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The map label for this gene is mltC [H]

Identifier: 157162425

GI number: 157162425

Start: 3133351

End: 3134430

Strand: Direct

Name: mltC [H]

Synonym: EcHS_A3124

Alternate gene names: 157162425

Gene position: 3133351-3134430 (Clockwise)

Preceding gene: 157162423

Following gene: 157162426

Centisome position: 67.48

GC content: 51.02

Gene sequence:

>1080_bases
ATGAAAAAATATCTCGCGCTGGCTTTGATTGCGCCGTTGCTCATCTCCTGTTCGACGACCAAAAAAGGCGATACCTATAA
CGAAGCCTGGGTCAAAGATACCAACGGTTTTGATATTCTGATGGGGCAATTTGCCCACAATATTGAGAACATCTGGGGAT
TCAAAGAGGTGGTGATCGCCGGTCCTAAGGACTACGTGAAATACACCGATCAATATCAGACCCGCAGCCACATCAACTTC
GATGACGGTACGATTACTATCGAAACTATCGCCGGGACAGAACCTGCCGCGCATTTGCGCCGGGCAATTATCAAAACGTT
GCTGATGGGTGACGATCCGAGTTCGGTCGATCTCTATTCCGACGTTGATGATATTACGATTTCGAAAGAACCTTTCCTTT
ACGGTCAGGTGGTGGACAACACCGGGCAGCCGATTCGCTGGGAAGGTCGCGCAAGCAACTTCGCGGATTATCTGCTGAAA
AACCGTCTGCAAAGCCGCAGTAACGGGCTGCGTATCATCTACAGCGTCACCATTAACATGGTACCGAACCACCTTGATAA
ACGTGCGCACAAATATCTCGGCATGGTCCGCCAGGCGTCACGGAAATATGGCGTTGATGAGTCGCTGATTCTGGCAATTA
TGCAGACCGAATCTTCCTTTAACCCGTATGCGGTCAGCCGTTCCGATGCGCTGGGATTAATGCAGGTGGTACAACATACT
GCCGGGAAAGATGTGTTCCGCTCGCAGGGGAAATCCGGCACGCCGAGCCGCAGTTTCTTGTTTGATCCTGCCAGCAATAT
TGATACCGGCACCGCGTATCTGGCGATGCTGAACAATGTTTATCTCGGCGGAATTGATAACCCAACATCGCGGCGTTATG
CCGTCATCACCGCCTATAACGGCGGCGCAGGCAGCGTGCTGCGAGTCTTTTCGAATGATAAGATTCAGGCTGCCAATATT
ATTAACACCATGACGCCGGGCGATGTTTATCAGACGCTGACGACCCGCCATCCCTCTGCGGAATCTCGCCGTTATCTTTA
TAAAGTGAATACCGCGCAAAAATCCTACCGCCGCCGATAA

Upstream 100 bases:

>100_bases
CATATCGAGGGCTATACGCCGGAAGATAAAAAATAAAAACAGTGCCGGAGCACGCCTCCGGCAACTTGCATAAAAACAAA
CACAACACGCACCCGGAATG

Downstream 100 bases:

>100_bases
TTCCATTAACCGCCCCTGACGATGCTCAGGGGCAAAAATGTTATCCACATCACAATTTCGTTTTGCAAATTGGGAATGTT
TGCAATTATTTGCCACAGGT

Product: murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIAGPKDYVKYTDQYQTRSHINF
DDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLK
NRLQSRSNGLRIIYSVTINMVPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHT
AGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANI
INTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR

Sequences:

>Translated_359_residues
MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIAGPKDYVKYTDQYQTRSHINF
DDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLK
NRLQSRSNGLRIIYSVTINMVPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHT
AGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANI
INTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR
>Mature_359_residues
MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIAGPKDYVKYTDQYQTRSHINF
DDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYSDVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLK
NRLQSRSNGLRIIYSVTINMVPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHT
AGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYNGGAGSVLRVFSNDKIQAANI
INTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=359, Percent_Identity=99.7214484679666, Blast_Score=742, Evalue=0.0,
Organism=Escherichia coli, GI87081855, Length=166, Percent_Identity=40.3614457831325, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 40113; Mature: 40113

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCEEEE
GPKDYVKYTDQYQTRSHINFDDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYS
CCHHHHHHCCCHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEECC
DVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLKNRLQSRSNGLRIIYSVTINM
CCCCCEECCCCEEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEC
VPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHT
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCEEECCHHHHHHHHHHHHH
AGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYN
CCHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCEEECCCCCCCCCEEEEEEEEC
GGAGSVLRVFSNDKIQAANIINTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR
CCCCCEEEEECCCCEEEHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEECHHHHHHCCC
>Mature Secondary Structure
MKKYLALALIAPLLISCSTTKKGDTYNEAWVKDTNGFDILMGQFAHNIENIWGFKEVVIA
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCEEEE
GPKDYVKYTDQYQTRSHINFDDGTITIETIAGTEPAAHLRRAIIKTLLMGDDPSSVDLYS
CCHHHHHHCCCHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEECC
DVDDITISKEPFLYGQVVDNTGQPIRWEGRASNFADYLLKNRLQSRSNGLRIIYSVTINM
CCCCCEECCCCEEEEEEECCCCCCEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEEEEEC
VPNHLDKRAHKYLGMVRQASRKYGVDESLILAIMQTESSFNPYAVSRSDALGLMQVVQHT
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCCCCCEEECCHHHHHHHHHHHHH
AGKDVFRSQGKSGTPSRSFLFDPASNIDTGTAYLAMLNNVYLGGIDNPTSRRYAVITAYN
CCHHHHHHCCCCCCCCCCEEECCCCCCCCHHHHHHHHHCEEECCCCCCCCCEEEEEEEEC
GGAGSVLRVFSNDKIQAANIINTMTPGDVYQTLTTRHPSAESRRYLYKVNTAQKSYRRR
CCCCCEEEEECCCCEEEHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEECHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA