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The map label for this gene is hisG [H]

Identifier: 157962277

GI number: 157962277

Start: 2999471

End: 3000370

Strand: Direct

Name: hisG [H]

Synonym: Spea_2456

Alternate gene names: 157962277

Gene position: 2999471-3000370 (Clockwise)

Preceding gene: 157962275

Following gene: 157962278

Centisome position: 57.97

GC content: 44.78

Gene sequence:

>900_bases
ATGTCAGAGTCAACTAGATTACGTATCGCAATCCAAAAATCAGGTCGTTTATCAAAAGAATCACAAAAACTGTTAAAGAG
CTGTGGCGTTAAATTTAACGTCAATGAACAACGTCTTATCGCCCACTCTGACAATATGCCAATTGATCTATTACGTGTTC
GTGATGACGATATTCCAGGCCTAGTCATGGATGGTGTTGTTGACCTTGGGATCATTGGCGAAAATGTACTAGAAGAGGAA
CAAATCGAGCGTCAAAGCTTAGGTAAACCTGCTGAATGCGTTAAGCTGCGTGAACTTGATTTTGGTGCTTGTCGCCTATC
TTTAGCGGTACCTAATGAATTTGAATACCAAGATGCAAGCTCACTCGAAGGGCTTCGAATCGCCACCTCTTACCCCAACC
TGCTACGTCGCTACATGCAAGAGCAAGGCATTAATTACCGTGATTGTATGCTTAAGGGCTCAGTTGAAGTCGCACCTCGT
GCAGGTTTATCGGACGGTATTTGTGATTTAGTCTCAACAGGTGCCACCCTTGAGGCAAACGGCCTTTACGAAACCGAAGT
CATTTACCGCTCTATGGCTTGCATCATTCAATCGACTCAGTCGCAACCCGATGACAAGCAAGCGCTTATCAACAAAATCT
TATCTCGCATCAACGGTGTGGTACGTGCAAAAGAGAGCAAATACATCTTGCTACACGCGCCAACAGAAACCTTAGAGCAA
ATTGTTGCCCTACTACCTGGTGCTGAAAACCCAACAGTATTGCCACTAAATGATGATACTAACCGTGTCGCTATCCACGC
TGTCAGCACCGAAGATCTGTTCTGGGACACCATGGAGCAATTAACTCAGTTAGGTGCCAGCTCTATTCTGGTCATGCCTA
TCGAAAAAATGATGGGGTAA

Upstream 100 bases:

>100_bases
AAATATCAAAAACCCTTGGAAGGAATTCCAAGGGTTTTTTGGTTTTATCTTAACAGCTTGTTTTATAAGAATTTTTAAAT
TAACTAATAGGAAGTACCCC

Downstream 100 bases:

>100_bases
GAGCATGCAGATCCTCAACTGGCAATCACTCTCACCACAAGCGCAATTAGCGGCGCTGAAACGCTCGCCATTAATTGGTG
ACAACAGCCTTGAGCAAAAT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSESTRLRIAIQKSGRLSKESQKLLKSCGVKFNVNEQRLIAHSDNMPIDLLRVRDDDIPGLVMDGVVDLGIIGENVLEEE
QIERQSLGKPAECVKLRELDFGACRLSLAVPNEFEYQDASSLEGLRIATSYPNLLRRYMQEQGINYRDCMLKGSVEVAPR
AGLSDGICDLVSTGATLEANGLYETEVIYRSMACIIQSTQSQPDDKQALINKILSRINGVVRAKESKYILLHAPTETLEQ
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTQLGASSILVMPIEKMMG

Sequences:

>Translated_299_residues
MSESTRLRIAIQKSGRLSKESQKLLKSCGVKFNVNEQRLIAHSDNMPIDLLRVRDDDIPGLVMDGVVDLGIIGENVLEEE
QIERQSLGKPAECVKLRELDFGACRLSLAVPNEFEYQDASSLEGLRIATSYPNLLRRYMQEQGINYRDCMLKGSVEVAPR
AGLSDGICDLVSTGATLEANGLYETEVIYRSMACIIQSTQSQPDDKQALINKILSRINGVVRAKESKYILLHAPTETLEQ
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTQLGASSILVMPIEKMMG
>Mature_298_residues
SESTRLRIAIQKSGRLSKESQKLLKSCGVKFNVNEQRLIAHSDNMPIDLLRVRDDDIPGLVMDGVVDLGIIGENVLEEEQ
IERQSLGKPAECVKLRELDFGACRLSLAVPNEFEYQDASSLEGLRIATSYPNLLRRYMQEQGINYRDCMLKGSVEVAPRA
GLSDGICDLVSTGATLEANGLYETEVIYRSMACIIQSTQSQPDDKQALINKILSRINGVVRAKESKYILLHAPTETLEQI
VALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTQLGASSILVMPIEKMMG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=298, Percent_Identity=65.7718120805369, Blast_Score=411, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6320896, Length=296, Percent_Identity=31.4189189189189, Blast_Score=133, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867 [H]

Pfam domain/function: PF01634 HisG; PF08029 HisG_C [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 33107; Mature: 32976

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESTRLRIAIQKSGRLSKESQKLLKSCGVKFNVNEQRLIAHSDNMPIDLLRVRDDDIPG
CCCCCEEEEEEECCCCCCHHHHHHHHHCCCEECCCCCEEEEECCCCCEEEEEECCCCCCC
LVMDGVVDLGIIGENVLEEEQIERQSLGKPAECVKLRELDFGACRLSLAVPNEFEYQDAS
HHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
SLEGLRIATSYPNLLRRYMQEQGINYRDCMLKGSVEVAPRAGLSDGICDLVSTGATLEAN
CCCCEEEECCCHHHHHHHHHHCCCCHHHHEEECCEEECCCCCCCCCHHHHHHCCCEEECC
GLYETEVIYRSMACIIQSTQSQPDDKQALINKILSRINGVVRAKESKYILLHAPTETLEQ
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHH
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTQLGASSILVMPIEKMMG
HHHHCCCCCCCEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure 
SESTRLRIAIQKSGRLSKESQKLLKSCGVKFNVNEQRLIAHSDNMPIDLLRVRDDDIPG
CCCCEEEEEEECCCCCCHHHHHHHHHCCCEECCCCCEEEEECCCCCEEEEEECCCCCCC
LVMDGVVDLGIIGENVLEEEQIERQSLGKPAECVKLRELDFGACRLSLAVPNEFEYQDAS
HHHHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
SLEGLRIATSYPNLLRRYMQEQGINYRDCMLKGSVEVAPRAGLSDGICDLVSTGATLEAN
CCCCEEEECCCHHHHHHHHHHCCCCHHHHEEECCEEECCCCCCCCCHHHHHHCCCEEECC
GLYETEVIYRSMACIIQSTQSQPDDKQALINKILSRINGVVRAKESKYILLHAPTETLEQ
CCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEECCCCEEEEECCHHHHHH
IVALLPGAENPTVLPLNDDTNRVAIHAVSTEDLFWDTMEQLTQLGASSILVMPIEKMMG
HHHHCCCCCCCEEEEECCCCCEEEEEEECCHHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA