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The map label for this gene is yjcC [H]

Identifier: 157163530

GI number: 157163530

Start: 4307236

End: 4308822

Strand: Direct

Name: yjcC [H]

Synonym: EcHS_A4303

Alternate gene names: 157163530

Gene position: 4307236-4308822 (Clockwise)

Preceding gene: 157163528

Following gene: 157163532

Centisome position: 92.76

GC content: 44.49

Gene sequence:

>1587_bases
ATGAGTCATCGTGCACGACACCAATTACTGGCGTTGCCGGGCATTATCTTTTTAGTTCTCTTTCCCATCATTCTTTCGCT
ATGGATTGCCTTCCTTTGGGCAAAATCAGAAGTGAATAATCAGCTCCGAACCTTTGCTCAACTGGCACTGGATAAATCCG
AGCTGGTCATTCGCCAGGCAGATTTAGTGAGCGATGCAGCTGAACGCTATCAGGGGCAAGTTTGCACTCCAGCCCATCAA
AAGCGAATGTTGAATATTATTCGTGGCTATCTTTATATTAATGAATTGATCTATGCCCGTGATAACCATTTTTTATGCTC
ATCGCTGATAGCGCCTGTAAACGGCTATACGATTGCACCGGCCGATTATAAGCGTGAACCTAACGTTTCTATCTATTATT
ACCGCGATACGCCTTTTTTCTCTGGCTATAAAATGACCTATATGCAGCGGGGAAATTATGTGGCGGTTATCAACCCTCTC
TTCTGGAGTGAAGTGATGTCTGATGACCCGACATTGCAATGGGGTGTGTATGATACGGTGACGAAAACCTTTTTCTCGTT
AAGCAAAGAGGCCTCGGCAGCAACGTTTTCTCCGCTGATTCATTTGAAGGATTTAACCGTACAAAGAAATGGCTATTTAT
ATGCGACAGTTTATTCGACAAAACGCCCAATTGCAGCCATTGTTGCGACTTCATATCAACGTCTTATAACCCATTTTTAT
AATCATCTTATTTTTGCGTTGCCCGCCGGTATTTTGGGGAGTCTTGTTCTGCTATTACTCTGGCTACGTATTCGACAAAA
CTATTTATCTCCCAAACGTAAATTGCAACGCGCCCTCGAAAAACATCAACTTTGTCTTTATTACCAGCCAATAATCGATA
TCAAAACAGAAAAATGTATCGGCGCTGAAGCGTTGTTACGTTGGCTTGGTGAGCAGGGGCAAATAATGAATCCGGCAGAG
TTTATTCCGCTGGCAGAAAAGGAGGGGATGATAGAACAGATAACTGATTATGTTATTGATAATGTCTTCCGCGATCTGGG
CGATTACCTGGCAACACATGCAGATCGCTATGTTTCTATTAACCTGTCGGCCTCCGATTTTCATACGTCACGGTTGATAG
CGCGAATCAATCAGAAAACAGAGCAATACGCGGTGCGTCCGCAGCAAATTAAATTTGAAGTGACTGAACATGCATTTCTT
GATGTTGACAAAATGACGCCGATTATTCTGGCTTTCCGCCAGGCAGGTTACGAAGTGGCAATTGATGATTTTGGTATTGG
CTACTCTAACTTGCATAACCTTAAATCATTGAATGTCGATATTTTGAAAATCGATAAATCGTTTGTTGAAACGCTGACCA
CCCACAAAACCAGTCATTTGATTGCGGAACACATCATCGAGCTGGCGCACAGCCTGGGGTTAAAAACGATCGCTGAAGGC
GTCGAAACTGAGGAGCAGGTTAACTGGCTGCGCAAACGCGGCGTGCGCTATTGCCAGGGATGGTTTTTTGCGAAGGCGAT
GCCGCCGCAGGTGTTTATGCAATGGATGGAGCAATTACCCGCGCGGGAGTTAACGCGCGGGCAATAA

Upstream 100 bases:

>100_bases
CAAAAGTGCTATTTATACCGTAAGATTTATCTAAAGACGTCGGTACCCAGGGTTTTCACCTTGCAATGGCCGGGTATAAA
CAGGCAGGAAATTGATAGCA

Downstream 100 bases:

>100_bases
AACTACAGGCGGTGGCGATAATCGCTGGGAGTGCGATCAAACTGCCGACGGAAAACGCGGGAGAAGGTCTGCTGCGAGAC
ATAACCCAGGTCCATTGCGA

Product: cyclic diguanylate phosphodiesterase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MSHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQADLVSDAAERYQGQVCTPAHQ
KRMLNIIRGYLYINELIYARDNHFLCSSLIAPVNGYTIAPADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPL
FWSEVMSDDPTLQWGVYDTVTKTFFSLSKEASAATFSPLIHLKDLTVQRNGYLYATVYSTKRPIAAIVATSYQRLITHFY
NHLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCIGAEALLRWLGEQGQIMNPAE
FIPLAEKEGMIEQITDYVIDNVFRDLGDYLATHADRYVSINLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFL
DVDKMTPIILAFRQAGYEVAIDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEG
VETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ

Sequences:

>Translated_528_residues
MSHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQADLVSDAAERYQGQVCTPAHQ
KRMLNIIRGYLYINELIYARDNHFLCSSLIAPVNGYTIAPADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPL
FWSEVMSDDPTLQWGVYDTVTKTFFSLSKEASAATFSPLIHLKDLTVQRNGYLYATVYSTKRPIAAIVATSYQRLITHFY
NHLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCIGAEALLRWLGEQGQIMNPAE
FIPLAEKEGMIEQITDYVIDNVFRDLGDYLATHADRYVSINLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFL
DVDKMTPIILAFRQAGYEVAIDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEG
VETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ
>Mature_527_residues
SHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQADLVSDAAERYQGQVCTPAHQK
RMLNIIRGYLYINELIYARDNHFLCSSLIAPVNGYTIAPADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPLF
WSEVMSDDPTLQWGVYDTVTKTFFSLSKEASAATFSPLIHLKDLTVQRNGYLYATVYSTKRPIAAIVATSYQRLITHFYN
HLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCIGAEALLRWLGEQGQIMNPAEF
IPLAEKEGMIEQITDYVIDNVFRDLGDYLATHADRYVSINLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFLD
VDKMTPIILAFRQAGYEVAIDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEGV
ETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ

Specific function: Overexpression reduces biofilm formation [H]

COG id: COG4943

COG function: function code T; Predicted signal transduction protein containing sensor and EAL domains

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI1790496, Length=528, Percent_Identity=99.8106060606061, Blast_Score=1095, Evalue=0.0,
Organism=Escherichia coli, GI87081743, Length=528, Percent_Identity=33.5227272727273, Blast_Score=297, Evalue=1e-81,
Organism=Escherichia coli, GI87081980, Length=259, Percent_Identity=35.1351351351351, Blast_Score=154, Evalue=2e-38,
Organism=Escherichia coli, GI1788502, Length=281, Percent_Identity=29.8932384341637, Blast_Score=152, Evalue=6e-38,
Organism=Escherichia coli, GI87081921, Length=247, Percent_Identity=36.4372469635627, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI87081845, Length=279, Percent_Identity=31.5412186379928, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI226510982, Length=251, Percent_Identity=37.4501992031873, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1787541, Length=249, Percent_Identity=32.5301204819277, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI1788849, Length=236, Percent_Identity=31.3559322033898, Blast_Score=128, Evalue=9e-31,
Organism=Escherichia coli, GI87082096, Length=235, Percent_Identity=31.9148936170213, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786507, Length=242, Percent_Identity=31.8181818181818, Blast_Score=122, Evalue=7e-29,
Organism=Escherichia coli, GI1787055, Length=254, Percent_Identity=31.1023622047244, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1787410, Length=225, Percent_Identity=28, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: NA

Molecular weight: Translated: 60818; Mature: 60687

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
DLVSDAAERYQGQVCTPAHQKRMLNIIRGYLYINELIYARDNHFLCSSLIAPVNGYTIAP
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEECC
ADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPLFWSEVMSDDPTLQWGVYDTV
CCCCCCCCCEEEEEECCCCCCCEEEEEEECCCEEEEECHHHHHHHHCCCCCEEECHHHHH
TKTFFSLSKEASAATFSPLIHLKDLTVQRNGYLYATVYSTKRPIAAIVATSYQRLITHFY
HHHHHHHHHCCCCHHHHHHHHHHHEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
NHLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCHHCCCCHHCC
GAEALLRWLGEQGQIMNPAEFIPLAEKEGMIEQITDYVIDNVFRDLGDYLATHADRYVSI
CHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFLDVDKMTPIILAFRQAGYEVA
EECCCHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEE
IDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEG
EECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
VETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ
CCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCC
>Mature Secondary Structure 
SHRARHQLLALPGIIFLVLFPIILSLWIAFLWAKSEVNNQLRTFAQLALDKSELVIRQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
DLVSDAAERYQGQVCTPAHQKRMLNIIRGYLYINELIYARDNHFLCSSLIAPVNGYTIAP
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCEECC
ADYKREPNVSIYYYRDTPFFSGYKMTYMQRGNYVAVINPLFWSEVMSDDPTLQWGVYDTV
CCCCCCCCCEEEEEECCCCCCCEEEEEEECCCEEEEECHHHHHHHHCCCCCEEECHHHHH
TKTFFSLSKEASAATFSPLIHLKDLTVQRNGYLYATVYSTKRPIAAIVATSYQRLITHFY
HHHHHHHHHCCCCHHHHHHHHHHHEEEEECCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
NHLIFALPAGILGSLVLLLLWLRIRQNYLSPKRKLQRALEKHQLCLYYQPIIDIKTEKCI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEECCHHCCCCHHCC
GAEALLRWLGEQGQIMNPAEFIPLAEKEGMIEQITDYVIDNVFRDLGDYLATHADRYVSI
CHHHHHHHHCCCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
NLSASDFHTSRLIARINQKTEQYAVRPQQIKFEVTEHAFLDVDKMTPIILAFRQAGYEVA
EECCCHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEE
IDDFGIGYSNLHNLKSLNVDILKIDKSFVETLTTHKTSHLIAEHIIELAHSLGLKTIAEG
EECCCCCHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHC
VETEEQVNWLRKRGVRYCQGWFFAKAMPPQVFMQWMEQLPARELTRGQ
CCHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8265357; 9278503 [H]