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The map label for this gene is pdxA [H]

Identifier: 157960691

GI number: 157960691

Start: 1060949

End: 1061932

Strand: Reverse

Name: pdxA [H]

Synonym: Spea_0863

Alternate gene names: 157960691

Gene position: 1061932-1060949 (Counterclockwise)

Preceding gene: 157960692

Following gene: 157960690

Centisome position: 20.52

GC content: 47.26

Gene sequence:

>984_bases
TTGTCGACTAAACGCATAGCCATCACGCCGGGTGAACCGGCGGGTGTTGGCCCAGATTTAGTGATACAACTAGCTCAGCA
GGCTTGGCCTGCTGAGCTAGTCGTTTGTGCTGATCCAGAATTATTACTGTCTCGCGCCAAGAAGCTTGGGCTTTCTATTC
AGTTGCGTCCATATCAACCGAATCAACCCCCTAAGGCGCAAGAGGCTGGCACACTGACAATCGTGCCTTTTACCCTAGAG
ACTGATTCTGTATGTGGCCAGCTAAATGAAATTAATAGCGCCTATGTCGTCGATACATTAAGATTCGCTGGCGAAAAAAA
CATGGTTGGCGAATTCGATGCAGTAGTAACAGGACCCGTTCATAAGGGGATTATCAACCAAGCTGGTATTCCGTTTAGCG
GCCACACCGAATATTTTGCCAATCAGGCAAACTGCCAAGATGTGGTAATGATGCTAGCGGCGCCAGGCTTGCAGGTTGCG
CTTGTGACAACTCACATACCATTAGCGTATGTGTCAAAAGCCATTACTCGCGACCGTTTGCATCAAATCGTCAAGATTTT
ACACAAAGACTTAGTCGAGAAATTCGCGATTGAGTCACCTCGCATCTATGTGTGTGGTTTAAACCCTCATGCTGGCGAGG
ACGGTCATTTAGGCAGAGAAGAGATAGATATCATCATCCCTGCACTAAATGAGCTTAGGGAACTCAATATGGATATCGTA
GGCCCACTGCCAGCTGATACCCTGTTCCAACCTAAATACTTAGAAGATGCTGACGTCGTACTCGCTATGTACCACGATCA
GGGGCTTCCAGTACTAAAATCTAGAGGATTTGGCAGTTCAGTCAACATCACTCTAGGATTACCCTATATAAGAACCTCGG
TCGACCATGGTACGGCCTTAGAGCTTGCAGGCACTGGCACTGCAGATATCGGCAGCTTTGTCTGCGCATTAAATAAAGCC
ATTGATTTGGCTGCAAAGAATTAG

Upstream 100 bases:

>100_bases
GTCGTAAATTTAATGAAGAGTTACAAAACTGGCTAGATGAAATGCGCGCTGAAGCATTTATCGATATATTTGAGCCAGAA
ACGAATCGAGGTTAATACTA

Downstream 100 bases:

>100_bases
TGATAAAAGTTACCTCATGAGCAATAAAGTACATTTAGGCCACACGGCCAGAAAACGTTTTGGACAAAACTTCTTAACCG
ACGAAAATGTGATTAACCGC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MSTKRIAITPGEPAGVGPDLVIQLAQQAWPAELVVCADPELLLSRAKKLGLSIQLRPYQPNQPPKAQEAGTLTIVPFTLE
TDSVCGQLNEINSAYVVDTLRFAGEKNMVGEFDAVVTGPVHKGIINQAGIPFSGHTEYFANQANCQDVVMMLAAPGLQVA
LVTTHIPLAYVSKAITRDRLHQIVKILHKDLVEKFAIESPRIYVCGLNPHAGEDGHLGREEIDIIIPALNELRELNMDIV
GPLPADTLFQPKYLEDADVVLAMYHDQGLPVLKSRGFGSSVNITLGLPYIRTSVDHGTALELAGTGTADIGSFVCALNKA
IDLAAKN

Sequences:

>Translated_327_residues
MSTKRIAITPGEPAGVGPDLVIQLAQQAWPAELVVCADPELLLSRAKKLGLSIQLRPYQPNQPPKAQEAGTLTIVPFTLE
TDSVCGQLNEINSAYVVDTLRFAGEKNMVGEFDAVVTGPVHKGIINQAGIPFSGHTEYFANQANCQDVVMMLAAPGLQVA
LVTTHIPLAYVSKAITRDRLHQIVKILHKDLVEKFAIESPRIYVCGLNPHAGEDGHLGREEIDIIIPALNELRELNMDIV
GPLPADTLFQPKYLEDADVVLAMYHDQGLPVLKSRGFGSSVNITLGLPYIRTSVDHGTALELAGTGTADIGSFVCALNKA
IDLAAKN
>Mature_326_residues
STKRIAITPGEPAGVGPDLVIQLAQQAWPAELVVCADPELLLSRAKKLGLSIQLRPYQPNQPPKAQEAGTLTIVPFTLET
DSVCGQLNEINSAYVVDTLRFAGEKNMVGEFDAVVTGPVHKGIINQAGIPFSGHTEYFANQANCQDVVMMLAAPGLQVAL
VTTHIPLAYVSKAITRDRLHQIVKILHKDLVEKFAIESPRIYVCGLNPHAGEDGHLGREEIDIIIPALNELRELNMDIVG
PLPADTLFQPKYLEDADVVLAMYHDQGLPVLKSRGFGSSVNITLGLPYIRTSVDHGTALELAGTGTADIGSFVCALNKAI
DLAAKN

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) [H]

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family [H]

Homologues:

Organism=Escherichia coli, GI1786237, Length=323, Percent_Identity=64.0866873065015, Blast_Score=426, Evalue=1e-121,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005255 [H]

Pfam domain/function: PF04166 PdxA [H]

EC number: =1.1.1.262 [H]

Molecular weight: Translated: 35182; Mature: 35051

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTKRIAITPGEPAGVGPDLVIQLAQQAWPAELVVCADPELLLSRAKKLGLSIQLRPYQP
CCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCEEEEECCCC
NQPPKAQEAGTLTIVPFTLETDSVCGQLNEINSAYVVDTLRFAGEKNMVGEFDAVVTGPV
CCCCCCHHCCEEEEEEEEECCHHHHHHHHHCCCHHEEHHHHHCCCCCCCCCCCEEEECCH
HKGIINQAGIPFSGHTEYFANQANCQDVVMMLAAPGLQVALVTTHIPLAYVSKAITRDRL
HHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHH
HQIVKILHKDLVEKFAIESPRIYVCGLNPHAGEDGHLGREEIDIIIPALNELRELNMDIV
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHEEEHHHHHHHHCCCCEE
GPLPADTLFQPKYLEDADVVLAMYHDQGLPVLKSRGFGSSVNITLGLPYIRTSVDHGTAL
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCCCCEEEEEEECCHHEECCCCCCEE
ELAGTGTADIGSFVCALNKAIDLAAKN
EEECCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STKRIAITPGEPAGVGPDLVIQLAQQAWPAELVVCADPELLLSRAKKLGLSIQLRPYQP
CCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCEEEEECCCC
NQPPKAQEAGTLTIVPFTLETDSVCGQLNEINSAYVVDTLRFAGEKNMVGEFDAVVTGPV
CCCCCCHHCCEEEEEEEEECCHHHHHHHHHCCCHHEEHHHHHCCCCCCCCCCCEEEECCH
HKGIINQAGIPFSGHTEYFANQANCQDVVMMLAAPGLQVALVTTHIPLAYVSKAITRDRL
HHHHHHCCCCCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHH
HQIVKILHKDLVEKFAIESPRIYVCGLNPHAGEDGHLGREEIDIIIPALNELRELNMDIV
HHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHHHHEEEHHHHHHHHCCCCEE
GPLPADTLFQPKYLEDADVVLAMYHDQGLPVLKSRGFGSSVNITLGLPYIRTSVDHGTAL
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEECCCCCCEEEEEEECCHHEECCCCCCEE
ELAGTGTADIGSFVCALNKAIDLAAKN
EEECCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]