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The map label for this gene is ccmE

Identifier: 157371624

GI number: 157371624

Start: 3748546

End: 3749040

Strand: Reverse

Name: ccmE

Synonym: Spro_3387

Alternate gene names: 157371624

Gene position: 3749040-3748546 (Counterclockwise)

Preceding gene: 157371625

Following gene: 157371623

Centisome position: 68.8

GC content: 56.97

Gene sequence:

>495_bases
GTGAATCCACGTCGTAAAAGTCGCCTGTATCTGGCGATCGTAGTGCTGATCGGCGTTGCGCTTACCGCGACCCTGATGCT
GTATGCGCTGCGCTCCAACATCGATCTGTTTTATACCCCGAGCGAAATTCTGCAGGGCAAGGGCGAAAATCATGAGAAGC
CGGAAGTGGGCCAACGCCTGCGTATCGGCGGCATGGTGATGCCTGGTTCGGTAAAACGCGATCAGAAAACGCTGCAGGTC
AGCTTCAAGGTCTACGATGCGCGCGGTGCCATCGATGTCACCTACACCGGTATTTTGCCGGACTTGTTCCGTGAGGGGCA
GGGCGTGGTAGCGCAGGGCGTATTGGGCGAAGGCAATGTGGTCAATGCGCGTGAAGTGCTGGCGAAACACGATGAAAAAT
ACACACCGCCGGAGGTGGCCGACGCAATGAAAGAAAACCATAAGGGGCCGGCTTCGGCTTACGCCACCCCGCAGAACGAG
GGCGCTAAATCATGA

Upstream 100 bases:

>100_bases
AATTGCTCGATGAGATCGGCCGCCGTCAGGCGCGCGAACGACGCATTCGTCAGTCGCAGCAGTCGAAACAAAAATCCGCC
AACCCGCGGGAGAAATCATT

Downstream 100 bases:

>100_bases
TGCCGGAAACGGGAAGTTTTCTGCTGTGTCTGGCGCTGGCGATTTCGCTGCTGCTGAGCATTTACCCGCAGTGGGGCGCA
GCGCGTCAGGATCGCCGCAT

Product: cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MNPRRKSRLYLAIVVLIGVALTATLMLYALRSNIDLFYTPSEILQGKGENHEKPEVGQRLRIGGMVMPGSVKRDQKTLQV
SFKVYDARGAIDVTYTGILPDLFREGQGVVAQGVLGEGNVVNAREVLAKHDEKYTPPEVADAMKENHKGPASAYATPQNE
GAKS

Sequences:

>Translated_164_residues
MNPRRKSRLYLAIVVLIGVALTATLMLYALRSNIDLFYTPSEILQGKGENHEKPEVGQRLRIGGMVMPGSVKRDQKTLQV
SFKVYDARGAIDVTYTGILPDLFREGQGVVAQGVLGEGNVVNAREVLAKHDEKYTPPEVADAMKENHKGPASAYATPQNE
GAKS
>Mature_164_residues
MNPRRKSRLYLAIVVLIGVALTATLMLYALRSNIDLFYTPSEILQGKGENHEKPEVGQRLRIGGMVMPGSVKRDQKTLQV
SFKVYDARGAIDVTYTGILPDLFREGQGVVAQGVLGEGNVVNAREVLAKHDEKYTPPEVADAMKENHKGPASAYATPQNE
GAKS

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=157, Percent_Identity=68.1528662420382, Blast_Score=225, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_SERP5 (A8GH95)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001479613.1
- ProteinModelPortal:   A8GH95
- SMR:   A8GH95
- STRING:   A8GH95
- GeneID:   5603547
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3387
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   HVEFAVH
- ProtClustDB:   PRK13165
- BioCyc:   SPRO399741:SPRO_3387-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 17910; Mature: 17910

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: BINDING 130-130

Signals:

None

Transmembrane regions:

HASH(0x10524630)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPRRKSRLYLAIVVLIGVALTATLMLYALRSNIDLFYTPSEILQGKGENHEKPEVGQRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCHHCEE
RIGGMVMPGSVKRDQKTLQVSFKVYDARGAIDVTYTGILPDLFREGQGVVAQGVLGEGNV
EECCEECCCCCCCCCEEEEEEEEEEECCCCEEEEECCCCHHHHHCCCCEEEECCCCCCCE
VNAREVLAKHDEKYTPPEVADAMKENHKGPASAYATPQNEGAKS
ECHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH
>Mature Secondary Structure
MNPRRKSRLYLAIVVLIGVALTATLMLYALRSNIDLFYTPSEILQGKGENHEKPEVGQRL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHCCCCCCCCCCCHHCEE
RIGGMVMPGSVKRDQKTLQVSFKVYDARGAIDVTYTGILPDLFREGQGVVAQGVLGEGNV
EECCEECCCCCCCCCEEEEEEEEEEECCCCEEEEECCCCHHHHHCCCCEEEECCCCCCCE
VNAREVLAKHDEKYTPPEVADAMKENHKGPASAYATPQNEGAKS
ECHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA