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The map label for this gene is pyrG [H]

Identifier: 157372659

GI number: 157372659

Start: 4899467

End: 4900165

Strand: Direct

Name: pyrG [H]

Synonym: Spro_4426

Alternate gene names: 157372659

Gene position: 4899467-4900165 (Clockwise)

Preceding gene: 157372658

Following gene: 157372662

Centisome position: 89.92

GC content: 56.94

Gene sequence:

>699_bases
ATGATGAAAGCTCAAGTTCGCATTGCTCTGGTCGGTGATTACAAACCCGAGGCCGTTTCTCACCAGGCCATCCCCATTGC
TCTCCAGCTTACCGCCACACACCTTAACGTCGATATCCAATCCCACTGGCTGCCCACAGAAACCATTACCGCCCCTTCGG
TACTGCAAGGCTATGATGCGATCTGGGTGGTGCCCGGCAGCCCGTATAATCATGACGACGGTGCCTTTATGGCCATCCGC
CATGCGCGTGAGCAAAACATCCCCTTCCTCGGCTCCTGCGGCGGCTTCCAGTATGCGATTGTGGAATACGCGCGCAACGT
TATGGGTTGGCACGACGCCGGACACGCAGAAACCGACACTGGCGGCAGGCTGGTGATTGCTCCGCTGAGCTGTTCGCTGG
TCGAAAAAAACGGCGCTATTATTTTCCAACCCAATACGCTGGCTGCCCGTGTCTACGGCAAGCTGGAAACGCACGAAGGT
TACCACTGCAACTTCGGCGTTAATCCGGAATTTGTCACCGATCTACAGCAGCACCCGCTGATTATCAGCGGCCACGACAG
CGAAGGTGACGTGCGGTCAATCGAGTTGCCGGGGCACCGTTTTTACGCCGCCACGCTGTTCCAGTCTGAACGCGCTGCGT
TACGCAACGAGCTTTCTCCACTGGTTGTGGAGCTGATCAAGACCGCCGCAACTCTCTGA

Upstream 100 bases:

>100_bases
CCGGCCAACGCCGGGCTTTTTTGTGCGCCGTGTTTAAAAAACTGCGGATTGGCGATCGGCTTTATTGTAATCTCCTTTTT
TACCCGCACAGGAAAAGGAA

Downstream 100 bases:

>100_bases
CAGCGGCGGATGATGGGGGCCATGCCGGTATGGCCTTCTCATCAGAAAGTTACCACATCAGTTGCCCTATCAGCGGCGCG
GCAATCACCGTGATAATCCC

Product: hypothetical protein

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 232; Mature: 232

Protein sequence:

>232_residues
MMKAQVRIALVGDYKPEAVSHQAIPIALQLTATHLNVDIQSHWLPTETITAPSVLQGYDAIWVVPGSPYNHDDGAFMAIR
HAREQNIPFLGSCGGFQYAIVEYARNVMGWHDAGHAETDTGGRLVIAPLSCSLVEKNGAIIFQPNTLAARVYGKLETHEG
YHCNFGVNPEFVTDLQQHPLIISGHDSEGDVRSIELPGHRFYAATLFQSERAALRNELSPLVVELIKTAATL

Sequences:

>Translated_232_residues
MMKAQVRIALVGDYKPEAVSHQAIPIALQLTATHLNVDIQSHWLPTETITAPSVLQGYDAIWVVPGSPYNHDDGAFMAIR
HAREQNIPFLGSCGGFQYAIVEYARNVMGWHDAGHAETDTGGRLVIAPLSCSLVEKNGAIIFQPNTLAARVYGKLETHEG
YHCNFGVNPEFVTDLQQHPLIISGHDSEGDVRSIELPGHRFYAATLFQSERAALRNELSPLVVELIKTAATL
>Mature_232_residues
MMKAQVRIALVGDYKPEAVSHQAIPIALQLTATHLNVDIQSHWLPTETITAPSVLQGYDAIWVVPGSPYNHDDGAFMAIR
HAREQNIPFLGSCGGFQYAIVEYARNVMGWHDAGHAETDTGGRLVIAPLSCSLVEKNGAIIFQPNTLAARVYGKLETHEG
YHCNFGVNPEFVTDLQQHPLIISGHDSEGDVRSIELPGHRFYAATLFQSERAALRNELSPLVVELIKTAATL

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=231, Percent_Identity=29.8701298701299, Blast_Score=82, Evalue=4e-16,
Organism=Homo sapiens, GI28559085, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI28559083, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI221316689, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=9e-14,
Organism=Escherichia coli, GI1789142, Length=259, Percent_Identity=23.9382239382239, Blast_Score=76, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322563, Length=238, Percent_Identity=27.3109243697479, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319432, Length=245, Percent_Identity=26.1224489795918, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357815, Length=253, Percent_Identity=29.2490118577075, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24664469, Length=253, Percent_Identity=29.2490118577075, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 25435; Mature: 25435

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKAQVRIALVGDYKPEAVSHQAIPIALQLTATHLNVDIQSHWLPTETITAPSVLQGYDA
CCCEEEEEEEEECCCCCCCCCCCEEEEEEEEEEEEEEEEHHCCCCCCCCCCCHHHCCCCE
IWVVPGSPYNHDDGAFMAIRHAREQNIPFLGSCGGFQYAIVEYARNVMGWHDAGHAETDT
EEEECCCCCCCCCCCEEEEEHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCC
GGRLVIAPLSCSLVEKNGAIIFQPNTLAARVYGKLETHEGYHCNFGVNPEFVTDLQQHPL
CCEEEEEECEEEEEECCCEEEECCCCEEEEEEEEEECCCCEEEECCCCHHHHHHHHHCCE
IISGHDSEGDVRSIELPGHRFYAATLFQSERAALRNELSPLVVELIKTAATL
EEECCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MMKAQVRIALVGDYKPEAVSHQAIPIALQLTATHLNVDIQSHWLPTETITAPSVLQGYDA
CCCEEEEEEEEECCCCCCCCCCCEEEEEEEEEEEEEEEEHHCCCCCCCCCCCHHHCCCCE
IWVVPGSPYNHDDGAFMAIRHAREQNIPFLGSCGGFQYAIVEYARNVMGWHDAGHAETDT
EEEECCCCCCCCCCCEEEEEHHHHCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCC
GGRLVIAPLSCSLVEKNGAIIFQPNTLAARVYGKLETHEGYHCNFGVNPEFVTDLQQHPL
CCEEEEEECEEEEEECCCEEEECCCCEEEEEEEEEECCCCEEEECCCCHHHHHHHHHCCE
IISGHDSEGDVRSIELPGHRFYAATLFQSERAALRNELSPLVVELIKTAATL
EEECCCCCCCEEEEECCCCEEEEEEHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA