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The map label for this gene is plsC [H]

Identifier: 157372491

GI number: 157372491

Start: 4721205

End: 4721942

Strand: Reverse

Name: plsC [H]

Synonym: Spro_4258

Alternate gene names: 157372491

Gene position: 4721942-4721205 (Counterclockwise)

Preceding gene: 157372492

Following gene: 157372490

Centisome position: 86.66

GC content: 53.12

Gene sequence:

>738_bases
ATGTTATTAATTTTACGTGCCGTGCTCGCCACTCTGTATTGTCTTCTGGTGTGCATTTTCGGTTCTATTTACTGTTTGGT
ATTCCGCCCCCGCGATCCCCGCCATGTGGCGACGTTCGGTCATTTGTTTGGTCGCCTGTCCGGGTTATTTGGTCTGAAAG
TGGAAGTCCGGGTACCGGCCGATGCGGCCAAAAACGGCAACTGCATTTATATTGCCAACCACCAGAATAACTACGATATG
GTGACGGCCGCCAAAGCGGTGCAGCCGCGCACCGTGACCGTGGGTAAAAAAAGCCTGCTGTGGGTTCCGTTCTTCGGCCC
GCTGTATTGGGTGACCGGTAACTTGCTGATTGACCGGGATAATCGCGCCAAGGCGCACGGTACCATTGCCCAGGTGGCTG
AACAGTTTAAAAAACGTGATATTTCGGTCTGGATGTTTCCAGAAGGTACGCGCAGCCGCGGGCGTGGGTTGATGCCGTTT
AAAACCGGTGCATTTCACGCGGCAATCGCTGCCGGGGTGCCGATTGTGCCGATCTGCGTTTCCACCACCAGCGGTAAAAT
TAATCTTAACCGTTGGGATAACGGTCATGCGATCGTAGAAGTGATGGAACCGATCGATATCAGTAATTACGGTAGAGAAA
ATGTGCGTGAGCTGGCAGCCCATTGCCATGAGCTGATGCTGGCGAAAATTGCCGAGCTGGACGCAGAAGTTGCCCAGCGC
AATGCAGCCGGAAAATAA

Upstream 100 bases:

>100_bases
AAAAAGGCAGGGCAGGTTTTCGAACCCTGCAAGCAAAGAATAAGTAAAGGGATCTGCGCAGCGTTTCAGGCTGCGCCGGC
AGTGTGCTAATGAGGTTGTT

Downstream 100 bases:

>100_bases
TATTCCTACCGGCTTCAAAGAATGAACTTTTAAACGGCGTAAAACGCCGTTAACACCTGGGCTCCTGCTAATCTGATTAA
CAGGAGCCCGGTCTTTGCAC

Product: 1-acyl-sn-glycerol-3-phosphate acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase [H]

Number of amino acids: Translated: 245; Mature: 245

Protein sequence:

>245_residues
MLLILRAVLATLYCLLVCIFGSIYCLVFRPRDPRHVATFGHLFGRLSGLFGLKVEVRVPADAAKNGNCIYIANHQNNYDM
VTAAKAVQPRTVTVGKKSLLWVPFFGPLYWVTGNLLIDRDNRAKAHGTIAQVAEQFKKRDISVWMFPEGTRSRGRGLMPF
KTGAFHAAIAAGVPIVPICVSTTSGKINLNRWDNGHAIVEVMEPIDISNYGRENVRELAAHCHELMLAKIAELDAEVAQR
NAAGK

Sequences:

>Translated_245_residues
MLLILRAVLATLYCLLVCIFGSIYCLVFRPRDPRHVATFGHLFGRLSGLFGLKVEVRVPADAAKNGNCIYIANHQNNYDM
VTAAKAVQPRTVTVGKKSLLWVPFFGPLYWVTGNLLIDRDNRAKAHGTIAQVAEQFKKRDISVWMFPEGTRSRGRGLMPF
KTGAFHAAIAAGVPIVPICVSTTSGKINLNRWDNGHAIVEVMEPIDISNYGRENVRELAAHCHELMLAKIAELDAEVAQR
NAAGK
>Mature_245_residues
MLLILRAVLATLYCLLVCIFGSIYCLVFRPRDPRHVATFGHLFGRLSGLFGLKVEVRVPADAAKNGNCIYIANHQNNYDM
VTAAKAVQPRTVTVGKKSLLWVPFFGPLYWVTGNLLIDRDNRAKAHGTIAQVAEQFKKRDISVWMFPEGTRSRGRGLMPF
KTGAFHAAIAAGVPIVPICVSTTSGKINLNRWDNGHAIVEVMEPIDISNYGRENVRELAAHCHELMLAKIAELDAEVAQR
NAAGK

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI6041665, Length=233, Percent_Identity=29.6137339055794, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI5453718, Length=226, Percent_Identity=29.2035398230088, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI15100175, Length=226, Percent_Identity=29.2035398230088, Blast_Score=115, Evalue=4e-26,
Organism=Escherichia coli, GI1789395, Length=245, Percent_Identity=73.8775510204082, Blast_Score=388, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17564032, Length=184, Percent_Identity=33.695652173913, Blast_Score=121, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17568319, Length=240, Percent_Identity=28.75, Blast_Score=101, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320151, Length=239, Percent_Identity=32.2175732217573, Blast_Score=118, Evalue=8e-28,
Organism=Drosophila melanogaster, GI281364648, Length=221, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24582856, Length=221, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24582854, Length=221, Percent_Identity=30.7692307692308, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24641614, Length=244, Percent_Identity=29.9180327868852, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24641612, Length=244, Percent_Identity=29.9180327868852, Blast_Score=113, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 27054; Mature: 27054

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLILRAVLATLYCLLVCIFGSIYCLVFRPRDPRHVATFGHLFGRLSGLFGLKVEVRVPA
CHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEEEECC
DAAKNGNCIYIANHQNNYDMVTAAKAVQPRTVTVGKKSLLWVPFFGPLYWVTGNLLIDRD
CCCCCCCEEEEEECCCCCCCEEHHHHCCCCEEEECCCEEEEEECCCCEEEEECCEEEECC
NRAKAHGTIAQVAEQFKKRDISVWMFPEGTRSRGRGLMPFKTGAFHAAIAAGVPIVPICV
CCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHCCCCCCCCCCCCHHHHHHCCCCEEEEEE
STTSGKINLNRWDNGHAIVEVMEPIDISNYGRENVRELAAHCHELMLAKIAELDAEVAQR
ECCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAAGK
CCCCC
>Mature Secondary Structure
MLLILRAVLATLYCLLVCIFGSIYCLVFRPRDPRHVATFGHLFGRLSGLFGLKVEVRVPA
CHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHCCEEEEEEEEECC
DAAKNGNCIYIANHQNNYDMVTAAKAVQPRTVTVGKKSLLWVPFFGPLYWVTGNLLIDRD
CCCCCCCEEEEEECCCCCCCEEHHHHCCCCEEEECCCEEEEEECCCCEEEEECCEEEECC
NRAKAHGTIAQVAEQFKKRDISVWMFPEGTRSRGRGLMPFKTGAFHAAIAAGVPIVPICV
CCCCHHHHHHHHHHHHHHCCCEEEECCCCCHHCCCCCCCCCCCCHHHHHHCCCCEEEEEE
STTSGKINLNRWDNGHAIVEVMEPIDISNYGRENVRELAAHCHELMLAKIAELDAEVAQR
ECCCCEEEEEECCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAAGK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1557036; 9278503 [H]