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The map label for this gene is rnb

Identifier: 157370878

GI number: 157370878

Start: 2904549

End: 2906483

Strand: Direct

Name: rnb

Synonym: Spro_2638

Alternate gene names: 157370878

Gene position: 2904549-2906483 (Clockwise)

Preceding gene: 157370877

Following gene: 157370879

Centisome position: 53.31

GC content: 57.93

Gene sequence:

>1935_bases
ATGTTTCAAGATAACCCGCTGCTGGCGCAGCTTAAACAGCAACTTCACTCTCAGACCCCGCGCGTTGAAGGCGTAGTAAA
AGGGACTGAGAAAGGCTTTGGCTTTCTTGAAGTAGACGGTCAAAAAAGCTATTTCATTCCGCCACCGTACATGAAGAAAG
TCATGCACGGCGACCGGGTGAGCGCGACTCTGCACACCGAGAAAGAGCGCGAAATCGCCGAGCCGGAAACTCTGATCGAG
CCATTCCTGTCGCGCTTTGTTGGCCGAGTGCAAAAGCGCGATGACCGCTTGTCAATCGTGCCCGATCATCCGTTGCTGAA
AGACGCGATTCAGTGTCGTCCCGTGCGTGGCCTGAACCACAATTTCCAGGCCGGTGACTGGGCAGTGGCAGAAATGTGTC
GCCACCCGCTGAAAGGCGACCGCGGTTTCAATGCCGATCTTACCCAATTCATTACCGATGGTGAAGATCACCTGGCGCCA
TGGTGGGTCACGCTGGCCCGTCATAATCTGGAAAAAGAAGCTCCGGAGATGATCGCCATCAGCGAGCCGGATGCTTCACT
GCCGCGTGAAGACCTGACTGCGCTGAATTTTGTCACCATCGACAGTGCCAGCACCGAAGATATGGACGATGCGTTGTTCG
TACAGGACAACGGTGACGGCTCACTGCAATTGACCATCGCCATTGCCGATCCGACCGCCTACGTCGAGCAAGGTAGCCCA
TTGGATGAAATCGCCCGCAAGCGCGCCTTCACCAACTACCTGCCGGGCTTCAATATCCCTATGTTGCCACGCGATCTGTC
AGACAACCTGTGTTCACTGCGCCCGAACCAACGCCGTCCGGTATTGGCCTGCCGCGTGACCATCGGTGCCGACGGCGCCC
TGGCTGACGACATTCGCTTCTTCGCCGCCGAGATTGAGTCAAAAGCCAAACTGGTTTATGACGAAGTGTCCGACTGGCTG
GAAGGCATTGCCGGCTGGCAACCGCCAAGTGACGACATTGCACAGCAAATCACCCTGCTCAAGCGTGTGTGTGACGTGCG
TAATTCCTGGCGCCACCAGCACGCTCTGGTATTTAAAGATCGCCCTGACTACCGCTTTGTTCTGGGCGAAAAAGGCGAAG
TGCTGGAGATCGTCACCGAGCAGCGCCGCACGGCCAACCGTATCGTTGAAGAGTGCATGATTGCTTCCAACGTTTGCGCC
GCTATCGTGCTGCGCGACCGTCTCGGCTTCGGCATTTACAACGTGCATACCGGTTTCGATCCGCTGCTGGTTGAGCAGGC
GGTTACCGTGCTGCAGGCCAACGGCGTGGAAGCCGATGCCGAGAAATTGCTGACGCTGGACGGGTTCTGCGAACTGCGCC
GTCACCTGGATTCACAGCCGACCCAGTTCCTCGACAGCCGCATCCGTCGTTCCCAAACTTATGCCGAGATCAGCACCACA
CCGGGCCCGCATTATGGCCTGGGGCTGGAAGCCTACGCCACCTGGACCTCACCGATCCGTAAATACGGCGATATGGTTAA
CCACCGTCTGCTGAAAGCCATTATCGCCGAGCAGCCCGCCGAAAAACCTCAGGATGAAGTCACCGTCCAACTGGCAGAGC
GCCGTCGTCTGAACCGCATGGCGGAGCGCGACGTGGGTGACTGGTTGTACGCTCGCTATCTGAAAGATAAAGCCGGCACC
GATGAGCGCTTCAATGCCGAGATCATCGACGTGACCCGCGGCGGCCTGCGTGTACGCCTGCTGGACAACGGCGCAGTGGC
CTTTATCCCGGCTCCATTTATTCACGCGGTGCGTGATGAAATGGTCTGCAGCCAGGAGACCGGCACGGTTCAGATCAAAG
GCGAAGTCGTCTATCGCCAGGGGGATAACCTGCAGGTCACCATCGCCGAAGTGCGCATGGAAACCCGCAGCGTGATCGCC
AGACCGGCGGCCTAA

Upstream 100 bases:

>100_bases
AACGCGGTAAAACCGTGACGTTAGGCTTGCCCGCAGCGGGTGATTCGCGTAAAACTGTCAGCCGCAAATCTTGCCACTCA
CAACCCATTCACTGGACGAT

Downstream 100 bases:

>100_bases
CCTCGCGAGATTAATCGCACGCCAGACAAACACCGGACGGGTCAACCTCCGGTGTTTTTTTTCGTCGCTCAAGCAGCCGC
GTCCCCGCTATTGCGCCACA

Product: exoribonuclease II

Products: NA

Alternate protein names: Exoribonuclease II; RNase II; Ribonuclease II

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MFQDNPLLAQLKQQLHSQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPYMKKVMHGDRVSATLHTEKEREIAEPETLIE
PFLSRFVGRVQKRDDRLSIVPDHPLLKDAIQCRPVRGLNHNFQAGDWAVAEMCRHPLKGDRGFNADLTQFITDGEDHLAP
WWVTLARHNLEKEAPEMIAISEPDASLPREDLTALNFVTIDSASTEDMDDALFVQDNGDGSLQLTIAIADPTAYVEQGSP
LDEIARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNQRRPVLACRVTIGADGALADDIRFFAAEIESKAKLVYDEVSDWL
EGIAGWQPPSDDIAQQITLLKRVCDVRNSWRHQHALVFKDRPDYRFVLGEKGEVLEIVTEQRRTANRIVEECMIASNVCA
AIVLRDRLGFGIYNVHTGFDPLLVEQAVTVLQANGVEADAEKLLTLDGFCELRRHLDSQPTQFLDSRIRRSQTYAEISTT
PGPHYGLGLEAYATWTSPIRKYGDMVNHRLLKAIIAEQPAEKPQDEVTVQLAERRRLNRMAERDVGDWLYARYLKDKAGT
DERFNAEIIDVTRGGLRVRLLDNGAVAFIPAPFIHAVRDEMVCSQETGTVQIKGEVVYRQGDNLQVTIAEVRMETRSVIA
RPAA

Sequences:

>Translated_644_residues
MFQDNPLLAQLKQQLHSQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPYMKKVMHGDRVSATLHTEKEREIAEPETLIE
PFLSRFVGRVQKRDDRLSIVPDHPLLKDAIQCRPVRGLNHNFQAGDWAVAEMCRHPLKGDRGFNADLTQFITDGEDHLAP
WWVTLARHNLEKEAPEMIAISEPDASLPREDLTALNFVTIDSASTEDMDDALFVQDNGDGSLQLTIAIADPTAYVEQGSP
LDEIARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNQRRPVLACRVTIGADGALADDIRFFAAEIESKAKLVYDEVSDWL
EGIAGWQPPSDDIAQQITLLKRVCDVRNSWRHQHALVFKDRPDYRFVLGEKGEVLEIVTEQRRTANRIVEECMIASNVCA
AIVLRDRLGFGIYNVHTGFDPLLVEQAVTVLQANGVEADAEKLLTLDGFCELRRHLDSQPTQFLDSRIRRSQTYAEISTT
PGPHYGLGLEAYATWTSPIRKYGDMVNHRLLKAIIAEQPAEKPQDEVTVQLAERRRLNRMAERDVGDWLYARYLKDKAGT
DERFNAEIIDVTRGGLRVRLLDNGAVAFIPAPFIHAVRDEMVCSQETGTVQIKGEVVYRQGDNLQVTIAEVRMETRSVIA
RPAA
>Mature_644_residues
MFQDNPLLAQLKQQLHSQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPYMKKVMHGDRVSATLHTEKEREIAEPETLIE
PFLSRFVGRVQKRDDRLSIVPDHPLLKDAIQCRPVRGLNHNFQAGDWAVAEMCRHPLKGDRGFNADLTQFITDGEDHLAP
WWVTLARHNLEKEAPEMIAISEPDASLPREDLTALNFVTIDSASTEDMDDALFVQDNGDGSLQLTIAIADPTAYVEQGSP
LDEIARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNQRRPVLACRVTIGADGALADDIRFFAAEIESKAKLVYDEVSDWL
EGIAGWQPPSDDIAQQITLLKRVCDVRNSWRHQHALVFKDRPDYRFVLGEKGEVLEIVTEQRRTANRIVEECMIASNVCA
AIVLRDRLGFGIYNVHTGFDPLLVEQAVTVLQANGVEADAEKLLTLDGFCELRRHLDSQPTQFLDSRIRRSQTYAEISTT
PGPHYGLGLEAYATWTSPIRKYGDMVNHRLLKAIIAEQPAEKPQDEVTVQLAERRRLNRMAERDVGDWLYARYLKDKAGT
DERFNAEIIDVTRGGLRVRLLDNGAVAFIPAPFIHAVRDEMVCSQETGTVQIKGEVVYRQGDNLQVTIAEVRMETRSVIA
RPAA

Specific function: Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction

COG id: COG4776

COG function: function code K; Exoribonuclease II

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain

Homologues:

Organism=Homo sapiens, GI190014623, Length=421, Percent_Identity=24.9406175771971, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI190014625, Length=421, Percent_Identity=24.9406175771971, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI134288890, Length=373, Percent_Identity=26.5415549597855, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1787542, Length=644, Percent_Identity=74.6894409937888, Blast_Score=1022, Evalue=0.0,
Organism=Escherichia coli, GI87082383, Length=656, Percent_Identity=27.8963414634146, Blast_Score=202, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI212645896, Length=472, Percent_Identity=25.635593220339, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI17553506, Length=396, Percent_Identity=25.5050505050505, Blast_Score=105, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6324552, Length=430, Percent_Identity=21.6279069767442, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24649634, Length=389, Percent_Identity=28.2776349614396, Blast_Score=123, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24654592, Length=433, Percent_Identity=26.7898383371824, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI19922976, Length=433, Percent_Identity=26.7898383371824, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24654597, Length=433, Percent_Identity=26.7898383371824, Blast_Score=120, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNB_SERP5 (A8GF49)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001478867.1
- ProteinModelPortal:   A8GF49
- SMR:   A8GF49
- STRING:   A8GF49
- GeneID:   5605444
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_2638
- eggNOG:   COG4776
- HOGENOM:   HBG401488
- OMA:   MDDALYI
- ProtClustDB:   PRK05054
- BioCyc:   SPRO399741:SPRO_2638-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01036
- InterPro:   IPR011129
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011804
- PANTHER:   PTHR23355:SF6
- SMART:   SM00357
- SMART:   SM00955
- SMART:   SM00316
- TIGRFAMs:   TIGR00358
- TIGRFAMs:   TIGR02062

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1; SSF50249 Nucleic_acid_OB

EC number: =3.1.13.1

Molecular weight: Translated: 72526; Mature: 72526

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS01175 RIBONUCLEASE_II; PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQDNPLLAQLKQQLHSQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPYMKKVMHGDRV
CCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCE
SATLHTEKEREIAEPETLIEPFLSRFVGRVQKRDDRLSIVPDHPLLKDAIQCRPVRGLNH
EEEEECCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCCC
NFQAGDWAVAEMCRHPLKGDRGFNADLTQFITDGEDHLAPWWVTLARHNLEKEAPEMIAI
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCHHCCCCEEEE
SEPDASLPREDLTALNFVTIDSASTEDMDDALFVQDNGDGSLQLTIAIADPTAYVEQGSP
CCCCCCCCHHHHCEEEEEEECCCCCCCCCCEEEEEECCCCEEEEEEEEECCHHHHCCCCC
LDEIARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNQRRPVLACRVTIGADGALADDIRF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEEEEEECCCCCHHHHHHH
FAAEIESKAKLVYDEVSDWLEGIAGWQPPSDDIAQQITLLKRVCDVRNSWRHQHALVFKD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
RPDYRFVLGEKGEVLEIVTEQRRTANRIVEECMIASNVCAAIVLRDRLGFGIYNVHTGFD
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PLLVEQAVTVLQANGVEADAEKLLTLDGFCELRRHLDSQPTQFLDSRIRRSQTYAEISTT
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECC
PGPHYGLGLEAYATWTSPIRKYGDMVNHRLLKAIIAEQPAEKPQDEVTVQLAERRRLNRM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AERDVGDWLYARYLKDKAGTDERFNAEIIDVTRGGLRVRLLDNGAVAFIPAPFIHAVRDE
HHHCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEECCHHHHHHHHH
MVCSQETGTVQIKGEVVYRQGDNLQVTIAEVRMETRSVIARPAA
HHHCCCCCEEEEEEEEEEEECCCEEEEHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFQDNPLLAQLKQQLHSQTPRVEGVVKGTEKGFGFLEVDGQKSYFIPPPYMKKVMHGDRV
CCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCE
SATLHTEKEREIAEPETLIEPFLSRFVGRVQKRDDRLSIVPDHPLLKDAIQCRPVRGLNH
EEEEECCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHCCCCCCCCC
NFQAGDWAVAEMCRHPLKGDRGFNADLTQFITDGEDHLAPWWVTLARHNLEKEAPEMIAI
CCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCHHCCCCEEEE
SEPDASLPREDLTALNFVTIDSASTEDMDDALFVQDNGDGSLQLTIAIADPTAYVEQGSP
CCCCCCCCHHHHCEEEEEEECCCCCCCCCCEEEEEECCCCEEEEEEEEECCHHHHCCCCC
LDEIARKRAFTNYLPGFNIPMLPRDLSDNLCSLRPNQRRPVLACRVTIGADGALADDIRF
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEEEEEECCCCCHHHHHHH
FAAEIESKAKLVYDEVSDWLEGIAGWQPPSDDIAQQITLLKRVCDVRNSWRHQHALVFKD
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEC
RPDYRFVLGEKGEVLEIVTEQRRTANRIVEECMIASNVCAAIVLRDRLGFGIYNVHTGFD
CCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCC
PLLVEQAVTVLQANGVEADAEKLLTLDGFCELRRHLDSQPTQFLDSRIRRSQTYAEISTT
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEECC
PGPHYGLGLEAYATWTSPIRKYGDMVNHRLLKAIIAEQPAEKPQDEVTVQLAERRRLNRM
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
AERDVGDWLYARYLKDKAGTDERFNAEIIDVTRGGLRVRLLDNGAVAFIPAPFIHAVRDE
HHHCHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCEEEEEECCCCEEEECCHHHHHHHHH
MVCSQETGTVQIKGEVVYRQGDNLQVTIAEVRMETRSVIARPAA
HHHCCCCCEEEEEEEEEEEECCCEEEEHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA