Click here to switch to the map view.

The map label for this gene is sppA [H]

Identifier: 157370962

GI number: 157370962

Start: 2998395

End: 3000251

Strand: Direct

Name: sppA [H]

Synonym: Spro_2722

Alternate gene names: 157370962

Gene position: 2998395-3000251 (Clockwise)

Preceding gene: 157370956

Following gene: 157370963

Centisome position: 55.03

GC content: 56.87

Gene sequence:

>1857_bases
ATGCGCACATTGTGGCAAATCATTGCCGGCGTTTTCAGGTGGACATGGCGTCTGCTGAACTTTATCAGGGAACTGATCCT
CAATTTGTTCCTGGTGTTGCTGATCCTGGTTGGGGTCGGTATCTATCTTTCATTCCAGAGTGCCACCACCCCTGCCGTGC
CTACCCGCGGTGCGTTGCTGGTGGACCTGAGCGGCGTGGTGGTTGACCAACCGTCGATGAACAACAAGGTTCGCCAATGG
GGTCGTGAACTGTTGGGCGCTTCCAGCAACCGCCTGCAGGAAAACTCCCTGTTTGACGTGGTTGACAGCATCCGCAAGGC
TAAAGACGACAAAAACATTACCGGCATGGTATTGCAGTTGAATGACTTTGCCGGTGCCGATCAGCCTTCGCTGCAGTACA
TCGGCAAGGCGCTACGTGAATTCCGTGACAGTGGCAAACCGATCTTTGCCATTGGCGACAGCTATAACCAGACGCAATAT
TATCTGGCCAGCTACGCCAACAAGGTTTATCTGTCGCCACAGGGTGCGGTCGACCTGCACGGCTTTGCCACCAACAACCT
TTACTACAAATCGTTGTTGGAAAAACTCAAGGTCACCACCAACATCTTCCGCGTCGGTACCTATAAATCCGCCGTGGAAC
CCTTGATCCGTGACGATATGTCACCGGCCGCCCGTGAGGCAGACAGCCGCTGGATTGGTGGATTGTGGCAAAACTATCTG
GATACCGTGGCGGCTAACCGTCAGATCACGGCGCAACAGCTGTTCCCAGGGGCCGCAGGCGTGCTGAGCGGTATGCAGGC
TGCCGGAGGGGATACGGCCAAGTATGCGCTGGATAACAAACTGGTCGATGAACTGGCGTCGCGCACCGTCATCGAAAACC
AACTGATCAAGACTTTCGGTTGGGACAAGCAGGCCAATGATTTCAACGCGACCAGCATCTACGACTACCAGCCGAAGCCG
ACGCCGGATCAAGGCGGTAAAATTGCCGTGATCTTCGCTAACGGCGCGATCATGGACGGTCCGCAAACACCAGGCACCGT
TGGCGGCGATACTACCGCCGCAGAACTGCGTCAGGCGCGACTGGATCCGGCCATCAAGGCGGTGATTTTCCGGGTCAACA
GCCCAGGGGGCAGCGTCAGCGCCTCGGAAGTGATCCGCTCCGAGTTGGCTGCGGTACGTGCCGCCGGCAAACCTGTGGTG
GTTTCCATGGGCGGCATGGCGGCCTCGGGCGGCTATTGGGTCTCTACACCGGCGGACTACATCATCGCCAGCCCGAGCAC
CCTCACCGGTTCCATTGGCATCTTCGGGGTGATTAACACCTACGAGCAGACGCTGGACAGCATCGGCGTGCATACCGACG
GCGTGGCAACCTCGCCGCTGGCGGATCTGGCGGTCACCAAGGCGCTGCCGCCGGAGTTCTCGCAGATGATGCAGTTGAAC
ATCGAGAAAGGTTATCAAAACTTTATCGACCTGGTCGCCAAGTCACGCAAAATGACACCGCAGCAGGTTGATCAGATTGC
TCAGGGCCACGTGTGGTTGGGCAGCGATGCCAAGACCAATGGTCTGGTCGATCAGTTGGGTGACTTCGACGACGCGGTGA
AGAAAGCCGCCGAACTGGCGCAATTGAAACAGTGGCAGCTTAACTGGTTTGTCGATACGCCAAGCCTGACCGATATGGTT
CTCAGTCAGTTTGGCGTTTCCATTCACGCCATGCTGCCGGCAGCCATCCAGTCGATGCTGCCTGCACCCTTGGCATCAGT
GGCTATGGCGGTCAAAGAGCAACCGGGTTTGTTCAATAACCTGAACGATCCGCAAAACCGTTATGCCATCTGTTTGACCT
GCGGAGAAGTCCGCTAA

Upstream 100 bases:

>100_bases
CAGCCTCGGCATTAGCCTCTGTGACCCACGATTTAAAGCTGACATTTCTTTGGCCGCTCATTAGGATAGCGGAACATTCT
CGACTCTTGCTGGAGAGCAC

Downstream 100 bases:

>100_bases
CAAATTAATCCTCAGCCCGGCACCCGCCGGGCTTTTTTTCTGCGCTTATCCCCCTATAATTCAGCCCATCTTATTTCTGT
TAAAACAATCACTATGCAAA

Product: protease 4

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV; Signal peptide peptidase [H]

Number of amino acids: Translated: 618; Mature: 618

Protein sequence:

>618_residues
MRTLWQIIAGVFRWTWRLLNFIRELILNLFLVLLILVGVGIYLSFQSATTPAVPTRGALLVDLSGVVVDQPSMNNKVRQW
GRELLGASSNRLQENSLFDVVDSIRKAKDDKNITGMVLQLNDFAGADQPSLQYIGKALREFRDSGKPIFAIGDSYNQTQY
YLASYANKVYLSPQGAVDLHGFATNNLYYKSLLEKLKVTTNIFRVGTYKSAVEPLIRDDMSPAAREADSRWIGGLWQNYL
DTVAANRQITAQQLFPGAAGVLSGMQAAGGDTAKYALDNKLVDELASRTVIENQLIKTFGWDKQANDFNATSIYDYQPKP
TPDQGGKIAVIFANGAIMDGPQTPGTVGGDTTAAELRQARLDPAIKAVIFRVNSPGGSVSASEVIRSELAAVRAAGKPVV
VSMGGMAASGGYWVSTPADYIIASPSTLTGSIGIFGVINTYEQTLDSIGVHTDGVATSPLADLAVTKALPPEFSQMMQLN
IEKGYQNFIDLVAKSRKMTPQQVDQIAQGHVWLGSDAKTNGLVDQLGDFDDAVKKAAELAQLKQWQLNWFVDTPSLTDMV
LSQFGVSIHAMLPAAIQSMLPAPLASVAMAVKEQPGLFNNLNDPQNRYAICLTCGEVR

Sequences:

>Translated_618_residues
MRTLWQIIAGVFRWTWRLLNFIRELILNLFLVLLILVGVGIYLSFQSATTPAVPTRGALLVDLSGVVVDQPSMNNKVRQW
GRELLGASSNRLQENSLFDVVDSIRKAKDDKNITGMVLQLNDFAGADQPSLQYIGKALREFRDSGKPIFAIGDSYNQTQY
YLASYANKVYLSPQGAVDLHGFATNNLYYKSLLEKLKVTTNIFRVGTYKSAVEPLIRDDMSPAAREADSRWIGGLWQNYL
DTVAANRQITAQQLFPGAAGVLSGMQAAGGDTAKYALDNKLVDELASRTVIENQLIKTFGWDKQANDFNATSIYDYQPKP
TPDQGGKIAVIFANGAIMDGPQTPGTVGGDTTAAELRQARLDPAIKAVIFRVNSPGGSVSASEVIRSELAAVRAAGKPVV
VSMGGMAASGGYWVSTPADYIIASPSTLTGSIGIFGVINTYEQTLDSIGVHTDGVATSPLADLAVTKALPPEFSQMMQLN
IEKGYQNFIDLVAKSRKMTPQQVDQIAQGHVWLGSDAKTNGLVDQLGDFDDAVKKAAELAQLKQWQLNWFVDTPSLTDMV
LSQFGVSIHAMLPAAIQSMLPAPLASVAMAVKEQPGLFNNLNDPQNRYAICLTCGEVR
>Mature_618_residues
MRTLWQIIAGVFRWTWRLLNFIRELILNLFLVLLILVGVGIYLSFQSATTPAVPTRGALLVDLSGVVVDQPSMNNKVRQW
GRELLGASSNRLQENSLFDVVDSIRKAKDDKNITGMVLQLNDFAGADQPSLQYIGKALREFRDSGKPIFAIGDSYNQTQY
YLASYANKVYLSPQGAVDLHGFATNNLYYKSLLEKLKVTTNIFRVGTYKSAVEPLIRDDMSPAAREADSRWIGGLWQNYL
DTVAANRQITAQQLFPGAAGVLSGMQAAGGDTAKYALDNKLVDELASRTVIENQLIKTFGWDKQANDFNATSIYDYQPKP
TPDQGGKIAVIFANGAIMDGPQTPGTVGGDTTAAELRQARLDPAIKAVIFRVNSPGGSVSASEVIRSELAAVRAAGKPVV
VSMGGMAASGGYWVSTPADYIIASPSTLTGSIGIFGVINTYEQTLDSIGVHTDGVATSPLADLAVTKALPPEFSQMMQLN
IEKGYQNFIDLVAKSRKMTPQQVDQIAQGHVWLGSDAKTNGLVDQLGDFDDAVKKAAELAQLKQWQLNWFVDTPSLTDMV
LSQFGVSIHAMLPAAIQSMLPAPLASVAMAVKEQPGLFNNLNDPQNRYAICLTCGEVR

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=618, Percent_Identity=68.2847896440129, Blast_Score=887, Evalue=0.0,
Organism=Escherichia coli, GI1787527, Length=171, Percent_Identity=30.4093567251462, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 67043; Mature: 67043

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLWQIIAGVFRWTWRLLNFIRELILNLFLVLLILVGVGIYLSFQSATTPAVPTRGALL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEE
VDLSGVVVDQPSMNNKVRQWGRELLGASSNRLQENSLFDVVDSIRKAKDDKNITGMVLQL
EEECCEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEE
NDFAGADQPSLQYIGKALREFRDSGKPIFAIGDSYNQTQYYLASYANKVYLSPQGAVDLH
ECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCEEEECCCCCEEEC
GFATNNLYYKSLLEKLKVTTNIFRVGTYKSAVEPLIRDDMSPAAREADSRWIGGLWQNYL
CEECCCHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHH
DTVAANRQITAQQLFPGAAGVLSGMQAAGGDTAKYALDNKLVDELASRTVIENQLIKTFG
HHHHCCCCEEHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WDKQANDFNATSIYDYQPKPTPDQGGKIAVIFANGAIMDGPQTPGTVGGDTTAAELRQAR
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCHHHHHHHHH
LDPAIKAVIFRVNSPGGSVSASEVIRSELAAVRAAGKPVVVSMGGMAASGGYWVSTPADY
CCHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCEECCCCEEECCCCCE
IIASPSTLTGSIGIFGVINTYEQTLDSIGVHTDGVATSPLADLAVTKALPPEFSQMMQLN
EEECCCCCCCCCHHEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
IEKGYQNFIDLVAKSRKMTPQQVDQIAQGHVWLGSDAKTNGLVDQLGDFDDAVKKAAELA
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEECCCCCCCCHHHHHCCHHHHHHHHHHHH
QLKQWQLNWFVDTPSLTDMVLSQFGVSIHAMLPAAIQSMLPAPLASVAMAVKEQPGLFNN
HHHHHEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
LNDPQNRYAICLTCGEVR
CCCCCCCEEEEEEECCCC
>Mature Secondary Structure
MRTLWQIIAGVFRWTWRLLNFIRELILNLFLVLLILVGVGIYLSFQSATTPAVPTRGALL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCEEE
VDLSGVVVDQPSMNNKVRQWGRELLGASSNRLQENSLFDVVDSIRKAKDDKNITGMVLQL
EEECCEEECCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEE
NDFAGADQPSLQYIGKALREFRDSGKPIFAIGDSYNQTQYYLASYANKVYLSPQGAVDLH
ECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHCCEEEECCCCCEEEC
GFATNNLYYKSLLEKLKVTTNIFRVGTYKSAVEPLIRDDMSPAAREADSRWIGGLWQNYL
CEECCCHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHCCCCHHHHHHCHHHHHHHHHHHH
DTVAANRQITAQQLFPGAAGVLSGMQAAGGDTAKYALDNKLVDELASRTVIENQLIKTFG
HHHHCCCCEEHHHHCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
WDKQANDFNATSIYDYQPKPTPDQGGKIAVIFANGAIMDGPQTPGTVGGDTTAAELRQAR
CCCCCCCCCCCEEEECCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCHHHHHHHHH
LDPAIKAVIFRVNSPGGSVSASEVIRSELAAVRAAGKPVVVSMGGMAASGGYWVSTPADY
CCHHEEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCEECCCCEEECCCCCE
IIASPSTLTGSIGIFGVINTYEQTLDSIGVHTDGVATSPLADLAVTKALPPEFSQMMQLN
EEECCCCCCCCCHHEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHH
IEKGYQNFIDLVAKSRKMTPQQVDQIAQGHVWLGSDAKTNGLVDQLGDFDDAVKKAAELA
HHHHHHHHHHHHHHHCCCCHHHHHHHHCCCEEECCCCCCCCHHHHHCCHHHHHHHHHHHH
QLKQWQLNWFVDTPSLTDMVLSQFGVSIHAMLPAAIQSMLPAPLASVAMAVKEQPGLFNN
HHHHHEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCC
LNDPQNRYAICLTCGEVR
CCCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]