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The map label for this gene is mdtL [H]

Identifier: 157370984

GI number: 157370984

Start: 3023095

End: 3024288

Strand: Direct

Name: mdtL [H]

Synonym: Spro_2744

Alternate gene names: 157370984

Gene position: 3023095-3024288 (Clockwise)

Preceding gene: 157370983

Following gene: 157370987

Centisome position: 55.48

GC content: 59.3

Gene sequence:

>1194_bases
ATGCAAAAATTTCTGTTTCTGCTTCTTAGCCTGGTGCTGCTCGGCCCGCTGGGTATCGATCTCTATCTGCCGACCATCCC
CGCTATCGCCGTTGGCCTTAACAGCAGTGAAGCGCTGATTCAGTCCACCATTTCTCTGTTCATTTTGGTGCTGGGCCTTG
GGCAGGTTATTGCCGGCCCGCTGGTGGATAACTACGGCCGCAAGCCGGTGGCTCTGGCCGGTATTGTGATTTACATGATT
GGCGCGGCGATGGCGGCGCTGGCCACCACGCCAACGATGTTTGTCGCCTCTCGCCTGTTGCAGGGTGTGGCGGTCTGCTG
TACCGCAGTGGTGGCATTCAGTGGCGTGCGCGATCGGATGAACGGCGACGATGCGGCCCGTGCCTTCGGTTTTCTCAACG
GTACGCTGAATATTATTCCTGCTCTGGCCCCCTTGCTGGGCGGGTTGCTGGCAGAAGCCTTTGGCTGGCGCGCCCCATTC
TGGTTCCTGGTGTGTTATGCGCTGGCGGTACTGGTACTGATCGCCCTTCGCCTGCCGGAAACCCGTCCGGCGGACACCGT
GCGCGTCAAAGGATTGCCGGTGCGACAATATGCACGCATCGCCCGCGATCGCCGCTTTCTGTCCTTCGCCGTAGTCAACT
CCGGTGCCATGGGCATGGCGCTGACCTACGTCTCGCTGGCCCCCAACGTGCTAATGGGCACCGCCGGGCTGACGCCGTTG
CAATTCTCGTTGGTGTTTGGCGCCAATGGTTTTTGGATCATGCTGGTGAGTTTTTTCGCCAACCGCATCATTCACAAGGT
CGGACGCCCAGTCTGTCTGGCAACCGGCGGTATATTGATGGGTATCGGGGCTATTGGGCTACTGCTGGGCGTCTCCTTAC
TGTCTGGTGCGGCACAAACTCACTGGCTGGCTTATATGCTACCGGTCGCTTTTGCCTGCGCTGGTTTAGCCTTTGTGATG
GGCCCGGCAACCAGCTACGCGCTGGAGCCGTATTCCAATGAGGCCGGGGTAGCTTCTGCATTGGTAGGTTTTGTGCAGAT
GGCCGGCGGTGCGGCTCTGGGCTTGTTGGCGATGGCGCTGCCATTGCAGCCCAAACTGTCACTGGCGCTGGTGATGCTGG
TGGGTTGCCTGCTAGCGCTGCACGCACGACAGCGCAGCAAGCAAATAAAAGGTCAGTTGAAGAAGATTGCCTGA

Upstream 100 bases:

>100_bases
GACTGGCGTACCGGCGGCGGGCCTATGTTTTGCCTCTTTCCATTTAGCGCCAGAATCTCTACTCTAGCCCTCTTTGTCAC
TCGGATGTGCTGTTTTTGTT

Downstream 100 bases:

>100_bases
GGCTTAGGCCTCGGTGTTGATTGGCACTCTAGCGGCCAGTGCCGTCAGTAATTCATAACCCAGCGTACCTGCCGCGGTGG
CGACATCGTCAACCGGCAGG

Product: Bcr/CflA subfamily drug resistance transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MQKFLFLLLSLVLLGPLGIDLYLPTIPAIAVGLNSSEALIQSTISLFILVLGLGQVIAGPLVDNYGRKPVALAGIVIYMI
GAAMAALATTPTMFVASRLLQGVAVCCTAVVAFSGVRDRMNGDDAARAFGFLNGTLNIIPALAPLLGGLLAEAFGWRAPF
WFLVCYALAVLVLIALRLPETRPADTVRVKGLPVRQYARIARDRRFLSFAVVNSGAMGMALTYVSLAPNVLMGTAGLTPL
QFSLVFGANGFWIMLVSFFANRIIHKVGRPVCLATGGILMGIGAIGLLLGVSLLSGAAQTHWLAYMLPVAFACAGLAFVM
GPATSYALEPYSNEAGVASALVGFVQMAGGAALGLLAMALPLQPKLSLALVMLVGCLLALHARQRSKQIKGQLKKIA

Sequences:

>Translated_397_residues
MQKFLFLLLSLVLLGPLGIDLYLPTIPAIAVGLNSSEALIQSTISLFILVLGLGQVIAGPLVDNYGRKPVALAGIVIYMI
GAAMAALATTPTMFVASRLLQGVAVCCTAVVAFSGVRDRMNGDDAARAFGFLNGTLNIIPALAPLLGGLLAEAFGWRAPF
WFLVCYALAVLVLIALRLPETRPADTVRVKGLPVRQYARIARDRRFLSFAVVNSGAMGMALTYVSLAPNVLMGTAGLTPL
QFSLVFGANGFWIMLVSFFANRIIHKVGRPVCLATGGILMGIGAIGLLLGVSLLSGAAQTHWLAYMLPVAFACAGLAFVM
GPATSYALEPYSNEAGVASALVGFVQMAGGAALGLLAMALPLQPKLSLALVMLVGCLLALHARQRSKQIKGQLKKIA
>Mature_397_residues
MQKFLFLLLSLVLLGPLGIDLYLPTIPAIAVGLNSSEALIQSTISLFILVLGLGQVIAGPLVDNYGRKPVALAGIVIYMI
GAAMAALATTPTMFVASRLLQGVAVCCTAVVAFSGVRDRMNGDDAARAFGFLNGTLNIIPALAPLLGGLLAEAFGWRAPF
WFLVCYALAVLVLIALRLPETRPADTVRVKGLPVRQYARIARDRRFLSFAVVNSGAMGMALTYVSLAPNVLMGTAGLTPL
QFSLVFGANGFWIMLVSFFANRIIHKVGRPVCLATGGILMGIGAIGLLLGVSLLSGAAQTHWLAYMLPVAFACAGLAFVM
GPATSYALEPYSNEAGVASALVGFVQMAGGAALGLLAMALPLQPKLSLALVMLVGCLLALHARQRSKQIKGQLKKIA

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtL (TC 2.A.1.2.22) subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790146, Length=351, Percent_Identity=34.1880341880342, Blast_Score=172, Evalue=3e-44,
Organism=Escherichia coli, GI1788509, Length=405, Percent_Identity=26.9135802469136, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI87082312, Length=354, Percent_Identity=30.225988700565, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI48994889, Length=206, Percent_Identity=32.0388349514563, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1790794, Length=238, Percent_Identity=27.3109243697479, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1787065, Length=206, Percent_Identity=26.2135922330097, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87081738, Length=193, Percent_Identity=26.4248704663212, Blast_Score=65, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324264, Length=171, Percent_Identity=27.4853801169591, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319517, Length=188, Percent_Identity=25.531914893617, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6322071, Length=164, Percent_Identity=30.4878048780488, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319480, Length=206, Percent_Identity=25.2427184466019, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41569; Mature: 41569

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKFLFLLLSLVLLGPLGIDLYLPTIPAIAVGLNSSEALIQSTISLFILVLGLGQVIAGP
CHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LVDNYGRKPVALAGIVIYMIGAAMAALATTPTMFVASRLLQGVAVCCTAVVAFSGVRDRM
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NGDDAARAFGFLNGTLNIIPALAPLLGGLLAEAFGWRAPFWFLVCYALAVLVLIALRLPE
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
TRPADTVRVKGLPVRQYARIARDRRFLSFAVVNSGAMGMALTYVSLAPNVLMGTAGLTPL
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCHH
QFSLVFGANGFWIMLVSFFANRIIHKVGRPVCLATGGILMGIGAIGLLLGVSLLSGAAQT
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCHHHH
HWLAYMLPVAFACAGLAFVMGPATSYALEPYSNEAGVASALVGFVQMAGGAALGLLAMAL
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHC
PLQPKLSLALVMLVGCLLALHARQRSKQIKGQLKKIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQKFLFLLLSLVLLGPLGIDLYLPTIPAIAVGLNSSEALIQSTISLFILVLGLGQVIAGP
CHHHHHHHHHHHHHCCCCCHHHHCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
LVDNYGRKPVALAGIVIYMIGAAMAALATTPTMFVASRLLQGVAVCCTAVVAFSGVRDRM
HHHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NGDDAARAFGFLNGTLNIIPALAPLLGGLLAEAFGWRAPFWFLVCYALAVLVLIALRLPE
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
TRPADTVRVKGLPVRQYARIARDRRFLSFAVVNSGAMGMALTYVSLAPNVLMGTAGLTPL
CCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHCCCCCCCHH
QFSLVFGANGFWIMLVSFFANRIIHKVGRPVCLATGGILMGIGAIGLLLGVSLLSGAAQT
EEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCHHHH
HWLAYMLPVAFACAGLAFVMGPATSYALEPYSNEAGVASALVGFVQMAGGAALGLLAMAL
HHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHC
PLQPKLSLALVMLVGCLLALHARQRSKQIKGQLKKIA
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA