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The map label for this gene is uraA [H]

Identifier: 157371759

GI number: 157371759

Start: 3895638

End: 3896927

Strand: Reverse

Name: uraA [H]

Synonym: Spro_3522

Alternate gene names: 157371759

Gene position: 3896927-3895638 (Counterclockwise)

Preceding gene: 157371760

Following gene: 157371756

Centisome position: 71.52

GC content: 57.6

Gene sequence:

>1290_bases
ATGACACGTCGCGTCATCGGCGTCAGTGAACGCCCGCCGCTACTGCAGACCATTCCGCTCAGCTTCCAGCATCTGTTCGC
CATGTTTGGTGCTACCGTGCTGGTGCCAATCCTGTTCAAGATCAACCCGGCGACGGTGTTGCTGTTTAACGGCATCGGCA
CGCTGCTGTATCTGTTTATCTGCAAGGGCAAGATCCCAGCCTATCTCGGTTCCAGCTTTGCCTTTATCTCCCCGGTACTG
TTGCTGCTGCCATTGGGTTATGAAGTGGCGTTGGGTGGTTTCATCATGTGTGGGGTGCTGTTCTGCCTGGTGGGGCTGCT
GGTCAAAAAAGCCGGTACCGGCTGGCTGGACGTGATATTCCCGCCGGCGGCGATGGGGGCGATTGTCGCGGTTATAGGTC
TGGAATTGGCGGGCGTGGCGGCCAATATGGCGGGCCTGCTGCCAGCCGACGGCGTCAGCGCGGATACCACGACCGTAACC
ATTTCGCTGGTGACGCTGGGCGTGACGATCCTCGGCTCAGTGCTGTTCCGCGGTTTTCTGGCGATTATCCCGATATTGAT
CGGCGTGCTGGTGGGCTATGCGCTGTCGTTCTTTATGGGCGTGGTGGATTTAACCCCGATCCGCGAAGCGCACTGGTTTG
CACTGCCGACTTTCTACACGCCACGTTTTGAATGGTTTGCCATCTTTACCATCCTGCCCGCGGCGCTGGTGGTGATCGCC
GAGCACGTCGGCCATCTGGTGGTGACGGCCAATATCGTAAAAAAAGATTTGCTGCGTGACCCTGGTTTGCACCGTTCCAT
GTTTGCCAACGGTATTTCGACGGTCATCTCCGGCTTCTTCGGCTCAACGCCAAATACTACCTACGGTGAGAATATCGGCG
TGATGGCCATCACCAAGGTTTACAGCACCTGGGTGATTGGTGGCGCGGCGGTTCTGGCGATCCTGCTTTCCTGTGTCGGT
AAGCTGGCGGCGGCCATTCAGGCGGTGCCGGTGCCGGTTATGGGCGGTGTATCTCTGCTGTTGTACGGGGTGATCGGCGC
GTCCGGTATTCGCGTGCTGATTGAATCCAAGGTGGATTACAACAAGGCGCAAAACTTGATTCTGACGTCGGTGATCCTGA
TTATCGGCGTCAGCGGGGCCAAGGTGCATATCGGAGCCGCCGAGCTGAAAGGTATGGCGTTGGCGACCATTGTTGGCATC
GGTCTCAGCCTGCTGTTTAAGGTGATCAGCCTGTACCGCAAGGAAGAGGTCGTGCTCGAAGGGCCAGACGAATCGGTCGA
ACAGAAGTAA

Upstream 100 bases:

>100_bases
TGGGTGATGCGGGCGATAAGATATTTGGTACCAAATAAAAATTGAAGCCGACGATGAGTCGGCTTTTTTTTGACCGGAAA
ATAATTAGAGGAAAAACCCC

Downstream 100 bases:

>100_bases
TGAAAACGGGCAGCCCATGAGGAGCTGCCCGTTTTATTAATGTGCCAGGAATTAGCTGCGGATTTTACGGTAAACAAACA
GCACCACGATGGCACCAATC

Product: uracil transporter

Products: Proton [Cytoplasm]; uracil [Cytoplasm] [C]

Alternate protein names: Uracil transporter [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTRRVIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVL
LLLPLGYEVALGGFIMCGVLFCLVGLLVKKAGTGWLDVIFPPAAMGAIVAVIGLELAGVAANMAGLLPADGVSADTTTVT
ISLVTLGVTILGSVLFRGFLAIIPILIGVLVGYALSFFMGVVDLTPIREAHWFALPTFYTPRFEWFAIFTILPAALVVIA
EHVGHLVVTANIVKKDLLRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKVYSTWVIGGAAVLAILLSCVG
KLAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGI
GLSLLFKVISLYRKEEVVLEGPDESVEQK

Sequences:

>Translated_429_residues
MTRRVIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVL
LLLPLGYEVALGGFIMCGVLFCLVGLLVKKAGTGWLDVIFPPAAMGAIVAVIGLELAGVAANMAGLLPADGVSADTTTVT
ISLVTLGVTILGSVLFRGFLAIIPILIGVLVGYALSFFMGVVDLTPIREAHWFALPTFYTPRFEWFAIFTILPAALVVIA
EHVGHLVVTANIVKKDLLRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKVYSTWVIGGAAVLAILLSCVG
KLAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGI
GLSLLFKVISLYRKEEVVLEGPDESVEQK
>Mature_428_residues
TRRVIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFICKGKIPAYLGSSFAFISPVLL
LLPLGYEVALGGFIMCGVLFCLVGLLVKKAGTGWLDVIFPPAAMGAIVAVIGLELAGVAANMAGLLPADGVSADTTTVTI
SLVTLGVTILGSVLFRGFLAIIPILIGVLVGYALSFFMGVVDLTPIREAHWFALPTFYTPRFEWFAIFTILPAALVVIAE
HVGHLVVTANIVKKDLLRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKVYSTWVIGGAAVLAILLSCVGK
LAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDYNKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGIG
LSLLFKVISLYRKEEVVLEGPDESVEQK

Specific function: Transport of uracil in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=220, Percent_Identity=28.1818181818182, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI40316845, Length=220, Percent_Identity=28.1818181818182, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI44680143, Length=451, Percent_Identity=23.7250554323725, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI44680145, Length=234, Percent_Identity=25.6410256410256, Blast_Score=70, Evalue=5e-12,
Organism=Escherichia coli, GI1788843, Length=429, Percent_Identity=88.5780885780886, Blast_Score=753, Evalue=0.0,
Organism=Escherichia coli, GI87081818, Length=439, Percent_Identity=38.2687927107062, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI87082181, Length=449, Percent_Identity=26.2806236080178, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1790087, Length=405, Percent_Identity=26.6666666666667, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI87082178, Length=369, Percent_Identity=24.6612466124661, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17541904, Length=233, Percent_Identity=25.3218884120172, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17542262, Length=216, Percent_Identity=25.9259259259259, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558856, Length=173, Percent_Identity=28.3236994219653, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21356175, Length=219, Percent_Identity=28.7671232876712, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 45162; Mature: 45031

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRVIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFI
CCCCEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVGLLVKKAGTGWLDVIF
HCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PPAAMGAIVAVIGLELAGVAANMAGLLPADGVSADTTTVTISLVTLGVTILGSVLFRGFL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
AIIPILIGVLVGYALSFFMGVVDLTPIREAHWFALPTFYTPRFEWFAIFTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKKDLLRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKV
HHHCHHEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
YSTWVIGGAAVLAILLSCVGKLAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCH
NKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGIGLSLLFKVISLYRKEEVVLE
HHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
GPDESVEQK
CCCCCCCCC
>Mature Secondary Structure 
TRRVIGVSERPPLLQTIPLSFQHLFAMFGATVLVPILFKINPATVLLFNGIGTLLYLFI
CCCEECCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEHHHHHHHHHHH
CKGKIPAYLGSSFAFISPVLLLLPLGYEVALGGFIMCGVLFCLVGLLVKKAGTGWLDVIF
HCCCCCHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PPAAMGAIVAVIGLELAGVAANMAGLLPADGVSADTTTVTISLVTLGVTILGSVLFRGFL
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHH
AIIPILIGVLVGYALSFFMGVVDLTPIREAHWFALPTFYTPRFEWFAIFTILPAALVVIA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHH
EHVGHLVVTANIVKKDLLRDPGLHRSMFANGISTVISGFFGSTPNTTYGENIGVMAITKV
HHHCHHEEHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHH
YSTWVIGGAAVLAILLSCVGKLAAAIQAVPVPVMGGVSLLLYGVIGASGIRVLIESKVDY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCH
NKAQNLILTSVILIIGVSGAKVHIGAAELKGMALATIVGIGLSLLFKVISLYRKEEVVLE
HHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
GPDESVEQK
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; uracil [Periplasm] [C]

Specific reaction: Proton [Periplasm] + uracil [Periplasm] = Proton [Cytoplasm] + uracil [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]