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The map label for this gene is ispA [H]

Identifier: 157369322

GI number: 157369322

Start: 1187631

End: 1188551

Strand: Reverse

Name: ispA [H]

Synonym: Spro_1079

Alternate gene names: 157369322

Gene position: 1188551-1187631 (Counterclockwise)

Preceding gene: 157369323

Following gene: 157369321

Centisome position: 21.81

GC content: 58.2

Gene sequence:

>921_bases
ATGTCCGAGACTGTCCAACAGACCGCCTTTTCTGACCAGTTGCAGGCTTTACGCCAGCGGGCCGACCGCACGCTGCTTAA
TTTTATCGCGCCACTGCCGTTCAATGATGGCAACATGGTGGCGGCAATGCGTCACGGCGCGCTGCTGGGCGGTAAACGTC
TGCGTCCGTTCCTGGTGTACACCACCGGACAGATGTTTGGCGTATCACTGAATAATTTGGATGCGCCCGCCGCTGCGGTA
GAATGCATTCACGCCTATTCTTTGATCCATGACGATCTGCCGGCGATGGACGACGACGATCTGCGTCGCGGTCAGCCGAC
CTGCCACATCAAATTTGGTGAGGCCAACGCCATTTTGGCCGGCGATGCCCTGCAAACGCTGGCATTTTCCATTCTGGCCG
ATGCCGAGATGCCCGACGTGGCACTGTGCGACCGGCTGGCGATGGTGTCCGAACTGGCAACCGCCAGCGGCGTTGCCGGC
ATGTGTGGCGGCCAGTCGCTGGATCTGGAAGCCGAAGACCGGCAGATTGGTCTGGAAGCGCTGGAGCAAATCCATCGACA
CAAAACCGGTGCCTTGATTCGCGCAGCCGTTCGCCTTGGGGCGTTAGCCGCCGGTGAGCCTGGCCGCGCCGCACTGGTGC
AGCTTGATCGCTACGCCGCTGCGATTGGCCTGGCGTTCCAGGTGCAGGATGATATTTTGGACGTGGTCGGCGAAACCGAA
AAAATCGGTAAACGCCAGGGGGCGGACCAGCAACACGGAAAGAGCACCTATCCAGCTTTGCTCGGGCTTGACAGCGCGAA
AGCAAAAGCGTGGGATCTCTATCAGGAAGCTTTAGCTGCATTAGACACTTTGGCAGCACAATCTTATAACACAGCGCCAT
TGCGAGCGTTAGCCAGCTTCATTATTGAACGCGACAATTAA

Upstream 100 bases:

>100_bases
AGAAACTGCAGCAGGCGGAGCAACGCGTACAAATTTTGCTTAACGACAGCGCCGATGATGCGGCGCTGACGCCTTTCACA
CCGGATGCCGAGTAATCACC

Downstream 100 bases:

>100_bases
CGTGTGACGTTAACTCCTCTGATATGAGTATCGAATGAGTCTTGATATAGCCAAATACCCGACCTTGGCGCTAGCGGAAA
ATCCGGATGAACTCCGTTCG

Product: geranyltranstransferase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MSETVQQTAFSDQLQALRQRADRTLLNFIAPLPFNDGNMVAAMRHGALLGGKRLRPFLVYTTGQMFGVSLNNLDAPAAAV
ECIHAYSLIHDDLPAMDDDDLRRGQPTCHIKFGEANAILAGDALQTLAFSILADAEMPDVALCDRLAMVSELATASGVAG
MCGGQSLDLEAEDRQIGLEALEQIHRHKTGALIRAAVRLGALAAGEPGRAALVQLDRYAAAIGLAFQVQDDILDVVGETE
KIGKRQGADQQHGKSTYPALLGLDSAKAKAWDLYQEALAALDTLAAQSYNTAPLRALASFIIERDN

Sequences:

>Translated_306_residues
MSETVQQTAFSDQLQALRQRADRTLLNFIAPLPFNDGNMVAAMRHGALLGGKRLRPFLVYTTGQMFGVSLNNLDAPAAAV
ECIHAYSLIHDDLPAMDDDDLRRGQPTCHIKFGEANAILAGDALQTLAFSILADAEMPDVALCDRLAMVSELATASGVAG
MCGGQSLDLEAEDRQIGLEALEQIHRHKTGALIRAAVRLGALAAGEPGRAALVQLDRYAAAIGLAFQVQDDILDVVGETE
KIGKRQGADQQHGKSTYPALLGLDSAKAKAWDLYQEALAALDTLAAQSYNTAPLRALASFIIERDN
>Mature_305_residues
SETVQQTAFSDQLQALRQRADRTLLNFIAPLPFNDGNMVAAMRHGALLGGKRLRPFLVYTTGQMFGVSLNNLDAPAAAVE
CIHAYSLIHDDLPAMDDDDLRRGQPTCHIKFGEANAILAGDALQTLAFSILADAEMPDVALCDRLAMVSELATASGVAGM
CGGQSLDLEAEDRQIGLEALEQIHRHKTGALIRAAVRLGALAAGEPGRAALVQLDRYAAAIGLAFQVQDDILDVVGETEK
IGKRQGADQQHGKSTYPALLGLDSAKAKAWDLYQEALAALDTLAAQSYNTAPLRALASFIIERDN

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=222, Percent_Identity=29.7297297297297, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1786623, Length=297, Percent_Identity=71.3804713804714, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1789578, Length=217, Percent_Identity=33.1797235023041, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17505681, Length=181, Percent_Identity=29.2817679558011, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24651612, Length=225, Percent_Identity=30.2222222222222, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32708; Mature: 32576

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETVQQTAFSDQLQALRQRADRTLLNFIAPLPFNDGNMVAAMRHGALLGGKRLRPFLVY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHCCCCCCCCEEEE
TTGQMFGVSLNNLDAPAAAVECIHAYSLIHDDLPAMDDDDLRRGQPTCHIKFGEANAILA
ECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEEECCCCEEEE
GDALQTLAFSILADAEMPDVALCDRLAMVSELATASGVAGMCGGQSLDLEAEDRQIGLEA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
LEQIHRHKTGALIRAAVRLGALAAGEPGRAALVQLDRYAAAIGLAFQVQDDILDVVGETE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHHHHHCCHH
KIGKRQGADQQHGKSTYPALLGLDSAKAKAWDLYQEALAALDTLAAQSYNTAPLRALASF
HHHHHCCCCHHCCCCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
IIERDN
HHCCCC
>Mature Secondary Structure 
SETVQQTAFSDQLQALRQRADRTLLNFIAPLPFNDGNMVAAMRHGALLGGKRLRPFLVY
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHCCCCCCCCEEEE
TTGQMFGVSLNNLDAPAAAVECIHAYSLIHDDLPAMDDDDLRRGQPTCHIKFGEANAILA
ECCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEEECCCCEEEE
GDALQTLAFSILADAEMPDVALCDRLAMVSELATASGVAGMCGGQSLDLEAEDRQIGLEA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
LEQIHRHKTGALIRAAVRLGALAAGEPGRAALVQLDRYAAAIGLAFQVQDDILDVVGETE
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEEEHHHHHHHHCCHH
KIGKRQGADQQHGKSTYPALLGLDSAKAKAWDLYQEALAALDTLAAQSYNTAPLRALASF
HHHHHCCCCHHCCCCCCHHHEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
IIERDN
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2089044; 9278503 [H]