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The map label for this gene is gntU [H]

Identifier: 157372731

GI number: 157372731

Start: 4983336

End: 4984673

Strand: Direct

Name: gntU [H]

Synonym: Spro_4498

Alternate gene names: 157372731

Gene position: 4983336-4984673 (Clockwise)

Preceding gene: 157372730

Following gene: 157372732

Centisome position: 91.46

GC content: 58.67

Gene sequence:

>1338_bases
GTGAATACTGTAACGCTGGTCGGTACCGCAGTCGGCTCGGTTCTCTTACTGCTGTTTCTGGTGATGAAGGCGCGTATGCA
CGCCTTTGTCGCATTAATGCTGGTGTCTATCGCTGCCGGGATCTTCTCCGGCATGCCGCTGGATCGCATTGCCGATACCA
TGCAAAAAGGCATGGGCGACACCTTGGGCTTCCTGGCCATCGTGGTGGCGCTGGGGGCGATGTTTGGCAAAATATTGCAT
GAAGTCGGCGCGCTGGACCAAATTGCGGCACATTTGCTGAAACGTTTCGGCCAAAGCAAGGCCCATTACGCACTCGGCAT
TGCCGGTTTGATCTGTGCCTTGCCGCTGTTCTTTGACGTGGCCGTGGTGCTGCTGATCGGCATCGTGTTTGCCGTGGCGC
GCCGCACCGACGGCAACATCGTTAAGCTGGCCATTCCGCTGTTTGCCGGTGTCGCCGCCGCCGCGTCGTTCTTGCTGCCG
GGGCCGGTACCGATGCTGCTGGCTTCACAAATGAAGGCCGACTTCGGCTGGATGATTGCCATCGGTCTGGTCGCCGCGGT
CCTCGGCATGCTGATTGCCGGCCCGTTGTACGGCAGCTTTATCAGCCGCTACGTTAACTGGTCAATGCCGGCGGATGAAA
ACGAACCGACGCTGAACACCGCCAAACTGCCGTCATTTGGCCTTAGTCTGGCGCTGGTACTCTGCCCACTGGTGCTGGTC
GGCATGAAAACCATTGGCGCCCGCCTGGTCACGCCTGGCTCGCAGTTACAACAATGGCTGGAGTTTATCGGCCACCCGTT
TATCGCCATTTTAGTCGCCTGTTTGATCGTGATTTATGGACTGGCGAAACCACGCGGCATGACCAACGAACAAACGCTGG
CCATTTGCTCTGCGGCAGTCCAGCCCGCCGGGATCATTTTGCTGATGACCGGGGCCGGTGGCGTCTTCAAACAGATTTTG
GTGGATTCCGGCGTCGGCCCAGCCCTGGGGGACGCCATGATCGGTACCGGTCTGCCGATCGCCGTCGCGGCCTTTGTGCT
GTCCGCCATGGTACGAGTGATTCAGGGATCTGCCACCGTGGCCTGTCTGACCACCGTCGGCCTGGTGTTACCGGTGACCA
GCCAACTGGGGCTTGGCGGCGGACAACTGGCCGCGCTGGCTATCTGTATTGCCGGTGGATCTATCGTACTCAGTCACGTC
AACGACGCCGGTTTCTGGCTGTTCGGCAAATTTACCGGTGCCAATGAGCTGCAAACGCTGAAAACCTGGACTGTGATGGA
AACCATTCTGGGTAGCGTGGGCGGGATTATCGGCATGATTGCTTTCACCCTGTTTTAA

Upstream 100 bases:

>100_bases
AGAGCGACGTGATGTCGGTGGACATCAACCAGCCGCTGGAAGCGGTGATCGCAGATACGGTGAAACATATCCAAAGTTTC
CTGCCACAGGATGTGTGCGC

Downstream 100 bases:

>100_bases
AACACCATAACGACATAACAGCGCCCCCGGCCTTGCACATCAGGGCTGCAATTCACCACCGGGGGCACCGCCACAGGCGG
CGTCTATAACAATAGCATGT

Product: gluconate transporter

Products: Proton [Cytoplasm]; gluconate [Cytoplasm] [C]

Alternate protein names: Gluconate permease; Gnt-I system [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MNTVTLVGTAVGSVLLLLFLVMKARMHAFVALMLVSIAAGIFSGMPLDRIADTMQKGMGDTLGFLAIVVALGAMFGKILH
EVGALDQIAAHLLKRFGQSKAHYALGIAGLICALPLFFDVAVVLLIGIVFAVARRTDGNIVKLAIPLFAGVAAAASFLLP
GPVPMLLASQMKADFGWMIAIGLVAAVLGMLIAGPLYGSFISRYVNWSMPADENEPTLNTAKLPSFGLSLALVLCPLVLV
GMKTIGARLVTPGSQLQQWLEFIGHPFIAILVACLIVIYGLAKPRGMTNEQTLAICSAAVQPAGIILLMTGAGGVFKQIL
VDSGVGPALGDAMIGTGLPIAVAAFVLSAMVRVIQGSATVACLTTVGLVLPVTSQLGLGGGQLAALAICIAGGSIVLSHV
NDAGFWLFGKFTGANELQTLKTWTVMETILGSVGGIIGMIAFTLF

Sequences:

>Translated_445_residues
MNTVTLVGTAVGSVLLLLFLVMKARMHAFVALMLVSIAAGIFSGMPLDRIADTMQKGMGDTLGFLAIVVALGAMFGKILH
EVGALDQIAAHLLKRFGQSKAHYALGIAGLICALPLFFDVAVVLLIGIVFAVARRTDGNIVKLAIPLFAGVAAAASFLLP
GPVPMLLASQMKADFGWMIAIGLVAAVLGMLIAGPLYGSFISRYVNWSMPADENEPTLNTAKLPSFGLSLALVLCPLVLV
GMKTIGARLVTPGSQLQQWLEFIGHPFIAILVACLIVIYGLAKPRGMTNEQTLAICSAAVQPAGIILLMTGAGGVFKQIL
VDSGVGPALGDAMIGTGLPIAVAAFVLSAMVRVIQGSATVACLTTVGLVLPVTSQLGLGGGQLAALAICIAGGSIVLSHV
NDAGFWLFGKFTGANELQTLKTWTVMETILGSVGGIIGMIAFTLF
>Mature_445_residues
MNTVTLVGTAVGSVLLLLFLVMKARMHAFVALMLVSIAAGIFSGMPLDRIADTMQKGMGDTLGFLAIVVALGAMFGKILH
EVGALDQIAAHLLKRFGQSKAHYALGIAGLICALPLFFDVAVVLLIGIVFAVARRTDGNIVKLAIPLFAGVAAAASFLLP
GPVPMLLASQMKADFGWMIAIGLVAAVLGMLIAGPLYGSFISRYVNWSMPADENEPTLNTAKLPSFGLSLALVLCPLVLV
GMKTIGARLVTPGSQLQQWLEFIGHPFIAILVACLIVIYGLAKPRGMTNEQTLAICSAAVQPAGIILLMTGAGGVFKQIL
VDSGVGPALGDAMIGTGLPIAVAAFVLSAMVRVIQGSATVACLTTVGLVLPVTSQLGLGGGQLAALAICIAGGSIVLSHV
NDAGFWLFGKFTGANELQTLKTWTVMETILGSVGGIIGMIAFTLF

Specific function: Part of the gluconate utilization system Gnt-I; low- affinity intake of gluconate [H]

COG id: COG2610

COG function: function code GE; H+/gluconate symporter and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gntP permease family [H]

Homologues:

Organism=Escherichia coli, GI48994939, Length=444, Percent_Identity=72.7477477477478, Blast_Score=600, Evalue=1e-173,
Organism=Escherichia coli, GI1790716, Length=428, Percent_Identity=32.9439252336449, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI48994935, Length=434, Percent_Identity=33.6405529953917, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1789097, Length=456, Percent_Identity=34.2105263157895, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI2367370, Length=421, Percent_Identity=32.0665083135392, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1790776, Length=437, Percent_Identity=31.350114416476, Blast_Score=197, Evalue=8e-52,
Organism=Escherichia coli, GI1788707, Length=440, Percent_Identity=31.3636363636364, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003474 [H]

Pfam domain/function: PF02447 GntP_permease [H]

EC number: NA

Molecular weight: Translated: 45940; Mature: 45940

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; gluconate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + gluconate [Periplasm] = Proton [Cytoplasm] + gluconate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]