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The map label for this gene is parC [H]

Identifier: 157372492

GI number: 157372492

Start: 4722183

End: 4724456

Strand: Reverse

Name: parC [H]

Synonym: Spro_4259

Alternate gene names: 157372492

Gene position: 4724456-4722183 (Counterclockwise)

Preceding gene: 157372495

Following gene: 157372491

Centisome position: 86.71

GC content: 58.53

Gene sequence:

>2274_bases
ATGAGTGATCTGACTCATGACGGTGTAGAGCGTTTACCGCTGCACACATTCACTGAAAACGCCTATCTGAACTATTCCAT
GTACGTCATCATGGATCGGGCGTTGCCGTACATTGGTGACGGTTTGAAGCCGGTACAACGCCGCATCATCTACGCCATGT
CTGAGCTGGGGCTGAATAACAGCGCCAAATTCAAAAAATCTGCCCGTACCGTGGGTGACGTGCTGGGTAAATATCATCCG
CACGGCGACAGTGCCTGCTATGAAGCCATGGTGTTGATGGCGCAGCCGTTCTCATATCGCTATCCGCTGGTAGACGGCCA
GGGGAACTGGGGGGCGCCGGATGACCCGAAATCCTTCGCCGCGATGCGTTATACCGAATCCCGCCTGTCCAAATATGCGG
AAGTGTTGCTGGCCGAATTGGGCCAGGGCACGGTTGACTGGGTGCCGAACTTTGACGGTACCATGCAGGAGCCGAAGATG
TTGCCGGCCCGCCTGCCCAACATCCTGCTGAACGGTACCACCGGTATTGCCGTGGGTATGGCGACCGATATTCCACCCCA
CAACGTGCGTGAAGTGGCCGCCGCTGCGGTGGCGTTGATCGACAAGCCTGGCGCTTCGCTGGAAGAGTTACTCGAGTTCG
TACAGGGCCCGGATTACCCGACCGAAGCCGAGATCATTACCCCGCGTGAAGAAATCCGCAAAATTTATCAGAACGGTCGT
GGCTCGGTCCGCATGCGCGCCGTCTGGAGTAAAGAAGACGGCAGCGCGGTGATCACTGCCTTGCCGCACCAGGTTTCCGG
TGCCAAGGTGCTGGAGCAGATTGCCAGCCAGATGCGTGCCAAAAAGCTGCCGATGGTCGAAGATCTGCGTGATGAATCCG
ATCACGAGAACCCAACGCGGCTGGTGATTGTGCCACGCTCGAATCGAATCGATCTCGATCAGGTGATGAATCACCTGTTT
GCCACGACCGATCTGGAACGCAGCTACCGCATCAACATGAACATGATTGGTCTGGACAACCGCCCGCAGGTGAAAGGGCT
GGTGGAAATCCTCACCGAGTGGCTGGCATTCCGTCGCGATACGGTGCGTCGCCGCCTGAACTACCGTCTGGAAAAAGTAC
TGAAACGCCTGCACATCCTGGAAGGTTTGCTGGTGGCGTTCCTCAATATCGATGAAGTGATCCACATCATCCGTAGCGAG
GACGAACCCAAGCCGGTGCTGATGCAGCGCTTTGGTATTTCCGATACCCAGGCCGAAGCGATCCTCGAACTGAAACTGCG
CCATTTGGCGAAGCTGGAAGAGTTCAAGATCCGCGGTGAGCAGGATGAGTTAGCCAAAGAGCGCGATCAACTGCAGGCGT
TGCTGGCCTCCGAGCGCAAGCTGAACACCCTGATCAAAAAAGAGATCCAGGCCGATGCGCAGGCCTATGGCGACGATCGT
CGCTCGCCGATTACCGAGCGTGCAGAAGCCAAGGCGATGAGCGAGCATGACTTTGTGCCGTCGGAGCCGGTGACTATCGT
GCTGTCTGAAATGGGCTGGGTGCGCAGCGCCAAGGGCCACGATATCGATCCAAGTGGCCTGAGCTACAAGGCCGGTGACA
GCTTCCGCAGTGCGGCACGCGGCAAGACCAACCAGCCGGTGGTGTTTATCGACTCCACCGGGCGCAGCTACGCGCTGGAT
CCGCTGACGCTGCCTTCGGCGCGTGGGCAGGGCGAACCGTTGACCGGCAAGCTGACGCCACCGCCGGGCGCGACCATTGA
ACAGGTGCTGATGGCTGCGGACGACCAGAAGTTGCTGATGGCTTCCGATGCCGGTTATGGCTTTGTCTGTACCTTCAACG
ACCTGGTGGCGCGTAACCGTGCCGGTAAGGTGATGATTACTCTGCCGGATAATGCCAAAGCGCTGGCGCCGATGGAAATC
CACGGTGAAGATGACATGCTGCTGTCGATCACTGCTGCCGGGCGCATGTTGTTCTTCCCGGTTGCTGACCTGCCGCAACT
GTCGAAGGGCAAGGGCAACAAGATTGTCTCCATCCCGTCGGCACAGGCCGCATCCGGTGAAGACAAGCTGGCATGGCTGT
TCGTGCTGCCGCCGCAAACCTCGGTGACCCTGCACGTGGGTAAACGCAAGCTGACGCTGCGTCCGGAAGATTTGCAGAAG
TTCCGTGCGGAACGTGGCCGTAAAGGCACCTCACTGCCACGTGGCCTGCAGCGAATCGATCGCGTAGAGGTTGATGCCCC
GGCACGTGCGCCTGGCGGTGACAGCGAAGAATAA

Upstream 100 bases:

>100_bases
CATCTGTGACAGCCACCCCGCTGATGAGTTACTATCGCGGACAGAATCAACCCTTTGTCGTCCAGGGATTGCCAAGCCAC
GGTCTGAGGATAATTGAGTA

Downstream 100 bases:

>100_bases
GCCTGTGAGGGCTGGATAACCCCACGGGCGCAGCATGCTGCGCCCGCTTTATTTCCCACCACCGGCAATTATTTTCAAAT
AGTTAACATTTCCCGGCATA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 757; Mature: 756

Protein sequence:

>757_residues
MSDLTHDGVERLPLHTFTENAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLNNSAKFKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAEVLLAELGQGTVDWVPNFDGTMQEPKM
LPARLPNILLNGTTGIAVGMATDIPPHNVREVAAAAVALIDKPGASLEELLEFVQGPDYPTEAEIITPREEIRKIYQNGR
GSVRMRAVWSKEDGSAVITALPHQVSGAKVLEQIASQMRAKKLPMVEDLRDESDHENPTRLVIVPRSNRIDLDQVMNHLF
ATTDLERSYRINMNMIGLDNRPQVKGLVEILTEWLAFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIHIIRSE
DEPKPVLMQRFGISDTQAEAILELKLRHLAKLEEFKIRGEQDELAKERDQLQALLASERKLNTLIKKEIQADAQAYGDDR
RSPITERAEAKAMSEHDFVPSEPVTIVLSEMGWVRSAKGHDIDPSGLSYKAGDSFRSAARGKTNQPVVFIDSTGRSYALD
PLTLPSARGQGEPLTGKLTPPPGATIEQVLMAADDQKLLMASDAGYGFVCTFNDLVARNRAGKVMITLPDNAKALAPMEI
HGEDDMLLSITAAGRMLFFPVADLPQLSKGKGNKIVSIPSAQAASGEDKLAWLFVLPPQTSVTLHVGKRKLTLRPEDLQK
FRAERGRKGTSLPRGLQRIDRVEVDAPARAPGGDSEE

Sequences:

>Translated_757_residues
MSDLTHDGVERLPLHTFTENAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLNNSAKFKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAEVLLAELGQGTVDWVPNFDGTMQEPKM
LPARLPNILLNGTTGIAVGMATDIPPHNVREVAAAAVALIDKPGASLEELLEFVQGPDYPTEAEIITPREEIRKIYQNGR
GSVRMRAVWSKEDGSAVITALPHQVSGAKVLEQIASQMRAKKLPMVEDLRDESDHENPTRLVIVPRSNRIDLDQVMNHLF
ATTDLERSYRINMNMIGLDNRPQVKGLVEILTEWLAFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIHIIRSE
DEPKPVLMQRFGISDTQAEAILELKLRHLAKLEEFKIRGEQDELAKERDQLQALLASERKLNTLIKKEIQADAQAYGDDR
RSPITERAEAKAMSEHDFVPSEPVTIVLSEMGWVRSAKGHDIDPSGLSYKAGDSFRSAARGKTNQPVVFIDSTGRSYALD
PLTLPSARGQGEPLTGKLTPPPGATIEQVLMAADDQKLLMASDAGYGFVCTFNDLVARNRAGKVMITLPDNAKALAPMEI
HGEDDMLLSITAAGRMLFFPVADLPQLSKGKGNKIVSIPSAQAASGEDKLAWLFVLPPQTSVTLHVGKRKLTLRPEDLQK
FRAERGRKGTSLPRGLQRIDRVEVDAPARAPGGDSEE
>Mature_756_residues
SDLTHDGVERLPLHTFTENAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLNNSAKFKKSARTVGDVLGKYHPH
GDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAEVLLAELGQGTVDWVPNFDGTMQEPKML
PARLPNILLNGTTGIAVGMATDIPPHNVREVAAAAVALIDKPGASLEELLEFVQGPDYPTEAEIITPREEIRKIYQNGRG
SVRMRAVWSKEDGSAVITALPHQVSGAKVLEQIASQMRAKKLPMVEDLRDESDHENPTRLVIVPRSNRIDLDQVMNHLFA
TTDLERSYRINMNMIGLDNRPQVKGLVEILTEWLAFRRDTVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIHIIRSED
EPKPVLMQRFGISDTQAEAILELKLRHLAKLEEFKIRGEQDELAKERDQLQALLASERKLNTLIKKEIQADAQAYGDDRR
SPITERAEAKAMSEHDFVPSEPVTIVLSEMGWVRSAKGHDIDPSGLSYKAGDSFRSAARGKTNQPVVFIDSTGRSYALDP
LTLPSARGQGEPLTGKLTPPPGATIEQVLMAADDQKLLMASDAGYGFVCTFNDLVARNRAGKVMITLPDNAKALAPMEIH
GEDDMLLSITAAGRMLFFPVADLPQLSKGKGNKIVSIPSAQAASGEDKLAWLFVLPPQTSVTLHVGKRKLTLRPEDLQKF
RAERGRKGTSLPRGLQRIDRVEVDAPARAPGGDSEE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Escherichia coli, GI1789396, Length=751, Percent_Identity=83.2223701731025, Blast_Score=1317, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=748, Percent_Identity=36.096256684492, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI212645845, Length=400, Percent_Identity=25.5, Blast_Score=73, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=388, Percent_Identity=23.7113402061856, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84073; Mature: 83942

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLTHDGVERLPLHTFTENAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLNN
CCCCCCCCHHHCCCEEECCCCEEEEEEEEEEEHHCHHHCCCHHHHHHHHHHHHHHHCCCC
SAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHH
AMRYTESRLSKYAEVLLAELGQGTVDWVPNFDGTMQEPKMLPARLPNILLNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEE
ATDIPPHNVREVAAAAVALIDKPGASLEELLEFVQGPDYPTEAEIITPREEIRKIYQNGR
ECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCCC
GSVRMRAVWSKEDGSAVITALPHQVSGAKVLEQIASQMRAKKLPMVEDLRDESDHENPTR
CCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCE
LVIVPRSNRIDLDQVMNHLFATTDLERSYRINMNMIGLDNRPQVKGLVEILTEWLAFRRD
EEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIHIIRSEDEPKPVLMQRFGISDTQAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHH
ILELKLRHLAKLEEFKIRGEQDELAKERDQLQALLASERKLNTLIKKEIQADAQAYGDDR
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RSPITERAEAKAMSEHDFVPSEPVTIVLSEMGWVRSAKGHDIDPSGLSYKAGDSFRSAAR
CCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHC
GKTNQPVVFIDSTGRSYALDPLTLPSARGQGEPLTGKLTPPPGATIEQVLMAADDQKLLM
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEE
ASDAGYGFVCTFNDLVARNRAGKVMITLPDNAKALAPMEIHGEDDMLLSITAAGRMLFFP
ECCCCCEEEEEHHHHHHCCCCCEEEEEECCCCCEECEEEECCCCCEEEEEECCCCEEEEE
VADLPQLSKGKGNKIVSIPSAQAASGEDKLAWLFVLPPQTSVTLHVGKRKLTLRPEDLQK
CCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCEEEEEECCEEEEECHHHHHH
FRAERGRKGTSLPRGLQRIDRVEVDAPARAPGGDSEE
HHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLTHDGVERLPLHTFTENAYLNYSMYVIMDRALPYIGDGLKPVQRRIIYAMSELGLNN
CCCCCCCHHHCCCEEECCCCEEEEEEEEEEEHHCHHHCCCHHHHHHHHHHHHHHHCCCC
SAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHH
AMRYTESRLSKYAEVLLAELGQGTVDWVPNFDGTMQEPKMLPARLPNILLNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEE
ATDIPPHNVREVAAAAVALIDKPGASLEELLEFVQGPDYPTEAEIITPREEIRKIYQNGR
ECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCCC
GSVRMRAVWSKEDGSAVITALPHQVSGAKVLEQIASQMRAKKLPMVEDLRDESDHENPTR
CCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCE
LVIVPRSNRIDLDQVMNHLFATTDLERSYRINMNMIGLDNRPQVKGLVEILTEWLAFRRD
EEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHH
TVRRRLNYRLEKVLKRLHILEGLLVAFLNIDEVIHIIRSEDEPKPVLMQRFGISDTQAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHH
ILELKLRHLAKLEEFKIRGEQDELAKERDQLQALLASERKLNTLIKKEIQADAQAYGDDR
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RSPITERAEAKAMSEHDFVPSEPVTIVLSEMGWVRSAKGHDIDPSGLSYKAGDSFRSAAR
CCCCHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHC
GKTNQPVVFIDSTGRSYALDPLTLPSARGQGEPLTGKLTPPPGATIEQVLMAADDQKLLM
CCCCCCEEEEECCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEE
ASDAGYGFVCTFNDLVARNRAGKVMITLPDNAKALAPMEIHGEDDMLLSITAAGRMLFFP
ECCCCCEEEEEHHHHHHCCCCCEEEEEECCCCCEECEEEECCCCCEEEEEECCCCEEEEE
VADLPQLSKGKGNKIVSIPSAQAASGEDKLAWLFVLPPQTSVTLHVGKRKLTLRPEDLQK
CCCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEEECCCCEEEEEECCEEEEECHHHHHH
FRAERGRKGTSLPRGLQRIDRVEVDAPARAPGGDSEE
HHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]