Click here to switch to the map view.

The map label for this gene is gmr [H]

Identifier: 157372974

GI number: 157372974

Start: 5244279

End: 5246273

Strand: Direct

Name: gmr [H]

Synonym: Spro_4742

Alternate gene names: 157372974

Gene position: 5244279-5246273 (Clockwise)

Preceding gene: 157372972

Following gene: 157372976

Centisome position: 96.25

GC content: 56.44

Gene sequence:

>1995_bases
ATGTTCGCAGACCAAGGCCCTATGCTTCTTAACGCTCACTTCGGCACCAACAGCCCTTATTGGCGGTTGGCGTTTGACAG
CAATGCGTTGGCGTTGTCGGCAGTCAAAGGTAAAACTCATATGGCCGTGGCGCTCAGCGCCATGCAGGCGGCTAAAATCC
GTCGCCTGAGCGGCATTACCGCCAGCCTTGATATCACCATCACGCTCGGCGGCGAACCGATACATCTGCATCTGGTCGGC
CGACGAGTCAACAATCTGGAATGGGCAGGCACCGCTTCCGCCTTCAGCGACACCCAATCGGTCGCCCGTGACCTGGTACA
CGGCCTATCCTTTGCCGAGCAGGTGGTGTCCGAAGCCAACTCCGTGATTGTGATTGTCGATCAACACGGCCGCATTCAGC
GTTTCAACCGCCTGAGCGAAGAGTACACCGGCCTGCACGAACATGATGTTATTGGTAAAAACGTCTTTCAATTATTTATG
AGCCCGGAGGAAGCCTCGGCATCACGGCGCAACATCGCCGGTTTTTTCCGTAATGGTTCCTCCTATGAGGTAGAACGCTG
GATCAAAACGGTGAAAGGCGAGCGGCTGTTTTTGTTCCGCAACAAGTTCGTCCACAGCGGCAGCGGCAAAAATGAAGTTT
TTTTGATTTGCTCCGGTACCGATATCACCGAAGAACGCCGCGCCCAGGAACGTCTGCGGGTGCTGGCCAATACCGACATC
ATTACCGGCCTGCCCAATCGCAATGCCATTCAGGACAAAATAACCCAGTCGATCGCCACTCGCGATGGCCACAGTGTTGG
CCTGGTGTACCTCGATCTCGACAATTTTAAAAAGGTTAACGACGCCTACGGCCATATGTTCGGCGACCGTTTATTGGTAG
AGGTGTCGCTGGCGGTGCTCGGCTGTCTGGATAACGACCAAACCCTGGCCCGCCTGGGTGGCGATGAATTCCTGGTGCTG
GCCCAGCAGGCCGACCGCGAAATGCTGCAACGCCTGGCCCAGCGCATTATCGACCGGCTGAAAACGCCGTTCCGCATAGG
GCTTATCGAAGTTTATACCGGCTGTTCTATTGGTATCGCACTGTGTCCCGAACACGGCAACGACCTCGACAGCCTGATCC
GCAGTGCCGACACCGCCATGTATGTCGCCAAAGAGCATGGCAAACGGACCTATACCGTGTTCTCGCCAGAAATGAATAAA
CGCGTCGCGGAATACATGTGGCTGGACACCAACCTGCGTAAGGGATTGGAACAAAATCAACTGGTGGTGTATTACCAGCC
AAAAATAGAGGCGCTCAGCGGCAGGGTATGTAGCGTGGAAGCGCTGGTGCGCTGGGATTCCCCCGAGCGCGGCCTGATCC
CGCCGCTGCAGTTTATCTCTTACGCGGAAGAGTCTGGTCTGATCGGCCCACTCGGCCGTTGGGTGCTGCAAACCGCCGCC
AAACAGGCCGCTCAGTGGCAACGACAGGGGTTGCAACTGCGGGTCGCGGTCAATCTTTCCGCCCGCCAGTTGGTGGATGA
CTCTATCGTTGAAGATCTGGCGCAGGTGTTGCAGCACAATCAGTTGACCCCCTGCCTGCTGGATTTTGAACTCACGGAAA
GCAGCCTGATTGAGGATGAGAAACGCGCTCGCGAAGTGATCACCCGGCTACGCGAGCTGGGCGCACAGGTCCATCTTGAT
GATTTTGGCACCGGCTACTCTTCGCTGGCGCAGCTGGCGCGTATTCCGCTGGATGCGATTAAGCTGGATAAAAGCTTTGT
GCGCGGAGTGAATGATAATCCGGTTTCACAATCGCTGGTGCGTGCCATCGTCGCGGCGGCCGAAGCGCTTAAATTCCGGG
TGATCGCCGAAGGCGTGGAAACAGAAAGCGAAAATCGGTTCCTCGATGAAATCGGCGTGGATGAAAAACAGGGGTTCCTG
TTTGCGCGGCCAATGCTCCCGGAACAGCTGGAGCATTGGCTGCAGTCTTATCGCCCGCCATCCTCCTCAGCGTGA

Upstream 100 bases:

>100_bases
ATATGATGGAGATACGTGCACTACGGCCACTCCCGGGCCAGAAACCTGCGGCTGCGCTCATCGCACAGACCTGGCTGTCG
TGCCCTTTTGAGGAATCATC

Downstream 100 bases:

>100_bases
GGCGGGCAGGGCAACATTAGCCGGCACGACGCAGGTTCAGAGTATGACGATCCTGCAGCATCACCAGACGTTCGATATAG
GCGCGATCTTTCTCCTCGAT

Product: RNase II stability modulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 664; Mature: 664

Protein sequence:

>664_residues
MFADQGPMLLNAHFGTNSPYWRLAFDSNALALSAVKGKTHMAVALSAMQAAKIRRLSGITASLDITITLGGEPIHLHLVG
RRVNNLEWAGTASAFSDTQSVARDLVHGLSFAEQVVSEANSVIVIVDQHGRIQRFNRLSEEYTGLHEHDVIGKNVFQLFM
SPEEASASRRNIAGFFRNGSSYEVERWIKTVKGERLFLFRNKFVHSGSGKNEVFLICSGTDITEERRAQERLRVLANTDI
ITGLPNRNAIQDKITQSIATRDGHSVGLVYLDLDNFKKVNDAYGHMFGDRLLVEVSLAVLGCLDNDQTLARLGGDEFLVL
AQQADREMLQRLAQRIIDRLKTPFRIGLIEVYTGCSIGIALCPEHGNDLDSLIRSADTAMYVAKEHGKRTYTVFSPEMNK
RVAEYMWLDTNLRKGLEQNQLVVYYQPKIEALSGRVCSVEALVRWDSPERGLIPPLQFISYAEESGLIGPLGRWVLQTAA
KQAAQWQRQGLQLRVAVNLSARQLVDDSIVEDLAQVLQHNQLTPCLLDFELTESSLIEDEKRAREVITRLRELGAQVHLD
DFGTGYSSLAQLARIPLDAIKLDKSFVRGVNDNPVSQSLVRAIVAAAEALKFRVIAEGVETESENRFLDEIGVDEKQGFL
FARPMLPEQLEHWLQSYRPPSSSA

Sequences:

>Translated_664_residues
MFADQGPMLLNAHFGTNSPYWRLAFDSNALALSAVKGKTHMAVALSAMQAAKIRRLSGITASLDITITLGGEPIHLHLVG
RRVNNLEWAGTASAFSDTQSVARDLVHGLSFAEQVVSEANSVIVIVDQHGRIQRFNRLSEEYTGLHEHDVIGKNVFQLFM
SPEEASASRRNIAGFFRNGSSYEVERWIKTVKGERLFLFRNKFVHSGSGKNEVFLICSGTDITEERRAQERLRVLANTDI
ITGLPNRNAIQDKITQSIATRDGHSVGLVYLDLDNFKKVNDAYGHMFGDRLLVEVSLAVLGCLDNDQTLARLGGDEFLVL
AQQADREMLQRLAQRIIDRLKTPFRIGLIEVYTGCSIGIALCPEHGNDLDSLIRSADTAMYVAKEHGKRTYTVFSPEMNK
RVAEYMWLDTNLRKGLEQNQLVVYYQPKIEALSGRVCSVEALVRWDSPERGLIPPLQFISYAEESGLIGPLGRWVLQTAA
KQAAQWQRQGLQLRVAVNLSARQLVDDSIVEDLAQVLQHNQLTPCLLDFELTESSLIEDEKRAREVITRLRELGAQVHLD
DFGTGYSSLAQLARIPLDAIKLDKSFVRGVNDNPVSQSLVRAIVAAAEALKFRVIAEGVETESENRFLDEIGVDEKQGFL
FARPMLPEQLEHWLQSYRPPSSSA
>Mature_664_residues
MFADQGPMLLNAHFGTNSPYWRLAFDSNALALSAVKGKTHMAVALSAMQAAKIRRLSGITASLDITITLGGEPIHLHLVG
RRVNNLEWAGTASAFSDTQSVARDLVHGLSFAEQVVSEANSVIVIVDQHGRIQRFNRLSEEYTGLHEHDVIGKNVFQLFM
SPEEASASRRNIAGFFRNGSSYEVERWIKTVKGERLFLFRNKFVHSGSGKNEVFLICSGTDITEERRAQERLRVLANTDI
ITGLPNRNAIQDKITQSIATRDGHSVGLVYLDLDNFKKVNDAYGHMFGDRLLVEVSLAVLGCLDNDQTLARLGGDEFLVL
AQQADREMLQRLAQRIIDRLKTPFRIGLIEVYTGCSIGIALCPEHGNDLDSLIRSADTAMYVAKEHGKRTYTVFSPEMNK
RVAEYMWLDTNLRKGLEQNQLVVYYQPKIEALSGRVCSVEALVRWDSPERGLIPPLQFISYAEESGLIGPLGRWVLQTAA
KQAAQWQRQGLQLRVAVNLSARQLVDDSIVEDLAQVLQHNQLTPCLLDFELTESSLIEDEKRAREVITRLRELGAQVHLD
DFGTGYSSLAQLARIPLDAIKLDKSFVRGVNDNPVSQSLVRAIVAAAEALKFRVIAEGVETESENRFLDEIGVDEKQGFL
FARPMLPEQLEHWLQSYRPPSSSA

Specific function: Part of a 2 protein system that seems to be dedicated to transcription of csgD. This protein decreases csgD transcription and thus decreases expression of adhesive curli fimbriae genes csgEFG, csgBAC/ymaD and adrA (yaic). Activity of this protein is antag

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1787541, Length=645, Percent_Identity=64.3410852713178, Blast_Score=848, Evalue=0.0,
Organism=Escherichia coli, GI87081921, Length=438, Percent_Identity=32.1917808219178, Blast_Score=235, Evalue=6e-63,
Organism=Escherichia coli, GI226510982, Length=416, Percent_Identity=30.7692307692308, Blast_Score=200, Evalue=3e-52,
Organism=Escherichia coli, GI87081743, Length=246, Percent_Identity=32.520325203252, Blast_Score=152, Evalue=7e-38,
Organism=Escherichia coli, GI1790496, Length=251, Percent_Identity=31.0756972111554, Blast_Score=144, Evalue=2e-35,
Organism=Escherichia coli, GI1788502, Length=268, Percent_Identity=29.8507462686567, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787055, Length=350, Percent_Identity=28.5714285714286, Blast_Score=139, Evalue=8e-34,
Organism=Escherichia coli, GI1788849, Length=435, Percent_Identity=27.5862068965517, Blast_Score=137, Evalue=3e-33,
Organism=Escherichia coli, GI87081980, Length=270, Percent_Identity=31.1111111111111, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI87081845, Length=235, Percent_Identity=31.9148936170213, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI1788381, Length=546, Percent_Identity=26.3736263736264, Blast_Score=128, Evalue=1e-30,
Organism=Escherichia coli, GI1786507, Length=232, Percent_Identity=32.7586206896552, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI87081977, Length=177, Percent_Identity=35.5932203389831, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI87082096, Length=427, Percent_Identity=24.824355971897, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI145693134, Length=154, Percent_Identity=34.4155844155844, Blast_Score=83, Evalue=6e-17,
Organism=Escherichia coli, GI1787262, Length=162, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787816, Length=171, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=5e-16,
Organism=Escherichia coli, GI87081881, Length=201, Percent_Identity=28.3582089552239, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1787410, Length=226, Percent_Identity=27.8761061946903, Blast_Score=76, Evalue=8e-15,
Organism=Escherichia coli, GI1788956, Length=152, Percent_Identity=35.5263157894737, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1786584, Length=173, Percent_Identity=27.7456647398844, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082007, Length=167, Percent_Identity=31.7365269461078, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR000014
- InterPro:   IPR013767 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF00989 PAS [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 74140; Mature: 74140

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50112 PAS ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFADQGPMLLNAHFGTNSPYWRLAFDSNALALSAVKGKTHMAVALSAMQAAKIRRLSGIT
CCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCE
ASLDITITLGGEPIHLHLVGRRVNNLEWAGTASAFSDTQSVARDLVHGLSFAEQVVSEAN
EEEEEEEEECCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SVIVIVDQHGRIQRFNRLSEEYTGLHEHDVIGKNVFQLFMSPEEASASRRNIAGFFRNGS
CEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCCHHHHHHHHCCCCC
SYEVERWIKTVKGERLFLFRNKFVHSGSGKNEVFLICSGTDITEERRAQERLRVLANTDI
CHHHHHHHHHHCCCEEEEEEHHEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCE
ITGLPNRNAIQDKITQSIATRDGHSVGLVYLDLDNFKKVNDAYGHMFGDRLLVEVSLAVL
EECCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
GCLDNDQTLARLGGDEFLVLAQQADREMLQRLAQRIIDRLKTPFRIGLIEVYTGCSIGIA
EECCCCCHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEHEEEECCCCEEEE
LCPEHGNDLDSLIRSADTAMYVAKEHGKRTYTVFSPEMNKRVAEYMWLDTNLRKGLEQNQ
ECCCCCCCHHHHHHHCCHHEEEEHHCCCEEEEEECCHHHHHHHHHHEECCHHHCCCCCCC
LVVYYQPKIEALSGRVCSVEALVRWDSPERGLIPPLQFISYAEESGLIGPLGRWVLQTAA
EEEEECCCHHHHCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
KQAAQWQRQGLQLRVAVNLSARQLVDDSIVEDLAQVLQHNQLTPCLLDFELTESSLIEDE
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
KRAREVITRLRELGAQVHLDDFGTGYSSLAQLARIPLDAIKLDKSFVRGVNDNPVSQSLV
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCHHHHHHCHHHHCCCCCCHHHHHHH
RAIVAAAEALKFRVIAEGVETESENRFLDEIGVDEKQGFLFARPMLPEQLEHWLQSYRPP
HHHHHHHHHHHHHEEHHCCCCCCCCHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHCCCC
SSSA
CCCC
>Mature Secondary Structure
MFADQGPMLLNAHFGTNSPYWRLAFDSNALALSAVKGKTHMAVALSAMQAAKIRRLSGIT
CCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCE
ASLDITITLGGEPIHLHLVGRRVNNLEWAGTASAFSDTQSVARDLVHGLSFAEQVVSEAN
EEEEEEEEECCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
SVIVIVDQHGRIQRFNRLSEEYTGLHEHDVIGKNVFQLFMSPEEASASRRNIAGFFRNGS
CEEEEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHCCHHHHHHHHCCCCC
SYEVERWIKTVKGERLFLFRNKFVHSGSGKNEVFLICSGTDITEERRAQERLRVLANTDI
CHHHHHHHHHHCCCEEEEEEHHEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCE
ITGLPNRNAIQDKITQSIATRDGHSVGLVYLDLDNFKKVNDAYGHMFGDRLLVEVSLAVL
EECCCCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
GCLDNDQTLARLGGDEFLVLAQQADREMLQRLAQRIIDRLKTPFRIGLIEVYTGCSIGIA
EECCCCCHHHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEHEEEECCCCEEEE
LCPEHGNDLDSLIRSADTAMYVAKEHGKRTYTVFSPEMNKRVAEYMWLDTNLRKGLEQNQ
ECCCCCCCHHHHHHHCCHHEEEEHHCCCEEEEEECCHHHHHHHHHHEECCHHHCCCCCCC
LVVYYQPKIEALSGRVCSVEALVRWDSPERGLIPPLQFISYAEESGLIGPLGRWVLQTAA
EEEEECCCHHHHCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHH
KQAAQWQRQGLQLRVAVNLSARQLVDDSIVEDLAQVLQHNQLTPCLLDFELTESSLIEDE
HHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHH
KRAREVITRLRELGAQVHLDDFGTGYSSLAQLARIPLDAIKLDKSFVRGVNDNPVSQSLV
HHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHCCHHHHHHCHHHHCCCCCCHHHHHHH
RAIVAAAEALKFRVIAEGVETESENRFLDEIGVDEKQGFLFARPMLPEQLEHWLQSYRPP
HHHHHHHHHHHHHEEHHCCCCCCCCHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHCCCC
SSSA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]