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The map label for this gene is edd [H]

Identifier: 157372732

GI number: 157372732

Start: 4984783

End: 4986597

Strand: Direct

Name: edd [H]

Synonym: Spro_4499

Alternate gene names: 157372732

Gene position: 4984783-4986597 (Clockwise)

Preceding gene: 157372731

Following gene: 157372733

Centisome position: 91.48

GC content: 60.28

Gene sequence:

>1815_bases
ATGATTAATCCAACCCTATCCCGTGTCACACAACGCATCATCGACCGTTCCAAATCGAGCCGTACCGCCTATCTGGCACG
CATTGAAGCAGCACGTTCACAAACCGTACATCGGGCCCAATTGGCCTGCGGTAATCTGGCCCATGGATTCGCCGCCTGCC
AGCCGGATGACAAAACTGCGCTGAAAAATATGGTGCGCAGCGATATCGCCATCATTACCGCTTATAACGACATGTTGTCC
GCCCACCAGCCCTACGAAAACTACCCGCAAAAGCTTAAACAGGCACTGCACGCAGTAGGGGCCGTCGGTCAGGTGGCCGG
TGGCGTCCCAGCGATGTGCGACGGTGTGACTCAAGGACAGGACGGCATGGAACTGTCACTGATGAGTCGTGACGTGATCG
CCATGTCCTCCGCCATCGGCCTGTCGCACAATATGTTCGACGGCGCGTTGTTCCTCGGCATCTGTGACAAAATCGTACCG
GGACTGGTGATGTCCGCCCTGTCCTTCGGCCATTTGCCGTCGCTGTTTGTCCCCGCCGGCCCGATGAGCAGCGGCTTGCC
GAACAAAGAGAAAGTCCGGGTGCGCCAACTGTATGCCGAAGGCAAGGCCGACCGTCTGGCACTGCTGGAGGCCGAGGCCG
CCTCCTACCATGGCATCGGTACCTGCACTTTCTACGGCACCGCCAACACCAACCAAATGGTGATGGAAGTGATGGGGCTG
CACCTGCCGGGTGCCTCTTTCGTCCACCCGGACACACCGCTGCGCGATGCGCTGACCGATGCCGCCGCACGCCAGGTCAC
TCGCCTGACCGAAACCGCCGGCAACTATCTGCCGATCGGCCGACTGGTGGATGAGAAGGTGGTGGTGAACGGTATCGTTG
CGCTGTTGGCTACCGGTGGCTCCACCAATCTGACCATGCACATGGTGGCAATGGCTCGCGCCGCCGGCATCATTATCAAC
TGGGATGATTTCTCCGAACTGTCGGACGCGGTGCCATTGTTATGTCGTATCTACCCGAACGGCCCGGCGGACATCAACCA
ATTCCAGGCCTCGGGCGGCGTAGCCCTGGTGGTACGCGAACTGTTGAAACACGGCCTGCTGCACGAAGACGTGCATACCG
TGGCCGGTTTTGGCCTGACGCGCTACACCCAGGAACCCTGGCTGGATAATGGCCAACTGGCCTGGCGCGAGGGTGTGGAG
AGTTCGCTCGACGCCCAGGTTATCGCCAGCGTGGCCGAACCTTTCGAGCACCACGGCGGTACCAAGGTGCTGGCCGGTAA
CCTCGGTCGAGCGGTGATGAAAACCTCGGCAGTCCCCGCTGAAAACCAGATTATCGAAGCGCCGGCGGTGGTCTTTGAAA
GCCAGCATGACATCGTACCGGCGTTTGAAGCCGGCAAACTGGATCGCGATTGTGTGGTGGTGGTGCGCTTCCAGGGGCCT
CAGGCCAATGGCATGCCAGAACTGCACAAACTGATGCCGCCGTTGGGCGTATTGATGGACCGTGGCTTTAAAGTGGCGCT
GGTGACCGATGGCCGCCTATCCGGCGCTTCCGGCAAGGTTCCGTCCGCCATTCACGTGACCCCGGAAGCCTACACCGGTG
GCATGCTGGCCAAGGTGCAAAACGGCGATCTGATCCGCGTAAATGGCCGCACTGGCGAGTTGGCACTGTTGGTCGATGCC
GACCTGCTGGCCCAGCGCGCACCTTATCAACCCGACCTGAGCGCAGAACACATCGGCTGTGGCCGTGAACTGTTCGGCGC
CTTGCGCAGCCAGCTTTCCGGTGCCGAACAGGGTGCCTGCTGCATTAAATTTTAA

Upstream 100 bases:

>100_bases
ACGACATAACAGCGCCCCCGGCCTTGCACATCAGGGCTGCAATTCACCACCGGGGGCACCGCCACAGGCGGCGTCTATAA
CAATAGCATGTGAGGAAGGT

Downstream 100 bases:

>100_bases
CCGATAGCATGGCCGTACAGCCCGACGGCGGCGGCCATAACTGGAGAAAACCGTTAATGAACAATTGGAAGACAAGCGCA
GAGCAGATCCTGATGGCAGG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 604; Mature: 604

Protein sequence:

>604_residues
MINPTLSRVTQRIIDRSKSSRTAYLARIEAARSQTVHRAQLACGNLAHGFAACQPDDKTALKNMVRSDIAIITAYNDMLS
AHQPYENYPQKLKQALHAVGAVGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSSAIGLSHNMFDGALFLGICDKIVP
GLVMSALSFGHLPSLFVPAGPMSSGLPNKEKVRVRQLYAEGKADRLALLEAEAASYHGIGTCTFYGTANTNQMVMEVMGL
HLPGASFVHPDTPLRDALTDAAARQVTRLTETAGNYLPIGRLVDEKVVVNGIVALLATGGSTNLTMHMVAMARAAGIIIN
WDDFSELSDAVPLLCRIYPNGPADINQFQASGGVALVVRELLKHGLLHEDVHTVAGFGLTRYTQEPWLDNGQLAWREGVE
SSLDAQVIASVAEPFEHHGGTKVLAGNLGRAVMKTSAVPAENQIIEAPAVVFESQHDIVPAFEAGKLDRDCVVVVRFQGP
QANGMPELHKLMPPLGVLMDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYTGGMLAKVQNGDLIRVNGRTGELALLVDA
DLLAQRAPYQPDLSAEHIGCGRELFGALRSQLSGAEQGACCIKF

Sequences:

>Translated_604_residues
MINPTLSRVTQRIIDRSKSSRTAYLARIEAARSQTVHRAQLACGNLAHGFAACQPDDKTALKNMVRSDIAIITAYNDMLS
AHQPYENYPQKLKQALHAVGAVGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSSAIGLSHNMFDGALFLGICDKIVP
GLVMSALSFGHLPSLFVPAGPMSSGLPNKEKVRVRQLYAEGKADRLALLEAEAASYHGIGTCTFYGTANTNQMVMEVMGL
HLPGASFVHPDTPLRDALTDAAARQVTRLTETAGNYLPIGRLVDEKVVVNGIVALLATGGSTNLTMHMVAMARAAGIIIN
WDDFSELSDAVPLLCRIYPNGPADINQFQASGGVALVVRELLKHGLLHEDVHTVAGFGLTRYTQEPWLDNGQLAWREGVE
SSLDAQVIASVAEPFEHHGGTKVLAGNLGRAVMKTSAVPAENQIIEAPAVVFESQHDIVPAFEAGKLDRDCVVVVRFQGP
QANGMPELHKLMPPLGVLMDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYTGGMLAKVQNGDLIRVNGRTGELALLVDA
DLLAQRAPYQPDLSAEHIGCGRELFGALRSQLSGAEQGACCIKF
>Mature_604_residues
MINPTLSRVTQRIIDRSKSSRTAYLARIEAARSQTVHRAQLACGNLAHGFAACQPDDKTALKNMVRSDIAIITAYNDMLS
AHQPYENYPQKLKQALHAVGAVGQVAGGVPAMCDGVTQGQDGMELSLMSRDVIAMSSAIGLSHNMFDGALFLGICDKIVP
GLVMSALSFGHLPSLFVPAGPMSSGLPNKEKVRVRQLYAEGKADRLALLEAEAASYHGIGTCTFYGTANTNQMVMEVMGL
HLPGASFVHPDTPLRDALTDAAARQVTRLTETAGNYLPIGRLVDEKVVVNGIVALLATGGSTNLTMHMVAMARAAGIIIN
WDDFSELSDAVPLLCRIYPNGPADINQFQASGGVALVVRELLKHGLLHEDVHTVAGFGLTRYTQEPWLDNGQLAWREGVE
SSLDAQVIASVAEPFEHHGGTKVLAGNLGRAVMKTSAVPAENQIIEAPAVVFESQHDIVPAFEAGKLDRDCVVVVRFQGP
QANGMPELHKLMPPLGVLMDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYTGGMLAKVQNGDLIRVNGRTGELALLVDA
DLLAQRAPYQPDLSAEHIGCGRELFGALRSQLSGAEQGACCIKF

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=603, Percent_Identity=78.7728026533997, Blast_Score=1015, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=539, Percent_Identity=29.3135435992579, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI2367371, Length=467, Percent_Identity=29.3361884368308, Blast_Score=145, Evalue=1e-35,
Organism=Escherichia coli, GI1786464, Length=547, Percent_Identity=29.0676416819013, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322476, Length=475, Percent_Identity=32.4210526315789, Blast_Score=188, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64302; Mature: 64302

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINPTLSRVTQRIIDRSKSSRTAYLARIEAARSQTVHRAQLACGNLAHGFAACQPDDKTA
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHH
LKNMVRSDIAIITAYNDMLSAHQPYENYPQKLKQALHAVGAVGQVAGGVPAMCDGVTQGQ
HHHHHHHCEEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC
DGMELSLMSRDVIAMSSAIGLSHNMFDGALFLGICDKIVPGLVMSALSFGHLPSLFVPAG
CCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
PMSSGLPNKEKVRVRQLYAEGKADRLALLEAEAASYHGIGTCTFYGTANTNQMVMEVMGL
CCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCEEEEEEECCCCHHHHHHHHHC
HLPGASFVHPDTPLRDALTDAAARQVTRLTETAGNYLPIGRLVDEKVVVNGIVALLATGG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCC
STNLTMHMVAMARAAGIIINWDDFSELSDAVPLLCRIYPNGPADINQFQASGGVALVVRE
CCCHHHHHHHHHHHCCEEEECCCHHHHHHHHCEEEEECCCCCCCHHHHHCCCCHHHHHHH
LLKHGLLHEDVHTVAGFGLTRYTQEPWLDNGQLAWREGVESSLDAQVIASVAEPFEHHGG
HHHHCCHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCC
TKVLAGNLGRAVMKTSAVPAENQIIEAPAVVFESQHDIVPAFEAGKLDRDCVVVVRFQGP
CEEEECCCCHHHHHHCCCCCCCCEECCCHHHCCCCCCCCCCHHCCCCCCCEEEEEEECCC
QANGMPELHKLMPPLGVLMDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYTGGMLAKVQ
CCCCCHHHHHHCCCHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEEC
NGDLIRVNGRTGELALLVDADLLAQRAPYQPDLSAEHIGCGRELFGALRSQLSGAEQGAC
CCCEEEEECCCCCEEEEECHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCCCCE
CIKF
EECC
>Mature Secondary Structure
MINPTLSRVTQRIIDRSKSSRTAYLARIEAARSQTVHRAQLACGNLAHGFAACQPDDKTA
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHH
LKNMVRSDIAIITAYNDMLSAHQPYENYPQKLKQALHAVGAVGQVAGGVPAMCDGVTQGQ
HHHHHHHCEEEEEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCC
DGMELSLMSRDVIAMSSAIGLSHNMFDGALFLGICDKIVPGLVMSALSFGHLPSLFVPAG
CCCEEEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCC
PMSSGLPNKEKVRVRQLYAEGKADRLALLEAEAASYHGIGTCTFYGTANTNQMVMEVMGL
CCCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHCCCCCCCEEEEEEECCCCHHHHHHHHHC
HLPGASFVHPDTPLRDALTDAAARQVTRLTETAGNYLPIGRLVDEKVVVNGIVALLATGG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHCCCC
STNLTMHMVAMARAAGIIINWDDFSELSDAVPLLCRIYPNGPADINQFQASGGVALVVRE
CCCHHHHHHHHHHHCCEEEECCCHHHHHHHHCEEEEECCCCCCCHHHHHCCCCHHHHHHH
LLKHGLLHEDVHTVAGFGLTRYTQEPWLDNGQLAWREGVESSLDAQVIASVAEPFEHHGG
HHHHCCHHHHHHHHHCCCHHHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCC
TKVLAGNLGRAVMKTSAVPAENQIIEAPAVVFESQHDIVPAFEAGKLDRDCVVVVRFQGP
CEEEECCCCHHHHHHCCCCCCCCEECCCHHHCCCCCCCCCCHHCCCCCCCEEEEEEECCC
QANGMPELHKLMPPLGVLMDRGFKVALVTDGRLSGASGKVPSAIHVTPEAYTGGMLAKVQ
CCCCCHHHHHHCCCHHHHHCCCEEEEEEECCCCCCCCCCCCCEEEECCCCCCCCEEEEEC
NGDLIRVNGRTGELALLVDADLLAQRAPYQPDLSAEHIGCGRELFGALRSQLSGAEQGAC
CCCEEEEECCCCCEEEEECHHHHHHCCCCCCCCCCHHCCCCHHHHHHHHHHHCCCCCCCE
CIKF
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]