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The map label for this gene is lpxP [H]

Identifier: 157372658

GI number: 157372658

Start: 4898427

End: 4899347

Strand: Direct

Name: lpxP [H]

Synonym: Spro_4425

Alternate gene names: 157372658

Gene position: 4898427-4899347 (Clockwise)

Preceding gene: 157372657

Following gene: 157372659

Centisome position: 89.9

GC content: 56.57

Gene sequence:

>921_bases
ATGAAGCGTCCGCAAAAATTCAAAATGGCCCTGCTACATCCTCGCTACTGGTTTACCTGGTTCGGGCTGGGCTGTTTGTT
CTTACTGGTTCAACTCCCCTATCCGGTGCTGCACAAGCTCGGTATATGGATGGGCCGCACCTCGATGCGCTTCCTGAAAC
GCCGCGTTTCCATTACTCGCCGTAACCTGGAACTTTGCTTCCCGGACATGGACGTGGAACAGCGCGAACGCAAAGTGACA
GGTAACTTCGAATCCCTCGGCATGGGCCTGCTGGAAACCGGTATGGCCTGGTTCTGGTCAGATAAGCGCGTTAAGCGCTG
GTTCAACGTTTCCGGCATCAATCACCTGAAAGCGGCACAGCAAAACCAACGCGGCGTACTGGTAATTGGCGTGCATTTTA
TGTCGCTGGAGCTGGGTGGTCGTGCCATGGGGCTGTGCCAGCCGATGATGGCGATGTACCGTCCACACAACAATAAAGCG
ATGGAATGGGCACAAACCAAAGGGCGTATGCGTTCCAACAAGGCCATGCTGGATCGCAAAGACCTGCGCGGCATGGTTCA
GGCTCTTAAGCGCGGCGAAGCCGTATGGTTCGCTCCGGATCAAGACTACGGCCCACGCGGCAGCGTATTCGCCCCGTTGT
TCGCCGTCGATCAGGCCGCCACCACCAGCGGGACCTATATGCTGGCACGCATGGCCAAGCCGGCGCTGGTACCGGTGGTG
CTGATCCGTCGCGAGAAAGGCCGTGGTTATGATCTATTGATCCAACCGGCACTGGAAAATTACCCTATCAGTGACGAAAT
CGCCGCCGCGGCTTACATGAATAAAGTGGTTGAGAAAGAGATCATGCGCGCTCCAGAGCAGTATATGTGGCTGCATCGTC
GCTTCAAAACCCGGCCGGCCGGTACCCCTTCGCTGTACTGA

Upstream 100 bases:

>100_bases
AACAATAGTGATGTCTGGGTGTCTGAGTGGTCGTATCGCAATTAAGTGGATCCTTGTGCGTTACAGGTTGCTGCCCCTTT
TAATGCATAAATGAGTTCAT

Downstream 100 bases:

>100_bases
GCCAAACCCCAAACCAAGCCCGGCCAACGCCGGGCTTTTTTGTGCGCCGTGTTTAAAAAACTGCGGATTGGCGATCGGCT
TTATTGTAATCTCCTTTTTT

Product: lipid A biosynthesis palmitoleoyl acyltransferase

Products: KDO2-(palmitoleoyl)-lipid IVA [C]

Alternate protein names: NA

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKRPQKFKMALLHPRYWFTWFGLGCLFLLVQLPYPVLHKLGIWMGRTSMRFLKRRVSITRRNLELCFPDMDVEQRERKVT
GNFESLGMGLLETGMAWFWSDKRVKRWFNVSGINHLKAAQQNQRGVLVIGVHFMSLELGGRAMGLCQPMMAMYRPHNNKA
MEWAQTKGRMRSNKAMLDRKDLRGMVQALKRGEAVWFAPDQDYGPRGSVFAPLFAVDQAATTSGTYMLARMAKPALVPVV
LIRREKGRGYDLLIQPALENYPISDEIAAAAYMNKVVEKEIMRAPEQYMWLHRRFKTRPAGTPSLY

Sequences:

>Translated_306_residues
MKRPQKFKMALLHPRYWFTWFGLGCLFLLVQLPYPVLHKLGIWMGRTSMRFLKRRVSITRRNLELCFPDMDVEQRERKVT
GNFESLGMGLLETGMAWFWSDKRVKRWFNVSGINHLKAAQQNQRGVLVIGVHFMSLELGGRAMGLCQPMMAMYRPHNNKA
MEWAQTKGRMRSNKAMLDRKDLRGMVQALKRGEAVWFAPDQDYGPRGSVFAPLFAVDQAATTSGTYMLARMAKPALVPVV
LIRREKGRGYDLLIQPALENYPISDEIAAAAYMNKVVEKEIMRAPEQYMWLHRRFKTRPAGTPSLY
>Mature_306_residues
MKRPQKFKMALLHPRYWFTWFGLGCLFLLVQLPYPVLHKLGIWMGRTSMRFLKRRVSITRRNLELCFPDMDVEQRERKVT
GNFESLGMGLLETGMAWFWSDKRVKRWFNVSGINHLKAAQQNQRGVLVIGVHFMSLELGGRAMGLCQPMMAMYRPHNNKA
MEWAQTKGRMRSNKAMLDRKDLRGMVQALKRGEAVWFAPDQDYGPRGSVFAPLFAVDQAATTSGTYMLARMAKPALVPVV
LIRREKGRGYDLLIQPALENYPISDEIAAAAYMNKVVEKEIMRAPEQYMWLHRRFKTRPAGTPSLY

Specific function: Unknown

COG id: COG1560

COG function: function code M; Lauroyl/myristoyl acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the htrB/msbB family [H]

Homologues:

Organism=Escherichia coli, GI87082094, Length=304, Percent_Identity=65.4605263157895, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI1787292, Length=301, Percent_Identity=59.8006644518272, Blast_Score=400, Evalue=1e-113,
Organism=Escherichia coli, GI1788161, Length=307, Percent_Identity=25.4071661237785, Blast_Score=104, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004960
- InterPro:   IPR011920 [H]

Pfam domain/function: PF03279 Lip_A_acyltrans [H]

EC number: NA

Molecular weight: Translated: 35408; Mature: 35408

Theoretical pI: Translated: 10.91; Mature: 10.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
6.9 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
6.9 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRPQKFKMALLHPRYWFTWFGLGCLFLLVQLPYPVLHKLGIWMGRTSMRFLKRRVSITR
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHH
RNLELCFPDMDVEQRERKVTGNFESLGMGLLETGMAWFWSDKRVKRWFNVSGINHLKAAQ
CCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHHCHHHEECCHHHHHHHCCCCCHHHHHHH
QNQRGVLVIGVHFMSLELGGRAMGLCQPMMAMYRPHNNKAMEWAQTKGRMRSNKAMLDRK
CCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
DLRGMVQALKRGEAVWFAPDQDYGPRGSVFAPLFAVDQAATTSGTYMLARMAKPALVPVV
HHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCHHEEEE
LIRREKGRGYDLLIQPALENYPISDEIAAAAYMNKVVEKEIMRAPEQYMWLHRRFKTRPA
EEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
GTPSLY
CCCCCC
>Mature Secondary Structure
MKRPQKFKMALLHPRYWFTWFGLGCLFLLVQLPYPVLHKLGIWMGRTSMRFLKRRVSITR
CCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHH
RNLELCFPDMDVEQRERKVTGNFESLGMGLLETGMAWFWSDKRVKRWFNVSGINHLKAAQ
CCCEEECCCCCHHHHHHHHCCCHHHHHHHHHHHCHHHEECCHHHHHHHCCCCCHHHHHHH
QNQRGVLVIGVHFMSLELGGRAMGLCQPMMAMYRPHNNKAMEWAQTKGRMRSNKAMLDRK
CCCCCEEEEEEEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
DLRGMVQALKRGEAVWFAPDQDYGPRGSVFAPLFAVDQAATTSGTYMLARMAKPALVPVV
HHHHHHHHHHCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCCCHHEEEE
LIRREKGRGYDLLIQPALENYPISDEIAAAAYMNKVVEKEIMRAPEQYMWLHRRFKTRPA
EEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCC
GTPSLY
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: KDO2-lipid IVA; palmitoleoyl-ACP [C]

Specific reaction: KDO2-lipid IVA + palmitoleoyl-ACP = KDO2-(palmitoleoyl)-lipid IVA + [acyl carrier protein] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]