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The map label for this gene is hisS

Identifier: 157825548

GI number: 157825548

Start: 420129

End: 421376

Strand: Direct

Name: hisS

Synonym: A1C_02295

Alternate gene names: 157825548

Gene position: 420129-421376 (Clockwise)

Preceding gene: 157825547

Following gene: 157825549

Centisome position: 34.13

GC content: 34.46

Gene sequence:

>1248_bases
ATGACTGAAAAGCTGCAGCCACTTCGAGGAATTAAAGATCTATTGCCGGATGATTATAAAGTCCACGACTATATAATTAG
CAAAGCAAGAGATGTTGGAGTATTGTACGGCTATAAGCAAATGAGTACTCCAATACTCGAGTATACCAAGGTTTTTAACC
GTTCGATGGGTGAAAGTTCTGACGTAATAAGTAAAGAAATATATAGTTTTCTAGATAAAAGCAATGAATCTGTAGCTCTT
AGACCTGAATTTACAGCCGGTATTATAAGAAGCTTCATCTCAAATGGTTTGCAGCACAAGCTACCTCTTAAACTTTTCTC
TACCGGTCCTGTTTTTCGTTATGATAGACCGCAAGCAGGGCGTCAACGTCAATTTCACCAACTGAATTATGAATATATTG
GAGCTAAAGGAGCTATTACTGATGCTGAAACTTTGAAGTTAGCGATAGACATACTTAAAGCACTCGCAATAGAGCAGGAT
ACTCTCTTGGAGCTTAACTCTCTTGGATGTAGTGAATCAAGAAGTGCTTATAAACAAAAGCTGGTAGAATATCTAAGTGA
TTTTAAAGATCAATTATCGGAAGAAAGCAAAATAAGGATGATTAAAAATCCAATGCGAATACTTGATTCTAAAAGTGAAA
TTGATCAAAAAATAGTTGCTTATGCTCCGATTTTATCTGAATATTACACTGATGAATCCAAAGAATATTTTGATGAGTTA
ATAAAGTATCTCGACATTTTAGGTGTGAAATATAGCATAAATCCACGTTTGGTTAGAGGGCTTGATTATTACTGCCATAC
TGCTTTTGAATTCACTACAAACAAGCTTGGGAGTCAATCTACTATTCTTGCCGGTGGTCGATATGACGGGCTTAGCCGAA
TCATGGGTAATAATGATGATGTTCCGGCTATCGGTTTTGCTGCCGGTATTGAGCGTATTGCTTTGATGCGAGAATATGAT
ATATCTGAAGTAAAGCCTGTATTTGTATTACCTATAGGCGACAATAATATTACTTACGCTTTAGAAATTGTAGATAAATT
GCGTGCACAAAATATTGCTACTATTGTAGAACCCTTAGGTAAAATAGCTAAAAGGATGCAACGTGTTCTTAATGAAAATG
CTAAATTTATTATTTTTATAGGTGATGAAGAACAAGAAAATAATAGCATCAAACTTAAAGATTTAGAAAAACAAGAAGAA
TATATAGTAGATTTTGCAAAAGCTTTTGAGTTATTGAAGAAGTATTAA

Upstream 100 bases:

>100_bases
TTTAATTTTTTTTGGATACCGTGTTCAAGCCACGGTATGACACCGAGCGGTTTTTTCGCTACATGCGAGATGACATTAAT
AAAACCATAAAATTAGCCAA

Downstream 100 bases:

>100_bases
ATATTTATAACTTTTCTAAAACCTTTTCAATTATTCCTGAATTTAACCACGACATCTAAAAATATGATTATTATAAACGA
TTTAGCCATGAGTTATGGTA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 415; Mature: 414

Protein sequence:

>415_residues
MTEKLQPLRGIKDLLPDDYKVHDYIISKARDVGVLYGYKQMSTPILEYTKVFNRSMGESSDVISKEIYSFLDKSNESVAL
RPEFTAGIIRSFISNGLQHKLPLKLFSTGPVFRYDRPQAGRQRQFHQLNYEYIGAKGAITDAETLKLAIDILKALAIEQD
TLLELNSLGCSESRSAYKQKLVEYLSDFKDQLSEESKIRMIKNPMRILDSKSEIDQKIVAYAPILSEYYTDESKEYFDEL
IKYLDILGVKYSINPRLVRGLDYYCHTAFEFTTNKLGSQSTILAGGRYDGLSRIMGNNDDVPAIGFAAGIERIALMREYD
ISEVKPVFVLPIGDNNITYALEIVDKLRAQNIATIVEPLGKIAKRMQRVLNENAKFIIFIGDEEQENNSIKLKDLEKQEE
YIVDFAKAFELLKKY

Sequences:

>Translated_415_residues
MTEKLQPLRGIKDLLPDDYKVHDYIISKARDVGVLYGYKQMSTPILEYTKVFNRSMGESSDVISKEIYSFLDKSNESVAL
RPEFTAGIIRSFISNGLQHKLPLKLFSTGPVFRYDRPQAGRQRQFHQLNYEYIGAKGAITDAETLKLAIDILKALAIEQD
TLLELNSLGCSESRSAYKQKLVEYLSDFKDQLSEESKIRMIKNPMRILDSKSEIDQKIVAYAPILSEYYTDESKEYFDEL
IKYLDILGVKYSINPRLVRGLDYYCHTAFEFTTNKLGSQSTILAGGRYDGLSRIMGNNDDVPAIGFAAGIERIALMREYD
ISEVKPVFVLPIGDNNITYALEIVDKLRAQNIATIVEPLGKIAKRMQRVLNENAKFIIFIGDEEQENNSIKLKDLEKQEE
YIVDFAKAFELLKKY
>Mature_414_residues
TEKLQPLRGIKDLLPDDYKVHDYIISKARDVGVLYGYKQMSTPILEYTKVFNRSMGESSDVISKEIYSFLDKSNESVALR
PEFTAGIIRSFISNGLQHKLPLKLFSTGPVFRYDRPQAGRQRQFHQLNYEYIGAKGAITDAETLKLAIDILKALAIEQDT
LLELNSLGCSESRSAYKQKLVEYLSDFKDQLSEESKIRMIKNPMRILDSKSEIDQKIVAYAPILSEYYTDESKEYFDELI
KYLDILGVKYSINPRLVRGLDYYCHTAFEFTTNKLGSQSTILAGGRYDGLSRIMGNNDDVPAIGFAAGIERIALMREYDI
SEVKPVFVLPIGDNNITYALEIVDKLRAQNIATIVEPLGKIAKRMQRVLNENAKFIIFIGDEEQENNSIKLKDLEKQEEY
IVDFAKAFELLKKY

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=442, Percent_Identity=24.6606334841629, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1788861, Length=411, Percent_Identity=38.9294403892944, Blast_Score=309, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6325290, Length=389, Percent_Identity=24.9357326478149, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_RICAH (A8GMY5)

Other databases:

- EMBL:   CP000847
- RefSeq:   YP_001493268.1
- ProteinModelPortal:   A8GMY5
- SMR:   A8GMY5
- STRING:   A8GMY5
- GeneID:   5645466
- GenomeReviews:   CP000847_GR
- KEGG:   rak:A1C_02295
- NMPDR:   fig|293614.3.peg.429
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- BioCyc:   RAKA293614:A1C_02295-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 47431; Mature: 47300

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKLQPLRGIKDLLPDDYKVHDYIISKARDVGVLYGYKQMSTPILEYTKVFNRSMGESS
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCHHEECHHHHCCHHHHHHHHHHHCCCCCH
DVISKEIYSFLDKSNESVALRPEFTAGIIRSFISNGLQHKLPLKLFSTGPVFRYDRPQAG
HHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCEEEECCCCEEECCCCCCH
RQRQFHQLNYEYIGAKGAITDAETLKLAIDILKALAIEQDTLLELNSLGCSESRSAYKQK
HHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHH
LVEYLSDFKDQLSEESKIRMIKNPMRILDSKSEIDQKIVAYAPILSEYYTDESKEYFDEL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IKYLDILGVKYSINPRLVRGLDYYCHTAFEFTTNKLGSQSTILAGGRYDGLSRIMGNNDD
HHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCC
VPAIGFAAGIERIALMREYDISEVKPVFVLPIGDNNITYALEIVDKLRAQNIATIVEPLG
CCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
KIAKRMQRVLNENAKFIIFIGDEEQENNSIKLKDLEKQEEYIVDFAKAFELLKKY
HHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TEKLQPLRGIKDLLPDDYKVHDYIISKARDVGVLYGYKQMSTPILEYTKVFNRSMGESS
CCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCHHEECHHHHCCHHHHHHHHHHHCCCCCH
DVISKEIYSFLDKSNESVALRPEFTAGIIRSFISNGLQHKLPLKLFSTGPVFRYDRPQAG
HHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCEEEECCCCEEECCCCCCH
RQRQFHQLNYEYIGAKGAITDAETLKLAIDILKALAIEQDTLLELNSLGCSESRSAYKQK
HHHHHHHCCCCEECCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHH
LVEYLSDFKDQLSEESKIRMIKNPMRILDSKSEIDQKIVAYAPILSEYYTDESKEYFDEL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
IKYLDILGVKYSINPRLVRGLDYYCHTAFEFTTNKLGSQSTILAGGRYDGLSRIMGNNDD
HHHHHHHCCEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHCCCCCC
VPAIGFAAGIERIALMREYDISEVKPVFVLPIGDNNITYALEIVDKLRAQNIATIVEPLG
CCCHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
KIAKRMQRVLNENAKFIIFIGDEEQENNSIKLKDLEKQEEYIVDFAKAFELLKKY
HHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA