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The map label for this gene is sthA

Identifier: 157373006

GI number: 157373006

Start: 5287993

End: 5289390

Strand: Direct

Name: sthA

Synonym: Spro_4774

Alternate gene names: 157373006

Gene position: 5287993-5289390 (Clockwise)

Preceding gene: 157373003

Following gene: 157373008

Centisome position: 97.05

GC content: 55.44

Gene sequence:

>1398_bases
ATGCAACAGCACTATCAATTTGATGCCATAGTTATTGGCTCGGGCCCTGGTGGTGAAGGTGCCGCTATGGGGTTGGTGAA
ACAGGGCGCCCGCGTGGCCGTTATCGAACGGTACAATAACGTAGGCGGCGGATGTACCCACTGGGGTACCATCCCGTCCA
AAGCCCTCCGCCACGCCGTTAGCCGCATTATCGAATTCAACCAGAACCCGCTTTATAACAACTCACGCACGCTCAGCGCG
ACATTCCCTGATATTTTGCGCCATGCCGATAACGTGATTAACCAGCAAACACGGATGCGCCAGGGATTCTATGAGCGTAA
CCAATGCAAGCTGTTTGCCGGCGACGCACGCTTTATCGACGCCAACACCGTCAGCGTCAGCTATATGGATGGCACTCAGG
ACACTATCCGCGCCGACCATATCGTCATCGCCTGTGGTTCGCGCCCTTACAATCCGTCGAGCGTCGATTTTAACCATCCG
CGCATTTACAACAGCGATTCAATCCTCGAACTGAACCACGAACCGCGTCACGTGATCATTTACGGCGCCGGGGTTATCGG
CTGCGAATATGCGTCTATCTTTCGCGGACTGAACGTGAAGGTCGATCTGATCAACACCCGCGATCGTCTGCTGGCGTTCC
TCGACCAGGAAATGTCGGACTCGCTGTCTTACCACTTCTGGAACAACGGCGTGGTGATCCGTCACAACGAAGAGTTCGAG
AAAATCGAAGGCACCGACGACGGCGTGATTGTTCACCTGAAATCCGGCAAAAAAGTGAAAGCGGACTGCCTGCTGTATGC
CAACGGCCGTACCGGTAACACCGACTCGCTGGGGCTGGAGAACGTCGGTCTGGAGTCAGACAGCCGTGGCCTGCTGAAAG
TGAACAGCATGTACCAGACTGCGCTGTCGCACATTTATGCCGTGGGTGACGTAATTGGTTATCCAAGCCTGGCATCTGCC
GCTTACGATCAGGGCCGTATTGCCGCGCAGGCGATTGCTTCAGGCGAAGCCAGCGGGCATCTGATTGAAGACATCCCGAC
CGGTATTTATACCATTCCGGAAATCAGCTCCGTCGGTAAAACCGAACAGGAACTGACGGCGATGAAGGTGCCGTATGAAG
TGGGCCGCGCCCAGTTCAAGCATCTGGCGCGTGCGCAGATTGCCGGGATGAACGTCGGCAGCCTGAAGATCCTGTTCCAT
CGCGACACCCTGCAGATCCTCGGGATCCACTGCTTCGGTGAGCGTGCGGCGGAGATCATTCACATCGGCCAGGCGATCAT
GGAACAGAAAGGTGAAGGCAATACTATCGAGTATTTCGTTAATACTACCTTCAACTATCCGACCATGGCCGAAGCCTACC
GGGTGGCAGCGCTGAACGGCTTAAACCGCCTGTTTTAG

Upstream 100 bases:

>100_bases
ATTTGTGCTTTGCCTCAAAAAGCCTAATGGTGATTGGGCACTCAGCGCTATGATGTTAAGATACCGTTGTAATTTTGTAA
TTAAGACAGGTCTCTCCCCT

Downstream 100 bases:

>100_bases
CGTGGTACCCAGGTAGTTTTGCATGTGCTCGCGGATCGCCTCGGCCAATTGCTCATAACGACTGCGCAATGGGGAGCCGG
GGCGGTACACCAGCGCAATG

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MQQHYQFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYNNSRTLSA
TFPDILRHADNVINQQTRMRQGFYERNQCKLFAGDARFIDANTVSVSYMDGTQDTIRADHIVIACGSRPYNPSSVDFNHP
RIYNSDSILELNHEPRHVIIYGAGVIGCEYASIFRGLNVKVDLINTRDRLLAFLDQEMSDSLSYHFWNNGVVIRHNEEFE
KIEGTDDGVIVHLKSGKKVKADCLLYANGRTGNTDSLGLENVGLESDSRGLLKVNSMYQTALSHIYAVGDVIGYPSLASA
AYDQGRIAAQAIASGEASGHLIEDIPTGIYTIPEISSVGKTEQELTAMKVPYEVGRAQFKHLARAQIAGMNVGSLKILFH
RDTLQILGIHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Sequences:

>Translated_465_residues
MQQHYQFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYNNSRTLSA
TFPDILRHADNVINQQTRMRQGFYERNQCKLFAGDARFIDANTVSVSYMDGTQDTIRADHIVIACGSRPYNPSSVDFNHP
RIYNSDSILELNHEPRHVIIYGAGVIGCEYASIFRGLNVKVDLINTRDRLLAFLDQEMSDSLSYHFWNNGVVIRHNEEFE
KIEGTDDGVIVHLKSGKKVKADCLLYANGRTGNTDSLGLENVGLESDSRGLLKVNSMYQTALSHIYAVGDVIGYPSLASA
AYDQGRIAAQAIASGEASGHLIEDIPTGIYTIPEISSVGKTEQELTAMKVPYEVGRAQFKHLARAQIAGMNVGSLKILFH
RDTLQILGIHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
>Mature_465_residues
MQQHYQFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAVSRIIEFNQNPLYNNSRTLSA
TFPDILRHADNVINQQTRMRQGFYERNQCKLFAGDARFIDANTVSVSYMDGTQDTIRADHIVIACGSRPYNPSSVDFNHP
RIYNSDSILELNHEPRHVIIYGAGVIGCEYASIFRGLNVKVDLINTRDRLLAFLDQEMSDSLSYHFWNNGVVIRHNEEFE
KIEGTDDGVIVHLKSGKKVKADCLLYANGRTGNTDSLGLENVGLESDSRGLLKVNSMYQTALSHIYAVGDVIGYPSLASA
AYDQGRIAAQAIASGEASGHLIEDIPTGIYTIPEISSVGKTEQELTAMKVPYEVGRAQFKHLARAQIAGMNVGSLKILFH
RDTLQILGIHCFGERAAEIIHIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family

Homologues:

Organism=Homo sapiens, GI91199540, Length=476, Percent_Identity=29.8319327731092, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI22035672, Length=463, Percent_Identity=26.9978401727862, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=27.4298056155508, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI291045266, Length=441, Percent_Identity=24.2630385487528, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI148277065, Length=458, Percent_Identity=22.9257641921397, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI148277071, Length=458, Percent_Identity=22.9257641921397, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI33519430, Length=458, Percent_Identity=22.9257641921397, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI33519428, Length=458, Percent_Identity=22.9257641921397, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI33519426, Length=458, Percent_Identity=22.9257641921397, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI291045268, Length=313, Percent_Identity=23.961661341853, Blast_Score=76, Evalue=7e-14,
Organism=Homo sapiens, GI226437568, Length=251, Percent_Identity=26.6932270916335, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI65787454, Length=251, Percent_Identity=26.6932270916335, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI21389617, Length=251, Percent_Identity=26.6932270916335, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=84.1201716738197, Blast_Score=829, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=468, Percent_Identity=29.7008547008547, Blast_Score=201, Evalue=6e-53,
Organism=Escherichia coli, GI87081717, Length=464, Percent_Identity=26.7241379310345, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1789915, Length=434, Percent_Identity=27.8801843317972, Blast_Score=138, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI32565766, Length=460, Percent_Identity=31.0869565217391, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17557007, Length=477, Percent_Identity=26.2054507337526, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71983419, Length=341, Percent_Identity=26.6862170087977, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI71983429, Length=341, Percent_Identity=26.6862170087977, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17559934, Length=310, Percent_Identity=24.1935483870968, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=473, Percent_Identity=27.906976744186, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6325166, Length=462, Percent_Identity=26.4069264069264, Blast_Score=141, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6325240, Length=473, Percent_Identity=26.215644820296, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=30.6553911205074, Blast_Score=207, Evalue=2e-53,
Organism=Drosophila melanogaster, GI24640549, Length=486, Percent_Identity=27.1604938271605, Blast_Score=135, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24640553, Length=482, Percent_Identity=27.1784232365145, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24640551, Length=482, Percent_Identity=27.1784232365145, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI17737741, Length=495, Percent_Identity=24.6464646464646, Blast_Score=118, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): STHA_SERP5 (A8GL77)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480995.1
- ProteinModelPortal:   A8GL77
- SMR:   A8GL77
- STRING:   A8GL77
- GeneID:   5604663
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_4774
- eggNOG:   COG1249
- HOGENOM:   HBG515043
- OMA:   NVKVDLI
- ProtClustDB:   PRK05249
- BioCyc:   SPRO399741:SPRO_4774-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00247
- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962
- Gene3D:   G3DSA:3.30.390.30
- PRINTS:   PR00368

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim; SSF55424 FAD/NAD-linked_reductase_dimer

EC number: =1.6.1.1

Molecular weight: Translated: 51219; Mature: 51219

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQHYQFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAV
CCCCEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
SRIIEFNQNPLYNNSRTLSATFPDILRHADNVINQQTRMRQGFYERNQCKLFAGDARFID
HHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEE
ANTVSVSYMDGTQDTIRADHIVIACGSRPYNPSSVDFNHPRIYNSDSILELNHEPRHVII
CCEEEEEEECCCCHHEECCEEEEEECCCCCCCCCCCCCCCEEECCCCEEEECCCCCEEEE
YGAGVIGCEYASIFRGLNVKVDLINTRDRLLAFLDQEMSDSLSYHFWNNGVVIRHNEEFE
EECCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCEEEEECCHHH
KIEGTDDGVIVHLKSGKKVKADCLLYANGRTGNTDSLGLENVGLESDSRGLLKVNSMYQT
HCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHH
ALSHIYAVGDVIGYPSLASAAYDQGRIAAQAIASGEASGHLIEDIPTGIYTIPEISSVGK
HHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHCCCCCCCCHHHCCCCEEECCCCHHCCC
TEQELTAMKVPYEVGRAQFKHLARAQIAGMNVGSLKILFHRDTLQILGIHCFGERAAEII
CHHHHHEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEEEEEEHHHHHHHHH
HIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQQHYQFDAIVIGSGPGGEGAAMGLVKQGARVAVIERYNNVGGGCTHWGTIPSKALRHAV
CCCCEEEEEEEEECCCCCCCHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
SRIIEFNQNPLYNNSRTLSATFPDILRHADNVINQQTRMRQGFYERNQCKLFAGDARFID
HHHHHCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCEEEEE
ANTVSVSYMDGTQDTIRADHIVIACGSRPYNPSSVDFNHPRIYNSDSILELNHEPRHVII
CCEEEEEEECCCCHHEECCEEEEEECCCCCCCCCCCCCCCEEECCCCEEEECCCCCEEEE
YGAGVIGCEYASIFRGLNVKVDLINTRDRLLAFLDQEMSDSLSYHFWNNGVVIRHNEEFE
EECCCHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEECCCEEEEECCHHH
KIEGTDDGVIVHLKSGKKVKADCLLYANGRTGNTDSLGLENVGLESDSRGLLKVNSMYQT
HCCCCCCCEEEEECCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHHH
ALSHIYAVGDVIGYPSLASAAYDQGRIAAQAIASGEASGHLIEDIPTGIYTIPEISSVGK
HHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHCCCCCCCCHHHCCCCEEECCCCHHCCC
TEQELTAMKVPYEVGRAQFKHLARAQIAGMNVGSLKILFHRDTLQILGIHCFGERAAEII
CHHHHHEEECCHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCEEEEEEEEHHHHHHHHH
HIGQAIMEQKGEGNTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA