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The map label for this gene is soxR

Identifier: 157163532

GI number: 157163532

Start: 4309234

End: 4309698

Strand: Direct

Name: soxR

Synonym: EcHS_A4305

Alternate gene names: 157163532

Gene position: 4309234-4309698 (Clockwise)

Preceding gene: 157163530

Following gene: 157163534

Centisome position: 92.8

GC content: 51.83

Gene sequence:

>465_bases
ATGGAAAAGAAATTACCCCGCATTAAAGCGCTGCTAACCCCCGGCGAAGTGGCGAAACGCAGCGGTGTGGCGGTATCGGC
GCTGCATTTCTATGAAAGTAAAGGGTTGATTACCAGTATCCGTAACAGCGGCAATCAGCGGCGATATAAACGTGATGTGT
TGCGATATGTTGCAATTATCAAAATTGCTCAGCGTATTGGCATTCCGCTGGCGACCATTGGTGAAGCGTTTGGCGTGTTG
CCCGAAGGGCATACGTTAAGTGCGAAAGAGTGGAAACAGCTTTCGTCCCAATGGCGAGAAGAGTTGGATCGGCGCATTCA
TACCTTAGTGGCGCTGCGTGATGAACTGGACGGATGTATTGGTTGTGGCTGCCTTTCGCGCAGTGATTGCCCGTTGCGTA
ACCCGGGCGACCGCTTAGGAGAAGAAGGTACCGGCGCACGCTTGCTGGAAGATGAACAAAACTAA

Upstream 100 bases:

>100_bases
TTTCTGATGGGACATAAATCTGCCTCTTTTCAGTGTTCAGTTCGTTAATTCATCTGTTGGGGAGTATAATTCCTCAAGTT
AACTTGAGGTAAAGCGATTT

Downstream 100 bases:

>100_bases
AGCGCCACAAGGGCGCTTTAGTTTGTTTTCCGGTCTTTGTCTTTCTCTCTATCCCGCTGGTACACAGGAGGGTTTCCCCC
GACGTCAACACACCTCATTC

Product: redox-sensitive transcriptional activator SoxR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGEAFGVL
PEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN

Sequences:

>Translated_154_residues
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGEAFGVL
PEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN
>Mature_154_residues
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAIIKIAQRIGIPLATIGEAFGVL
PEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCIGCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN

Specific function: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster i

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain

Homologues:

Organism=Escherichia coli, GI1790498, Length=154, Percent_Identity=100, Blast_Score=313, Evalue=4e-87,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SOXR_ECO57 (P0ACS3)

Other databases:

- EMBL:   AE005174
- EMBL:   BA000007
- PIR:   A86100
- PIR:   E91259
- RefSeq:   NP_290696.1
- RefSeq:   NP_313072.1
- ProteinModelPortal:   P0ACS3
- SMR:   P0ACS3
- EnsemblBacteria:   EBESCT00000024596
- EnsemblBacteria:   EBESCT00000060036
- GeneID:   914292
- GeneID:   960061
- GenomeReviews:   AE005174_GR
- GenomeReviews:   BA000007_GR
- KEGG:   ece:Z5662
- KEGG:   ecs:ECs5045
- GeneTree:   EBGT00050000009853
- HOGENOM:   HBG710951
- OMA:   RGNQRRY
- ProtClustDB:   PRK15002
- BioCyc:   ECOL83334:ECS5045-MONOMER
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR010211
- InterPro:   IPR015358
- PRINTS:   PR00040
- SMART:   SM00422
- TIGRFAMs:   TIGR01950

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind; SSF46955 Putativ_DNA_bind

EC number: NA

Molecular weight: Translated: 17150; Mature: 17150

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS00552 HTH_MERR_1; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAII
CCCCCCHHHHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHH
KIAQRIGIPLATIGEAFGVLPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCI
HHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN
HCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAII
CCCCCCHHHHHCCCHHHHHHCCCCHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHH
KIAQRIGIPLATIGEAFGVLPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCI
HHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN
HCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796