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The map label for this gene is cah [H]

Identifier: 157372655

GI number: 157372655

Start: 4895666

End: 4896400

Strand: Direct

Name: cah [H]

Synonym: Spro_4422

Alternate gene names: 157372655

Gene position: 4895666-4896400 (Clockwise)

Preceding gene: 157372654

Following gene: 157372656

Centisome position: 89.85

GC content: 54.83

Gene sequence:

>735_bases
ATGAAAGGGAAATTATTACTCGCCGCTTTACTGATCGCCGGCTTTTCGGCCAACGCCACAGAGCAAGCCCATTGGGGCTA
TGAAGGTCAGGAAGATCCGGCACACTGGGGAAAACTCTCTCCGGATTTTTCGCTGTGCGAAACCGGTAAGAACCAGTCAC
CGGTTAATGTTAAAGGTGCTCTGAAAACCCAGCACGACAAACTGAAACTGGCTTTCCAACCAGGCAAACAGCAGATCGTC
AATAACGGCCATACCGTGCAGGTAAACGTCAGCGGCGGCAATACCCTGGTGCTGGATAACGACACTTTCACGCTGCAACA
ATTTCACTTCCACGCCCCGAGCGAAAACGAAATTGACGGTAAGCAATTCCCCCTTGAGGCGCACTTTGTCTATAAAGACC
AACAGGGTGCACTGGCAGTCCTGGCATTGATGTTCCAGCAAGGCAAAGCCAACCCGCAGCTGGCGCAGGCCTGGCGGCAA
ATGCCGACCGCCGTCGATCAGACCGCGGTGCTGACCACGCCGCTGGATATCAAGGCGCTGCTCCCTCAAAACTTTAACTT
CTATCGGTTCAGCGGTTCGTTAACCACGCCCCCTTGTTCCGAAGGGGTAAGCTGGATGGTGCTGGATAAGCCTGTCAGCG
CCTCTGCCGAGCAGATCGCTCAATTCCGCGCCGTGGTACAGCATGCGAACAATCGTCCGCTACAGGCGCTGAACGGCCGC
GTAATCATCGACTAA

Upstream 100 bases:

>100_bases
GACAAAAAGCAGGCGTATTCTGCTGCAGGCGCGATCGCAGCCGATTTTTTTAGCCGCTGTCCGCCAAAGACAATTAACGA
TTTTTCAATAAGGATTGGCA

Downstream 100 bases:

>100_bases
GGCTGTCGGAATAACTTCACCGCCGGTTTGATCCCCGGCGGTGAACAAATGCGTTTTTAATCGAAACCTTCACCACGCGA
TTTCAGCGTAATTGTGCCCC

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MKGKLLLAALLIAGFSANATEQAHWGYEGQEDPAHWGKLSPDFSLCETGKNQSPVNVKGALKTQHDKLKLAFQPGKQQIV
NNGHTVQVNVSGGNTLVLDNDTFTLQQFHFHAPSENEIDGKQFPLEAHFVYKDQQGALAVLALMFQQGKANPQLAQAWRQ
MPTAVDQTAVLTTPLDIKALLPQNFNFYRFSGSLTTPPCSEGVSWMVLDKPVSASAEQIAQFRAVVQHANNRPLQALNGR
VIID

Sequences:

>Translated_244_residues
MKGKLLLAALLIAGFSANATEQAHWGYEGQEDPAHWGKLSPDFSLCETGKNQSPVNVKGALKTQHDKLKLAFQPGKQQIV
NNGHTVQVNVSGGNTLVLDNDTFTLQQFHFHAPSENEIDGKQFPLEAHFVYKDQQGALAVLALMFQQGKANPQLAQAWRQ
MPTAVDQTAVLTTPLDIKALLPQNFNFYRFSGSLTTPPCSEGVSWMVLDKPVSASAEQIAQFRAVVQHANNRPLQALNGR
VIID
>Mature_244_residues
MKGKLLLAALLIAGFSANATEQAHWGYEGQEDPAHWGKLSPDFSLCETGKNQSPVNVKGALKTQHDKLKLAFQPGKQQIV
NNGHTVQVNVSGGNTLVLDNDTFTLQQFHFHAPSENEIDGKQFPLEAHFVYKDQQGALAVLALMFQQGKANPQLAQAWRQ
MPTAVDQTAVLTTPLDIKALLPQNFNFYRFSGSLTTPPCSEGVSWMVLDKPVSASAEQIAQFRAVVQHANNRPLQALNGR
VIID

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI258679498, Length=259, Percent_Identity=32.046332046332, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI192447434, Length=259, Percent_Identity=32.046332046332, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI192447432, Length=259, Percent_Identity=32.046332046332, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI192447430, Length=259, Percent_Identity=32.046332046332, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4502517, Length=259, Percent_Identity=32.046332046332, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI4885101, Length=256, Percent_Identity=31.640625, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI4557395, Length=256, Percent_Identity=32.03125, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI169636420, Length=260, Percent_Identity=32.6923076923077, Blast_Score=103, Evalue=9e-23,
Organism=Homo sapiens, GI38348436, Length=257, Percent_Identity=28.4046692607004, Blast_Score=101, Evalue=5e-22,
Organism=Homo sapiens, GI70167127, Length=258, Percent_Identity=32.5581395348837, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI62240989, Length=198, Percent_Identity=32.8282828282828, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI4885099, Length=261, Percent_Identity=26.8199233716475, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI6005723, Length=237, Percent_Identity=27.8481012658228, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI4502521, Length=236, Percent_Identity=28.8135593220339, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI4502519, Length=272, Percent_Identity=27.9411764705882, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI22027500, Length=256, Percent_Identity=26.953125, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI9951923, Length=252, Percent_Identity=27.7777777777778, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI130979954, Length=255, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI130979679, Length=255, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI9910366, Length=255, Percent_Identity=26.6666666666667, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI6912284, Length=285, Percent_Identity=28.0701754385965, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4502515, Length=244, Percent_Identity=29.5081967213115, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI45935383, Length=244, Percent_Identity=29.5081967213115, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI194097398, Length=272, Percent_Identity=26.4705882352941, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI91208428, Length=242, Percent_Identity=28.9256198347107, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17568715, Length=253, Percent_Identity=31.2252964426877, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI71995280, Length=269, Percent_Identity=27.5092936802974, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24645604, Length=278, Percent_Identity=28.7769784172662, Blast_Score=116, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21358169, Length=279, Percent_Identity=29.3906810035842, Blast_Score=115, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17737413, Length=251, Percent_Identity=29.0836653386454, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI18858185, Length=249, Percent_Identity=27.710843373494, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221329761, Length=286, Percent_Identity=24.1258741258741, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI161079350, Length=274, Percent_Identity=27.3722627737226, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24650523, Length=247, Percent_Identity=27.1255060728745, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI161079354, Length=268, Percent_Identity=27.6119402985075, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 26741; Mature: 26741

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00162 ALPHA_CA_1 ; PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKLLLAALLIAGFSANATEQAHWGYEGQEDPAHWGKLSPDFSLCETGKNQSPVNVKGA
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEC
LKTQHDKLKLAFQPGKQQIVNNGHTVQVNVSGGNTLVLDNDTFTLQQFHFHAPSENEIDG
EECCCCEEEEEECCCHHHHHCCCCEEEEEECCCCEEEECCCCEEEEEEEECCCCCCCCCC
KQFPLEAHFVYKDQQGALAVLALMFQQGKANPQLAQAWRQMPTAVDQTAVLTTPLDIKAL
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHCCCEEEECCCCEEEE
LPQNFNFYRFSGSLTTPPCSEGVSWMVLDKPVSASAEQIAQFRAVVQHANNRPLQALNGR
CCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCE
VIID
EEEC
>Mature Secondary Structure
MKGKLLLAALLIAGFSANATEQAHWGYEGQEDPAHWGKLSPDFSLCETGKNQSPVNVKGA
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEC
LKTQHDKLKLAFQPGKQQIVNNGHTVQVNVSGGNTLVLDNDTFTLQQFHFHAPSENEIDG
EECCCCEEEEEECCCHHHHHCCCCEEEEEECCCCEEEECCCCEEEEEEEECCCCCCCCCC
KQFPLEAHFVYKDQQGALAVLALMFQQGKANPQLAQAWRQMPTAVDQTAVLTTPLDIKAL
CCCCEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHCCCEEEECCCCEEEE
LPQNFNFYRFSGSLTTPPCSEGVSWMVLDKPVSASAEQIAQFRAVVQHANNRPLQALNGR
CCCCCCEEEEECCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCHHHHCCE
VIID
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]