLSQAEHGADSQVMLVTDSTELAEAVNTALANQLKQLSRTEIATTALKSSRTLIVDDIQMAALVSNQ
YGPEHLIIQTKQPRDVLRNIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSKTVSSLSLADFSRRFTVQELNAKGLQT
IADSVMTLAAAELLDAHKNAIAIRLASLSADDDTNSGNEEEL
>Mature_442_residues
MQILNWQSLSPQAQLAALKRSPLIGDNSLEQNVARIIEAVVANGDQALKDFNREFDGVNLETLKLTTTQIEQSCKLVPES
LKQAIAQAKNNIERFHQAQLQPKVDIETQAGIRCELRSEPIERVGLYIPGGTAPLISTVLMLALPAKIAGCNKRVLVSPP
PINDAIIYAANECGIEEIYQVGGAQAIAALAFGTESLPQVDKIFGPGNRFVTEAKRAVSQDNRCTVSIDMPAGPSEVLII
ADGQANAEFVAADLLSQAEHGADSQVMLVTDSTELAEAVNTALANQLKQLSRTEIATTALKSSRTLIVDDIQMAALVSNQ
YGPEHLIIQTKQPRDVLRNIRAAGSVFLGAYTPESVGDYASGTNHVLPTYGYSKTVSSLSLADFSRRFTVQELNAKGLQT
IADSVMTLAAAELLDAHKNAIAIRLASLSADDDTNSGNEEEL

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=426, Percent_Identity=55.3990610328638, Blast_Score=482, Evalue=1e-137,
Organism=Saccharomyces cerevisiae, GI6319819, Length=417, Percent_Identity=46.0431654676259, Blast_Score=367, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 47401; Mature: 47401

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQILNWQSLSPQAQLAALKRSPLIGDNSLEQNVARIIEAVVANGDQALKDFNREFDGVNL
CCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCE
ETLKLTTTQIEQSCKLVPESLKQAIAQAKNNIERFHQAQLQPKVDIETQAGIRCELRSEP
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCC
IERVGLYIPGGTAPLISTVLMLALPAKIAGCNKRVLVSPPPINDAIIYAANECGIEEIYQ
HHHCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCHHHHHH
VGGAQAIAALAFGTESLPQVDKIFGPGNRFVTEAKRAVSQDNRCTVSIDMPAGPSEVLII
CCCHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEE
ADGQANAEFVAADLLSQAEHGADSQVMLVTDSTELAEAVNTALANQLKQLSRTEIATTAL
ECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSSRTLIVDDIQMAALVSNQYGPEHLIIQTKQPRDVLRNIRAAGSVFLGAYTPESVGDYA
HCCCEEEEEHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCEEEECCCCHHHCCCC
SGTNHVLPTYGYSKTVSSLSLADFSRRFTVQELNAKGLQTIADSVMTLAAAELLDAHKNA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCE
IAIRLASLSADDDTNSGNEEEL
EEEEEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MQILNWQSLSPQAQLAALKRSPLIGDNSLEQNVARIIEAVVANGDQALKDFNREFDGVNL
CCCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCE
ETLKLTTTQIEQSCKLVPESLKQAIAQAKNNIERFHQAQLQPKVDIETQAGIRCELRSEP
EEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCC
IERVGLYIPGGTAPLISTVLMLALPAKIAGCNKRVLVSPPPINDAIIYAANECGIEEIYQ
HHHCEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEEEEECCCCHHHHHH
VGGAQAIAALAFGTESLPQVDKIFGPGNRFVTEAKRAVSQDNRCTVSIDMPAGPSEVLII
CCCHHHHHHHHHCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEE
ADGQANAEFVAADLLSQAEHGADSQVMLVTDSTELAEAVNTALANQLKQLSRTEIATTAL
ECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KSSRTLIVDDIQMAALVSNQYGPEHLIIQTKQPRDVLRNIRAAGSVFLGAYTPESVGDYA
HCCCEEEEEHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHCCEEEECCCCHHHCCCC
SGTNHVLPTYGYSKTVSSLSLADFSRRFTVQELNAKGLQTIADSVMTLAAAELLDAHKNA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCE
IAIRLASLSADDDTNSGNEEEL
EEEEEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]