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The map label for this gene is mltA [H]

Identifier: 157372045

GI number: 157372045

Start: 4209362

End: 4210504

Strand: Reverse

Name: mltA [H]

Synonym: Spro_3810

Alternate gene names: 157372045

Gene position: 4210504-4209362 (Counterclockwise)

Preceding gene: 157372046

Following gene: 157372044

Centisome position: 77.27

GC content: 56.87

Gene sequence:

>1143_bases
ATGAAAGGATGTTGGGGCAAATACCTGCTGGGCGGGTTAATGGTAGCGGTACTGGCGGGCTGTTCTTCCAAGCCGACCGA
CCGGGGACAACAATATAAGGATGGTCACCTGGATCAGTCGCTGGAGTTGGTGAATCAACCCAACGCCAGGGGCGTACCGG
TTAATGCCAAGGATTACTCGGATCAGCTGATGGAGATTAAATACGCCTCTCCTTCACTTTTTAATCGCAACAACACTACC
TTCCAGGCGGTACAAAGCTGGATGGCGTCCGGTGCCGACACTCGTACTCTGAACCAATATGGCCTCAGCGCTTATCAAAT
GGAAGGCGTGGACAGCTATGGCAACGTGCAGTTCACCGGTTACTACACACCGGTGCTGCAGGCGCGTTATACCCAGCAGG
GTGAGTTCCGTTACCCGCTGTACCGCATGCCACCAAAAGGTAAAGGCCGTCTGCCCGATCGCGCGGGCATTTATTCGGGC
GCACTGGATGACCGATATATCGTGGCGTATACCAATTCGCTGATGGACAACTTTATGATGGAAGTCCAGGGCAGTGGCTA
TGTGGATTATGGCAACGGCCAGCCGTTGGTGTTCTTCGGTTACGGCGGCAAGAACGGCCATGCGTATCGCAGCATTGGTA
AAGTGCTGATCGATCGCGGTGAAGTGGCCAAGGCGGATATGTCGATGCAGGCGATCCGCCAGTGGGCGGACACTCACAGC
GCCGCCGAAGTGCGCGAATTGCTGGAGCAAAACCCTTCCTTTGTCTTCTTCCGTCCTGAAGCCTTTGCGCCGGTACGCGG
TGCCAGCGCCGTGCCGCTGGTTGCCAAGGCGTCGGTGGCTTCCGACCGTTCACTGATCCCGGCGGGTACCACGCTGCTGG
CAGAGGTGCCGCTACTGGACAACAAGGGTAAATTCACGGGAAAATATGAGATGCGCCTGATGGTGGCTCTGGACGTAGGT
GGGGCAATCAAAGGCCAGCACTTCGATATGTACCAGGGCATCGGGCCGGATGCTGGTCACTCGGCCGGTTTTTATAACCA
CTACGGCCGCGTTTGGGTGCTGAAAGGCGCTAACGTTAATGCGCCGTTGTTCACCAGCCAGACCCGTTCCGCCTCTGGCG
GCTCGCTGTTAGTCACCCGCTAA

Upstream 100 bases:

>100_bases
CGTTATTGCCCCTGGGGCTTTTTTTATTGGCGGCGATTCCTTTATCTATGGGCGTTTGTTATCGTTCGCCGGGAGATCAT
ATATGTAGAGAGTGTGCGCG

Downstream 100 bases:

>100_bases
CGGCAATAATTGACCGCAAGGGCCGGACATTCCGGCCCTTATTATTTGCAATGTTAAGGTAATTAAAGCGTTATGAGCAC
AGCCTATTCTGAAGCCTACC

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MKGCWGKYLLGGLMVAVLAGCSSKPTDRGQQYKDGHLDQSLELVNQPNARGVPVNAKDYSDQLMEIKYASPSLFNRNNTT
FQAVQSWMASGADTRTLNQYGLSAYQMEGVDSYGNVQFTGYYTPVLQARYTQQGEFRYPLYRMPPKGKGRLPDRAGIYSG
ALDDRYIVAYTNSLMDNFMMEVQGSGYVDYGNGQPLVFFGYGGKNGHAYRSIGKVLIDRGEVAKADMSMQAIRQWADTHS
AAEVRELLEQNPSFVFFRPEAFAPVRGASAVPLVAKASVASDRSLIPAGTTLLAEVPLLDNKGKFTGKYEMRLMVALDVG
GAIKGQHFDMYQGIGPDAGHSAGFYNHYGRVWVLKGANVNAPLFTSQTRSASGGSLLVTR

Sequences:

>Translated_380_residues
MKGCWGKYLLGGLMVAVLAGCSSKPTDRGQQYKDGHLDQSLELVNQPNARGVPVNAKDYSDQLMEIKYASPSLFNRNNTT
FQAVQSWMASGADTRTLNQYGLSAYQMEGVDSYGNVQFTGYYTPVLQARYTQQGEFRYPLYRMPPKGKGRLPDRAGIYSG
ALDDRYIVAYTNSLMDNFMMEVQGSGYVDYGNGQPLVFFGYGGKNGHAYRSIGKVLIDRGEVAKADMSMQAIRQWADTHS
AAEVRELLEQNPSFVFFRPEAFAPVRGASAVPLVAKASVASDRSLIPAGTTLLAEVPLLDNKGKFTGKYEMRLMVALDVG
GAIKGQHFDMYQGIGPDAGHSAGFYNHYGRVWVLKGANVNAPLFTSQTRSASGGSLLVTR
>Mature_380_residues
MKGCWGKYLLGGLMVAVLAGCSSKPTDRGQQYKDGHLDQSLELVNQPNARGVPVNAKDYSDQLMEIKYASPSLFNRNNTT
FQAVQSWMASGADTRTLNQYGLSAYQMEGVDSYGNVQFTGYYTPVLQARYTQQGEFRYPLYRMPPKGKGRLPDRAGIYSG
ALDDRYIVAYTNSLMDNFMMEVQGSGYVDYGNGQPLVFFGYGGKNGHAYRSIGKVLIDRGEVAKADMSMQAIRQWADTHS
AAEVRELLEQNPSFVFFRPEAFAPVRGASAVPLVAKASVASDRSLIPAGTTLLAEVPLLDNKGKFTGKYEMRLMVALDVG
GAIKGQHFDMYQGIGPDAGHSAGFYNHYGRVWVLKGANVNAPLFTSQTRSASGGSLLVTR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=357, Percent_Identity=72.8291316526611, Blast_Score=562, Evalue=1e-161,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 41588; Mature: 41588

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGCWGKYLLGGLMVAVLAGCSSKPTDRGQQYKDGHLDQSLELVNQPNARGVPVNAKDYS
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHH
DQLMEIKYASPSLFNRNNTTFQAVQSWMASGADTRTLNQYGLSAYQMEGVDSYGNVQFTG
CCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCEEEECCCCCCCCEEEEE
YYTPVLQARYTQQGEFRYPLYRMPPKGKGRLPDRAGIYSGALDDRYIVAYTNSLMDNFMM
EECHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHE
EVQGSGYVDYGNGQPLVFFGYGGKNGHAYRSIGKVLIDRGEVAKADMSMQAIRQWADTHS
EECCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
AAEVRELLEQNPSFVFFRPEAFAPVRGASAVPLVAKASVASDRSLIPAGTTLLAEVPLLD
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCC
NKGKFTGKYEMRLMVALDVGGAIKGQHFDMYQGIGPDAGHSAGFYNHYGRVWVLKGANVN
CCCCCCEEEEEEEEEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCC
APLFTSQTRSASGGSLLVTR
CCEEECCCCCCCCCEEEEEC
>Mature Secondary Structure
MKGCWGKYLLGGLMVAVLAGCSSKPTDRGQQYKDGHLDQSLELVNQPNARGVPVNAKDYS
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHH
DQLMEIKYASPSLFNRNNTTFQAVQSWMASGADTRTLNQYGLSAYQMEGVDSYGNVQFTG
CCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCCEEEECCCCCCCCEEEEE
YYTPVLQARYTQQGEFRYPLYRMPPKGKGRLPDRAGIYSGALDDRYIVAYTNSLMDNFMM
EECHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHE
EVQGSGYVDYGNGQPLVFFGYGGKNGHAYRSIGKVLIDRGEVAKADMSMQAIRQWADTHS
EECCCCEEECCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCC
AAEVRELLEQNPSFVFFRPEAFAPVRGASAVPLVAKASVASDRSLIPAGTTLLAEVPLLD
HHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCC
NKGKFTGKYEMRLMVALDVGGAIKGQHFDMYQGIGPDAGHSAGFYNHYGRVWVLKGANVN
CCCCCCEEEEEEEEEEEECCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCC
APLFTSQTRSASGGSLLVTR
CCEEECCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]