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The map label for this gene is mazG [H]

Identifier: 157961011

GI number: 157961011

Start: 1437311

End: 1438114

Strand: Direct

Name: mazG [H]

Synonym: Spea_1183

Alternate gene names: 157961011

Gene position: 1437311-1438114 (Clockwise)

Preceding gene: 157961010

Following gene: 157961012

Centisome position: 27.78

GC content: 46.89

Gene sequence:

>804_bases
ATGACTCAACTAGTTGGCGATACCCGCCCTCTACTTAATATTATGCAAAAGCTGCGCGACCCAGAAACAGGTTGCCCTTG
GGACAAGGCACAAGACTTTCAAACAATCGTGCCATTTACTATAGAAGAAGCCTATGAGGTCGCCGATACCATAGAGCGCA
TGGCGCTCGATGAACTGCCTGATGAACTCGGTGACTTGCTGTTTCAGGTGGTTTTTTATTGTCAGCTGGGTAAAGAGCAG
GGGCTTTTCGATTTCGATACAGTGGTTAACCGTATTTGTGACAAGCTCACCCGTCGCCATCCCCATGTATTTGAAGGCTT
AGCGGCCACTAGCACGGCAGAGATAAAGCATAATTGGGAGCAACTGAAAGCAGATGAACGCAGTCAGCGCGCGTTAAACT
CTGTTCTTGATGATATTCCATTGGCGCTACCAGCGTTATCACGCTCGATAAAAATCCAGAAACGAGTGGCTCGGGTTGGA
TTTGACTGGGCAGAACTTGATCCTGTAGTCGCAAAAATCCATGAAGAGATCGATGAAGTGCTTTATGAAGTGAAGCAAGA
CACGGTGGATGCAGACAAAGTAAAAGATGAGATGGGGGACTTATTGTTCGCCGTGGTGAATCTTGCTAGGCACTTAGGTG
TAGAGCCAGAACAGGCATTAAGGCAAGCAAATCAAAAGTTTGAAAGGCGCTTTCGTGGCGTTGAAGCCTATGCGCAAGCC
GACGGTCGATTGATGACCGAACACACATTAACAGAGCTTGATGGCTACTGGGATAAGGTTAAACAGGATGAAGCAAATAA
ATAA

Upstream 100 bases:

>100_bases
AACTTAAAGATAACGGCAACCATAAGGTTGCCGTTTTTATATGTAATTATTAATCGTGACTTTAGCGTGACAGCGTTAAA
GCACTGTATAGGAAAGTGGA

Downstream 100 bases:

>100_bases
CTTAGCTTTTAAGTTAATTGTAGTTTGTCGAATCAAGCTTGCTTTGGTATAATATTGCCCCGTCCTAGTGCTTTCTTACA
AGCACATATTTCCAACTCAT

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTQLVGDTRPLLNIMQKLRDPETGCPWDKAQDFQTIVPFTIEEAYEVADTIERMALDELPDELGDLLFQVVFYCQLGKEQ
GLFDFDTVVNRICDKLTRRHPHVFEGLAATSTAEIKHNWEQLKADERSQRALNSVLDDIPLALPALSRSIKIQKRVARVG
FDWAELDPVVAKIHEEIDEVLYEVKQDTVDADKVKDEMGDLLFAVVNLARHLGVEPEQALRQANQKFERRFRGVEAYAQA
DGRLMTEHTLTELDGYWDKVKQDEANK

Sequences:

>Translated_267_residues
MTQLVGDTRPLLNIMQKLRDPETGCPWDKAQDFQTIVPFTIEEAYEVADTIERMALDELPDELGDLLFQVVFYCQLGKEQ
GLFDFDTVVNRICDKLTRRHPHVFEGLAATSTAEIKHNWEQLKADERSQRALNSVLDDIPLALPALSRSIKIQKRVARVG
FDWAELDPVVAKIHEEIDEVLYEVKQDTVDADKVKDEMGDLLFAVVNLARHLGVEPEQALRQANQKFERRFRGVEAYAQA
DGRLMTEHTLTELDGYWDKVKQDEANK
>Mature_266_residues
TQLVGDTRPLLNIMQKLRDPETGCPWDKAQDFQTIVPFTIEEAYEVADTIERMALDELPDELGDLLFQVVFYCQLGKEQG
LFDFDTVVNRICDKLTRRHPHVFEGLAATSTAEIKHNWEQLKADERSQRALNSVLDDIPLALPALSRSIKIQKRVARVGF
DWAELDPVVAKIHEEIDEVLYEVKQDTVDADKVKDEMGDLLFAVVNLARHLGVEPEQALRQANQKFERRFRGVEAYAQAD
GRLMTEHTLTELDGYWDKVKQDEANK

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=254, Percent_Identity=58.6614173228346, Blast_Score=305, Evalue=2e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 30610; Mature: 30479

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLVGDTRPLLNIMQKLRDPETGCPWDKAQDFQTIVPFTIEEAYEVADTIERMALDELP
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHH
DELGDLLFQVVFYCQLGKEQGLFDFDTVVNRICDKLTRRHPHVFEGLAATSTAEIKHNWE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
QLKADERSQRALNSVLDDIPLALPALSRSIKIQKRVARVGFDWAELDPVVAKIHEEIDEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LYEVKQDTVDADKVKDEMGDLLFAVVNLARHLGVEPEQALRQANQKFERRFRGVEAYAQA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DGRLMTEHTLTELDGYWDKVKQDEANK
CCCCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TQLVGDTRPLLNIMQKLRDPETGCPWDKAQDFQTIVPFTIEEAYEVADTIERMALDELP
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHH
DELGDLLFQVVFYCQLGKEQGLFDFDTVVNRICDKLTRRHPHVFEGLAATSTAEIKHNWE
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
QLKADERSQRALNSVLDDIPLALPALSRSIKIQKRVARVGFDWAELDPVVAKIHEEIDEV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
LYEVKQDTVDADKVKDEMGDLLFAVVNLARHLGVEPEQALRQANQKFERRFRGVEAYAQA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
DGRLMTEHTLTELDGYWDKVKQDEANK
CCCCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]