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The map label for this gene is upp [H]

Identifier: 157371760

GI number: 157371760

Start: 3896990

End: 3897619

Strand: Reverse

Name: upp [H]

Synonym: Spro_3523

Alternate gene names: 157371760

Gene position: 3897619-3896990 (Counterclockwise)

Preceding gene: 157371763

Following gene: 157371759

Centisome position: 71.53

GC content: 53.65

Gene sequence:

>630_bases
ATGATGAAGATCGTTGAGGTGAAACACCCGCTGGTGAAACACAAGCTTGGTCTGATGCGTGAAAATGACATCAGCACCAA
ACGCTTCCGTGAGCTGGCTTCGGAAGTGGGTAGTTTGCTGACCTATGAAGCGACCGCCGATCTGGAAACGGAGAAAGTGA
CCATCGATGGCTGGTGTGGTCCGGTTGAAATTGACCAGATTAAAGGGAAAAAAATTACCGTCGTACCTATCCTGCGTGCC
GGTCTGGGCATGATGGAAGGGGTATTGGAAAACGTTCCTAGCGCGCGCATCAGCGTGGTTGGCGTTTACCGTGACGAAGA
AACCCTGGAGCCGGTACCTTATTTCCAAAAGCTGGTTTCCAACATCGAAGAGCGTCTGGCGCTGGTGGTTGACCCGATGC
TGGCGACCGGTGGCTCGATGATCGCCACTATCGATCTGCTGAAGAAAGCCGGCTGCAACAGCATCAAGGTGCTGGTACTG
GTCGCGGCACCGGAAGGTATCGCTGCGCTGGAGAAAGCGCACCCGGACGTCGAACTCTACACTGCTTCTATCGATCAATG
CCTGAATGACAAGGGCTACATCGTGCCGGGCCTGGGTGATGCGGGCGATAAGATATTTGGTACCAAATAA

Upstream 100 bases:

>100_bases
TTTTGTTGATCCCGATCGGGCTATTGTGGGTGGCGCAGTCGGCAAAAGGAGGTATAATCCGGCGATTTTTTTGGCCGTCA
ACCACCTTAATAGGAGAAAA

Downstream 100 bases:

>100_bases
AAATTGAAGCCGACGATGAGTCGGCTTTTTTTTGACCGGAAAATAATTAGAGGAAAAACCCCATGACACGTCGCGTCATC
GGCGTCAGTGAACGCCCGCC

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MMKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCGPVEIDQIKGKKITVVPILRA
GLGMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIEERLALVVDPMLATGGSMIATIDLLKKAGCNSIKVLVL
VAAPEGIAALEKAHPDVELYTASIDQCLNDKGYIVPGLGDAGDKIFGTK

Sequences:

>Translated_209_residues
MMKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCGPVEIDQIKGKKITVVPILRA
GLGMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIEERLALVVDPMLATGGSMIATIDLLKKAGCNSIKVLVL
VAAPEGIAALEKAHPDVELYTASIDQCLNDKGYIVPGLGDAGDKIFGTK
>Mature_209_residues
MMKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCGPVEIDQIKGKKITVVPILRA
GLGMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVSNIEERLALVVDPMLATGGSMIATIDLLKKAGCNSIKVLVL
VAAPEGIAALEKAHPDVELYTASIDQCLNDKGYIVPGLGDAGDKIFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=142, Percent_Identity=30.2816901408451, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI57863312, Length=142, Percent_Identity=30.2816901408451, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87082118, Length=208, Percent_Identity=92.7884615384615, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.8756218905473, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.8756218905473, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=41.304347826087, Blast_Score=104, Evalue=1e-23,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=27.0935960591133, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=27.0935960591133, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=27.0935960591133, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=27.0935960591133, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 22659; Mature: 22659

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCG
CCEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCC
PVEIDQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVS
CCCHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHH
NIEERLALVVDPMLATGGSMIATIDLLKKAGCNSIKVLVLVAAPEGIAALEKAHPDVELY
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCCEEE
TASIDQCLNDKGYIVPGLGDAGDKIFGTK
HHHHHHHHCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MMKIVEVKHPLVKHKLGLMRENDISTKRFRELASEVGSLLTYEATADLETEKVTIDGWCG
CCEEEHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHEEEECCCCCCCCEEEECCCCC
PVEIDQIKGKKITVVPILRAGLGMMEGVLENVPSARISVVGVYRDEETLEPVPYFQKLVS
CCCHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHH
NIEERLALVVDPMLATGGSMIATIDLLKKAGCNSIKVLVLVAAPEGIAALEKAHPDVELY
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHCCCCCEEE
TASIDQCLNDKGYIVPGLGDAGDKIFGTK
HHHHHHHHCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA