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The map label for this gene is serA [H]

Identifier: 157372157

GI number: 157372157

Start: 4346348

End: 4347586

Strand: Reverse

Name: serA [H]

Synonym: Spro_3923

Alternate gene names: 157372157

Gene position: 4347586-4346348 (Counterclockwise)

Preceding gene: 157372158

Following gene: 157372154

Centisome position: 79.79

GC content: 55.53

Gene sequence:

>1239_bases
ATGGCAAAAGTATCATTGGAGAAAGACAGGATTAAATTCCTGTTGGTGGAAGGGGTTCATCAGAGCACGGTAGATAATCT
GCTGGCAGCCGGATATACCAACATTGAATATCACAAAGGTGCGTTAGACACCGAATCGCTTAAGGCATCGATTCGCGATG
CTCACTTCGTCGGTATCCGATCGCGCACAAATCTGACCGAAGAAGTTTTCGCTGCCGCAGAGAAGCTGGTGGCGGTGGGC
TGTTTCTGTATCGGCACTAACCAGGTTGATTTGAAGGCGGCGACCAAACGCGGCGTCCCGGTGTTTAACGCACCTTTCTC
TAATACCCGATCCGTGGCTGAAATGGTGCTGGGCGAACTGCTGCTGATGTTGCGCGGCATTCCGTCCGCCAACGCCAAAG
CGCACCGTGGCGAATGGCAGAAGCTGGCCGTCGGCTCGTTTGAAGCGCGCGGCAAGAAGCTGGGGATTATTGGCTACGGC
CATATCGGCACCCAACTGGGTATCCTGGCCGAAGGCCTGGGCATGAAAGTGTTCTTCTACGATATCGAGAACAAGCTGCC
GTTGGGTAATGCCCAGCAGGTGCGCCACCTGTCCGATCTGCTCAATATGAGCGACGTAGTGACGCTGCACGTGCCGGAAA
CCCTGTCGACCAAGAATATGATGGGTGCAGAAGAGCTGGCGTTGATGAAGCCAGGCTCGATTCTGATCAACGCCTCGCGC
GGTACCGTGGTGGATATCCCAGAATTGTGCAAAGTCCTGGCCAGCAAGCATTTGGCCGGTGCGGCGATCGACGTCTTCCC
GGAAGAACCTGCGACCAACAGTGAGCCGTTCATCTCACCGTTGTGCGAGTTTGACAACGTGATCCTGACTCCGCACATTG
GCGGTTCTACGCAGGAAGCGCAGGAGAACATCGGTGACGAAGTGGCCGGTAAGCTGGCAAAATACTCCGACAACGGTTCG
ACCCTGTCGGCGGTTAACTTCCCGGAAGTATCACTGCCGGCGCATGGCCCTAATGCCAGCCGTCTGCTGCACATCCATGA
AAACCGTCCTGGTGTACTGACGCAGATTAACCAGATCTTCGCTGAAGAAGGGGTGAACATCGCCGCGCAGTACCTGCAAA
CCGGTCCGGAAATCGGCTACGTGGTTATCGATATCGAAGCGGAAACCGAACGTGCTGATGCTGCACTGCAACGCATGAAG
GCTATTGACGGCACTATCCGTGCTCGCCTGCTGCTCTGA

Upstream 100 bases:

>100_bases
CGGGCAATCGTTTGTATTGCCGCCCGCGATATTTTTGTTATGTTGGATGCGTGCTGTTTCACAACAGCCGCTTCTGAAGT
CTGAACATAGGGTCGGGTAA

Downstream 100 bases:

>100_bases
TTGAATACGCGGTGACAAAAAGGCCGGATTTTTCCGGCCTTTTCTATTTGGCTATCTGCCATGTCCAATTTTGAGATGGG
GTAATGATTTCCGGCAGCGG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MAKVSLEKDRIKFLLVEGVHQSTVDNLLAAGYTNIEYHKGALDTESLKASIRDAHFVGIRSRTNLTEEVFAAAEKLVAVG
CFCIGTNQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMLRGIPSANAKAHRGEWQKLAVGSFEARGKKLGIIGYG
HIGTQLGILAEGLGMKVFFYDIENKLPLGNAQQVRHLSDLLNMSDVVTLHVPETLSTKNMMGAEELALMKPGSILINASR
GTVVDIPELCKVLASKHLAGAAIDVFPEEPATNSEPFISPLCEFDNVILTPHIGGSTQEAQENIGDEVAGKLAKYSDNGS
TLSAVNFPEVSLPAHGPNASRLLHIHENRPGVLTQINQIFAEEGVNIAAQYLQTGPEIGYVVIDIEAETERADAALQRMK
AIDGTIRARLLL

Sequences:

>Translated_412_residues
MAKVSLEKDRIKFLLVEGVHQSTVDNLLAAGYTNIEYHKGALDTESLKASIRDAHFVGIRSRTNLTEEVFAAAEKLVAVG
CFCIGTNQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMLRGIPSANAKAHRGEWQKLAVGSFEARGKKLGIIGYG
HIGTQLGILAEGLGMKVFFYDIENKLPLGNAQQVRHLSDLLNMSDVVTLHVPETLSTKNMMGAEELALMKPGSILINASR
GTVVDIPELCKVLASKHLAGAAIDVFPEEPATNSEPFISPLCEFDNVILTPHIGGSTQEAQENIGDEVAGKLAKYSDNGS
TLSAVNFPEVSLPAHGPNASRLLHIHENRPGVLTQINQIFAEEGVNIAAQYLQTGPEIGYVVIDIEAETERADAALQRMK
AIDGTIRARLLL
>Mature_411_residues
AKVSLEKDRIKFLLVEGVHQSTVDNLLAAGYTNIEYHKGALDTESLKASIRDAHFVGIRSRTNLTEEVFAAAEKLVAVGC
FCIGTNQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGELLLMLRGIPSANAKAHRGEWQKLAVGSFEARGKKLGIIGYGH
IGTQLGILAEGLGMKVFFYDIENKLPLGNAQQVRHLSDLLNMSDVVTLHVPETLSTKNMMGAEELALMKPGSILINASRG
TVVDIPELCKVLASKHLAGAAIDVFPEEPATNSEPFISPLCEFDNVILTPHIGGSTQEAQENIGDEVAGKLAKYSDNGST
LSAVNFPEVSLPAHGPNASRLLHIHENRPGVLTQINQIFAEEGVNIAAQYLQTGPEIGYVVIDIEAETERADAALQRMKA
IDGTIRARLLL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=291, Percent_Identity=36.0824742268041, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=30, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=30, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI145580578, Length=260, Percent_Identity=29.2307692307692, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI4557499, Length=260, Percent_Identity=29.2307692307692, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI145580575, Length=270, Percent_Identity=28.5185185185185, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI6912396, Length=240, Percent_Identity=27.5, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1789279, Length=411, Percent_Identity=82.4817518248175, Blast_Score=692, Evalue=0.0,
Organism=Escherichia coli, GI87082289, Length=273, Percent_Identity=30.7692307692308, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1787645, Length=232, Percent_Identity=27.1551724137931, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1788660, Length=309, Percent_Identity=28.8025889967638, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=33.5403726708075, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI25147481, Length=242, Percent_Identity=28.099173553719, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=47.1014492753623, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=46.6183574879227, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6324964, Length=253, Percent_Identity=28.4584980237154, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324055, Length=284, Percent_Identity=27.8169014084507, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=220, Percent_Identity=26.8181818181818, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI19921140, Length=301, Percent_Identity=31.5614617940199, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=28.8461538461538, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24646446, Length=238, Percent_Identity=32.7731092436975, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646448, Length=238, Percent_Identity=32.7731092436975, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646452, Length=238, Percent_Identity=32.7731092436975, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24646450, Length=238, Percent_Identity=32.7731092436975, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571528, Length=259, Percent_Identity=28.957528957529, Blast_Score=96, Evalue=6e-20,
Organism=Drosophila melanogaster, GI62472511, Length=238, Percent_Identity=32.7731092436975, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551003, Length=249, Percent_Identity=24.0963855421687, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585514, Length=249, Percent_Identity=24.0963855421687, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574282, Length=249, Percent_Identity=24.0963855421687, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574284, Length=249, Percent_Identity=24.0963855421687, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI45552429, Length=249, Percent_Identity=24.0963855421687, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24585516, Length=254, Percent_Identity=24.8031496062992, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44377; Mature: 44245

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKVSLEKDRIKFLLVEGVHQSTVDNLLAAGYTNIEYHKGALDTESLKASIRDAHFVGIR
CCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHCCCEEEEEC
SRTNLTEEVFAAAEKLVAVGCFCIGTNQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGEL
CCCCHHHHHHHHHHHHHHHEEEEECCCCEEEEHHHHCCCEEEECCCCCHHHHHHHHHHHH
LLMLRGIPSANAKAHRGEWQKLAVGSFEARGKKLGIIGYGHIGTQLGILAEGLGMKVFFY
HHHHCCCCCCCCCCCCCCCCEEECCCHHCCCCEEEEEEECCHHHHHHHHHCCCCCEEEEE
DIENKLPLGNAQQVRHLSDLLNMSDVVTLHVPETLSTKNMMGAEELALMKPGSILINASR
ECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCHHHHHEECCCCEEEECCC
GTVVDIPELCKVLASKHLAGAAIDVFPEEPATNSEPFISPLCEFDNVILTPHIGGSTQEA
CCEECHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHCCCCEEEECCCCCCHHHH
QENIGDEVAGKLAKYSDNGSTLSAVNFPEVSLPAHGPNASRLLHIHENRPGVLTQINQIF
HHHCCHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCCCCEEEEEECCCCCHHHHHHHHH
AEEGVNIAAQYLQTGPEIGYVVIDIEAETERADAALQRMKAIDGTIRARLLL
HHCCHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCHHHEEEECC
>Mature Secondary Structure 
AKVSLEKDRIKFLLVEGVHQSTVDNLLAAGYTNIEYHKGALDTESLKASIRDAHFVGIR
CCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHCCCEEEEEC
SRTNLTEEVFAAAEKLVAVGCFCIGTNQVDLKAATKRGVPVFNAPFSNTRSVAEMVLGEL
CCCCHHHHHHHHHHHHHHHEEEEECCCCEEEEHHHHCCCEEEECCCCCHHHHHHHHHHHH
LLMLRGIPSANAKAHRGEWQKLAVGSFEARGKKLGIIGYGHIGTQLGILAEGLGMKVFFY
HHHHCCCCCCCCCCCCCCCCEEECCCHHCCCCEEEEEEECCHHHHHHHHHCCCCCEEEEE
DIENKLPLGNAQQVRHLSDLLNMSDVVTLHVPETLSTKNMMGAEELALMKPGSILINASR
ECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCHHHCCCHHHHHEECCCCEEEECCC
GTVVDIPELCKVLASKHLAGAAIDVFPEEPATNSEPFISPLCEFDNVILTPHIGGSTQEA
CCEECHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHCCCCEEEECCCCCCHHHH
QENIGDEVAGKLAKYSDNGSTLSAVNFPEVSLPAHGPNASRLLHIHENRPGVLTQINQIF
HHHCCHHHHHHHHHCCCCCCEEEEECCCCEECCCCCCCCCEEEEEECCCCCHHHHHHHHH
AEEGVNIAAQYLQTGPEIGYVVIDIEAETERADAALQRMKAIDGTIRARLLL
HHCCHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHHHHHHHCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]