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The map label for this gene is dxs

Identifier: 157369321

GI number: 157369321

Start: 1185731

End: 1187596

Strand: Reverse

Name: dxs

Synonym: Spro_1078

Alternate gene names: 157369321

Gene position: 1187596-1185731 (Counterclockwise)

Preceding gene: 157369322

Following gene: 157369320

Centisome position: 21.8

GC content: 58.25

Gene sequence:

>1866_bases
ATGAGTCTTGATATAGCCAAATACCCGACCTTGGCGCTAGCGGAAAATCCGGATGAACTCCGTTCGCTGCCAAAAGAGAG
CCTACCGAAGCTGTGTGACGAACTTCGGCAATACCTGCTGGACAGCGTCAGCCGCTCCAGCGGCCACTTTGCCTCCGGGC
TGGGTACCGTCGAACTGACGGTGGCATTGCACTATGTTTACCAAACCCCCTTCGATCATCTGGTATGGGACGTTGGCCAC
CAGGCCTACCCGCATAAAATTCTGACCGGTCGTCGCGACAAAATCGCCACCATCCGCCAGAAAAATGGCCTGCACCCTTT
CCCGTGGCGGGCAGAAAGTGAATACGACGTCCTGTCGGTCGGTCATTCTTCCACCTCGATCAGTGCCGGTCTCGGCATGG
CGGTAGCCGCTGCGCGTGAAGGCAAAAATCGCCGAACGGTCTGCGTGATCGGCGATGGCGCGATCACTGCCGGCATGGCG
TTTGAAGCCATGAACCACGCCGGTGACATCGATCCGGATATGCTGGTGGTGCTGAACGATAACGAAATGTCGATTTCGGA
AAACGTCGGCGCGCTGAACAACCATCTGGCGCAGTTGCTGTCCGGCAAGCTCTACTCCACCCTGCGTGAGGGCGGTAAAA
AAGTGCTGTCCGGCCTGCCGCCGATTAAAGAGCTGGTCAAACGCACCGAAGAACACCTGAAAGGCATGGTGGTACCGGGC
ACGCTGTTCGAAGAGCTGGGCTTTAACTATATCGGCCCGGTCGACGGCCACGATGTCCAGGGGCTGGTTGCCACGCTGAA
AAACATGCGTGACCTGAAAGGCCCGCAACTGCTGCACATCATGACCAAAAAAGGCCGTGGTTACGCCCCGGCGGAAAAAG
ACCCGATCAGCTTCCACGCGGTGCCGAAATTCGATCCGGCCAGCGGTACCCTGCCGAAAAGCGCCGGCGGCCTGCCAACT
TATTCAAAAGTTTTTGGCGACTGGCTGTGTGAAACCGCCGCCAAGGACAGCTCGCTGATGGCCATCACCCCGGCCATGCG
TGAAGGCTCGGGCATGGTGCAGTTCTCCCGTGACTATCCGCAGCAATATTTTGACGTGGCGATTGCCGAACAGCACGCGG
TGACCTTCGCTGCCGGTTTGGCCATTGGCGGTTATAAGCCGGTGGTGGCGATTTATTCCACCTTCCTGCAGCGCGCTTAC
GATCAGTTGATCCACGACGTCGCCATTCAAAAGCTGCCGGTGATGTTTGCCATCGATCGCGGCGGTATTGTCGGCGCTGA
CGGCCAGACTCACCAGGGAGCCTTTGACCTGTCATTTATGCGTTGCATCCCGACCATGGTGATCATGACGCCAAGTGATG
AAAACGAATGCCGTCAGATGCTGTACACCGGCTATCACTATAACGAAGGCCCAAGCGCCGTGCGTTATCCTCGTGGCAAT
GGTACCGGTGCACCGCTGGAACCTCTCAACTCTCTGCCGATCGGCAAAGGCGTTGTCCGTCGTGAAGGTGAAAAGCTGGC
GATCCTGAATTTCGGCACATTGCTGCCGGAAGCCGCGCAGGTAGCGGAAACGCTCAACGCAACGCTGGTGGATATGCGCT
TTGTGAAGCCACTGGACGAACAGCTGATACTGGAACTGGCAGCCAGCCACGACGCACTGGTCACGCTGGAAGAGAACGCC
ATTATGGGCGGTGCCGGCAGCGGCGTGAACGAGTTGCTGATGGCCAGGCGCCGTGTGGTACCGGTGCTGAATATCGGCCT
GCCGGACTTCTTTGTCTCCCAGGGTAGCCAGGAAGAAGTCCGTAGCGATCTCGGCCTGGACGCCGCCGGCATCCAGCGGC
AAATTGAGGTCTGGCTGGCGCAATAA

Upstream 100 bases:

>100_bases
GCACAATCTTATAACACAGCGCCATTGCGAGCGTTAGCCAGCTTCATTATTGAACGCGACAATTAACGTGTGACGTTAAC
TCCTCTGATATGAGTATCGA

Downstream 100 bases:

>100_bases
TCGTCGCGCCCGCTCGATCGACGCCTCCGCTTTGCGGGGGCGTTTTTATTTCTGTCATCCGAAAATCCGCTACAGTTAAA
GTTCTGTGCTGACACCGGGA

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MSLDIAKYPTLALAENPDELRSLPKESLPKLCDELRQYLLDSVSRSSGHFASGLGTVELTVALHYVYQTPFDHLVWDVGH
QAYPHKILTGRRDKIATIRQKNGLHPFPWRAESEYDVLSVGHSSTSISAGLGMAVAAAREGKNRRTVCVIGDGAITAGMA
FEAMNHAGDIDPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVLSGLPPIKELVKRTEEHLKGMVVPG
TLFEELGFNYIGPVDGHDVQGLVATLKNMRDLKGPQLLHIMTKKGRGYAPAEKDPISFHAVPKFDPASGTLPKSAGGLPT
YSKVFGDWLCETAAKDSSLMAITPAMREGSGMVQFSRDYPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY
DQLIHDVAIQKLPVMFAIDRGGIVGADGQTHQGAFDLSFMRCIPTMVIMTPSDENECRQMLYTGYHYNEGPSAVRYPRGN
GTGAPLEPLNSLPIGKGVVRREGEKLAILNFGTLLPEAAQVAETLNATLVDMRFVKPLDEQLILELAASHDALVTLEENA
IMGGAGSGVNELLMARRRVVPVLNIGLPDFFVSQGSQEEVRSDLGLDAAGIQRQIEVWLAQ

Sequences:

>Translated_621_residues
MSLDIAKYPTLALAENPDELRSLPKESLPKLCDELRQYLLDSVSRSSGHFASGLGTVELTVALHYVYQTPFDHLVWDVGH
QAYPHKILTGRRDKIATIRQKNGLHPFPWRAESEYDVLSVGHSSTSISAGLGMAVAAAREGKNRRTVCVIGDGAITAGMA
FEAMNHAGDIDPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVLSGLPPIKELVKRTEEHLKGMVVPG
TLFEELGFNYIGPVDGHDVQGLVATLKNMRDLKGPQLLHIMTKKGRGYAPAEKDPISFHAVPKFDPASGTLPKSAGGLPT
YSKVFGDWLCETAAKDSSLMAITPAMREGSGMVQFSRDYPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAY
DQLIHDVAIQKLPVMFAIDRGGIVGADGQTHQGAFDLSFMRCIPTMVIMTPSDENECRQMLYTGYHYNEGPSAVRYPRGN
GTGAPLEPLNSLPIGKGVVRREGEKLAILNFGTLLPEAAQVAETLNATLVDMRFVKPLDEQLILELAASHDALVTLEENA
IMGGAGSGVNELLMARRRVVPVLNIGLPDFFVSQGSQEEVRSDLGLDAAGIQRQIEVWLAQ
>Mature_620_residues
SLDIAKYPTLALAENPDELRSLPKESLPKLCDELRQYLLDSVSRSSGHFASGLGTVELTVALHYVYQTPFDHLVWDVGHQ
AYPHKILTGRRDKIATIRQKNGLHPFPWRAESEYDVLSVGHSSTSISAGLGMAVAAAREGKNRRTVCVIGDGAITAGMAF
EAMNHAGDIDPDMLVVLNDNEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVLSGLPPIKELVKRTEEHLKGMVVPGT
LFEELGFNYIGPVDGHDVQGLVATLKNMRDLKGPQLLHIMTKKGRGYAPAEKDPISFHAVPKFDPASGTLPKSAGGLPTY
SKVFGDWLCETAAKDSSLMAITPAMREGSGMVQFSRDYPQQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYD
QLIHDVAIQKLPVMFAIDRGGIVGADGQTHQGAFDLSFMRCIPTMVIMTPSDENECRQMLYTGYHYNEGPSAVRYPRGNG
TGAPLEPLNSLPIGKGVVRREGEKLAILNFGTLLPEAAQVAETLNATLVDMRFVKPLDEQLILELAASHDALVTLEENAI
MGGAGSGVNELLMARRRVVPVLNIGLPDFFVSQGSQEEVRSDLGLDAAGIQRQIEVWLAQ

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=498, Percent_Identity=23.8955823293173, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI4507521, Length=498, Percent_Identity=23.8955823293173, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI133778974, Length=497, Percent_Identity=23.3400402414487, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI225637461, Length=494, Percent_Identity=23.6842105263158, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI225637463, Length=494, Percent_Identity=23.6842105263158, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI225637459, Length=494, Percent_Identity=23.6842105263158, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=86.2903225806452, Blast_Score=1138, Evalue=0.0,
Organism=Drosophila melanogaster, GI45551847, Length=529, Percent_Identity=24.7637051039698, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI45550715, Length=529, Percent_Identity=24.7637051039698, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24645119, Length=529, Percent_Identity=24.7637051039698, Blast_Score=86, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_SERP5 (A8GAP2)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477310.1
- ProteinModelPortal:   A8GAP2
- SMR:   A8GAP2
- STRING:   A8GAP2
- GeneID:   5606888
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1078
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   SPRO399741:SPRO_1078-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 67414; Mature: 67283

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLDIAKYPTLALAENPDELRSLPKESLPKLCDELRQYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCCCEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEEE
VALHYVYQTPFDHLVWDVGHQAYPHKILTGRRDKIATIRQKNGLHPFPWRAESEYDVLSV
HHHHHHHHCCHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEE
GHSSTSISAGLGMAVAAAREGKNRRTVCVIGDGAITAGMAFEAMNHAGDIDPDMLVVLND
CCCCCCHHHCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVLSGLPPIKELVKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVQGLVATLKNMRDLKGPQLLHIMTKKGRGYAPAEKDPISFHA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEE
VPKFDPASGTLPKSAGGLPTYSKVFGDWLCETAAKDSSLMAITPAMREGSGMVQFSRDYP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHCCCCCEEECHHCC
QQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQLIHDVAIQKLPVMFAIDR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GGIVGADGQTHQGAFDLSFMRCIPTMVIMTPSDENECRQMLYTGYHYNEGPSAVRYPRGN
CCEECCCCCCCCCCHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCEECCCCC
GTGAPLEPLNSLPIGKGVVRREGEKLAILNFGTLLPEAAQVAETLNATLVDMRFVKPLDE
CCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCHHCHHHHHHHHHHHHHHHHHHHHCCHHH
QLILELAASHDALVTLEENAIMGGAGSGVNELLMARRRVVPVLNIGLPDFFVSQGSQEEV
HHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHHHHCCCEEECCCCHHHHCCCCHHHH
RSDLGLDAAGIQRQIEVWLAQ
HHHCCCCHHHHHHHHHEEECC
>Mature Secondary Structure 
SLDIAKYPTLALAENPDELRSLPKESLPKLCDELRQYLLDSVSRSSGHFASGLGTVELT
CCCCCCCCCEEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEEE
VALHYVYQTPFDHLVWDVGHQAYPHKILTGRRDKIATIRQKNGLHPFPWRAESEYDVLSV
HHHHHHHHCCHHHHHHHCCCCCCCCHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEE
GHSSTSISAGLGMAVAAAREGKNRRTVCVIGDGAITAGMAFEAMNHAGDIDPDMLVVLND
CCCCCCHHHCCHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLLSGKLYSTLREGGKKVLSGLPPIKELVKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPVDGHDVQGLVATLKNMRDLKGPQLLHIMTKKGRGYAPAEKDPISFHA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEE
VPKFDPASGTLPKSAGGLPTYSKVFGDWLCETAAKDSSLMAITPAMREGSGMVQFSRDYP
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHCCCCCEEECHHCC
QQYFDVAIAEQHAVTFAAGLAIGGYKPVVAIYSTFLQRAYDQLIHDVAIQKLPVMFAIDR
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GGIVGADGQTHQGAFDLSFMRCIPTMVIMTPSDENECRQMLYTGYHYNEGPSAVRYPRGN
CCEECCCCCCCCCCHHHHHHHHCCEEEEECCCCHHHHHHHHHCCCCCCCCCCCEECCCCC
GTGAPLEPLNSLPIGKGVVRREGEKLAILNFGTLLPEAAQVAETLNATLVDMRFVKPLDE
CCCCCCCCCCCCCCCCCHHHCCCCEEEEEECCHHCHHHHHHHHHHHHHHHHHHHHCCHHH
QLILELAASHDALVTLEENAIMGGAGSGVNELLMARRRVVPVLNIGLPDFFVSQGSQEEV
HHHHHHHCCCCEEEEEECCEEECCCCCCHHHHHHHHHHCCCEEECCCCHHHHCCCCHHHH
RSDLGLDAAGIQRQIEVWLAQ
HHHCCCCHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA