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The map label for this gene is grxC [C]

Identifier: 157373008

GI number: 157373008

Start: 5290442

End: 5291173

Strand: Direct

Name: grxC [C]

Synonym: Spro_4776

Alternate gene names: 157373008

Gene position: 5290442-5291173 (Clockwise)

Preceding gene: 157373006

Following gene: 157373009

Centisome position: 97.09

GC content: 55.6

Gene sequence:

>732_bases
ATGTTTACCAGTCAAGAAGGCAAAAAAGTTCCTCAGGTGACCTTCCACACCCGCCAGGGTGACCAATGGATCGATGTGAC
TACCAACGACCTGTTTAAAGATAAAACCGTCATCGTATTTTCACTGCCGGGCGCGTTCACTCCGACCTGCTCTTCCAGCC
ATCTGCCGCGCTACAACGAGCTGTCCAGCGTATTCAAGCAGCACGGCGTTGACAACATTCTGTGCGTCTCGGTGAACGAC
ACCTTCGTGATGAACGCCTGGAAAGCCGATCAACATGCTGAAAACATCACCTTCGTGCCGGACGGCAACGGTGAATTCAC
CAAAGGCATGAACATGCTGGTCGAGAAAGCCGATTTGGGCTTCGGCCCACGCTCATGGCGTTACTCGATGCTGGTGCGTA
ACGGCGTAGTGGAAAAAATGTTTGTCGAGCCCAACAAGCCGGGCGACCCGTTTGAGGTGTCTGACGCCGACACCATGCTG
AAATACCTGGCGCCAGAATTCAAAGTGCAGGAGTCGGTTTCGCTGTTTACCAAGCCGGGCTGCCCGTTCTGCGCCAAAGC
CAAACAAATGCTGCAGGAACGTGGCATTCAGTATGAAGAGATCGTACTGGGTCAGGACGCGACGACCGTCAGCCTGCGCG
CCGTCAGCGGCCGTGCCACGGTACCGCAGGTGTTCATCGGCGGCCGTCATATTGGCGGTAGCGATGACCTGGAAAGCTTC
CTGTCAGCCTGA

Upstream 100 bases:

>100_bases
GCGATTAGATCTATCAACCCCCGGCGGCAATAATGTGTCCCATCAAAGCGGCATAACGCTGAAAGCTAAAAATTATTTTT
CCTAATTAAGGGGTTAATTC

Downstream 100 bases:

>100_bases
TTTATAAGTAATAACAAAGCCAACGTGAACTTTTGGCGGGCTCCGGCCCGCCCTTTTTTTAGCTTTCAGGAGCGGATATG
AAACAGTTGAATGTTGACGT

Product: glutaredoxin family protein

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MFTSQEGKKVPQVTFHTRQGDQWIDVTTNDLFKDKTVIVFSLPGAFTPTCSSSHLPRYNELSSVFKQHGVDNILCVSVND
TFVMNAWKADQHAENITFVPDGNGEFTKGMNMLVEKADLGFGPRSWRYSMLVRNGVVEKMFVEPNKPGDPFEVSDADTML
KYLAPEFKVQESVSLFTKPGCPFCAKAKQMLQERGIQYEEIVLGQDATTVSLRAVSGRATVPQVFIGGRHIGGSDDLESF
LSA

Sequences:

>Translated_243_residues
MFTSQEGKKVPQVTFHTRQGDQWIDVTTNDLFKDKTVIVFSLPGAFTPTCSSSHLPRYNELSSVFKQHGVDNILCVSVND
TFVMNAWKADQHAENITFVPDGNGEFTKGMNMLVEKADLGFGPRSWRYSMLVRNGVVEKMFVEPNKPGDPFEVSDADTML
KYLAPEFKVQESVSLFTKPGCPFCAKAKQMLQERGIQYEEIVLGQDATTVSLRAVSGRATVPQVFIGGRHIGGSDDLESF
LSA
>Mature_243_residues
MFTSQEGKKVPQVTFHTRQGDQWIDVTTNDLFKDKTVIVFSLPGAFTPTCSSSHLPRYNELSSVFKQHGVDNILCVSVND
TFVMNAWKADQHAENITFVPDGNGEFTKGMNMLVEKADLGFGPRSWRYSMLVRNGVVEKMFVEPNKPGDPFEVSDADTML
KYLAPEFKVQESVSLFTKPGCPFCAKAKQMLQERGIQYEEIVLGQDATTVSLRAVSGRATVPQVFIGGRHIGGSDDLESF
LSA

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=145, Percent_Identity=36.551724137931, Blast_Score=96, Evalue=4e-20,
Organism=Escherichia coli, GI1790039, Length=70, Percent_Identity=41.4285714285714, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323138, Length=137, Percent_Identity=32.8467153284672, Blast_Score=72, Evalue=7e-14,
Organism=Drosophila melanogaster, GI78706776, Length=125, Percent_Identity=46.4, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI78709078, Length=125, Percent_Identity=46.4, Blast_Score=108, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26971; Mature: 26971

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTSQEGKKVPQVTFHTRQGDQWIDVTTNDLFKDKTVIVFSLPGAFTPTCSSSHLPRYNE
CCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHH
LSSVFKQHGVDNILCVSVNDTFVMNAWKADQHAENITFVPDGNGEFTKGMNMLVEKADLG
HHHHHHHCCCCEEEEEEECCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
FGPRSWRYSMLVRNGVVEKMFVEPNKPGDPFEVSDADTMLKYLAPEFKVQESVSLFTKPG
CCCCCHHHHHHHHCCCHHEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHEEECCC
CPFCAKAKQMLQERGIQYEEIVLGQDATTVSLRAVSGRATVPQVFIGGRHIGGSDDLESF
CCHHHHHHHHHHHCCCCCHHEEECCCCCEEEEEEECCCCCCCEEEECCEECCCCHHHHHH
LSA
HCC
>Mature Secondary Structure
MFTSQEGKKVPQVTFHTRQGDQWIDVTTNDLFKDKTVIVFSLPGAFTPTCSSSHLPRYNE
CCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCHHH
LSSVFKQHGVDNILCVSVNDTFVMNAWKADQHAENITFVPDGNGEFTKGMNMLVEKADLG
HHHHHHHCCCCEEEEEEECCEEEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCC
FGPRSWRYSMLVRNGVVEKMFVEPNKPGDPFEVSDADTMLKYLAPEFKVQESVSLFTKPG
CCCCCHHHHHHHHCCCHHEEEECCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHEEECCC
CPFCAKAKQMLQERGIQYEEIVLGQDATTVSLRAVSGRATVPQVFIGGRHIGGSDDLESF
CCHHHHHHHHHHHCCCCCHHEEECCCCCEEEEEEECCCCCCCEEEECCEECCCCHHHHHH
LSA
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]