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The map label for this gene is sapA [H]

Identifier: 157370869

GI number: 157370869

Start: 2892644

End: 2894296

Strand: Direct

Name: sapA [H]

Synonym: Spro_2629

Alternate gene names: 157370869

Gene position: 2892644-2894296 (Clockwise)

Preceding gene: 157370865

Following gene: 157370870

Centisome position: 53.09

GC content: 58.38

Gene sequence:

>1653_bases
ATGCGTGGTTTACCCCTTTGGATTTTGTCGCTGAGTTGCCTGGCGAGCACCGCCCTGGCCTCAACACCTCCTGCGCCCGC
CGCGGCCCCCCCGCTGCCGGACATCCGCCAAAGCGGCTTTGTCTATTGTGTCAGCGGCATACTGAACACCTTTAACCCGC
AGATGGCCAGCAGCGGCCTGACGGTCGATACCCTGTCCGCACAGCTGTACGACCGTCTGCTGGATGTTGACCCCTATACT
TATCGGTTGATCCCCGAACTGGCGCAAAGCTGGGAGGTGCTGGATAACGGCGCGACCTACCGTTTCCATCTGCGAAAGGA
TGTGCCCTTCCAGACCACCGCCTGGTTCAAGCCGACCCGTAAACTGAACGCCGACGACGTGGTATTCAGCTTTGAGCGCG
TGTTCAACCAGAAGCACCCATACCATGACGTCAACGGCGGCGAGTATCCGTACTTCGACAGCCTGCAGTTTGGCGACTCG
GTGCAAAGCGTGAAAAAGCTCGACGAGTACACGGTCGAGATCCGTCTGCAAGCGCCGGACGCCTCCTTCCTGTGGCATAT
CGCGACCCACTATGCGCCAGTGCTGTCGGCGGAATATGCTGACAACCTGACGCGTGAAGGCCGTCAGGAGATGATCGACC
GTGAACCTGTCGGTAGCGGGCCCTTCCTGTTGAATGAATATCGCTCCGGGCAATACATTCGGCTGGCTCGTAACGACCTG
TATTGGAAAGGTAAACCACGCATGCCGCAGGTGGTGATCGACCTGGGTGCCGGCGGCACCGGTCGGTTGTCGAAGCTGCT
GACCGGCGAGTGTGATGTGCTGGCCTATCCGGCCGCCAGCCAGCTTTCTATTCTGCGTGATGATCCGCGTCTGCGCCTGA
CGCTGCGCCCGGGGATGAATATCGCCTATCTGGCCTTTAATACCCGTAAACCGCCGCTTGACGATTTGAAGGTCCGTCAG
GCAATTTCGCTGGCAATCAATAACCAGCGTCTGATGCAGTCGATTTACTACGGCACGGCGGAAACCGCCGCATCCATATT
GCCGCGCGCTTCGTGGGCATACGACAATGACGCGCACGTCACCGAGTTTGACCCGGCCAAATCACGCGAAATGCTGAAAC
AGGCAGGCATTGAGTCGCTAAACCTGCGCTTGTGGGTGCCTACCGCATCGCAATCCTACAACCCCAGCCCGCTGAAGACC
GCCGAGCTGATCCAGGCCGACTTGGCCCAGGTGGGGATCAAAGTCACCATAGTTCCGGTTGAAGGTCGCTTCCAGGAAGC
CCGGCTGATGGAGATGAATCACGACCTGACCCTGACCGGCTGGGCCACCGACAGTAACGACCCGGACAGTTTCTTCCGGC
CGCTGCTGAGCTGCGCGGCAATCCGTTCACAAACCAACTATGCTCACTGGTGTGATCCAGGATTTGACGAAGTGCTGCAA
AATGCCCTGCTGTCACAACAGTTGGCGCAGCGAATCGAAAACTATCAGAAGGCGCAGAAAATTCTCGAACAACAACTGCC
GGTGTTGCCGCTGGCGTCTTCATTGCGCCTGCAGGCCTATCGTTACGACATTAAGGGACTGGTTCTGAGCCCGTTCGGCA
ATGCGTCATTTGCCGGCGTGTTCCGTGAATCTGCCCAGGGGCCGAAAAAGTGA

Upstream 100 bases:

>100_bases
AATCAAGTAGCAGAAAACTCAGCCATTTTGCTCAATGGATTGGGCTGTTCGTCAGAGTGCGATACACTAAGGCTATTGCT
TATTAACCCATGAAGCCTCT

Downstream 100 bases:

>100_bases
TTATCTTTACCTTACGCCGTTGCCTGCTGCTGCTGATCACGCTGTTCTTCCTGACGCTGGTCAGCTTTAGCCTGAGCTAT
TTCACACCGCGCGCTCCGCT

Product: extracellular solute-binding protein

Products: ADP; phosphate; peptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 550; Mature: 550

Protein sequence:

>550_residues
MRGLPLWILSLSCLASTALASTPPAPAAAPPLPDIRQSGFVYCVSGILNTFNPQMASSGLTVDTLSAQLYDRLLDVDPYT
YRLIPELAQSWEVLDNGATYRFHLRKDVPFQTTAWFKPTRKLNADDVVFSFERVFNQKHPYHDVNGGEYPYFDSLQFGDS
VQSVKKLDEYTVEIRLQAPDASFLWHIATHYAPVLSAEYADNLTREGRQEMIDREPVGSGPFLLNEYRSGQYIRLARNDL
YWKGKPRMPQVVIDLGAGGTGRLSKLLTGECDVLAYPAASQLSILRDDPRLRLTLRPGMNIAYLAFNTRKPPLDDLKVRQ
AISLAINNQRLMQSIYYGTAETAASILPRASWAYDNDAHVTEFDPAKSREMLKQAGIESLNLRLWVPTASQSYNPSPLKT
AELIQADLAQVGIKVTIVPVEGRFQEARLMEMNHDLTLTGWATDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPGFDEVLQ
NALLSQQLAQRIENYQKAQKILEQQLPVLPLASSLRLQAYRYDIKGLVLSPFGNASFAGVFRESAQGPKK

Sequences:

>Translated_550_residues
MRGLPLWILSLSCLASTALASTPPAPAAAPPLPDIRQSGFVYCVSGILNTFNPQMASSGLTVDTLSAQLYDRLLDVDPYT
YRLIPELAQSWEVLDNGATYRFHLRKDVPFQTTAWFKPTRKLNADDVVFSFERVFNQKHPYHDVNGGEYPYFDSLQFGDS
VQSVKKLDEYTVEIRLQAPDASFLWHIATHYAPVLSAEYADNLTREGRQEMIDREPVGSGPFLLNEYRSGQYIRLARNDL
YWKGKPRMPQVVIDLGAGGTGRLSKLLTGECDVLAYPAASQLSILRDDPRLRLTLRPGMNIAYLAFNTRKPPLDDLKVRQ
AISLAINNQRLMQSIYYGTAETAASILPRASWAYDNDAHVTEFDPAKSREMLKQAGIESLNLRLWVPTASQSYNPSPLKT
AELIQADLAQVGIKVTIVPVEGRFQEARLMEMNHDLTLTGWATDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPGFDEVLQ
NALLSQQLAQRIENYQKAQKILEQQLPVLPLASSLRLQAYRYDIKGLVLSPFGNASFAGVFRESAQGPKK
>Mature_550_residues
MRGLPLWILSLSCLASTALASTPPAPAAAPPLPDIRQSGFVYCVSGILNTFNPQMASSGLTVDTLSAQLYDRLLDVDPYT
YRLIPELAQSWEVLDNGATYRFHLRKDVPFQTTAWFKPTRKLNADDVVFSFERVFNQKHPYHDVNGGEYPYFDSLQFGDS
VQSVKKLDEYTVEIRLQAPDASFLWHIATHYAPVLSAEYADNLTREGRQEMIDREPVGSGPFLLNEYRSGQYIRLARNDL
YWKGKPRMPQVVIDLGAGGTGRLSKLLTGECDVLAYPAASQLSILRDDPRLRLTLRPGMNIAYLAFNTRKPPLDDLKVRQ
AISLAINNQRLMQSIYYGTAETAASILPRASWAYDNDAHVTEFDPAKSREMLKQAGIESLNLRLWVPTASQSYNPSPLKT
AELIQADLAQVGIKVTIVPVEGRFQEARLMEMNHDLTLTGWATDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPGFDEVLQ
NALLSQQLAQRIENYQKAQKILEQQLPVLPLASSLRLQAYRYDIKGLVLSPFGNASFAGVFRESAQGPKK

Specific function: Involved in a peptide intake transport system that plays a role in the resistance to antimicrobial peptides [H]

COG id: COG4166

COG function: function code E; ABC-type oligopeptide transport system, periplasmic component

Gene ontology:

Cell location: Periplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1787551, Length=550, Percent_Identity=74.9090909090909, Blast_Score=848, Evalue=0.0,
Organism=Escherichia coli, GI1789966, Length=533, Percent_Identity=38.2739212007505, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1787052, Length=510, Percent_Identity=26.2745098039216, Blast_Score=149, Evalue=6e-37,
Organism=Escherichia coli, GI1787762, Length=489, Percent_Identity=23.9263803680982, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789887, Length=458, Percent_Identity=24.235807860262, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1789397, Length=535, Percent_Identity=25.981308411215, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1787495, Length=483, Percent_Identity=25.4658385093168, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081878, Length=461, Percent_Identity=24.5119305856833, Blast_Score=95, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 61645; Mature: 61645

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00027 HOMEOBOX_1 ; PS01040 SBP_BACTERIAL_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGLPLWILSLSCLASTALASTPPAPAAAPPLPDIRQSGFVYCVSGILNTFNPQMASSGL
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCHHEEHHHHHHHCCHHHHCCCC
TVDTLSAQLYDRLLDVDPYTYRLIPELAQSWEVLDNGATYRFHLRKDVPFQTTAWFKPTR
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCC
KLNADDVVFSFERVFNQKHPYHDVNGGEYPYFDSLQFGDSVQSVKKLDEYTVEIRLQAPD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEEECCC
ASFLWHIATHYAPVLSAEYADNLTREGRQEMIDREPVGSGPFLLNEYRSGQYIRLARNDL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEECCCC
YWKGKPRMPQVVIDLGAGGTGRLSKLLTGECDVLAYPAASQLSILRDDPRLRLTLRPGMN
EECCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEECCCHHHHHEEECCCCEEEEECCCCC
IAYLAFNTRKPPLDDLKVRQAISLAINNQRLMQSIYYGTAETAASILPRASWAYDNDAHV
EEEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCE
TEFDPAKSREMLKQAGIESLNLRLWVPTASQSYNPSPLKTAELIQADLAQVGIKVTIVPV
ECCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEC
EGRFQEARLMEMNHDLTLTGWATDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPGFDEVLQ
CCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
NALLSQQLAQRIENYQKAQKILEQQLPVLPLASSLRLQAYRYDIKGLVLSPFGNASFAGV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEECEEEECCCCCCHHHHH
FRESAQGPKK
HHHCCCCCCC
>Mature Secondary Structure
MRGLPLWILSLSCLASTALASTPPAPAAAPPLPDIRQSGFVYCVSGILNTFNPQMASSGL
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCHHEEHHHHHHHCCHHHHCCCC
TVDTLSAQLYDRLLDVDPYTYRLIPELAQSWEVLDNGATYRFHLRKDVPFQTTAWFKPTR
CHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEECCCCCC
KLNADDVVFSFERVFNQKHPYHDVNGGEYPYFDSLQFGDSVQSVKKLDEYTVEIRLQAPD
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEEEECCC
ASFLWHIATHYAPVLSAEYADNLTREGRQEMIDREPVGSGPFLLNEYRSGQYIRLARNDL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCEEEEECCCC
YWKGKPRMPQVVIDLGAGGTGRLSKLLTGECDVLAYPAASQLSILRDDPRLRLTLRPGMN
EECCCCCCCEEEEEECCCCCHHHHHHHCCCCCEEECCCHHHHHEEECCCCEEEEECCCCC
IAYLAFNTRKPPLDDLKVRQAISLAINNQRLMQSIYYGTAETAASILPRASWAYDNDAHV
EEEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCCCE
TEFDPAKSREMLKQAGIESLNLRLWVPTASQSYNPSPLKTAELIQADLAQVGIKVTIVPV
ECCCCHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHCCEEEEEEEC
EGRFQEARLMEMNHDLTLTGWATDSNDPDSFFRPLLSCAAIRSQTNYAHWCDPGFDEVLQ
CCCCCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
NALLSQQLAQRIENYQKAQKILEQQLPVLPLASSLRLQAYRYDIKGLVLSPFGNASFAGV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEEEECEEEECCCCCCHHHHH
FRESAQGPKK
HHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; peptides [Periplasm]; H2O [C]

Specific reaction: ATP + peptides [Periplasm] + H2O = ADP + phosphate + peptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8223423; 11677609 [H]